MicroRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling

Radiotherapy and Oncology

Volumn 101, Issue 1, 2011, Pages 171-176

  Lee, Kyung Min ^b   Choi, Eun Jung ^b   Kim, In Ah ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

Author keywords

Akt; EGFR; microRNA 7; PI3K; Radiosensitivity

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MICRORNA; MICRORNA 7; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENE TARGETING; GLIOBLASTOMA; HUMAN; HUMAN CELL; LARYNX CARCINOMA; LUNG CARCINOMA; PRIORITY JOURNAL; RADIOSENSITIVITY; SQUAMOUS CELL CARCINOMA;

BLOTTING, WESTERN; DOWN-REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MICRORNAS; RADIATION TOLERANCE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 80655149145     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.05.050     Document Type: Article

References (25)

1. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism and function Cell 116 2004 282 297
2. G.A. Calin, C. Sevignani, and C.D. Dumitru Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers Proc Natl Acad Sci USA 101 2004 2999 3004 (Pubitemid 38327724)
3. C. Caldas, and J.D. Brenton Sizing up miRNAs as cancer genes Nat Med 11 2005 712 714 (Pubitemid 41021196)
4. C.L. Arteaga The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia J Clin Oncol 19 2001 30s 40s
5. X. Li, and R.W. Carthew A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophilia eye Cell 123 2005 1267 1277 (Pubitemid 41821784)
6. I.A. Kim, S.S. Bae, and A. Fernandes Selective inhibition of Ras, Phosphoinositide 3 kinase and Akt isoforms increases the radiosensitivity of human carcinoma cell lines Cancer Res 65 2005 7902 7910 (Pubitemid 41297268)
7. I.A. Kim, M. No, and J.M. Lee Epigenetic modulation of radiation response in human cancer cells with activated EGFR or HER-2 signaling: potential role of histone deacetylase 6 Radiother Oncol 92 2009 125 132
8. B. Kefas, J. Godlewski, and L. Comeau MicroRNA-7 inhibits the epidermal growth factor receptor and Akt pathway and is down-regulated in glioblastoma Cancer Res 68 2008 3566 3572
9. R.J. Webster, K.M. Giles, K.J. Price, P.M. Zhang, J.S. Mattick, and P.J. Leedman Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7 J Biol Chem 284 2009 5731 5741
10. C.Z. Chen MicroRNAs as oncogene and tumor suppressors N Engl J Med 353 2005 1768 1771
11. A. Esquela-Kerscher, and F.J. Slack Oncomirs - microRNAs with a role in cancer Nat Rev Cancer 6 2006 259 267
12. J.A. Calin, and C.M. Croce MicroRNA-cancer connection: the beginning of a new tale Cancer Res 66 2006 1390 1394
13. S.M. Johnson, H. Grosshans, and J. Shingara RAS is regulated by the let-7 microRNA family Cell 120 2005 635 647 (Pubitemid 40343076)
14. J.S. Oh, J.J. Kim, J.Y. Byun, and I.A. Kim Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-RAS Int J Radiat Oncol Biol Phys 76 2010 5 8
15. E.V. Makeyev, and T. Maniatis Multilevel regulation of gene expression by microRNAs Science 319 2008 1789 1790 (Pubitemid 351451555)
16. MicroRNA-7, a Homeobox D10 target, inhibits p21-activated kinase1 and regulates its functions. Cancer Res 2008;68:8195-9.
17. R. Kumar, A.E. Gururaj, and C.J. Barnes P21-activated kinases in cancer Nat Rev Cancer 6 2006 459 471
18. E.J. Choi, Y.K. Ryu, S.Y. Kim, H.G. Wu, J.S. Kim, and I.H. Kim Targeting epidermal growth factor receptor-associated signaling pathways in non-small cell lung cancer cells: implication in radiation response Mol Cancer Res 8 2010 1027 1036
19. K. Berns, H.M. Horlings, B.T. Hennessy, M. Madiredjo, E.M. Hijmans, and K. Beelen A functional genetic approach identifies the PI3K pathway as a major determinant of tratuzumab resistance in breast cancer Cancer Cell 12 2007 395 402 (Pubitemid 47539306)
20. M. Toulany, K. Dittmann, M. Kruger, M. Baumann, and H.P. Rodemann Radioresistance of K-RAS mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway Radiother Oncol 76 2005 143 150 (Pubitemid 41725440)
21. M. Toulany, U. Kasten-Pisula, I. Brammer, S. Wang, J. Chen, and K. Dittmann Blockage of epidermal growth factor receptor - phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair Clin Cancer Res 12 2006 4119 4126 (Pubitemid 44078101)
22. M. Toulany, R. Kehlbach, and U. Florczak Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKs-dependent DNA double-strand break repair Mol Can Ther 7 2008 1772 1781
23. L. Bozulic, B. Surucu, D. Hynx, and B.A. Hemmings PKBα/AKT1 acts downstream of DNA-PK in DNA double-stand break response and promotes survival Mol Cell 30 2008 203 213 (Pubitemid 351626686)
24. Trang P, Wiggins JF, Daige CL, Cho C, Omotola M, Brown D, Weidhaas JB, Bader AG, Slack FJ. Systemic delivery of tumor suppressor microRNA mimics using neutral lipid emulsion inhibits lung tumors in mice. Mol Ther 2011 Mar 22 [Epub ahead of print].
25. J. Su, H. Baigude, J. McCarroll, and T.M. Rana Silencing microRNA by interfering nanoparticles in mice Nucleic Acids Res 39 2011 e38