Performance evaluation of the DNA methylation biomarker SHOX2 for the aid in diagnosis of lung cancer based on the analysis of bronchial aspirates

International Journal of Oncology

Volumn 40, Issue 3, 2012, Pages 825-832

  Dietrich, Dimo ^a   Kneip, Christoph ^b   Raji, Olaide ^c   Liloglou, Triantafillos ^c   Seegebarth, Anke ^d   Schlegel, Thomas ^a   Flemming, Nadja ^a   Rausch, Sebastian ^a   Distler, Jürgen ^a   Fleischhacker, Michael ^e   Schmidt, Bernd ^e   Giles, Thomas ^f   Walshaw, Martin ^f   Warburton, Chris ^g   Liebenberg, Volker ^h   Field, John K ^c  

^a EPIGENOMICS AG   (Germany)

^b Theracode GmbH   (Germany)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e MARTIN LUTHER UNIVERSITÄT HALLE WITTENBERG   (Germany)

^f ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^g UNIVERSITY HOSPITAL AINTREE   (United Kingdom)

^h Metanomics Health GmbH   (Germany)

Author keywords

Bronchial aspirate; Diagnosis; DNA methylation biomarker; Lung cancer; SHOX2

Indexed keywords

BIOLOGICAL MARKER; BISULFITE; FIXATIVE; SACCOMANNO FIXATIVE; UNCLASSIFIED DRUG;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BRONCHIAL ASPIRATION PROCEDURE; CANCER DIAGNOSIS; CLINICAL EVALUATION; CONFIDENCE INTERVAL; CONTROLLED STUDY; CROSS REACTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC KIT; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; DNA METHYLATION; FEMALE; GENE; GENE LOCUS; HUMAN; IN VITRO STUDY; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; RELIABILITY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SHOX2 GENE; VALIDITY; WORKFLOW;

AGED; AGED, 80 AND OVER; BRONCHI; BRONCHOALVEOLAR LAVAGE; CASE-CONTROL STUDIES; CROSS REACTIONS; DNA METHYLATION; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; QUALITY CONTROL; REAGENT KITS, DIAGNOSTIC; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 84857159930     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1264     Document Type: Article

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