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Volumn 18, Issue 4, 2012, Pages 783-792

RUNX3 downregulation in human lung adenocarcinoma is independent of p53, EGFR or KRAS status

Author keywords

EGFR; KRAS; Lung adenocarcinoma; P53; Promoter hypermethylation; RUNX3

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; K RAS PROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR RUNX3;

EID: 84868487326     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-011-9485-5     Document Type: Article
Times cited : (14)

References (59)
  • 3
    • 18844383718 scopus 로고    scopus 로고
    • Asbestos, asbestosis, and lung cancer: A critical assessment of the epidemiological evidence
    • Hessel PA, Gamble JF, McDonald JC (2005) Asbestos, asbestosis, and lung cancer: a critical assessment of the epidemiological evidence. Thorax 60(5):433-436
    • (2005) Thorax , vol.60 , Issue.5 , pp. 433-436
    • Hessel, P.A.1    Gamble, J.F.2    McDonald, J.C.3
  • 4
    • 0031019579 scopus 로고    scopus 로고
    • Lung cancer risk from residential radon: Meta-analysis of eight epidemiologic studies
    • Lubin JH, Boice JD Jr (1997) Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. J Natl Cancer Inst 89(1):49-57
    • (1997) J Natl Cancer Inst , vol.89 , Issue.1 , pp. 49-57
    • Lubin, J.H.1    Boice Jr., J.D.2
  • 5
    • 33747074100 scopus 로고    scopus 로고
    • Immunohistochemical markers of prognosis in non-small cell lung cancer: A review and proposal for a multiphase approach to marker evaluation
    • Zhu CQ, ShihW, Ling CH, Tsao MS (2006) Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation. J Clin Pathol 59(8):790-800
    • (2006) J Clin Pathol , vol.59 , Issue.8 , pp. 790-800
    • Zhu, C.Q.1    Shih, W.2    Ling, C.H.3    Tsao, M.S.4
  • 6
    • 0032578509 scopus 로고    scopus 로고
    • Aberrant methylation of p16INK4a is an early event in lung cancer and a potential biomarker for early diagnosis
    • Belinsky SA, Nikula KJ, Palmisano WA, Michels R, Saccomanno G, Gabrielson E et al (1998) Aberrant methylation of p16INK4a is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci 95(20):11891-11896
    • (1998) Proc Natl Acad Sci , vol.95 , Issue.20 , pp. 11891-11896
    • Belinsky, S.A.1    Nikula, K.J.2    Palmisano, W.A.3    Michels, R.4    Saccomanno, G.5    Gabrielson, E.6
  • 7
    • 0030047286 scopus 로고    scopus 로고
    • The effect of tobacco on lung cancer risk depends on CYP2D6 activity
    • Bouchardy C, Benhamou S, Dayer P (1996) The effect of tobacco on lung cancer risk depends on CYP2D6 activity. Cancer Res 56 (2):251-253
    • (1996) Cancer Res , vol.56 , Issue.2 , pp. 251-253
    • Bouchardy, C.1    Benhamou, S.2    Dayer, P.3
  • 9
    • 0032211358 scopus 로고    scopus 로고
    • Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens
    • Marchand LL, Sivaraman L, Pierce L, Seifried A, Lum A, Wilkens LR et al (1998) Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens. Cancer Res 58(21):4858-4863
    • (1998) Cancer Res , vol.58 , Issue.21 , pp. 4858-4863
    • Marchand, L.L.1    Sivaraman, L.2    Pierce, L.3    Seifried, A.4    Lum, A.5    Wilkens, L.R.6
  • 11
    • 0026708293 scopus 로고
    • Lung Cancer Detection and Prevention: Evidence for an Interaction between Smoking and Genetic Predisposition
    • Sellers TA, Potter JD, Bailey-Wilson JE, Rich SS, Rothschild H, Elston RC (1992) Lung Cancer Detection and Prevention: Evidence for an Interaction between Smoking and Genetic Predisposition. Cancer Res. 52(9-Supplement):2694s-7
    • (1992) Cancer Res , vol.52 , Issue.9 SUPPL.
    • Sellers, T.A.1    Potter, J.D.2    Bailey-Wilson, J.E.3    Rich, S.S.4    Rothschild, H.5    Elston, R.C.6
  • 13
    • 0037152658 scopus 로고    scopus 로고
    • Smoking molecular damage in bronchial epithelium
    • Wistuba II, Mao L, Gazdar AF (2002) Smoking molecular damage in bronchial epithelium. Oncogene 21(48):7298-7306
    • (2002) Oncogene , vol.21 , Issue.48 , pp. 7298-7306
    • Wistuba, I.I.1    Mao, L.2    Gazdar, A.F.3
  • 14
    • 34047270776 scopus 로고    scopus 로고
    • Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas
    • Yamabuki T, Takano A, Hayama S, Ishikawa N, Kato T, Miyamoto M et al (2007) Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas. Cancer Res 67 (6):2517-2525
    • (2007) Cancer Res , vol.67 , Issue.6 , pp. 2517-2525
    • Yamabuki, T.1    Takano, A.2    Hayama, S.3    Ishikawa, N.4    Kato, T.5    Miyamoto, M.6
  • 15
    • 4143073654 scopus 로고    scopus 로고
    • In search of the holy grail: Lung cancer biomarkers
    • Arenberg D (2004) In search of the holy grail: lung cancer biomarkers. Chest 126(2):325-326
    • (2004) Chest , vol.126 , Issue.2 , pp. 325-326
    • Arenberg, D.1
  • 16
    • 55449120805 scopus 로고    scopus 로고
    • Genetic mapping in human disease
    • Altshuler D, Daly MJ, Lander ES (2008) Genetic mapping in human disease. Science 322(5903):881-888
    • (2008) Science , vol.322 , Issue.5903 , pp. 881-888
    • Altshuler, D.1    Daly, M.J.2    Lander, E.S.3
  • 17
    • 55349099142 scopus 로고    scopus 로고
    • A personalized approach to cancer treatment: How biomarkers can help
    • Duffy MJ, Crown J (2008) A personalized approach to cancer treatment: how biomarkers can help. Clin Chem 54(11):1770-1779
    • (2008) Clin Chem , vol.54 , Issue.11 , pp. 1770-1779
    • Duffy, M.J.1    Crown, J.2
  • 20
    • 36348962321 scopus 로고    scopus 로고
    • RUNX genes in development and cancer: Regulation of viral gene expression and the discovery of RUNX family genes
    • Ito Y (2008) RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes. Adv Cancer Res 99:33-76
    • (2008) Adv Cancer Res , vol.99 , pp. 33-76
    • Ito, Y.1
  • 21
    • 0039844411 scopus 로고    scopus 로고
    • Interaction and Functional Cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Cα promoter
    • Hanai J-i, Chen LF, Kanno T, Ohtani-Fujita N, Kim WY, Guo W-H et al (1999) Interaction and Functional Cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Cá promoter. J Biol Chem 274(44):31577-31582
    • (1999) J Biol Chem , vol.274 , Issue.44 , pp. 31577-31582
    • Hanai, J.-I.1    Chen, L.F.2    Kanno, T.3    Ohtani-Fujita, N.4    Guo, W.-H.5
  • 22
    • 50649086570 scopus 로고    scopus 로고
    • RUNX3 attenuates β-Catenin/T cell factors in intestinal tumorigenesis
    • Ito K, Lim AC-B, Salto-Tellez M, Motoda L, Osato M, Chuang LSH et al (2008) RUNX3 attenuates β-Catenin/T cell factors in intestinal tumorigenesis. Cancer Cell 14(3):226-237
    • (2008) Cancer Cell , vol.14 , Issue.3 , pp. 226-237
    • Ito, K.1    Ac-B, L.2    Salto-Tellez, M.3    Motoda, L.4    Osato, M.5    Chuang, L.S.H.6
  • 25
    • 79952117740 scopus 로고    scopus 로고
    • Lung tissue regeneration after induced injury in Runx3 KO mice
    • Lee JM, Kwon HJ, Bae SC, Jung HS (2010) Lung tissue regeneration after induced injury in Runx3 KO mice. Cell Tissue Res 341(3):465-470
    • (2010) Cell Tissue Res , vol.341 , Issue.3 , pp. 465-470
    • Lee, J.M.1    Kwon, H.J.2    Bae, S.C.3    Jung, H.S.4
  • 26
    • 77953480629 scopus 로고    scopus 로고
    • Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer
    • Lee KS, Lee YS, Lee JM, Ito K, Cinghu S, Kim JH et al (2010) Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer. Oncogene 29(23):3349-3361
    • (2010) Oncogene , vol.29 , Issue.23 , pp. 3349-3361
    • Lee, K.S.1    Lee, Y.S.2    Lee, J.M.3    Ito, K.4    Cinghu, S.5    Kim, J.H.6
  • 27
    • 33746121227 scopus 로고    scopus 로고
    • RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer
    • Lau QC, Raja E, Salto-Tellez M, Liu Q, Ito K, Inoue Met al (2006) RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Res 66(13):6512-6520
    • (2006) Cancer Res , vol.66 , Issue.13 , pp. 6512-6520
    • Lau, Q.C.1    Raja, E.2    Salto-Tellez, M.3    Liu, Q.4    Met Al. Inoue, I.K.5
  • 28
    • 58049221118 scopus 로고    scopus 로고
    • RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression
    • Subramaniam MM, Chan JY, Soong R, Ito K, Ito Y, Yeoh KG et al (2008) RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression. Breast Cancer Res Treat
    • (2008) Breast Cancer Res Treat
    • Subramaniam, M.M.1    Chan, J.Y.2    Soong, R.3    Ito, K.4    Ito, Y.5    Yeoh, K.G.6
  • 29
    • 24744470103 scopus 로고    scopus 로고
    • RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization
    • Ito K, Liu Q, Salto-Tellez M, Yano T, Tada K, Ida H et al (2005) RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Res 65(17):7743-7750
    • (2005) Cancer Res , vol.65 , Issue.17 , pp. 7743-7750
    • Ito, K.1    Liu, Q.2    Salto-Tellez, M.3    Yano, T.4    Tada, K.5    Ida, H.6
  • 30
    • 4644363411 scopus 로고    scopus 로고
    • Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines
    • Ku J-L, Kang S-B, Shin Y-K, Kang HC, Hong S-H, Kim I-J et al (2004) Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines. Oncogene 23(40):6736-6742
    • (2004) Oncogene , vol.23 , Issue.40 , pp. 6736-6742
    • Ku, J.-L.1    Kang, S.-B.2    Shin, Y.-K.3    Kang, H.C.4    Hong, S.-H.5    Kim, I.-J.6
  • 31
    • 18344389720 scopus 로고    scopus 로고
    • Causal relationship between the loss of RUNX3 expression and gastric cancer
    • Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ et al (2002) Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109(1):113-124
    • (2002) Cell , vol.109 , Issue.1 , pp. 113-124
    • Li, Q.L.1    Ito, K.2    Sakakura, C.3    Fukamachi, H.4    Inoue, K.5    Chi, X.Z.6
  • 32
    • 33845513110 scopus 로고    scopus 로고
    • RUNX3 protein is overexpressed in human basal cell carcinomas
    • Salto-Tellez M, Peh BK, Ito K, Tan SH, Chong PY, Han HC et al (2006) RUNX3 protein is overexpressed in human basal cell carcinomas. Oncogene 25(58):7646-7649
    • (2006) Oncogene , vol.25 , Issue.58 , pp. 7646-7649
    • Salto-Tellez, M.1    Peh, B.K.2    Ito, K.3    Tan, S.H.4    Chong, P.Y.5    Han, H.C.6
  • 33
    • 2342641616 scopus 로고    scopus 로고
    • Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma
    • Kim TY, Lee HJ, Hwang KS, Lee M, Kim JW, Bang YJ et al (2004) Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma. Lab Invest 84 (4):479-484
    • (2004) Lab Invest , vol.84 , Issue.4 , pp. 479-484
    • Kim, T.Y.1    Lee, H.J.2    Hwang, K.S.3    Lee, M.4    Kim, J.W.5    Bang, Y.J.6
  • 34
    • 33644827114 scopus 로고    scopus 로고
    • Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines
    • Yanada M, Yaoi T, Shimada J, Sakakura C, Nishimura M, Ito K et al (2005) Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. Oncol Rep 14(4):817-822
    • (2005) Oncol Rep , vol.14 , Issue.4 , pp. 817-822
    • Yanada, M.1    Yaoi, T.2    Shimada, J.3    Sakakura, C.4    Nishimura, M.5    Ito, K.6
  • 35
    • 3242770719 scopus 로고    scopus 로고
    • P53 from pathway to therapy
    • Lane D (2004) p53 from pathway to therapy. Carcinogenesis 25 (7):1077-1081
    • (2004) Carcinogenesis , vol.25 , Issue.7 , pp. 1077-1081
    • Lane, D.1
  • 36
    • 0037307872 scopus 로고    scopus 로고
    • Prognostic prediction of the immunohistochemical expression of p53 and p16 in resected non-small cell lung cancer
    • Cheng Y-L, Lee S-C, Harn H-J, Chen C-J, Chang Y-C, Chen J-C et al (2003) Prognostic prediction of the immunohistochemical expression of p53 and p16 in resected non-small cell lung cancer. Eur J Cardiothorac Surg 23(2):221-228
    • (2003) Eur J Cardiothorac Surg , vol.23 , Issue.2 , pp. 221-228
    • Cheng, Y.-L.1    Lee, S.-C.2    Harn, H.-J.3    Chen, C.-J.4    Chang, Y.-C.5    Chen, J.-C.6
  • 37
    • 0034831375 scopus 로고    scopus 로고
    • Association of p53 gene mutation and telomerase activity in resectable non-small cell lung cancer*
    • Maniwa Y, Yoshimura M, Obayashi C, Inaba M, Kiyooka K, Kanki M et al (2001) Association of p53 gene mutation and telomerase activity in resectable non-small cell lung cancer*. Chest 120(2):589-594
    • (2001) Chest , vol.120 , Issue.2 , pp. 589-594
    • Maniwa, Y.1    Yoshimura, M.2    Obayashi, C.3    Inaba, M.4    Kiyooka, K.5    Kanki, M.6
  • 38
    • 0037243172 scopus 로고    scopus 로고
    • Nuclear accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokers*
    • Piyathilake CJ, Frost AR, Manne U, Weiss H, Heimburger DC, Grizzle WE (2003) Nuclear accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokers*. Chest 123(1):181-186
    • (2003) Chest , vol.123 , Issue.1 , pp. 181-186
    • Piyathilake, C.J.1    Frost, A.R.2    Manne, U.3    Weiss, H.4    Heimburger, D.C.5    Grizzle, W.E.6
  • 39
    • 33645761156 scopus 로고    scopus 로고
    • Clinical implications of EGFR expression in the development and progression of solid tumors: Focus on nonsmall cell lung cancer
    • Ettinger DS (2006) Clinical implications of EGFR expression in the development and progression of solid tumors: focus on nonsmall cell lung cancer. Oncologist 11(4):358-373
    • (2006) Oncologist , vol.11 , Issue.4 , pp. 358-373
    • Ettinger, D.S.1
  • 40
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW et al (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350(21):2129-2139
    • (2004) N Engl J Med , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 41
    • 64249109679 scopus 로고    scopus 로고
    • EGFR and KRAS mutations in patients with adenocarcinoma of the lung
    • Jang TW, Oak CH, Chang HK, Suo SJ, Jung MH (2009) EGFR and KRAS mutations in patients with adenocarcinoma of the lung. Korean J Intern Med 24(1):48-54
    • (2009) Korean J Intern Med , vol.24 , Issue.1 , pp. 48-54
    • Jang, T.W.1    Oak, C.H.2    Chang, H.K.3    Suo, S.J.4    Jung, M.H.5
  • 42
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M,Wistuba II et al (2005) Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97(5):339-346
    • (2005) J Natl Cancer Inst , vol.97 , Issue.5 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3    Nomura, M.4    Suzuki, M.5    Wistuba, I.I.6
  • 43
    • 68049088934 scopus 로고    scopus 로고
    • EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases
    • Schmid K, Oehl N, Wrba F, Pirker R, Pirker C, Filipits M (2009) EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases. Clin Cancer Res 15(14):4554-4560
    • (2009) Clin Cancer Res , vol.15 , Issue.14 , pp. 4554-4560
    • Schmid, K.1    Oehl, N.2    Wrba, F.3    Pirker, R.4    Pirker, C.5    Filipits, M.6
  • 44
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard DA, Johnson BE, Amler LC, Goddard AD, Heldens SL, Herbst RS et al (2005) Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 23 (25):5900-5909
    • (2005) J Clin Oncol , vol.23 , Issue.25 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3    Goddard, A.D.4    Heldens, S.L.5    Herbst, R.S.6
  • 46
    • 79956115427 scopus 로고    scopus 로고
    • Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: Relation with smoking status
    • Yanagawa N, Tamura G, Oizumi H, Endoh M, Sadahiro M, Motoyama T (2011) Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: relation with smoking status. Anticancer Res 31(4):1211-1214
    • (2011) Anticancer Res , vol.31 , Issue.4 , pp. 1211-1214
    • Yanagawa, N.1    Tamura, G.2    Oizumi, H.3    Endoh, M.4    Sadahiro, M.5    Motoyama, T.6
  • 47
    • 46749139206 scopus 로고    scopus 로고
    • TRARESA: A tissue microarray-based hospital systemfor biomarker validation and discovery
    • Das K, Mohd Omar MF, Ong CW, Bin Abdul Rashid S, Peh BK, Putti TC et al (2008) TRARESA: a tissue microarray-based hospital systemfor biomarker validation and discovery. Pathology 40 (5):441-449
    • (2008) Pathology , vol.40 , Issue.5 , pp. 441-449
    • Das, K.1    Mohd Omar, M.F.2    Ong, C.W.3    Bin Abdul Rashid, S.4    Peh, B.K.5    Putti, T.C.6
  • 48
    • 33745018595 scopus 로고    scopus 로고
    • The RUNX3 tumor suppressor upregulates bim in gastric epithelial cells undergoing transforming growth factor â-induced apoptosis
    • Yano T, Ito K, Fukamachi H, Chi X-Z, Wee H-J, Inoue K-i et al (2006) The RUNX3 tumor suppressor upregulates bim in gastric epithelial cells undergoing transforming growth factor â-induced apoptosis. Mol Cell Biol 26(12):4474-4488
    • (2006) Mol Cell Biol , vol.26 , Issue.12 , pp. 4474-4488
    • Yano, T.1    Ito, K.2    Fukamachi, H.3    Chi, X.-Z.4    Wee, H.-J.5    Inoue, K.-I.6
  • 49
    • 16044375068 scopus 로고    scopus 로고
    • Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas
    • Soong R, Robbins PD, Dix BR, Grieu F, Lim B, Knowles S et al (1996) Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas. Hum Pathol 27(10):1050-1055
    • (1996) Hum Pathol , vol.27 , Issue.10 , pp. 1050-1055
    • Soong, R.1    Robbins, P.D.2    Dix, B.R.3    Grieu, F.4    Lim, B.5    Knowles, S.6
  • 50
    • 0029843950 scopus 로고    scopus 로고
    • Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
    • Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93 (18):9821-9826
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.18 , pp. 9821-9826
    • Herman, J.G.1    Graff, J.R.2    Myohanen, S.3    Nelkin, B.D.4    Baylin, S.B.5
  • 51
    • 33846641709 scopus 로고    scopus 로고
    • High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer
    • Krypuy M, Newnham G, Thomas D, Conron M, Dobrovic A (2006) High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer. BMC Cancer 6(1):295
    • (2006) BMC Cancer , vol.6 , Issue.1 , pp. 295
    • Krypuy, M.1    Newnham, G.2    Thomas, D.3    Conron, M.4    Dobrovic, A.5
  • 52
    • 33845989517 scopus 로고    scopus 로고
    • Detection of epidermal growth factor receptor variations by partially denaturing HPLC
    • Chin TM, Anuar D, Soo R, Salto-Tellez M, Li WQ, Ahmad B et al (2007) Detection of epidermal growth factor receptor variations by partially denaturing HPLC. Clin Chem 53(1):62-70
    • (2007) Clin Chem , vol.53 , Issue.1 , pp. 62-70
    • Chin, T.M.1    Anuar, D.2    Soo, R.3    Salto-Tellez, M.4    Li, W.Q.5    Ahmad, B.6
  • 53
    • 20044379409 scopus 로고    scopus 로고
    • Expression of RUNX3 protein in human lung adenocarcinoma: Implications for tumor progression and prognosis
    • Araki K, Osaki M, Nagahama Y, Hiramatsu T, Nakamura H, Ohgi S et al (2005) Expression of RUNX3 protein in human lung adenocarcinoma: implications for tumor progression and prognosis. Cancer Sci 96(4):227-231
    • (2005) Cancer Sci , vol.96 , Issue.4 , pp. 227-231
    • Araki, K.1    Osaki, M.2    Nagahama, Y.3    Hiramatsu, T.4    Nakamura, H.5    Ohgi, S.6
  • 54
    • 62249151768 scopus 로고    scopus 로고
    • Runx3 expression in gastrointestinal tract epithelium: Resolving the controversy
    • Ito K, Inoue Ki, Bae SC, Ito Y (2009) Runx3 expression in gastrointestinal tract epithelium: resolving the controversy. Oncogene 28(10):1379-1384
    • (2009) Oncogene , vol.28 , Issue.10 , pp. 1379-1384
    • Ito, K.1    Ki, I.2    Bae, S.C.3    Ito, Y.4
  • 55
    • 9144223364 scopus 로고    scopus 로고
    • Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer
    • Li QL, Kim HR, Kim WJ, Choi JK, Lee YH, Kim HM et al (2004) Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer. Biochem Biophys Res Commun 314(1):223-228
    • (2004) Biochem Biophys Res Commun , vol.314 , Issue.1 , pp. 223-228
    • Li, Q.L.1    Kim, H.R.2    Kim, W.J.3    Choi, J.K.4    Lee, Y.H.5    Kim, H.M.6
  • 57
    • 0042563143 scopus 로고    scopus 로고
    • Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers
    • Yanagawa N, Tamura G, Oizumi H, Takahashi N, Shimazaki Y, Motoyama T (2003) Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers. Cancer Sci 94 (7):589-592
    • (2003) Cancer Sci , vol.94 , Issue.7 , pp. 589-592
    • Yanagawa, N.1    Tamura, G.2    Oizumi, H.3    Takahashi, N.4    Shimazaki, Y.5    Motoyama, T.6
  • 58
    • 79958147099 scopus 로고    scopus 로고
    • Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression
    • Ibrahim AEK, Arends MJ, Silva A-L, Wyllie AH, Greger L, Ito Y et al (2010) Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression. Gut
    • (2010) Gut
    • Ibrahim, A.E.K.1    Arends, M.J.2    Silva, A.-L.3    Wyllie, A.H.4    Greger, L.5    Ito, Y.6
  • 59
    • 21244500107 scopus 로고    scopus 로고
    • Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas
    • Soung YH, Lee JW, Kim SY, Seo SH, Park WS, Nam SW et al (2005) Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas. Virchows Arch 446(5):483-488
    • (2005) Virchows Arch , vol.446 , Issue.5 , pp. 483-488
    • Soung, Y.H.1    Lee, J.W.2    Kim, S.Y.3    Seo, S.H.4    Park, W.S.5    Nam, S.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.