-
1
-
-
67650874081
-
Cancer statistics, 2009
-
19474385 10.3322/caac.20006
-
A. Jemal R. Siegel E. Ward Y. Hao J. Xu M.J. Thun 2009 Cancer statistics, 2009 CA Cancer J Clin 59 225 249 19474385 10.3322/caac.20006
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Thun, M.J.6
-
2
-
-
41049100716
-
Mutations in the epidermal growth factor receptor gene and effects of EGFR-tyrosine kinase inhibitors on lung cancers
-
DOI 10.1007/s11748-007-0193-8
-
T. Fukui T. Mitsudomi 2008 Mutations in the epidermal growth factor receptor gene and effects of EGFR-tyrosine kinase inhibitors on lung cancers Gen Thorac Cardiovasc Surg 56 97 103 18340507 10.1007/s11748-007-0193-8 (Pubitemid 351419126)
-
(2008)
General Thoracic and Cardiovascular Surgery
, vol.56
, Issue.3
, pp. 97-103
-
-
Fukui, T.1
Mitsudomi, T.2
-
3
-
-
70349591635
-
Usefulness of cumulative smoking dose for identifying the EGFR mutation and patients with non-small-cell lung cancer for gefitinib treatment
-
19650855 10.1111/j.1349-7006.2009.01273.x 1:CAS:528:DC%2BD1MXht12qs7nP
-
M. Jida S. Toyooka T. Mitsudomi T. Takano K. Matsuo K. Hotta, et al. 2009 Usefulness of cumulative smoking dose for identifying the EGFR mutation and patients with non-small-cell lung cancer for gefitinib treatment Cancer Sci 100 1931 1934 19650855 10.1111/j.1349-7006.2009.01273.x 1:CAS:528:DC%2BD1MXht12qs7nP
-
(2009)
Cancer Sci
, vol.100
, pp. 1931-1934
-
-
Jida, M.1
Toyooka, S.2
Mitsudomi, T.3
Takano, T.4
Matsuo, K.5
Hotta, K.6
-
4
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
DOI 10.1056/NEJMoa061884
-
A. Sandler R. Gray M.C. Perry J. Brahmer J.H. Schiller A. Dowlati, et al. 2006 Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer N Engl J Med 355 2542 2550 17167137 10.1056/NEJMoa061884 1:CAS:528:DC%2BD28XhtlWqsbzI (Pubitemid 44917502)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
5
-
-
0034773992
-
The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities
-
10.1016/S0959-8049(01)00230-1
-
Y. Yarden 2001 The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities Eur J Cancer 4 S3 S8 10.1016/S0959-8049(01)00230-1
-
(2001)
Eur J Cancer
, vol.4
-
-
Yarden, Y.1
-
6
-
-
2342624080
-
EGFR mutations in lung, cancer: Correlation with clinical response to gefitinib therapy
-
DOI 10.1126/science.1099314
-
J.G. Paez P.A. Janne J.C. Lee S. Tracy H. Greulich S. Gabriel, et al. 2004 EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 304 1497 1500 15118125 10.1126/science.1099314 1:CAS:528:DC%2BD2cXksVGmsbs%3D (Pubitemid 38720929)
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
Naoki, K.11
Sasaki, H.12
Fujii, Y.13
Eck, M.J.14
Sellers, W.R.15
Johnson, B.E.16
Meyerson, M.17
-
7
-
-
2342471392
-
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib
-
DOI 10.1056/NEJMoa040938
-
T.J. Lynch D.W. Bell R. Sordella S. Gurubhagavatula R.A. Okimoto B.W. Brannigan, et al. 2004 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med 350 2129 2139 15118073 10.1056/NEJMoa040938 1:CAS:528: DC%2BD2cXktF2js7c%3D (Pubitemid 38637993)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
8
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
DOI 10.1093/jnci/dji055
-
H. Shigematsu L. Lin T. Takahashi M. Nomura M. Suzuki I.I. Wistuba, et al. 2005 Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers J Natl Cancer Inst 97 339 346 15741570 10.1093/jnci/dji055 1:CAS:528:DC%2BD2MXitV2jsb4%3D (Pubitemid 40425952)
-
(2005)
Journal of the National Cancer Institute
, vol.97
, Issue.5
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
Nomura, M.4
Suzuki, M.5
Wistuba, I.I.6
Fong, K.M.7
Lee, H.8
Toyooka, S.9
Shimizu, N.10
Fujisawa, T.11
Feng, Z.12
Roth, J.A.13
Herz, J.14
Minna, J.D.15
Gazdar, A.F.16
-
9
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
DOI 10.1056/NEJMoa044238
-
S. Kobayashi T.J. Boggon T. Dayaram P.A. Janne O. Kocher M. Meyerson, et al. 2005 EGFR mutation and resistance of nonsmall-cell lung cancer to gefitinib N Engl J Med 352 786 792 15728811 10.1056/NEJMoa044238 1:CAS:528: DC%2BD2MXhsFCiurk%3D (Pubitemid 40271173)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.8
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
Janne, P.A.4
Kocher, O.5
Meyerson, M.6
Johnson, B.E.7
Eck, M.J.8
Tenen, D.G.9
Halmos, B.10
-
10
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
DOI 10.1371/journal.pmed.0020073, e73
-
W. Pao V.A. Miller K.A. Politi G.J. Riely R. Somwar M.F. Zakowski, et al. 2005 Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain PLoS Med 2 e73 15737014 10.1371/journal.pmed.0020073 (Pubitemid 40629469)
-
(2005)
PLoS Medicine
, vol.2
, Issue.3
, pp. 0225-0235
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
Riely, G.J.4
Somwar, R.5
Zakowski, M.F.6
Kris, M.G.7
Varmus, H.8
-
11
-
-
33748074447
-
Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer
-
DOI 10.1158/0008-5472.CAN-06-1951
-
M. Inukai S. Toyooka S. Ito H. Asano S. Ichihara J. Soh, et al. 2006 Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer Cancer Res 66 7854 7858 16912157 10.1158/0008-5472.CAN-06-1951 1:CAS:528:DC%2BD28XotFWqsbo%3D (Pubitemid 44299146)
-
(2006)
Cancer Research
, vol.66
, Issue.16
, pp. 7854-7858
-
-
Inukai, M.1
Toyooka, S.2
Ito, S.3
Asano, H.4
Ichihara, S.5
Soh, J.6
Suehisa, H.7
Ouchida, M.8
Aoe, K.9
Aoe, M.10
Kiura, K.11
Shimizu, N.12
Date, H.13
-
12
-
-
70449433271
-
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells
-
Soh J, Okumura N, Lockwood WW, Yamamoto H, Shigematsu H, Zhang W, et al. Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells. PLoS One 2009:e7464.
-
(2009)
PLoS One
-
-
Soh, J.1
Okumura, N.2
Lockwood, W.W.3
Yamamoto, H.4
Shigematsu, H.5
Zhang, W.6
-
13
-
-
20444498630
-
Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
-
DOI 10.1093/jnci/dji112
-
F. Cappuzzo F.R. Hirsch E. Rossi S. Bartolini G.L. Ceresoli L. Bemis, et al. 2005 Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer J Natl Cancer Inst 97 643 655 15870435 10.1093/jnci/dji112 1:CAS:528:DC%2BD2MXjvFymt70%3D (Pubitemid 40812628)
-
(2005)
Journal of the National Cancer Institute
, vol.97
, Issue.9
, pp. 643-655
-
-
Cappuzzo, F.1
Hirsch, F.R.2
Rossi, E.3
Bartolini, S.4
Ceresoli, G.L.5
Bemis, L.6
Haney, J.7
Witta, S.8
Danenberg, K.9
Domenichini, I.10
Ludovini, V.11
Magrini, E.12
Gregorc, V.13
Doglioni, C.14
Sidoni, A.15
Tonato, M.16
Franklin, W.A.17
Crino, L.18
Bunn Jr., P.A.19
Varella-Garcia, M.20
more..
-
14
-
-
33846994719
-
The impact of epidermal growth factor receptor gene status on gefitinib-treated Japanese patients with non-small-cell lung cancer
-
17192902 10.1002/ijc.22513 1:CAS:528:DC%2BD2sXhvVOjurk%3D
-
S. Ichihara S. Toyooka Y. Fujiwara K. Hotta H. Shigematsu M. Tokumo, et al. 2007 The impact of epidermal growth factor receptor gene status on gefitinib-treated Japanese patients with non-small-cell lung cancer Int J Cancer 120 1239 1247 17192902 10.1002/ijc.22513 1:CAS:528:DC%2BD2sXhvVOjurk%3D
-
(2007)
Int J Cancer
, vol.120
, pp. 1239-1247
-
-
Ichihara, S.1
Toyooka, S.2
Fujiwara, Y.3
Hotta, K.4
Shigematsu, H.5
Tokumo, M.6
-
15
-
-
84887212361
-
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines
-
19238210 10.1371/journal.pone.0004576
-
J. Gandhi J. Zhang Y. Xie J. Soh H. Shigematsu W. Zhang, et al. 2009 Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines PLoS One 4 e4576 19238210 10.1371/journal.pone.0004576
-
(2009)
PLoS One
, vol.4
, pp. 4576
-
-
Gandhi, J.1
Zhang, J.2
Xie, Y.3
Soh, J.4
Shigematsu, H.5
Zhang, W.6
-
16
-
-
28844501639
-
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
-
DOI 10.1002/ijc.21496
-
H. Shigematsu A.F. Gazdar 2006 Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers Int J Cancer 118 257 262 16231326 10.1002/ijc.21496 1:CAS:528:DC%2BD2MXhtlWqs7bF (Pubitemid 41779062)
-
(2006)
International Journal of Cancer
, vol.118
, Issue.2
, pp. 257-262
-
-
Shigematsu, H.1
Gazdar, A.F.2
-
17
-
-
24644445676
-
Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients
-
DOI 10.1200/JCO.2005.09.111
-
F. Cappuzzo M. Varella-Garcia H. Shigematsu I. Domenichini S. Bartolini G.L. Ceresoli, et al. 2005 Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients J Clin Oncol 23 5007 5018 16051952 10.1200/JCO.2005.09.111 1:CAS:528:DC%2BD2MXpsFWmtLo%3D (Pubitemid 46224007)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.22
, pp. 5007-5018
-
-
Cappuzzo, F.1
Varella-Garcia, M.2
Shigematsu, H.3
Domenichini, I.4
Bartolini, S.5
Ceresoli, G.L.6
Rossi, E.7
Ludovini, V.8
Gregorc, V.9
Toschi, L.10
Franklin, W.A.11
Crino, L.12
Gazdar, A.F.13
Bunn Jr., P.A.14
Hirsch, F.R.15
-
18
-
-
34547098367
-
Impact of HER2 and EGFR gene status on gefitinib-treated patients with nonsmall-cell lung cancer
-
DOI 10.1002/ijc.22818
-
J. Soh S. Toyooka S. Ichihara Y. Fujiwara K. Hotta H. Suehisa, et al. 2007 Impact of HER2 and EGFR gene status on gefitinibtreated patients with nonsmall-cell lung cancer Int J Cancer 121 1162 1167 17487844 10.1002/ijc.22818 1:CAS:528:DC%2BD2sXhtFGhu7nI (Pubitemid 47101657)
-
(2007)
International Journal of Cancer
, vol.121
, Issue.5
, pp. 1162-1167
-
-
Soh, J.1
Toyooka, S.2
Ichihara, S.3
Fujiwara, Y.4
Hotta, K.5
Suehisa, H.6
Kobayashi, N.7
Ichimura, K.8
Aoe, K.9
Aoe, M.10
Kiura, K.11
Date, H.12
-
19
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
DOI 10.1126/science.1141478
-
J.A. Engelman K. Zejnullahu T. Mitsudomi Y. Song C. Hyland J.O. Park, et al. 2007 MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling Science 316 1039 1043 17463250 10.1126/science. 1141478 1:CAS:528:DC%2BD2sXltlOjt7g%3D (Pubitemid 46799492)
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Joon, O.P.6
Lindeman, N.7
Gale, C.-M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
Cappuzzo, F.14
Mok, T.15
Lee, C.16
Johnson, B.E.17
Cantley, L.C.18
Janne, P.A.19
-
20
-
-
62449250134
-
MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors
-
19117057 10.1002/ijc.24150 1:CAS:528:DC%2BD1MXjslSmsrY%3D
-
T. Kubo H. Yamamoto W.W. Lockwood I. Valencia J. Soh M. Peyton, et al. 2009 MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors Int J Cancer 124 1778 1784 19117057 10.1002/ijc.24150 1:CAS:528:DC%2BD1MXjslSmsrY%3D
-
(2009)
Int J Cancer
, vol.124
, pp. 1778-1784
-
-
Kubo, T.1
Yamamoto, H.2
Lockwood, W.W.3
Valencia, I.4
Soh, J.5
Peyton, M.6
-
21
-
-
61549138135
-
Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
-
19096300 10.1097/JTO.0b013e3181913e0e
-
R. Onozato T. Kosaka H. Kuwano Y. Sekido Y. Yatabe T. Mitsudomi 2009 Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers J Thorac Oncol 4 5 11 19096300 10.1097/JTO.0b013e3181913e0e
-
(2009)
J Thorac Oncol
, vol.4
, pp. 5-11
-
-
Onozato, R.1
Kosaka, T.2
Kuwano, H.3
Sekido, Y.4
Yatabe, Y.5
Mitsudomi, T.6
-
22
-
-
56449089812
-
Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
-
19010923 10.1158/0008-5472.CAN-08-1643 1:CAS:528:DC%2BD1cXhtlOmt7jE
-
S. Yano W. Wang Q. Li K. Matsumoto H. Sakurama T. Nakamura, et al. 2008 Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations Cancer Res 68 9479 9487 19010923 10.1158/0008-5472.CAN-08-1643 1:CAS:528:DC%2BD1cXhtlOmt7jE
-
(2008)
Cancer Res
, vol.68
, pp. 9479-9487
-
-
Yano, S.1
Wang, W.2
Li, Q.3
Matsumoto, K.4
Sakurama, H.5
Nakamura, T.6
-
23
-
-
73649102105
-
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
-
20129249 10.1016/j.ccr.2009.11.022 1:CAS:528:DC%2BC3cXkvFKgs7Y%3D
-
A.B. Turke K. Zejnullahu Y.L. Wu Y. Song D. Dias-Santagata E. Lifshits, et al. 2010 Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC Cancer Cell 17 77 88 20129249 10.1016/j.ccr.2009.11.022 1:CAS:528:DC%2BC3cXkvFKgs7Y%3D
-
(2010)
Cancer Cell
, vol.17
, pp. 77-88
-
-
Turke, A.B.1
Zejnullahu, K.2
Wu, Y.L.3
Song, Y.4
Dias-Santagata, D.5
Lifshits, E.6
-
24
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
I. Vivanco C.L. Sawyers 2002 The phosphatidylinositol 3-kinase AKT pathway in human cancer Nat Rev Cancer 2 489 501 12094235 10.1038/nrc839 1:CAS:528:DC%2BD38XkvFKltLs%3D (Pubitemid 37328931)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
25
-
-
28844448182
-
Oncogenic PI3K deregulates transcription and translation
-
DOI 10.1038/nrc1753
-
A.G. Bader S. Kang L. Zhao P.K. Vogt 2005 Oncogenic PI3K deregulates transcription and translation Nat Rev Cancer 5 921 929 16341083 10.1038/nrc1753 1:CAS:528:DC%2BD2MXht1ykurbF (Pubitemid 41766781)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.12
, pp. 921-929
-
-
Bader, A.G.1
Kang, S.2
Zhao, L.3
Vogt, P.K.4
-
26
-
-
52049099853
-
PIK3CA mutations and copy number gains in human lung cancers
-
18757405 10.1158/0008-5472.CAN-07-5084 1:CAS:528:DC%2BD1cXhtVCrs7%2FK
-
H. Yamamoto H. Shigematsu M. Nomura W.W. Lockwood M. Sato N. Okumura, et al. 2008 PIK3CA mutations and copy number gains in human lung cancers Cancer Res 68 6913 6921 18757405 10.1158/0008-5472.CAN-07-5084 1:CAS:528: DC%2BD1cXhtVCrs7%2FK
-
(2008)
Cancer Res
, vol.68
, pp. 6913-6921
-
-
Yamamoto, H.1
Shigematsu, H.2
Nomura, M.3
Lockwood, W.W.4
Sato, M.5
Okumura, N.6
-
27
-
-
43249115083
-
Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias
-
DOI 10.1038/sj.bjc.6604212, PII 6604212
-
M.S. Kim E.G. Jeong N.J. Yoo S.H. Lee 2008 Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias Br J Cancer 98 1533 1535 18392055 10.1038/sj.bjc.6604212 1:CAS:528: DC%2BD1cXltl2itrc%3D (Pubitemid 351652321)
-
(2008)
British Journal of Cancer
, vol.98
, Issue.9
, pp. 1533-1535
-
-
Kim, M.S.1
Jeong, E.G.2
Yoo, N.J.3
Lee, S.H.4
-
28
-
-
0033517189
-
NF-κB activation by tumour necrosis factor requires tie Akt serine- threonine kinase
-
DOI 10.1038/43466
-
O.N. Ozes L.D. Mayo J.A. Gustin S.R. Pfeffer L.M. Pfeffer D.B. Donner 1999 NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase Nature 401 82 85 10485710 10.1038/43466 1:CAS:528:DyaK1MXlvVGmsbY%3D (Pubitemid 29418447)
-
(1999)
Nature
, vol.401
, Issue.6748
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
Pfeffer, S.R.4
Pfeffer, L.M.5
Donner, D.B.6
-
29
-
-
4444332925
-
Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer
-
F. Cappuzzo E. Magrini G.L. Ceresoli S. Bartolini E. Rossi V. Ludovini, et al. 2004 Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer J Natl Cancer Inst 96 1133 1141 15292385 10.1093/jnci/djh217 1:CAS:528:DC%2BD2cXntFamsbg%3D (Pubitemid 39207049)
-
(2004)
Journal of the National Cancer Institute
, vol.96
, Issue.15
, pp. 1133-1141
-
-
Cappuzzo, F.1
Magrini, E.2
Ceresoli, G.L.3
Bartolini, S.4
Rossi, E.5
Ludovini, V.6
Gregorc, V.7
Ligorio, C.8
Cancellieri, A.9
Damiani, S.10
Spreafico, A.11
Paties, C.T.12
Lombardo, L.13
Calandri, C.14
Bellezza, G.15
Tonato, M.16
Crino, L.17
-
30
-
-
59449101488
-
The role of targeting mammalian target of rapamycin in lung cancer
-
19073516 10.3816/CLC.2008.n.049 1:CAS:528:DC%2BD1MXlvF2mtQ%3D%3D
-
S.K. Pal R.A. Figlin K.L. Reckamp 2008 The role of targeting mammalian target of rapamycin in lung cancer Clin Lung Cancer 9 340 345 19073516 10.3816/CLC.2008.n.049 1:CAS:528:DC%2BD1MXlvF2mtQ%3D%3D
-
(2008)
Clin Lung Cancer
, vol.9
, pp. 340-345
-
-
Pal, S.K.1
Figlin, R.A.2
Reckamp, K.L.3
-
31
-
-
40349106029
-
The potential role of mTOR inhibitors in non-small cell lung cancer
-
DOI 10.1634/theoncologist.2007-0171
-
C. Gridelli P. Maione A. Rossi 2008 The potential role of mTOR inhibitors in non-small cell lung cancer Oncologist 13 139 147 18305058 10.1634/theoncologist.2007-0171 1:CAS:528:DC%2BD1cXktVSgs78%3D (Pubitemid 351342577)
-
(2008)
Oncologist
, vol.13
, Issue.2
, pp. 139-147
-
-
Gridelli, C.1
Maione, P.2
Rossi, A.3
-
32
-
-
0019978519
-
Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus
-
N. Tsuchida E. Ohtsubo T. Ryder 1982 Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus Science 217 937 939 6287573 10.1126/science.6287573 1:CAS:528:DyaL38XmtV2ntr8%3D (Pubitemid 12047353)
-
(1982)
Science
, vol.217
, Issue.4563
, pp. 937-939
-
-
Tsuchida, N.1
Ryder, T.2
Ohtsubo, E.3
-
33
-
-
0025785811
-
Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines
-
T. Mitsudomi J. Viallet J.L. Mulshine R.I. Linnoila J.D. Minna A.F. Gazdar 1991 Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines Oncogene 6 1353 1362 1679529 1:CAS:528:DyaK3MXlslKmtr8%3D (Pubitemid 21924231)
-
(1991)
Oncogene
, vol.6
, Issue.8
, pp. 1353-1362
-
-
Mitsudomi, T.1
Viallet, J.2
Mulshine, J.L.3
Linnoila, R.I.4
Minna, J.D.5
Gazdar, A.F.6
-
34
-
-
69349088824
-
Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: Results of an online tumor registry of clinical trials
-
19671843 10.1158/1078-0432.CCR-09-0888 1:CAS:528:DC%2BD1MXpvFeitLs%3D
-
D.M. Jackman V.A. Miller L.A. Cioffredi B.Y. Yeap P.A. Janne G.J. Riely, et al. 2009 Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trials Clin Cancer Res 15 5267 5273 19671843 10.1158/1078-0432.CCR-09-0888 1:CAS:528:DC%2BD1MXpvFeitLs%3D
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5267-5273
-
-
Jackman, D.M.1
Miller, V.A.2
Cioffredi, L.A.3
Yeap, B.Y.4
Janne, P.A.5
Riely, G.J.6
-
35
-
-
48649107410
-
Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma
-
18632602 10.1158/0008-5472.CAN-08-0099 1:CAS:528:DC%2BD1cXovVCgurs%3D
-
J.L. Marks Y. Gong D. Chitale B. Golas M.D. McLellan Y. Kasai, et al. 2008 Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma Cancer Res 68 5524 5528 18632602 10.1158/0008-5472.CAN-08-0099 1:CAS:528:DC%2BD1cXovVCgurs%3D
-
(2008)
Cancer Res
, vol.68
, pp. 5524-5528
-
-
Marks, J.L.1
Gong, Y.2
Chitale, D.3
Golas, B.4
McLellan, M.D.5
Kasai, Y.6
-
36
-
-
0028786336
-
Transcriptional regulation by MAP kinases
-
8607977 10.1002/mrd.1080420414 1:CAS:528:DyaK2MXpvVGisbo%3D
-
R.J. Davis 1995 Transcriptional regulation by MAP kinases Mol Reprod Dev 42 459 467 8607977 10.1002/mrd.1080420414 1:CAS:528:DyaK2MXpvVGisbo%3D
-
(1995)
Mol Reprod Dev
, vol.42
, pp. 459-467
-
-
Davis, R.J.1
-
37
-
-
17744371335
-
EGFR mutation is specific for terminal respiratory unit type adenocarcinoma
-
DOI 10.1097/01.pas.0000157935.28066.35
-
Y. Yatabe T. Kosaka T. Takahashi T. Mitsudomi 2005 EGFR mutation is specific for terminal respiratory unit type adenocarcinoma Am J Surg Pathol 29 633 639 15832087 10.1097/01.pas.0000157935.28066.35 (Pubitemid 40577873)
-
(2005)
American Journal of Surgical Pathology
, vol.29
, Issue.5
, pp. 633-639
-
-
Yatabe, Y.1
Kosaka, T.2
Takahashi, T.3
Mitsudomi, T.4
-
38
-
-
36248980204
-
Characterizing the cancer genome in lung adenocarcinoma
-
DOI 10.1038/nature06358, PII NATURE06358
-
B.A. Weir M.S. Woo G. Getz S. Perner L. Ding R. Beroukhim, et al. 2007 Characterizing the cancer genome in lung adenocarcinoma Nature 450 893 898 17982442 10.1038/nature06358 1:CAS:528:DC%2BD2sXhtl2gsbvM (Pubitemid 350231325)
-
(2007)
Nature
, vol.450
, Issue.7171
, pp. 893-898
-
-
Weir, B.A.1
Woo, M.S.2
Getz, G.3
Perner, S.4
Ding, L.5
Beroukhim, R.6
Lin, W.M.7
Province, M.A.8
Kraja, A.9
Johnson, L.A.10
Shah, K.11
Sato, M.12
Thomas, R.K.13
Barletta, J.A.14
Borecki, I.B.15
Broderick, S.16
Chang, A.C.17
Chiang, D.Y.18
Chirieac, L.R.19
Cho, J.20
Fujii, Y.21
Gazdar, A.F.22
Giordano, T.23
Greulich, H.24
Hanna, M.25
Johnson, B.E.26
Kris, M.G.27
Lash, A.28
Lin, L.29
Lindeman, N.30
Mardis, E.R.31
McPherson, J.D.32
Minna, J.D.33
Morgan, M.B.34
Nadel, M.35
Orringer, M.B.36
Osborne, J.R.37
Ozenberger, B.38
Ramos, A.H.39
Robinson, J.40
Roth, J.A.41
Rusch, V.42
Sasaki, H.43
Shepherd, F.44
Sougnez, C.45
Spitz, M.R.46
Tsao, M.-S.47
Twomey, D.48
Verhaak, R.G.W.49
Weinstock, G.M.50
Wheeler, D.A.51
Winckler, W.52
Yoshizawa, A.53
Yu, S.54
Zakowski, M.F.55
Zhang, Q.56
Beer, D.G.57
Wistuba, I.I.58
Watson, M.A.59
Garraway, L.A.60
Ladanyi, M.61
Travis, W.D.62
Pao, W.63
Rubin, M.A.64
Gabriel, S.B.65
Gibbs, R.A.66
Varmus, H.E.67
Wilson, R.K.68
Lander, E.S.69
Meyerson, M.70
more..
-
39
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
DOI 10.1038/nature05945, PII NATURE05945
-
M. Soda Y.L. Choi M. Enomoto S. Takada Y. Yamashita S. Ishikawa, et al. 2007 Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer Nature 448 561 566 17625570 10.1038/nature05945 1:CAS:528: DC%2BD2sXosVSrtrs%3D (Pubitemid 47206930)
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
Takada, S.4
Yamashita, Y.5
Ishikawa, S.6
Fujiwara, S.-I.7
Watanabe, H.8
Kurashina, K.9
Hatanaka, H.10
Bando, M.11
Ohno, S.12
Ishikawa, Y.13
Aburatani, H.14
Niki, T.15
Sohara, Y.16
Sugiyama, Y.17
Mano, H.18
-
40
-
-
45849103492
-
Recurrent gene fusions in prostate cancer
-
18563191 10.1038/nrc2402 1:CAS:528:DC%2BD1cXnsFOkt7s%3D
-
C. Kumar-Sinha S.A. Tomlins A.M. Chinnaiyan 2008 Recurrent gene fusions in prostate cancer Nat Rev Cancer 8 497 511 18563191 10.1038/nrc2402 1:CAS:528:DC%2BD1cXnsFOkt7s%3D
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 497-511
-
-
Kumar-Sinha, C.1
Tomlins, S.A.2
Chinnaiyan, A.M.3
-
41
-
-
2342635959
-
Anaplastic Lymphoma Kinase Proteins in Growth Control and Cancer
-
DOI 10.1002/jcp.10472
-
K. Pulford S.W. Morris F. Turturro 2004 Anaplastic lymphoma kinase proteins in growth control and cancer J Cell Physiol 199 330 358 15095281 10.1002/jcp.10472 1:CAS:528:DC%2BD2cXjvVOqsb4%3D (Pubitemid 38580430)
-
(2004)
Journal of Cellular Physiology
, vol.199
, Issue.3
, pp. 330-358
-
-
Pulford, K.1
Morris, S.W.2
Turturro, F.3
-
42
-
-
63949086127
-
KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer
-
19383809 10.1158/1078-0432.CCR-08-3248 1:CAS:528:DC%2BD1MXltFOrtbY%3D
-
K. Takeuchi Y.L. Choi Y. Togashi M. Soda S. Hatano K. Inamura, et al. 2009 KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry- based diagnostic system for ALK-positive lung cancer Clin Cancer Res 15 3143 3149 19383809 10.1158/1078-0432.CCR-08-3248 1:CAS:528:DC%2BD1MXltFOrtbY%3D
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3143-3149
-
-
Takeuchi, K.1
Choi, Y.L.2
Togashi, Y.3
Soda, M.4
Hatano, S.5
Inamura, K.6
-
43
-
-
63949087355
-
EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset
-
19234440 10.1038/modpathol.2009.2 1:CAS:528:DC%2BD1MXjslyqtLc%3D
-
K. Inamura K. Takeuchi Y. Togashi S. Hatano H. Ninomiya N. Motoi, et al. 2009 EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset Mod Pathol 22 508 515 19234440 10.1038/modpathol.2009.2 1:CAS:528:DC%2BD1MXjslyqtLc%3D
-
(2009)
Mod Pathol
, vol.22
, pp. 508-515
-
-
Inamura, K.1
Takeuchi, K.2
Togashi, Y.3
Hatano, S.4
Ninomiya, H.5
Motoi, N.6
-
44
-
-
70349336416
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
-
19667264 10.1200/JCO.2009.22.6993 1:CAS:528:DC%2BD1MXht1WisbvF
-
A.T. Shaw B.Y. Yeap M. Mino-Kenudson S.R. Digumarthy D.B. Costa R.S. Heist, et al. 2009 Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK J Clin Oncol 27 4247 4253 19667264 10.1200/JCO.2009.22.6993 1:CAS:528:DC%2BD1MXht1WisbvF
-
(2009)
J Clin Oncol
, vol.27
, pp. 4247-4253
-
-
Shaw, A.T.1
Yeap, B.Y.2
Mino-Kenudson, M.3
Digumarthy, S.R.4
Costa, D.B.5
Heist, R.S.6
-
45
-
-
44849126091
-
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
-
18451166 10.1158/0008-5472.CAN-07-6186 1:CAS:528:DC%2BD1cXltlSlsbg%3D
-
U. McDermott A.J. Iafrate N.S. Gray T. Shioda M. Classon S. Maheswaran, et al. 2008 Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors Cancer Res 68 3389 3395 18451166 10.1158/0008-5472.CAN-07-6186 1:CAS:528:DC%2BD1cXltlSlsbg%3D
-
(2008)
Cancer Res
, vol.68
, pp. 3389-3395
-
-
McDermott, U.1
Iafrate, A.J.2
Gray, N.S.3
Shioda, T.4
Classon, M.5
Maheswaran, S.6
-
46
-
-
0029849620
-
Cancer cell cycles
-
DOI 10.1126/science.274.5293.1672
-
C.J. Sherr 1996 Cancer cell cycles Science 274 1672 1677 8939849 10.1126/science.274.5293.1672 1:CAS:528:DyaK28XntlyktLs%3D (Pubitemid 26414890)
-
(1996)
Science
, vol.274
, Issue.5293
, pp. 1672-1674
-
-
Sherr, C.J.1
-
47
-
-
0028009849
-
The cell cycle and the retinoblastoma protein family
-
M.E. Ewen 1994 The cell cycle and the retinoblastoma protein family Cancer Metastasis Rev 13 45 66 8143345 10.1007/BF00690418 1:CAS:528: DyaK2cXjt1Shu70%3D (Pubitemid 24053339)
-
(1994)
Cancer and Metastasis Reviews
, vol.13
, Issue.1
, pp. 45-66
-
-
Ewen, M.E.1
-
48
-
-
0034910622
-
Molecular genetics of small cell lung carcinoma
-
I.I. Wistuba A.F. Gazdar J.D. Minna 2001 Molecular genetics of small cell lung carcinoma Semin Oncol 28 suppl4 3 13 11479891 10.1016/S0093-7754(01)90072- 7 1:CAS:528:DC%2BD3MXmsVyktbw%3D (Pubitemid 32730372)
-
(2001)
Seminars in Oncology
, vol.28
, Issue.2 SUPPL. 4
, pp. 3-13
-
-
Wistuba, I.I.1
Gazdar, A.F.2
Minna, J.D.3
-
49
-
-
0029993450
-
Role of the INK4a locus in tumor suppression and cell mortality
-
DOI 10.1016/S0092-8674(00)81079-X
-
M. Serrano H. Lee L. Chin C. Cordon-Cardo D. Beach R.A. DePinho 1996 Role of the INK4a locus in tumor suppression and cell mortality Cell 85 27 37 8620534 10.1016/S0092-8674(00)81079-X 1:CAS:528:DyaK28Xit1aksb8%3D (Pubitemid 26116804)
-
(1996)
Cell
, vol.85
, Issue.1
, pp. 27-37
-
-
Serrano, M.1
Lee, H.-W.2
Chin, L.3
Cordon-Cardo, C.4
Beach, D.5
DePinho, R.A.6
-
51
-
-
0029922621
-
p53 tumor suppressor gene: From the basic research laboratory to the clinic - An abridged historical perspective
-
DOI 10.1093/carcin/17.6.1187
-
C.C. Harris 1996 p53 tumor suppressor gene: from the basic research laboratory to the clinic: an abridged historical perspective Carcinogenesis 17 1187 1198 8681432 10.1093/carcin/17.6.1187 1:CAS:528:DyaK28XjvFegtLc%3D (Pubitemid 26196329)
-
(1996)
Carcinogenesis
, vol.17
, Issue.6
, pp. 1187-1198
-
-
Harris, C.C.1
-
52
-
-
0034745389
-
Patterns of p53 T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke
-
P. Hainaut G.P. Pfeifer 2001 Patterns of p53 G→T transversions in lung cancers refl ect the primary mutagenic signature of DNAdamage by tobacco smoke Carcinogenesis 22 367 374 11238174 10.1093/carcin/22.3.367 1:CAS:528:DC%2BD3MXitFKhsLc%3D (Pubitemid 32203813)
-
(2001)
Carcinogenesis
, vol.22
, Issue.3
, pp. 367-374
-
-
Hainaut, P.1
Pfeifer, G.P.2
-
53
-
-
0024452546
-
p53: A frequent target for genetic abnormalities in lung cancer
-
T. Takahashi M.M. Nau I. Chiba M.J. Birrer R.K. Rosenberg M. Vinocour, et al. 1989 p53: a frequent target for genetic abnormalities in lung cancer Science 246 491 494 2554494 10.1126/science.2554494 1:CAS:528:DyaL1MXmt1Knu7Y%3D (Pubitemid 19273938)
-
(1989)
Science
, vol.246
, Issue.4929
, pp. 491-494
-
-
Takahashi, T.1
Nau, M.M.2
Chiba, I.3
Birrer, M.J.4
Rosenberg, R.K.5
Vinocour, M.6
Levitt, M.7
Pass, H.8
Gazdar, A.D.9
Minna, J.D.10
-
54
-
-
0026543204
-
P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features
-
1311061 1:CAS:528:DyaK38XhslWhtb0%3D
-
T. Mitsudomi S.M. Steinberg M.M. Nau D. Carbone D. D'Amico S. Bodner, et al. 1992 p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features Oncogene 7 171 180 1311061 1:CAS:528:DyaK38XhslWhtb0%3D
-
(1992)
Oncogene
, vol.7
, pp. 171-180
-
-
Mitsudomi, T.1
Steinberg, S.M.2
Nau, M.M.3
Carbone, D.4
D'Amico, D.5
Bodner, S.6
-
55
-
-
0037129342
-
ARF inactivation are two mutually exclusive events in primary human lung tumors
-
DOI 10.1038/sj.onc.1205359
-
B. Eymin S. Gazzeri C. Brambilla E. Brambilla 2002 Mdm2 overexpression and p14(ARF) inactivation are two mutually exclusive events in primary human lung tumors Oncogene 21 2750 2761 11965548 10.1038/sj.onc.1205359 1:CAS:528:DC%2BD38XjsVSmsrY%3D (Pubitemid 34478333)
-
(2002)
Oncogene
, vol.21
, Issue.17
, pp. 2750-2761
-
-
Eymin, B.1
Gazzeri, S.2
Brambilla, C.3
Brambilla, E.4
-
56
-
-
33750480907
-
Effect of an hdm-2 antagonist peptide inhibitor on cell cycle progression in p53-deficient H1299 human lung carcinoma cells
-
DOI 10.1038/sj.onc.1209667, PII 1209667
-
A. VanderBorght A. Valckx J. Van Dun T. Grand-Perret S. De Schepper J. Vialard, et al. 2006 Effect of an hdm-2 antagonist peptide inhibitor on cell cycle progression in p53-deficient H1299 human lung carcinoma cells Oncogene 25 6672 6677 16732328 10.1038/sj.onc.1209667 1:CAS:528:DC%2BD28XhtFaks77E (Pubitemid 44646195)
-
(2006)
Oncogene
, vol.25
, Issue.50
, pp. 6672-6677
-
-
VanderBorght, A.1
Valckx, A.2
Van Dun, J.3
Grand-Perret, T.4
De Schepper, S.5
Vialard, J.6
Janicot, M.7
Arts, J.8
-
57
-
-
0032549711
-
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
-
DOI 10.1016/S0092-8674(00)81401-4
-
Y. Zhang Y. Xiong W.G. Yarbrough 1998 ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways Cell 92 725 734 9529249 10.1016/S0092-8674(00)81401-4 1:CAS:528:DyaK1cXit1KlsLw%3D (Pubitemid 28155312)
-
(1998)
Cell
, vol.92
, Issue.6
, pp. 725-734
-
-
Zhang, Y.1
Xiong, Y.2
Yarbrough, W.G.3
-
58
-
-
0015043748
-
Mutation and cancer: Statistical study of retinoblastoma
-
5279523 10.1073/pnas.68.4.820
-
A.G. Knudson Jr 1971 Mutation and cancer: statistical study of retinoblastoma Proc Natl Acad Sci U S A 68 820 823 5279523 10.1073/pnas.68.4.820
-
(1971)
Proc Natl Acad Sci U S A
, vol.68
, pp. 820-823
-
-
Knudson Jr., A.G.1
-
59
-
-
0034282535
-
Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering
-
10987304 1:CAS:528:DC%2BD3cXmsFWhsLY%3D
-
L. Girard S. Zochbauer-Muller A.K. Virmani A.F. Gazdar J.D. Minna 2000 Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering Cancer Res 60 4894 4906 10987304 1:CAS:528:DC%2BD3cXmsFWhsLY%3D
-
(2000)
Cancer Res
, vol.60
, pp. 4894-4906
-
-
Girard, L.1
Zochbauer-Muller, S.2
Virmani, A.K.3
Gazdar, A.F.4
Minna, J.D.5
-
60
-
-
0027185801
-
A homozygous deletion on chromosome 3 in a small cell lung cancer cell line correlates with a region of tumor suppressor activity
-
M.C. Daly R.H. Xiang D. Buchhagen C.H. Hensel D.K. Garcia A.M. Killary, et al. 1993 A homozygous deletion on chromosome 3 in a small cell lung cancer cell line correlates with a region of tumor suppressor activity Oncogene 8 1721 1729 8390035 1:CAS:528:DyaK3sXmt1aqtLY%3D (Pubitemid 23212403)
-
(1993)
Oncogene
, vol.8
, Issue.7
, pp. 1721-1729
-
-
Daly, M.C.1
Xiang, R.-H.2
Buchhagen, D.3
Hensel, C.H.4
Garcia, D.K.5
Killary, A.M.6
Minna, J.D.7
Naylor, S.L.8
-
61
-
-
9244251007
-
Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin
-
J. Roche F. Boldog M. Robinson L. Robinson M. Varella-Garcia M. Swanton, et al. 1996 Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin Oncogene 12 1289 1297 8649831 1:CAS:528:DyaK28XhvFymt78%3D (Pubitemid 26128926)
-
(1996)
Oncogene
, vol.12
, Issue.6
, pp. 1289-1297
-
-
Roche, J.1
Boldog, F.2
Robinson, M.3
Robinson, L.4
Varella-Garcia, M.5
Swanton, M.6
Waggoner, B.7
Fishel, R.8
Franklin, W.9
Gemmill, R.10
Drabkin, H.11
-
62
-
-
0033918563
-
Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
-
DOI 10.1038/77083
-
R. Dammann C. Li J.H. Yoon P.L. Chin S. Bates G.P. Pfeifer 2000 Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3 Nat Genet 25 315 319 10888881 10.1038/77083 1:CAS:528:DC%2BD3cXkvFKks7o%3D (Pubitemid 30437320)
-
(2000)
Nature Genetics
, vol.25
, Issue.3
, pp. 315-319
-
-
Dammann, R.1
Li, C.2
Yoon, J.-H.3
Chin, P.L.4
Bates, S.5
Pfeifer, G.P.6
-
63
-
-
0035795676
-
Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression
-
D.G. Burbee E. Forgacs S. Zochbauer-Muller L. Shivakumar K. Fong B. Gao, et al. 2001 Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression J Natl Cancer Inst 93 691 699 11333291 10.1093/jnci/93.9.691 1:CAS:528:DC%2BD3MXjvVamu7o%3D (Pubitemid 32492810)
-
(2001)
Journal of the National Cancer Institute
, vol.93
, Issue.9
, pp. 691-699
-
-
Burbee, D.G.1
Forgacs, E.2
Zochbauer-Muller, S.3
Shivakumar, L.4
Fong, K.5
Gao, B.6
Randle, D.7
Kondo, M.8
Virmani, A.9
Bader, S.10
Sekido, Y.11
Latif, F.12
Milchgrub, S.13
Toyooka, S.14
Gazdar, A.F.15
Lerman, M.I.16
Zabarovsky, E.17
White, M.18
Minna, J.D.19
-
64
-
-
15844384990
-
The FHIT gene at 3p14.2 is abnormal in lung cancer
-
DOI 10.1016/S0092-8674(00)81078-8
-
G. Sozzi M.L. Veronese M. Negrini R. Baffa M.G. Cotticelli H. Inoue, et al. 1996 The FHIT gene 3p14.2 is abnormal in lung cancer Cell 85 17 26 8620533 10.1016/S0092-8674(00)81078-8 1:CAS:528:DyaK28Xit1aksb4%3D (Pubitemid 26116803)
-
(1996)
Cell
, vol.85
, Issue.1
, pp. 17-26
-
-
Sozzi, G.1
Veronese, M.L.2
Negrini, M.3
Baffa, R.4
Cotticelli, M.G.5
Inoue, H.6
Tornielli, S.7
Pilotti, S.8
De Gregorio, L.9
Pastorino, U.10
Pierotti, M.A.11
Ohta, M.12
Huebner, K.13
Croce, C.M.14
-
65
-
-
19944427560
-
Prognostic relevance of fragile histidine triad protein expression in patients with small cell lung cancer
-
U.P. Rohr N. Rehfeld H. Geddert L. Pflugfelder I. Bruns J. Neukirch, et al. 2005 Prognostic relevance of fragile histidine triad protein expression in patients with small cell lung cancer Clin Cancer Res 11 180 185 15671544 1:CAS:528:DC%2BD2MXhtVegs7s%3D (Pubitemid 40075793)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.1
, pp. 180-185
-
-
Rohr, U.-P.1
Rehfeld, N.2
Geddert, H.3
Pflugfelder, L.4
Bruns, I.5
Neukirch, J.6
Rohrbeck, A.7
Grote, H.J.8
Steidl, U.9
Fenk, R.10
Opalka, B.11
Gabbert, H.E.12
Kronenwett, R.13
Haas, R.14
-
66
-
-
0035324425
-
5′ CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer
-
S. Zochbauer-Muller K.M. Fong A. Maitra S. Lam J. Geradts R. Ashfaq, et al. 2001 5′ CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer Cancer Res 61 3581 3585 11325823 1:CAS:528:DC%2BD3MXjsFCgtLo%3D (Pubitemid 32694965)
-
(2001)
Cancer Research
, vol.61
, Issue.9
, pp. 3581-3585
-
-
Zochbauer-Muller, S.1
Fong, K.M.2
Maitra, A.3
Lam, S.4
Geradts, J.5
Ashfaq, R.6
Virmani, A.K.7
Milchgrub, S.8
Gazdar, A.F.9
Minna, J.D.10
-
67
-
-
0023663881
-
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
-
3319189 10.1016/0092-8674(87)90576-9 1:CAS:528:DyaL1cXptVKhsQ%3D%3D
-
C.W. Greider E.H. Blackburn 1987 The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity Cell 51 887 898 3319189 10.1016/0092-8674(87)90576-9 1:CAS:528: DyaL1cXptVKhsQ%3D%3D
-
(1987)
Cell
, vol.51
, pp. 887-898
-
-
Greider, C.W.1
Blackburn, E.H.2
-
68
-
-
0029072561
-
Telomerase activity in small-cell and nonsmall-cell lung cancers
-
7666478 10.1093/jnci/87.12.895 1:CAS:528:DyaK2MXmvFCgsbw%3D
-
K. Hiyama E. Hiyama S. Ishioka M. Yamakido K. Inai A.F. Gazdar, et al. 1995 Telomerase activity in small-cell and nonsmall-cell lung cancers J Natl Cancer Inst 87 895 902 7666478 10.1093/jnci/87.12.895 1:CAS:528: DyaK2MXmvFCgsbw%3D
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 895-902
-
-
Hiyama, K.1
Hiyama, E.2
Ishioka, S.3
Yamakido, M.4
Inai, K.5
Gazdar, A.F.6
-
69
-
-
0030724731
-
High telomerase activity in primary lung cancers: Association with increased cell proliferation rates and advanced pathologic stage
-
J. Albanell F. Lonardo V. Rusch M. Engelhardt J. Langenfeld W. Han, et al. 1997 High telomerase activity in primary lung cancers: association with increased cell proliferation rates and advanced pathologic stage J Natl Cancer Inst 89 1609 1615 9362159 10.1093/jnci/89.21.1609 1:STN:280: DyaK1c%2Fis1CrsA%3D%3D (Pubitemid 27479721)
-
(1997)
Journal of the National Cancer Institute
, vol.89
, Issue.21
, pp. 1609-1615
-
-
Albanell, J.1
Lonardo, F.2
Rusch, V.3
Engelhardt, M.4
Langenfeld, J.5
Han, W.6
Klimstra, D.7
Venkatraman, E.8
Moore, M.A.S.9
Dmitrovsky, E.10
-
70
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
D.W. Leung G. Cachianes W.J. Kuang D.V. Goeddel N. Ferrara 1989 Vascular endothelial growth factor is a secreted angiogenic mitogen Science 246 1306 1309 2479986 10.1126/science.2479986 1:CAS:528:DyaK3cXls1GltLo%3D (Pubitemid 20066716)
-
(1989)
Science
, vol.246
, Issue.4935
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.-J.3
Goeddel, D.V.4
Ferrara, N.5
-
71
-
-
0030969559
-
Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma
-
G. Fontanini S. Vignati L. Boldrini S. Chine V. Silvestri M. Lucchi, et al. 1997 Vascular endothelial growth factor is associated with neovascularization and infl uences progression of non-small cell lung carcinoma Clin Cancer Res 3 861 865 9815760 1:CAS:528:DyaK2sXkt1Ohs70%3D (Pubitemid 27252933)
-
(1997)
Clinical Cancer Research
, vol.3
, Issue.6
, pp. 861-865
-
-
Fontanini, G.1
Vignati, S.2
Boldrini, L.3
Chine, S.4
Silvestri, V.5
Lucchi, M.6
Mussi, A.7
Angeletti, C.A.8
Bevilacqua, G.9
-
72
-
-
67650999875
-
The basics of epithelial-mesenchymal transition
-
19487818 10.1172/JCI39104 1:CAS:528:DC%2BD1MXntVCjtr0%3D
-
R. Kalluri R.A. Weinberg 2009 The basics of epithelial-mesenchymal transition J Clin Invest 119 1420 1428 19487818 10.1172/JCI39104 1:CAS:528:DC%2BD1MXntVCjtr0%3D
-
(2009)
J Clin Invest
, vol.119
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.A.2
-
74
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
DOI 10.1016/0092-8674(90)90186-I
-
E.R. Fearon B. Vogelstein 1990 A genetic model for colorectal tumorigenesis Cell 61 759 767 2188735 10.1016/0092-8674(90)90186-I 1:CAS:528:DyaK3cXktlyhtrg%3D (Pubitemid 20185636)
-
(1990)
Cell
, vol.61
, Issue.5
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
75
-
-
0032578509
-
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
-
DOI 10.1073/pnas.95.20.11891
-
S.A. Belinsky K.J. Nikula W.A. Palmisano R. Michels G. Saccomanno E. Gabrielson, et al. 1998 Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis Proc Natl Acad Sci U S A 95 11891 11896 9751761 10.1073/pnas.95.20.11891 1:CAS:528:DyaK1cXmsV2hsbo%3D (Pubitemid 28460510)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.20
, pp. 11891-11896
-
-
Belinsky, S.A.1
Nikula, K.J.2
Palmisano, W.A.3
Michels, R.4
Saccomanno, G.5
Gabrielson, E.6
Baylin, S.B.7
Herman, J.G.8
-
76
-
-
24744461722
-
EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients
-
DOI 10.1158/0008-5472.CAN-05-1705
-
X. Tang H. Shigematsu B.N. Bekele J.A. Roth J.D. Minna W.K. Hong, et al. 2005 EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients Cancer Res 65 7568 7572 16140919 1:CAS:528:DC%2BD2MXpslaitLw%3D (Pubitemid 41297226)
-
(2005)
Cancer Research
, vol.65
, Issue.17
, pp. 7568-7572
-
-
Tang, X.1
Shigematsu, H.2
Bekele, B.N.3
Roth, J.A.4
Minna, J.D.5
Hong, W.K.6
Gazdar, A.F.7
Wistuba, I.I.8
-
77
-
-
67651224821
-
DNA methylation in small lung adenocarcinoma with bronchioloalveolar carcinoma components
-
19144441 10.1016/j.lungcan.2008.12.001
-
T. Kubo H. Yamamoto K. Ichimura M. Jida T. Hayashi H. Otani, et al. 2009 DNA methylation in small lung adenocarcinoma with bronchioloalveolar carcinoma components Lung Cancer 65 328 332 19144441 10.1016/j.lungcan.2008.12.001
-
(2009)
Lung Cancer
, vol.65
, pp. 328-332
-
-
Kubo, T.1
Yamamoto, H.2
Ichimura, K.3
Jida, M.4
Hayashi, T.5
Otani, H.6
-
78
-
-
0032107870
-
Precursors to pulmonary neoplasia
-
9859753 10.1097/00125480-199807000-00001 1:STN:280:DyaK1M%2Fns1ymsg%3D%3D
-
T.V. Colby I.I. Wistuba A. Gazdar 1998 Precursors to pulmonary neoplasia Adv Anat Pathol 5 205 215 9859753 10.1097/00125480-199807000-00001 1:STN:280:DyaK1M%2Fns1ymsg%3D%3D
-
(1998)
Adv Anat Pathol
, vol.5
, pp. 205-215
-
-
Colby, T.V.1
Wistuba, I.I.2
Gazdar, A.3
-
79
-
-
77349109478
-
Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy
-
10.1007/s10555-010-9216-5
-
J.P. Sullivan J.D. Minna J.W. Shay 2010 Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy Cancer Metastasis Rev 29 12 10.1007/s10555-010-9216-5
-
(2010)
Cancer Metastasis Rev
, vol.29
, pp. 12
-
-
Sullivan, J.P.1
Minna, J.D.2
Shay, J.W.3
-
80
-
-
40249108437
-
ALDH1A1 and ALDH3A1 expression in lung cancers: Correlation with histologic type and potential precursors
-
DOI 10.1016/j.lungcan.2007.08.033, PII S0169500207005004
-
M. Patel L. Lu D.S. Zander L. Sreerama D. Coco J.S. Moreb 2008 ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors Lung Cancer 59 340 349 17920722 10.1016/j.lungcan.2007.08. 033 (Pubitemid 351335102)
-
(2008)
Lung Cancer
, vol.59
, Issue.3
, pp. 340-349
-
-
Patel, M.1
Lu, L.2
Zander, D.S.3
Sreerama, L.4
Coco, D.5
Moreb, J.S.6
-
81
-
-
76049110053
-
Alterations of the Notch pathway in lung cancer
-
20007775 10.1073/pnas.0907781106 1:CAS:528:DC%2BC3cXmtlagsQ%3D%3D
-
B. Westhoff I.N. Colaluca G. D'Ario M. Donzelli D. Tosoni S. Volorio, et al. 2009 Alterations of the Notch pathway in lung cancer Proc Natl Acad Sci U S A 106 22293 22298 20007775 10.1073/pnas.0907781106 1:CAS:528: DC%2BC3cXmtlagsQ%3D%3D
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 22293-22298
-
-
Westhoff, B.1
Colaluca, I.N.2
D'Ario, G.3
Donzelli, M.4
Tosoni, D.5
Volorio, S.6
-
82
-
-
0242669237
-
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
-
DOI 10.1038/nature01493
-
D.N. Watkins D.M. Berman S.G. Burkholder B. Wang P.A. Beachy S.B. Baylin 2003 Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer Nature 422 313 317 12629553 10.1038/nature01493 1:CAS:528: DC%2BD3sXitFKmu7s%3D (Pubitemid 36378358)
-
(2003)
Nature
, vol.422
, Issue.6929
, pp. 313-317
-
-
Watkins, D.N.1
Berman, D.M.2
Burkholder, S.G.3
Wang, B.4
Beachy, P.A.5
Baylin, S.B.6
-
83
-
-
34848928181
-
Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer
-
17183725 10.1371/journal.pone.0000093
-
H. Lemjabbar-Alaoui V. Dasari S.S. Sidhu A. Mengistab W. Finkbeiner M. Gallup, et al. 2006 Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer PLoS One 1 e93 17183725 10.1371/journal.pone.0000093
-
(2006)
PLoS One
, vol.1
, pp. 93
-
-
Lemjabbar-Alaoui, H.1
Dasari, V.2
Sidhu, S.S.3
Mengistab, A.4
Finkbeiner, W.5
Gallup, M.6
-
84
-
-
33746961739
-
Mechanisms of Disease: Oncogene addiction - A rationale for molecular targeting in cancer therapy
-
DOI 10.1038/ncponc0558, PII NCPONC0558
-
I.B. Weinstein A.K. Joe 2006 Mechanisms of disease: oncogene addiction-a rationale for molecular targeting in cancer therapy Nat Clin Pract Oncol 3 448 457 16894390 10.1038/ncponc0558 1:CAS:528:DC%2BD28Xpt1OktL8%3D (Pubitemid 44203817)
-
(2006)
Nature Clinical Practice Oncology
, vol.3
, Issue.8
, pp. 448-457
-
-
Weinstein, I.B.1
Joe, A.K.2
-
85
-
-
32944468706
-
Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers
-
DOI 10.1158/0008-5472.CAN-05-2625
-
S. Toyooka M. Tokumo H. Shigematsu K. Matsuo H. Asano K. Tomii, et al. 2006 Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers Cancer Res 66 1371 1375 16452191 10.1158/0008-5472.CAN-05-2625 1:CAS:528:DC%2BD28XpsVeiuw%3D%3D (Pubitemid 43259916)
-
(2006)
Cancer Research
, vol.66
, Issue.3
, pp. 1371-1375
-
-
Toyooka, S.1
Tokumo, M.2
Shigematsu, H.3
Matsuo, K.4
Asano, H.5
Tomii, K.6
Ichihara, S.7
Suzuki, M.8
Aoe, M.9
Date, H.10
Gazdar, A.F.11
Shimizu, N.12
-
86
-
-
33750627972
-
A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes
-
DOI 10.1016/j.ccr.2006.09.014, PII S1535610806002923
-
S.V. Sharma P. Gajowniczek I.P. Way D.Y. Lee J. Jiang Y. Yuza, et al. 2006 A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes Cancer Cell 10 425 435 17097564 10.1016/j.ccr.2006.09.014 1:CAS:528:DC%2BD28Xht1Glu7nF (Pubitemid 44693471)
-
(2006)
Cancer Cell
, vol.10
, Issue.5
, pp. 425-435
-
-
Sharma, S.V.1
Gajowniczek, P.2
Way, I.P.3
Lee, D.Y.4
Jiang, J.5
Yuza, Y.6
Classon, M.7
Haber, D.A.8
Settleman, J.9
-
87
-
-
77954217479
-
Exploiting the balance between life and death: Targeted cancer therapy and "oncogenic shock
-
20211150 10.1016/j.bcp.2010.03.001 1:CAS:528:DC%2BC3cXosV2is7c%3D
-
S.V. Sharma J. Settleman 2010 Exploiting the balance between life and death: targeted cancer therapy and "oncogenic shock Biochem Pharmacol 80 666 673 20211150 10.1016/j.bcp.2010.03.001 1:CAS:528:DC%2BC3cXosV2is7c%3D
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 666-673
-
-
Sharma, S.V.1
Settleman, J.2
-
88
-
-
0347444723
-
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
-
DOI 10.1016/S0092-8674(04)00045-5
-
D.P. Bartel 2004 MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 281 297 14744438 10.1016/S0092-8674(04)00045-5 1:CAS:528: DC%2BD2cXhtVals7o%3D (Pubitemid 38167318)
-
(2004)
Cell
, vol.116
, Issue.2
, pp. 281-297
-
-
Bartel, D.P.1
-
89
-
-
67650711156
-
MicroRNAs in cancer
-
19630570 10.1146/annurev.med.59.053006.104707 1:CAS:528: DC%2BD1MXitlynt7Y%3D
-
R. Garzon G.A. Calin C.M. Croce 2009 MicroRNAs in cancer Annu Rev Med 60 167 179 19630570 10.1146/annurev.med.59.053006.104707 1:CAS:528: DC%2BD1MXitlynt7Y%3D
-
(2009)
Annu Rev Med
, vol.60
, pp. 167-179
-
-
Garzon, R.1
Calin, G.A.2
Croce, C.M.3
-
90
-
-
2542626605
-
Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
-
DOI 10.1158/0008-5472.CAN-04-0637
-
J. Takamizawa H. Konishi K. Yanagisawa S. Tomida H. Osada H. Endoh, et al. 2004 Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival Cancer Res 64 3753 3756 15172979 10.1158/0008-5472.CAN-04-0637 1:CAS:528:DC%2BD2cXksVKgurs%3D (Pubitemid 38697282)
-
(2004)
Cancer Research
, vol.64
, Issue.11
, pp. 3753-3756
-
-
Takamizawa, J.1
Konishi, H.2
Yanagisawa, K.3
Tomida, S.4
Osada, H.5
Endoh, H.6
Harano, T.7
Yatabe, Y.8
Nagino, M.9
Nimura, Y.10
Mitsudomi, T.11
Takahashi, T.12
-
91
-
-
33644819964
-
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
-
DOI 10.1016/j.ccr.2006.01.025, PII S153561080600033X
-
N. Yanaihara N. Caplen E. Bowman M. Seike K. Kumamoto M. Yi, et al. 2006 Unique microRNA molecular profiles in lung cancer diagnosis and prognosis Cancer Cell 9 189 198 16530703 10.1016/j.ccr.2006.01.025 1:CAS:528: DC%2BD28XivFWjtLw%3D (Pubitemid 43357945)
-
(2006)
Cancer Cell
, vol.9
, Issue.3
, pp. 189-198
-
-
Yanaihara, N.1
Caplen, N.2
Bowman, E.3
Seike, M.4
Kumamoto, K.5
Yi, M.6
Stephens, R.M.7
Okamoto, A.8
Yokota, J.9
Tanaka, T.10
Calin, G.A.11
Liu, C.-G.12
Croce, C.M.13
Harris, C.C.14
-
92
-
-
67651002796
-
MicroRNA classifiers for predicting prognosis of squamous cell lung cancer
-
19584273 10.1158/0008-5472.CAN-09-0587 1:CAS:528:DC%2BD1MXosV2msLs%3D
-
M. Raponi L. Dossey T. Jatkoe X. Wu G. Chen H. Fan, et al. 2009 MicroRNA classifiers for predicting prognosis of squamous cell lung cancer Cancer Res 69 5776 5783 19584273 10.1158/0008-5472.CAN-09-0587 1:CAS:528:DC%2BD1MXosV2msLs%3D
-
(2009)
Cancer Res
, vol.69
, pp. 5776-5783
-
-
Raponi, M.1
Dossey, L.2
Jatkoe, T.3
Wu, X.4
Chen, G.5
Fan, H.6
-
93
-
-
27544495514
-
A polycistronic MicroRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation
-
DOI 10.1158/0008-5472.CAN-05-2352
-
Y. Hayashita H. Osada Y. Tatematsu H. Yamada K. Yanagisawa S. Tomida, et al. 2005 A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation Cancer Res 65 9628 9632 16266980 10.1158/0008-5472.CAN-05-2352 1:CAS:528:DC%2BD2MXhtFKkt7jE (Pubitemid 41541436)
-
(2005)
Cancer Research
, vol.65
, Issue.21
, pp. 9628-9632
-
-
Hayashita, Y.1
Osada, H.2
Tatematsu, Y.3
Yamada, H.4
Yanagisawa, K.5
Tomida, S.6
Yatabe, Y.7
Kawahara, K.8
Sekido, Y.9
Takahashi, T.10
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