Determination of O6-methylguanine DNA methyltransferase promoter methylation in non-small cell lung cancer

Genetic Testing and Molecular Biomarkers

Volumn 15, Issue 5, 2011, Pages 357-360

  Ekim, Mehmet ^a   Caner, Vildan ^a   Büyükpinarbaşili, Nur ^b   Tepeli, Emre ^a   Elmas, Levent ^a   Baǧci, Gülseren ^a  

^a PAMUKKALE UNIVERSITY   (Turkey)

^b Yedikule Teaching Hospital   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; DNA METHYLTRANSFERASE; MGMT PROTEIN, HUMAN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGE; ARTICLE; CANCER STAGING; DNA METHYLATION; FEMALE; GENDER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; SMOKING; ADENOCARCINOMA; GENETICS; LUNG TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; PROMOTER REGION; SQUAMOUS CELL CARCINOMA;

ADENOCARCINOMA; ADULT; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 79956110885     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2010.0211     Document Type: Article

References (19)

1. Anglim PP, Alonzo TA (2008) DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an update. Laird-Offringa IA. Mol Cancer 7:81.
2. Belinsky SA, Palmisano WA, Gilliland FD, et al. (2002) Aberrant promoter methylation in bronchial epithelium and sputum from currentand former smokers. Cancer Res 62: 2370-2377. (Pubitemid 34411720)
3. Brabender J, Usadel H, Metzger R, et al. (2003) Quantitative O6- methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome. Clin Cancer Res 9:223-227. (Pubitemid 36109737)
4. Esteller M (2007) Epigenetic gene silencing in cancer: the DNA hypermethylome Hum Mol Genet 6:50-59.
5. Esteller M, Hamilton SR, Burger PC, et al. (1999a) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 59:793-797. (Pubitemid 29086728)
6. Esteller M, Sanchez-Cespedes M, Rosell R, et al. (1999b) Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res 59:67-70. (Pubitemid 29062958)
7. Genereux DP, Johnson WC, Burden AF, et al. (2008) Errors in the bisulfite conversion of DNA: modulating inappropriate- and failed-conversion frequencies. Nucleic Acids Res 36:e150.
8. Jacinto FV, Esteller M (2007) Mutator pathways unleashed by epigenetic silencing in human cancer. Mutagenesis 22: 247-253. (Pubitemid 47216613)
9. Li J, Li ZN, Du YJ, et al. (2009) Expression of MRP1, BCRP, LRP, and ERCC1 in advanced non-small-cell lung cancer: correlation with response to chemotherapy and survival. Clin Lung Cancer 10:414-421.
10. Liu Y, Lan Q, Siegfried JM, et al. (2006) Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients. Neoplasia 8:46-51.
11. Ministry of Health, Republic of Turkey (2009). Cancer Statistics in Turkey. Available at www.kanser.gov.tr .
12. Pegg AE (2000) Repair of O(6)-alkylguanine by alkyltransferases. Mutat Res 462:83-100.
13. Pulling LC, Divine KK, Klinge DM, et al. (2003) Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression. Cancer Res 63:4842-4848. (Pubitemid 37022615)
14. Raizis AM, Schmitt F, Jost JP (1995) A bisulfite method of 5- methylcytosine mapping that minimizes template degradation. Anal Biochem 226:161-166.
15. Silber JR, Blank A, Bobola MS, et al. (1999) O6-methylguanine- DNA methyltransferase-deficient phenotype in human gliomas: frequency and time to tumor progression after alkylating agent-based chemotherapy. Clin Cancer Res 5:807-814. (Pubitemid 29180832)
16. Silber JR, Bobola MS, Ghatan S, et al. (1998) O6-methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics. Cancer Res 58:1068-1073. (Pubitemid 28182481)
17. Sobin LH, Wittekind Ch (eds) (1997) TNM Classification of Malignant Tumours, 5th edition. International Union Against Cancer, Wiley-Liss, NY.
18. Toyooka S, Maruyama R, Toyooka KO, et al. (2003) Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int J Cancer 103:153-160. (Pubitemid 35461506)
19. Zöchbauer-Müller S, Fong KM, Virmani AK, et al. (2001) Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res 61: 249-255. (Pubitemid 32095725)