Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation

Clinical Cancer Research

Volumn 8, Issue 5, 2002, Pages 1178-1184

  Soria, Jean Charles ^a   Lee, Ho Young ^a   Lee, Janet I ^a   Wang, Luo ^a   Issa, Jean Pierre ^a   Kemp, Bonnie L ^a   Liu, Diane D ^a   Kurie, Jonathan M ^a   Mao, Li ^a   Khuri, Fadlo R ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ADULT; AGED; ARTICLE; CHROMOSOME 10Q; CONTROLLED STUDY; FEMALE; GENE INACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; METHYLATION; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELLS, CULTURED; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PHOSPHORIC MONOESTER HYDROLASES; PROMOTER REGIONS (GENETICS); PTEN PHOSPHOHYDROLASE; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0036094196     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Cancer statistics, 2001
2. Revision in the international system for staging of lung cancer
3. The multiple roles of PTEN in tumor suppression
4. PTEN mutations in gliomas and glioneuronal tumors
5. Identification of PTEN/MMAC 1 alterations in uncultured melanomas and melanoma cell lines
6. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
7. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
8. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
9. PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines
10. Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers
11. PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers
12. Mutation analysis of the PTEN/MMAC1 gene in lung cancer
13. Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis
14. Loss of PTEN expression as a prognostic marker for tongue cancer
15. Methylation-specific PCR. A novel PCR assay for methylation status of CpG islands
16. Mutational spectra of PTEN/MMAC1: A tumor suppressor with lipid phosphatase activity
17. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β
18. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function
19. 1 growth arrest in glioma cells
20. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
21. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells
22. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
23. Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: Differential involvement of focal adhesion kinase and pl30Cas
24. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
25. Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues
26. Loss of expression of the pten gene protein product is associated with poor outcome in breast cancer
27. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
28. PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma
29. ink4a is an early event in lung cancer and a potential biomarker for early diagnosis
30. Aberrant promoter methylation of multiple genes in non-small cell lung cancers
31. A highly conserved processed PTEN pseudogene is located on chromosome band 9p21
32. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas
33. Mutter a protean tumor suppressor
34. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
35. Suppression of c-Myc-induced apoptosis by Ras signaling through PI(3)K and PKB
36. Matrix adhesion and ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
37. Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway