Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer

Journal of the National Cancer Institute

Volumn 92, Issue 18, 2000, Pages 1511-1516

  Tang, Ximing ^a,b   Khuri, Fadlo R ^a   Jack Lee, J ^b   Kemp, Bonnie L ^b   Liu, Diane ^a   Hong, Waun Ki ^a   Mao, Li ^a  

^a Molecular Biology Laboratory   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEATH ASSOCIATED PROTEIN KINASE; PROTEIN KINASE; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER MORTALITY; CANCER STAGING; CANCER SURVIVAL; CAUSE OF DEATH; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION;

EID: 0034692447     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/92.18.1511     Document Type: Article

References (37)

1. Global cancer statistics
2. Cancer statistics, 1998
3. Survival of patients surgically treated for stage I lung cancer
4. Early Lung Cancer Action Project: Overall design and findings from baseline screening
5. Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types
6. Genetic events in the pathogenesis of lung cancer
7. Evidence of cumulative gene losses with progression of pre-malignant epithelial lesions to carcinoma of the bronchus
8. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
9. Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer. The Lung Cancer Study Group
10. K-ras genotypes and prognosis in non-small-cell lung cancer
11. Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines
12. Assignment of DAP1 and DAPK - Genes that positively mediate programmed cell death triggered by IFN-gamma - To chromosome regions 5p12.2 and 9q34.1, respectively
13. DAP kinase links the control of apoptosis to metastasis
14. Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies
15. DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: Possible implications for role as tumor suppressor gene
16. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients
17. Revisions in the International System for Staging Lung Cancer
18. Identification of three distinct tumor suppressor loci on the short arm of chromosome 9 in small cell lung cancer
19. Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment
20. Value of the new TNM staging system for lung cancer
21. Tumor ne1 crosis factor can induce both apoptotic and necrotic forms of cell lysis
22. Environmental signals influencing expression of the IFN-gamma receptor on human T cells control whether IFN-gamma promotes proliferation or apoptosis
23. In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1
24. Aberrant TGF-beta production and regulation in metastatic malignancy
25. 2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity
26. A novel molecular staging protocol for non-small cell lung cancer
27. Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer
28. Molecular pathologic substaging in 244 stage I non-small-cell lung cancer patients: Clinical implications
29. Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients
30. Prognostic implication of micro-satellite alteration profiles in early-stage non-small cell lung cancer
31. Differential expression of E-cadherin and type IV collagenase genes predicts outcome in patients with stage I non-small cell lung carcinoma
32. Prognostic value of the expression of p53, bcl-2, and bax oncoproteins, and neovascularization in patients with radically resected non-small cell lung cancer
33. Immunocyto-chemical markers in stage I lung cancer: Relevance to prognosis
34. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
35. DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain
36. Bcl-2 protein expression in lung cancer and close correlation with neuroendocrine differentiation
37. bcl-2 protein in non-small-cell lung carcinoma