Epigenetic inactivation of 14-3-3 σ in oral carcinoma: Association with p16INK4asilencing and human papillomavirus negativity

Cancer Research

Volumn 62, Issue 7, 2002, Pages 2072-2076

  Gasco, Milena ^a   Bell, Alexandra K ^g   Heath, Victoria ^g   Sullivan, Alex ^b   Smith, Paul ^c   Hiller, Louise ^d   Yulug, Isik ^e   Numico, Gianmauro ^a   Merlano, Marco ^a   Farrell, Paul J ^b   Tavassoli, Mahvash ^f   Gusterson, Barry ^g   Crook, Tim ^b  

^a S CROCE E CARLE HOSPITAL   (Italy)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c BRUNEL UNIVERSITY   (United Kingdom)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e BILKENT UNIVERSITY   (Turkey)

^f KING'S COLLEGE LONDON   (United Kingdom)

^g WESTERN INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

14 3 3 SIGMA FACTOR; MESSENGER RNA; PROTEIN; PROTEIN P16; PROTEIN P53; SIGMA FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA METHYLATION; DNA SEQUENCE; DYSPLASIA; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE MUTATION; GENE SEQUENCE; GENE SILENCING; GENETIC CODE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; METHYLATION; MOUTH CARCINOMA; PAPILLOMA VIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATOR GENE; SQUAMOUS CELL CARCINOMA; WILD TYPE;

CARCINOMA, SQUAMOUS CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA, VIRAL; EXONUCLEASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; LOSS OF HETEROZYGOSITY; MOUTH NEOPLASMS; MUTATION; NEOPLASM PROTEINS; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PRECANCEROUS CONDITIONS; PROTEIN BIOSYNTHESIS; PROTEINS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; TUMOR VIRUS INFECTIONS;

EID: 17444448913     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx and esophagus in northern Italy
2. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers
3. Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells
4. Cloning of putative regulatory genes from primary human keratinocytes by subtractive hybridisation
5. Down-regulation of 14-3-3σ prevents clonal evolution and leads to immortalization of primary human keratinocytes
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7. INK4aupon immortalization
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13. Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3σ gene in human hepatocellular carcinoma
14. Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck
15. Methylation-specific PCR: A novel assay for methylation status of CpG islands
16. Methylation of the 5′ CpG island of the pl6/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
17. Detection and typing of human papillomavirus in archival cervical cancer specimens by DNA amplification with consensus primers
18. PCR amplification from paraffin-embedded tissues: Effects of fixative and fixation time
19. Detection and typing of human papillomaviruses present in fixed and stained archival cervical smears by a consensus polymerase chain reaction and direct sequence analysis allow the identification of a broad spectrum of human papillomavirus types
20. HPV 16E6 and E7 proteins co-operate to immortalize human foreskin keratinocytes
21. Surfing the p53 network
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25. 2/M checkpoint