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Volumn 20, Issue 38, 2014, Pages 13804-13819

Pathogenetic mechanisms in gastric cancer

Author keywords

Epigenetic alterations; Gastric cancer; Genetic alterations; Risk factors; Signaling pathways

Indexed keywords

AZACITIDINE; BEVACIZUMAB; CAPECITABINE; CEDIRANIB; CETUXIMAB; CISPLATIN; CYCLOOXYGENASE 2; EVEROLIMUS; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAPATINIB; MARIMASTAT; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROSTAGLANDIN E2; PROTEIN KINASE B; PROTEIN P53; RAMUCIRUMAB; RETINOBLASTOMA PROTEIN; RILOTUMUMAB; SORAFENIB; SUNITINIB; TRANSCRIPTION FACTOR RUNX3; TRANSFORMING GROWTH FACTOR BETA; TRASTUZUMAB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; VORINOSTAT; ZEBULARINE; TUMOR MARKER;

EID: 84910011097     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i38.13804     Document Type: Article
Times cited : (92)

References (236)
  • 1
    • 31144445320 scopus 로고    scopus 로고
    • Incidence and mortality of gastric cancer in China
    • PMID: 16440411
    • Yang L. Incidence and mortality of gastric cancer in China. World J Gastroenterol 2006; 12: 17-20 [PMID: 16440411]
    • (2006) World J Gastroenterol , vol.12 , pp. 17-20
    • Yang, L.1
  • 2
    • 11044225555 scopus 로고    scopus 로고
    • Gastric adenocarcinoma: Review and considerations for future directions
    • PMID: 15621988
    • Dicken BJ, Bigam DL, Cass C, Mackey JR, Joy AA, Hamilton SM. Gastric adenocarcinoma: review and considerations for future directions. Ann Surg 2005; 241: 27-39 [PMID: 15621988]
    • (2005) Ann Surg , vol.241 , pp. 27-39
    • Dicken, B.J.1    Bigam, D.L.2    Cass, C.3    Mackey, J.R.4    Joy, A.A.5    Hamilton, S.M.6
  • 3
    • 33644681327 scopus 로고    scopus 로고
    • Epidemiology of gastric cancer
    • PMID: 16489633
    • Crew KD, Neugut AI. Epidemiology of gastric cancer. World J Gastroenterol 2006; 12: 354-362 [PMID: 16489633]
    • (2006) World J Gastroenterol , vol.12 , pp. 354-362
    • Crew, K.D.1    Neugut, A.I.2
  • 5
    • 0030612426 scopus 로고    scopus 로고
    • The mixed type in Laurén's classification of gastric carcinoma. Histologic description and biologic behavior
    • PMID: 9269907
    • Stelzner S, Emmrich P. The mixed type in Laurén's classification of gastric carcinoma. Histologic description and biologic behavior. Gen Diagn Pathol 1997; 143: 39-48 [PMID: 9269907]
    • (1997) Gen Diagn Pathol , vol.143 , pp. 39-48
    • Stelzner, S.1    Emmrich, P.2
  • 7
    • 84868138497 scopus 로고    scopus 로고
    • Recent development of gastric cancer prevention
    • PMID: 23018579
    • Kato M, Asaka M. Recent development of gastric cancer prevention. Jpn J Clin Oncol 2012; 42: 987-994 [PMID: 23018579 DOI: 10.1093/jjco/hys151]
    • (2012) Jpn J Clin Oncol , vol.42 , pp. 987-994
    • Kato, M.1    Asaka, M.2
  • 8
    • 84859940334 scopus 로고    scopus 로고
    • Multifactorial etiology of gastric cancer
    • PMID: 22359309
    • Zabaleta J. Multifactorial etiology of gastric cancer. Methods Mol Biol 2012; 863: 411-435 [PMID: 22359309 DOI: 10.1007/978-1-61779-612-8-26]
    • (2012) Methods Mol Biol , vol.863 , pp. 411-435
    • Zabaleta, J.1
  • 9
    • 84883753695 scopus 로고    scopus 로고
    • Molecular pathogenesis of gastric cancer
    • PMID: 24011242
    • Figueiredo C, Garcia-Gonzalez MA, Machado JC. Molecular pathogenesis of gastric cancer. Helicobacter 2013; 18 Suppl 1: 28-33 [PMID: 24011242 DOI: 10.1111/hel.12083]
    • (2013) Helicobacter , vol.18 , pp. 28-33
    • Figueiredo, C.1    Garcia-Gonzalez, M.A.2    Machado, J.C.3
  • 10
    • 78249282604 scopus 로고    scopus 로고
    • Genetic and epigenetic alteration in gastric carcinogenesis
    • PMID: 21054651
    • Resende C, Ristimäki A, Machado JC. Genetic and epigenetic alteration in gastric carcinogenesis. Helicobacter 2010; 15 Suppl 1: 34-39 [PMID: 21054651 DOI: 10.1111/j.1523-5378.2010.00782.x]
    • (2010) Helicobacter , vol.15 , pp. 34-39
    • Resende, C.1    Ristimäki, A.2    Machado, J.C.3
  • 12
    • 84879131073 scopus 로고    scopus 로고
    • Gene methylation in gastric cancer
    • PMID: 23669186
    • Qu Y, Dang S, Hou P. Gene methylation in gastric cancer. Clin Chim Acta 2013; 424: 53-65 [PMID: 23669186 DOI: 10.1016/j.cca.2013.05.002]
    • (2013) Clin Chim Acta , vol.424 , pp. 53-65
    • Qu, Y.1    Dang, S.2    Hou, P.3
  • 13
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • PMID: 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674 [PMID: 21376230 DOI: 10.1016/j.cell.2011.02.013]
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 14
    • 34250722637 scopus 로고    scopus 로고
    • Diet and the risk of gastric cancer: Review of epidemiological evidence
    • PMID: 17577615
    • Tsugane S, Sasazuki S. Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer 2007; 10: 75-83 [PMID: 17577615 DOI: 10.1007/s10120-007-0420-0]
    • (2007) Gastric Cancer , vol.10 , pp. 75-83
    • Tsugane, S.1    Sasazuki, S.2
  • 16
    • 18844439381 scopus 로고    scopus 로고
    • Helicobacter pylori and gastric cancer: A new paradigm for inflammation-associated epithelial cancers
    • PMID: 15887152
    • Houghton J, Wang TC. Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology 2005; 128: 1567-1578 [PMID: 15887152]
    • (2005) Gastroenterology , vol.128 , pp. 1567-1578
    • Houghton, J.1    Wang, T.C.2
  • 17
    • 77649208684 scopus 로고    scopus 로고
    • Epidemiology of Helicobacter pylori infection and gastric cancer in Asia
    • PMID: 20370726
    • Fock KM, Ang TL. Epidemiology of Helicobacter pylori infection and gastric cancer in Asia. J Gastroenterol Hepatol 2010; 25: 479-486 [PMID: 20370726 DOI: 10.1111/j.1440-1746.2009.06188.x]
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 479-486
    • Fock, K.M.1    Ang, T.L.2
  • 20
    • 1842633077 scopus 로고    scopus 로고
    • The future of gastric cancer prevention
    • PMID: 15052434
    • Correa P, Piazuelo MB, Camargo MC. The future of gastric cancer prevention. Gastric Cancer 2004; 7: 9-16 [PMID: 15052434 DOI: 10.1007/s10120-003-0265-0]
    • (2004) Gastric Cancer , vol.7 , pp. 9-16
    • Correa, P.1    Piazuelo, M.B.2    Camargo, M.C.3
  • 21
    • 34249712537 scopus 로고    scopus 로고
    • Oxidative stress expression status associated to Helicobacter pylori virulence in gastric diseases
    • PMID: 17466292
    • Augusto AC, Miguel F, Mendonc¸a S, Pedrazzoli J, Gurgueira SA. Oxidative stress expression status associated to Helicobacter pylori virulence in gastric diseases. Clin Biochem 2007; 40: 615-622 [PMID: 17466292 DOI: 10.1016/j.clinbiochem.2007.03.014]
    • (2007) Clin Biochem , vol.40 , pp. 615-622
    • Augusto, A.C.1    Miguel, F.2    Mendonc¸a, S.3    Pedrazzoli, J.4    Gurgueira, S.A.5
  • 22
    • 84865606611 scopus 로고    scopus 로고
    • Gastric intestinal metaplasia revisited: Function and regulation of CDX2
    • PMID: 22871898
    • Barros R, Freund JN, David L, Almeida R. Gastric intestinal metaplasia revisited: function and regulation of CDX2. Trends Mol Med 2012; 18: 555-563 [PMID: 22871898 DOI: 10.1016/j.molmed.2012.07.006]
    • (2012) Trends Mol Med , vol.18 , pp. 555-563
    • Barros, R.1    Freund, J.N.2    David, L.3    Almeida, R.4
  • 23
    • 58149468085 scopus 로고    scopus 로고
    • The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae
    • PMID: 19035455
    • Nakajima T, Yamashita S, Maekita T, Niwa T, Nakazawa K, Ushijima T. The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae. Int J Cancer 2009; 124: 905-910 [PMID: 19035455 DOI: 10.1002/ijc.24018]
    • (2009) Int J Cancer , vol.124 , pp. 905-910
    • Nakajima, T.1    Yamashita, S.2    Maekita, T.3    Niwa, T.4    Nakazawa, K.5    Ushijima, T.6
  • 24
    • 76649145629 scopus 로고    scopus 로고
    • Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells
    • PMID: 20124475
    • Niwa T, Tsukamoto T, Toyoda T, Mori A, Tanaka H, Maekita T, Ichinose M, Tatematsu M, Ushijima T. Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res 2010; 70: 1430-1440 [PMID: 20124475 DOI: 10.1158/0008-5472.can-09-2755]
    • (2010) Cancer Res , vol.70 , pp. 1430-1440
    • Niwa, T.1    Tsukamoto, T.2    Toyoda, T.3    Mori, A.4    Tanaka, H.5    Maekita, T.6    Ichinose, M.7    Tatematsu, M.8    Ushijima, T.9
  • 25
    • 77954162426 scopus 로고    scopus 로고
    • Role of Helicobacter pylori infection in aberrant DNA methylation along multistep gastric carcinogenesis
    • PMID: 20345486
    • Shin CM, Kim N, Jung Y, Park JH, Kang GH, Kim JS, Jung HC, Song IS. Role of Helicobacter pylori infection in aberrant DNA methylation along multistep gastric carcinogenesis. Cancer Sci 2010; 101: 1337-1346 [PMID: 20345486 DOI: 10.1111/j.1349-7006.2010.01535.x]
    • (2010) Cancer Sci , vol.101 , pp. 1337-1346
    • Shin, C.M.1    Kim, N.2    Jung, Y.3    Park, J.H.4    Kang, G.H.5    Kim, J.S.6    Jung, H.C.7    Song, I.S.8
  • 26
    • 79952119029 scopus 로고    scopus 로고
    • Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation
    • PMID: 20980348
    • Hur K, Niwa T, Toyoda T, Tsukamoto T, Tatematsu M, Yang HK, Ushijima T. Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation. Carcinogenesis 2011; 32: 35-41 [PMID: 20980348 DOI: 10.1093/carcin/bgq219]
    • (2011) Carcinogenesis , vol.32 , pp. 35-41
    • Hur, K.1    Niwa, T.2    Toyoda, T.3    Tsukamoto, T.4    Tatematsu, M.5    Yang, H.K.6    Ushijima, T.7
  • 27
    • 14144249629 scopus 로고    scopus 로고
    • Salt, salted food intake, and risk of gastric cancer: Epidemiologic evidence
    • PMID: 15649247
    • Tsugane S. Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence. Cancer Sci 2005; 96: 1-6 [PMID: 15649247 DOI: 10.1111/j.1349-7006.2005.00006.x]
    • (2005) Cancer Sci , vol.96 , pp. 1-6
    • Tsugane, S.1
  • 28
    • 0016818405 scopus 로고
    • Effects in rats of sodium chloride on experimental gastric cancers induced by N-methyl-N-nitro-N-nitrosoguanidine or 4-nitroquinoline-1-oxide
    • PMID: 808633
    • Tatematsu M, Takahashi M, Fukushima S, Hananouchi M, Shirai T. Effects in rats of sodium chloride on experimental gastric cancers induced by N-methyl-N-nitro-N-nitrosoguanidine or 4-nitroquinoline-1-oxide. J Natl Cancer Inst 1975; 55: 101-106 [PMID: 808633]
    • (1975) J Natl Cancer Inst , vol.55 , pp. 101-106
    • Tatematsu, M.1    Takahashi, M.2    Fukushima, S.3    Hananouchi, M.4    Shirai, T.5
  • 30
    • 27444444034 scopus 로고    scopus 로고
    • Nitrate and nitrosative chemistry within Barrett's oesophagus during acid reflux
    • PMID: 16227357
    • Suzuki H, Iijima K, Scobie G, Fyfe V, McColl KE. Nitrate and nitrosative chemistry within Barrett's oesophagus during acid reflux. Gut 2005; 54: 1527-1535 [PMID: 16227357 DOI: 10.1136/gut.2005.066043]
    • (2005) Gut , vol.54 , pp. 1527-1535
    • Suzuki, H.1    Iijima, K.2    Scobie, G.3    Fyfe, V.4    McColl, K.E.5
  • 32
    • 43049097903 scopus 로고    scopus 로고
    • Nutrition and gastric cancer risk: An update
    • PMID: 18454810
    • Liu C, Russell RM. Nutrition and gastric cancer risk: an update. Nutr Rev 2008; 66: 237-249 [PMID: 18454810 DOI: 10.1111/j.1753-4887.2008.00029.x]
    • (2008) Nutr Rev , vol.66 , pp. 237-249
    • Liu, C.1    Russell, R.M.2
  • 33
    • 0842265108 scopus 로고    scopus 로고
    • Salt and salted food intake and subsequent risk of gastric cancer among middle-aged Japanese men and women
    • PMID: 14710219
    • Tsugane S, Sasazuki S, Kobayashi M, Sasaki S. Salt and salted food intake and subsequent risk of gastric cancer among middle-aged Japanese men and women. Br J Cancer 2004; 90: 128-134 [PMID: 14710219 DOI: 10.1038/sj.bjc.6601511]
    • (2004) Br J Cancer , vol.90 , pp. 128-134
    • Tsugane, S.1    Sasazuki, S.2    Kobayashi, M.3    Sasaki, S.4
  • 34
    • 67650137086 scopus 로고    scopus 로고
    • Review of salt consumption and stomach cancer risk: Epidemiological and biological evidence
    • PMID: 19437559
    • Wang XQ, Terry PD, Yan H. Review of salt consumption and stomach cancer risk: epidemiological and biological evidence. World J Gastroenterol 2009; 15: 2204-2213 [PMID: 19437559]
    • (2009) World J Gastroenterol , vol.15 , pp. 2204-2213
    • Wang, X.Q.1    Terry, P.D.2    Yan, H.3
  • 35
    • 78649389947 scopus 로고    scopus 로고
    • Gastric cancer: Epidemiology and risk factors
    • PMID: 21088409
    • Krejs GJ. Gastric cancer: epidemiology and risk factors. Dig Dis 2010; 28: 600-603 [PMID: 21088409 DOI: 10.1159/000320277]
    • (2010) Dig Dis , vol.28 , pp. 600-603
    • Krejs, G.J.1
  • 36
    • 84879574291 scopus 로고    scopus 로고
    • Green tea and the risk of gastric cancer: Epidemiological evidence
    • PMID: 23840110
    • Hou IC, Amarnani S, Chong MT, Bishayee A. Green tea and the risk of gastric cancer: epidemiological evidence. World J Gastroenterol 2013; 19: 3713-3722 [PMID: 23840110 DOI: 10.3748/wjg.v19.i24.3713]
    • (2013) World J Gastroenterol , vol.19 , pp. 3713-3722
    • Hou, I.C.1    Amarnani, S.2    Chong, M.T.3    Bishayee, A.4
  • 37
    • 1842294620 scopus 로고    scopus 로고
    • Tobacco smoking and gastric cancer: Review and meta-analysis
    • PMID: 9259392
    • Trédaniel J, Boffetta P, Buiatti E, Saracci R, Hirsch A. Tobacco smoking and gastric cancer: review and meta-analysis. Int J Cancer 1997; 72: 565-573 [PMID: 9259392]
    • (1997) Int J Cancer , vol.72 , pp. 565-573
    • Trédaniel, J.1    Boffetta, P.2    Buiatti, E.3    Saracci, R.4    Hirsch, A.5
  • 38
    • 84871551022 scopus 로고    scopus 로고
    • Gastric cancer epidemiology and risk factors
    • PMID: 23129495
    • Guggenheim DE, Shah MA. Gastric cancer epidemiology and risk factors. J Surg Oncol 2013; 107: 230-236 [PMID: 23129495 DOI: 10.1002/jso.23262]
    • (2013) J Surg Oncol , vol.107 , pp. 230-236
    • De Guggenheim1    Shah, M.A.2
  • 39
    • 84874418549 scopus 로고    scopus 로고
    • Epidemiology and risk factors for gastroesophageal junction tumors: Understanding the rising incidence of this disease
    • PMID: 23207041
    • Buas MF, Vaughan TL. Epidemiology and risk factors for gastroesophageal junction tumors: understanding the rising incidence of this disease. Semin Radiat Oncol 2013; 23: 3-9 [PMID: 23207041 DOI: 10.1016/j.semradonc.2012.09.008]
    • (2013) Semin Radiat Oncol , vol.23 , pp. 3-9
    • Buas, M.F.1    Vaughan, T.L.2
  • 40
    • 0029076163 scopus 로고
    • The relation of gastroesophageal reflux disease and its treatment to adenocarcinomas of the esophagus and gastric cardia
    • PMID: 7629956
    • Chow WH, Finkle WD, McLaughlin JK, Frankl H, Ziel HK, Fraumeni JF. The relation of gastroesophageal reflux disease and its treatment to adenocarcinomas of the esophagus and gastric cardia. JAMA 1995; 274: 474-477 [PMID: 7629956]
    • (1995) JAMA , vol.274 , pp. 474-477
    • Chow, W.H.1    Finkle, W.D.2    McLaughlin, J.K.3    Frankl, H.4    Ziel, H.K.5    Fraumeni, J.F.6
  • 42
    • 84866082525 scopus 로고    scopus 로고
    • Alterations of the TP53 gene in gastric and esophageal carcinogenesis
    • PMID: 22919278
    • Bellini MF, Cadamuro AC, Succi M, Proenc¸a MA, Silva AE. Alterations of the TP53 gene in gastric and esophageal carcinogenesis. J Biomed Biotechnol 2012; 2012: 891961 [PMID: 22919278 DOI: 10.1155/2012/891961]
    • (2012) J Biomed Biotechnol , vol.2012 , pp. 891961
    • Bellini, M.F.1    Cadamuro, A.C.2    Succi, M.3    Proenc¸a, M.A.4    Silva, A.E.5
  • 43
    • 19344378616 scopus 로고    scopus 로고
    • Correlation of Wnt-2 expression and beta-catenin intracellular accumulation in Chinese gastric cancers: Relevance with tumour dissemination
    • PMID: 15896469
    • Cheng XX, Wang ZC, Chen XY, Sun Y, Kong QY, Liu J, Li H. Correlation of Wnt-2 expression and beta-catenin intracellular accumulation in Chinese gastric cancers: relevance with tumour dissemination. Cancer Lett 2005; 223: 339-347 [PMID: 15896469 DOI: 10.1016/j.canlet.2004.11.013]
    • (2005) Cancer Lett , vol.223 , pp. 339-347
    • Cheng, X.X.1    Wang, Z.C.2    Chen, X.Y.3    Sun, Y.4    Kong, Q.Y.5    Liu, J.6    Li, H.7
  • 44
    • 14544275028 scopus 로고    scopus 로고
    • Tumor metastasis and the reciprocal regulation of heparanase gene expression by nuclear factor kappa B in human gastric carcinoma tissue
    • PMID: 15682491
    • Cao HJ, Fang Y, Zhang X, Chen WJ, Zhou WP, Wang H, Wang LB, Wu JM. Tumor metastasis and the reciprocal regulation of heparanase gene expression by nuclear factor kappa B in human gastric carcinoma tissue. World J Gastroenterol 2005; 11: 903-907 [PMID: 15682491]
    • (2005) World J Gastroenterol , vol.11 , pp. 903-907
    • Cao, H.J.1    Fang, Y.2    Zhang, X.3    Chen, W.J.4    Zhou, W.P.5    Wang, H.6    Wang, L.B.7    Wu, J.M.8
  • 45
    • 36849015047 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death
    • PMID: 17935137
    • Yu HG, Ai YW, Yu LL, Zhou XD, Liu J, Li JH, Xu XM, Liu S, Chen J, Liu F, Qi YL, Deng Q, Cao J, Liu SQ, Luo HS, Yu JP. Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. Int J Cancer 2008; 122: 433-443 [PMID: 17935137 DOI: 10.1002/ijc.23049]
    • (2008) Int J Cancer , vol.122 , pp. 433-443
    • Yu, H.G.1    Ai, Y.W.2    Yu, L.L.3    Zhou, X.D.4    Liu, J.5    Li, J.H.6    Xu, X.M.7    Liu, S.8    Chen, J.9    Liu, F.10    Qi, Y.L.11    Deng, Q.12    Cao, J.13    Liu, S.Q.14    Luo, H.S.15    Yu, J.P.16
  • 47
    • 0036545242 scopus 로고    scopus 로고
    • Molecular and biologic basis of upper gastrointestinal malignancy - esophageal carcinoma
    • PMID: 12424849
    • Souza RF. Molecular and biologic basis of upper gastrointestinal malignancy - esophageal carcinoma. Surg Oncol Clin N Am 2002; 11: 257-72, viii [PMID: 12424849]
    • (2002) Surg Oncol Clin N Am , vol.11
    • Souza, R.F.1
  • 48
    • 33644757018 scopus 로고    scopus 로고
    • Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer
    • PMID: 16482617
    • Tamura G. Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer. World J Gastroenterol 2006; 12: 192-198 [PMID: 16482617]
    • (2006) World J Gastroenterol , vol.12 , pp. 192-198
    • Tamura, G.1
  • 49
  • 50
    • 84871963013 scopus 로고    scopus 로고
    • El-Deiry WS. P21WAF1 and tumourigenesis: 20 years after
    • PMID: 23159848
    • Warfel NA, El-Deiry WS. p21WAF1 and tumourigenesis: 20 years after. Curr Opin Oncol 2013; 25: 52-58 [PMID: 23159848 DOI: 10.1097/CCO.0b013e32835b639e]
    • (2013) Curr Opin Oncol , vol.25 , pp. 52-58
    • Warfel, N.A.1
  • 52
    • 27744459507 scopus 로고    scopus 로고
    • Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers
    • PMID: 16220453
    • Michl P, Downward J. Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers. Z Gastroenterol 2005; 43: 1133-1139 [PMID: 16220453 DOI: 10.1055/s-2005-858638]
    • (2005) Z Gastroenterol , vol.43 , pp. 1133-1139
    • Michl, P.1    Downward, J.2
  • 54
    • 84855895252 scopus 로고    scopus 로고
    • Targeting the PI3K signaling pathway in cancer therapy
    • PMID: 22239433
    • Bartholomeusz C, Gonzalez-Angulo AM. Targeting the PI3K signaling pathway in cancer therapy. Expert Opin Ther Targets 2012; 16: 121-130 [PMID: 22239433 DOI: 10.1517/147 28222.2011.644788]
    • (2012) Expert Opin Ther Targets , vol.16 , pp. 121-130
    • Bartholomeusz, C.1    Gonzalez-Angulo, A.M.2
  • 55
    • 84862789569 scopus 로고    scopus 로고
    • Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer
    • PMID: 22292935
    • Shi J, Yao D, Liu W, Wang N, Lv H, Zhang G, Ji M, Xu L, He N, Shi B, Hou P. Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer. BMC Cancer 2012; 12: 50 [PMID: 22292935 DOI: 10.1186/1471-2407-12-50]
    • (2012) BMC Cancer , vol.12 , pp. 50
    • Shi, J.1    Yao, D.2    Liu, W.3    Wang, N.4    Lv, H.5    Zhang, G.6    Ji, M.7    Xu, L.8    He, N.9    Shi, B.10    Hou, P.11
  • 59
    • 72949103929 scopus 로고    scopus 로고
    • A census of amplified and overexpressed human cancer genes
    • PMID: 20029424
    • Santarius T, Shipley J, Brewer D, Stratton MR, Cooper CS. A census of amplified and overexpressed human cancer genes. Nat Rev Cancer 2010; 10: 59-64 [PMID: 20029424 DOI: 10.1038/nrc2771]
    • (2010) Nat Rev Cancer , vol.10 , pp. 59-64
    • Santarius, T.1    Shipley, J.2    Brewer, D.3    Stratton, M.R.4    Cooper, C.S.5
  • 60
    • 0242558946 scopus 로고    scopus 로고
    • Alterations of chromosomal copy number during progression of diffuse-type gastric carcinomas: Metaphase- and array-based comparative genomic hybridization analyses of multiple samples from individual tumours
    • PMID: 14595756
    • Peng DF, Sugihara H, Mukaisho K, Tsubosa Y, Hattori T. Alterations of chromosomal copy number during progression of diffuse-type gastric carcinomas: metaphase- and array-based comparative genomic hybridization analyses of multiple samples from individual tumours. J Pathol 2003; 201: 439-450 [PMID: 14595756 DOI: 10.1002/path.1459]
    • (2003) J Pathol , vol.201 , pp. 439-450
    • Peng, D.F.1    Sugihara, H.2    Mukaisho, K.3    Tsubosa, Y.4    Hattori, T.5
  • 62
    • 79251494775 scopus 로고    scopus 로고
    • Analysis of DNA copy number aberrations by multiple ligation-dependent probe amplification on 50 intestinal type gastric cancers
    • PMID: 21259245
    • Zhang D, Wang Z, Luo Y, Xu Y, Liu Y, Yang W, Zhang X. Analysis of DNA copy number aberrations by multiple ligation-dependent probe amplification on 50 intestinal type gastric cancers. J Surg Oncol 2011; 103: 124-132 [PMID: 21259245 DOI: 10.1002/jso.21792]
    • (2011) J Surg Oncol , vol.103 , pp. 124-132
    • Zhang, D.1    Wang, Z.2    Luo, Y.3    Xu, Y.4    Liu, Y.5    Yang, W.6    Zhang, X.7
  • 63
    • 0032104542 scopus 로고    scopus 로고
    • Amplification of oncogenes in human cancer cells
    • PMID: 9699459
    • Schwab M. Amplification of oncogenes in human cancer cells. Bioessays 1998; 20: 473-479 [PMID: 9699459 DOI: 10.100 2/(sici)1521-1878(199806)20:6〈473::aid-bies5〉3.0.co;2-n]
    • (1998) Bioessays , vol.20 , pp. 473-479
    • Schwab, M.1
  • 64
    • 33746255899 scopus 로고    scopus 로고
    • Gene amplification in cancer
    • PMID: 16787682
    • Albertson DG. Gene amplification in cancer. Trends Genet 2006; 22: 447-455 [PMID: 16787682 DOI: 10.1016/j.tig.2006.06.007]
    • (2006) Trends Genet , vol.22 , pp. 447-455
    • Albertson, D.G.1
  • 65
    • 54349106979 scopus 로고    scopus 로고
    • PCR-SSCP-DNA sequencing method in detecting PTEN gene mutation and its significance in human gastric cancer
    • PMID: 18609703
    • Guo CY, Xu XF, Wu JY, Liu SF. PCR-SSCP-DNA sequencing method in detecting PTEN gene mutation and its significance in human gastric cancer. World J Gastroenterol 2008; 14: 3804-3811 [PMID: 18609703]
    • (2008) World J Gastroenterol , vol.14 , pp. 3804-3811
    • Guo, C.Y.1    Xu, X.F.2    Wu, J.Y.3    Liu, S.F.4
  • 66
    • 77952975814 scopus 로고    scopus 로고
    • Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway
    • PMID: 20514448
    • Wen YG, Wang Q, Zhou CZ, Qiu GQ, Peng ZH, Tang HM. Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway. Oncol Rep 2010; 24: 89-95 [PMID: 20514448]
    • (2010) Oncol Rep , vol.24 , pp. 89-95
    • Wen, Y.G.1    Wang, Q.2    Zhou, C.Z.3    Qiu, G.Q.4    Peng, Z.H.5    Tang, H.M.6
  • 67
    • 84876705235 scopus 로고    scopus 로고
    • Targeting HER receptors in cancer
    • PMID: 22973952
    • Ocaña A, Pandiella A. Targeting HER receptors in cancer. Curr Pharm Des 2013; 19: 808-817 [PMID: 22973952]
    • (2013) Curr Pharm des , vol.19 , pp. 808-817
    • Ocaña, A.1    Pandiella, A.2
  • 68
    • 70349327606 scopus 로고    scopus 로고
    • Comparative study on overexpression of HER2/neu and HER3 in gastric cancer
    • PMID: 19636613
    • Zhang XL, Yang YS, Xu DP, Qu JH, Guo MZ, Gong Y, Huang J. Comparative study on overexpression of HER2/neu and HER3 in gastric cancer. World J Surg 2009; 33: 2112-2118 [PMID: 19636613 DOI: 10.1007/s00268-009-0142-z]
    • (2009) World J Surg , vol.33 , pp. 2112-2118
    • Zhang, X.L.1    Yang, Y.S.2    Xu, D.P.3    Qu, J.H.4    Guo, M.Z.5    Gong, Y.6    Huang, J.7
  • 69
    • 76749088358 scopus 로고    scopus 로고
    • Pathological roles of MAPK signaling pathways in human diseases
    • PMID: 20079433
    • Kim EK, Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 2010; 1802: 396-405 [PMID: 20079433 DOI: 10.1016/j.bbadis.2009.12.009]
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 396-405
    • Kim, E.K.1    Choi, E.J.2
  • 72
    • 0036770443 scopus 로고    scopus 로고
    • Kang CS. Ras Gene mutations and expression of Ras signal transduction mediators in gastric adenocarcinomas
    • PMID: 12204060
    • Yoo J, Park SY, Robinson RA, Kang SJ, Ahn WS, Kang CS. ras Gene mutations and expression of Ras signal transduction mediators in gastric adenocarcinomas. Arch Pathol Lab Med 2002; 126: 1096-1100 [PMID: 12204060 DOI: 10.1043/0003-9985(2002)126〈1096:rgmaeo〉2.0.co;2]
    • (2002) Arch Pathol Lab Med , vol.126 , pp. 1096-1100
    • Yoo, J.1    Park, S.Y.2    Robinson, R.A.3    Kang, S.J.4    Ahn, W.S.5
  • 73
    • 79953786463 scopus 로고    scopus 로고
    • Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan
    • PMID: 21080251
    • Chen HC, Chen HJ, Khan MA, Rao ZZ, Wan XX, Tan B, Zhang DZ. Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China. Tumour Biol 2011; 32: 367-373 [PMID: 21080251 DOI: 10.1007/s13277-010-0129-2]
    • (2011) China. Tumour Biol , vol.32 , pp. 367-373
    • Chen, H.C.1    Chen, H.J.2    Khan, M.A.3    Rao, Z.Z.4    Wan, X.X.5    Tan, B.6    Zhang, D.Z.7
  • 74
    • 13544271958 scopus 로고    scopus 로고
    • Increased expression of mitogen-activated protein kinase and its upstream regulating signal in human gastric cancer
    • PMID: 15655810
    • Liang B, Wang S, Zhu XG, Yu YX, Cui ZR, Yu YZ. Increased expression of mitogen-activated protein kinase and its upstream regulating signal in human gastric cancer. World J Gastroenterol 2005;11: 623-8 [PMID: 15655810]
    • (2005) World J Gastroenterol , vol.11 , pp. 623-628
    • Liang, B.1    Wang, S.2    Zhu, X.G.3    Yu, Y.X.4    Cui, Z.R.5    Yu, Y.Z.6
  • 75
    • 84863097904 scopus 로고    scopus 로고
    • Prognostic significance of aberrant gene methylation in gastric cancer
    • PMID: 22206050
    • Shi J, Zhang G, Yao D, Liu W, Wang N, Ji M, He N, Shi B, Hou P. Prognostic significance of aberrant gene methylation in gastric cancer. Am J Cancer Res 2012; 2: 116-129 [PMID: 22206050]
    • (2012) Am J Cancer Res , vol.2 , pp. 116-129
    • Shi, J.1    Zhang, G.2    Yao, D.3    Liu, W.4    Wang, N.5    Ji, M.6    He, N.7    Shi, B.8    Hou, P.9
  • 76
    • 84862832734 scopus 로고    scopus 로고
    • Quantitative assessment of gene methylation and their impact on clinical outcome in gastric cancer
    • PMID: 22285775
    • Yao D, Shi J, Shi B, Wang N, Liu W, Zhang G, Ji M, Xu L, He N, Hou P. Quantitative assessment of gene methylation and their impact on clinical outcome in gastric cancer. Clin Chim Acta 2012; 413: 787-794 [PMID: 22285775 DOI: 10.1016/j.cca.2012.01.013]
    • (2012) Clin Chim Acta , vol.413 , pp. 787-794
    • Yao, D.1    Shi, J.2    Shi, B.3    Wang, N.4    Liu, W.5    Zhang, G.6    Ji, M.7    Xu, L.8    He, N.9    Hou, P.10
  • 78
    • 28644450906 scopus 로고    scopus 로고
    • RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer
    • PMID: 16265349
    • Endoh M, Tamura G, Honda T, Homma N, Terashima M, Nishizuka S, Motoyama T. RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer. Br J Cancer 2005; 93: 1395-1399 [PMID: 16265349 DOI: 10.1038/sj.bjc.6602854]
    • (2005) Br J Cancer , vol.93 , pp. 1395-1399
    • Endoh, M.1    Tamura, G.2    Honda, T.3    Homma, N.4    Terashima, M.5    Nishizuka, S.6    Motoyama, T.7
  • 80
    • 70249141245 scopus 로고    scopus 로고
    • ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor
    • PMID: 19718021
    • Alvarado D, Klein DE, Lemmon MA. ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor. Nature 2009; 461: 287-291 [PMID: 19718021 DOI: 10.1038/nature08297]
    • (2009) Nature , vol.461 , pp. 287-291
    • Alvarado, D.1    De Klein2    Ma, L.3
  • 81
    • 0031865433 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor family proteins (EGFR, c-erbB-2 and c-erbB-3) in gastric cancer and chronic gastritis
    • PMID: 9703936
    • Slesak B, Harlozinska A, Porebska I, Bojarowski T, Lapinska J, Rzeszutko M, Wojnar A. Expression of epidermal growth factor receptor family proteins (EGFR, c-erbB-2 and c-erbB-3) in gastric cancer and chronic gastritis. Anticancer Res 1998; 18: 2727-2732 [PMID: 9703936]
    • (1998) Anticancer Res , vol.18 , pp. 2727-2732
    • Slesak, B.1    Harlozinska, A.2    Porebska, I.3    Bojarowski, T.4    Lapinska, J.5    Rzeszutko, M.6    Wojnar, A.7
  • 83
    • 20044372721 scopus 로고    scopus 로고
    • Amplification of HER-2 in gastric carcinoma: Association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab
    • PMID: 15668283
    • Tanner M, Hollmén M, Junttila TT, Kapanen AI, Tommola S, Soini Y, Helin H, Salo J, Joensuu H, Sihvo E, Elenius K, Isola J. Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann Oncol 2005; 16: 273-278 [PMID: 15668283 DOI: 10.1093/annonc/mdi064]
    • (2005) Ann Oncol , vol.16 , pp. 273-278
    • Tanner, M.1    Hollmén, M.2    Junttila, T.T.3    Kapanen, A.I.4    Tommola, S.5    Soini, Y.6    Helin, H.7    Salo, J.8    Joensuu, H.9    Sihvo, E.10    Elenius, K.11    Isola, J.12
  • 84
    • 84885578812 scopus 로고    scopus 로고
    • HER2 therapies and gastric cancer: A step forward
    • PMID: 24115812
    • de Mello RA, Marques AM, Araújo A. HER2 therapies and gastric cancer: a step forward. World J Gastroenterol 2013; 19: 6165-6169 [PMID: 24115812 DOI: 10.3748/wjg.v19.i37.6165]
    • (2013) World J Gastroenterol , vol.19 , pp. 6165-6169
    • De Mello, R.A.1    Marques, A.M.2    Araújo, A.3
  • 85
    • 80051647503 scopus 로고    scopus 로고
    • Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome
    • PMID: 21709195
    • Begnami MD, Fukuda E, Fregnani JH, Nonogaki S, Montagnini AL, da Costa WL, Soares FA. Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome. J Clin Oncol 2011; 29: 3030-3036 [PMID: 21709195 DOI: 10.1200/jco.2010.33.6313]
    • (2011) J Clin Oncol , vol.29 , pp. 3030-3036
    • Begnami, M.D.1    Fukuda, E.2    Fregnani, J.H.3    Nonogaki, S.4    Montagnini, A.L.5    Da Costa, W.L.6    Soares, F.A.7
  • 86
    • 84860157670 scopus 로고    scopus 로고
    • Frequent gene amplification predicts poor prognosis in gastric cancer
    • PMID: 22606006
    • Shi J, Yao D, Liu W, Wang N, Lv H, He N, Shi B, Hou P, Ji M. Frequent gene amplification predicts poor prognosis in gastric cancer. Int J Mol Sci 2012; 13: 4714-4726 [PMID: 22606006 DOI: 10.3390/ijms13044714]
    • (2012) Int J Mol Sci , vol.13 , pp. 4714-4726
    • Shi, J.1    Yao, D.2    Liu, W.3    Wang, N.4    Lv, H.5    He, N.6    Shi, B.7    Hou, P.8    Ji, M.9
  • 87
    • 79955513982 scopus 로고    scopus 로고
    • MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab
    • PMID: 21220473
    • Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M. MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Clin Cancer Res 2011; 17: 2725-2733 [PMID: 21220473 DOI: 10.1158/1078-0432.ccr-10-2132]
    • (2011) Clin Cancer Res , vol.17 , pp. 2725-2733
    • Nishida, N.1    Mimori, K.2    Fabbri, M.3    Yokobori, T.4    Sudo, T.5    Tanaka, F.6    Shibata, K.7    Ishii, H.8    Doki, Y.9    Mori, M.10
  • 88
    • 79960336510 scopus 로고    scopus 로고
    • Clinical significance of miR-146a in gastric cancer cases
    • PMID: 21632853
    • Kogo R, Mimori K, Tanaka F, Komune S, Mori M. Clinical significance of miR-146a in gastric cancer cases. Clin Cancer Res 2011; 17: 4277-4284 [PMID: 21632853 DOI: 10.1158/1078-0432.ccr-10-2866]
    • (2011) Clin Cancer Res , vol.17 , pp. 4277-4284
    • Kogo, R.1    Mimori, K.2    Tanaka, F.3    Komune, S.4    Mori, M.5
  • 89
    • 84865109330 scopus 로고    scopus 로고
    • Wnt signaling in cancer
    • PMID: 22438566
    • Polakis P. Wnt signaling in cancer. Cold Spring Harb Perspect Biol 2012; 4: [PMID: 22438566 DOI: 10.1101/cshperspect.a008052]
    • (2012) Cold Spring Harb Perspect Biol , vol.4
    • Polakis, P.1
  • 90
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • PMID: 22682243
    • Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell 2012; 149: 1192-1205 [PMID: 22682243 DOI: 10.1016/j.cell.2012.05.012]
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 91
    • 47149111867 scopus 로고    scopus 로고
    • Wnt pathway is involved in advanced gastric carcinoma
    • PMID: 18705344
    • Zhang H, Xue Y. Wnt pathway is involved in advanced gastric carcinoma. Hepatogastroenterology 2008; 55: 1126-1130 [PMID: 18705344]
    • (2008) Hepatogastroenterology , vol.55 , pp. 1126-1130
    • Zhang, H.1    Xue, Y.2
  • 92
    • 41549110689 scopus 로고    scopus 로고
    • Mutations in components of the Wnt signaling pathway in gastric cancer
    • PMID: 18330950
    • Pan KF, Liu WG, Zhang L, You WC, Lu YY. Mutations in components of the Wnt signaling pathway in gastric cancer. World J Gastroenterol 2008; 14: 1570-1574 [PMID: 18330950]
    • (2008) World J Gastroenterol , vol.14 , pp. 1570-1574
    • Pan, K.F.1    Liu, W.G.2    Zhang, L.3    You, W.C.4    Lu, Y.Y.5
  • 93
    • 33751295132 scopus 로고    scopus 로고
    • Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion
    • PMID: 17079465
    • Kurayoshi M, Oue N, Yamamoto H, Kishida M, Inoue A, Asahara T, Yasui W, Kikuchi A. Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res 2006; 66: 10439-10448 [PMID: 17079465 DOI: 10.1158/0008-5472.can-06-2359]
    • (2006) Cancer Res , vol.66 , pp. 10439-10448
    • Kurayoshi, M.1    Oue, N.2    Yamamoto, H.3    Kishida, M.4    Inoue, A.5    Asahara, T.6    Yasui, W.7    Kikuchi, A.8
  • 94
  • 95
    • 80051800542 scopus 로고    scopus 로고
    • Mechanisms Regulating Microtubule Binding, DNA Replication, and Apoptosis are Controlled by the Intestinal Tumor Suppressor APC
    • PMID: 23308069
    • Perchiniak EM, Groden J. Mechanisms Regulating Microtubule Binding, DNA Replication, and Apoptosis are Controlled by the Intestinal Tumor Suppressor APC. Curr Colorectal Cancer Rep 2011; 7: 145-151 [PMID: 23308069 DOI: 10.1007/s11888-011-0088-z]
    • (2011) Curr Colorectal Cancer Rep , vol.7 , pp. 145-151
    • Perchiniak, E.M.1    Groden, J.2
  • 99
    • 0026734665 scopus 로고
    • The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer
    • PMID: 1317264
    • Horii A, Nakatsuru S, Miyoshi Y, Ichii S, Nagase H, Kato Y, Yanagisawa A, Nakamura Y. The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer. Cancer Res 1992; 52: 3231-3233 [PMID: 1317264]
    • (1992) Cancer Res , vol.52 , pp. 3231-3233
    • Horii, A.1    Nakatsuru, S.2    Miyoshi, Y.3    Ichii, S.4    Nagase, H.5    Kato, Y.6    Yanagisawa, A.7    Nakamura, Y.8
  • 100
    • 57349114162 scopus 로고    scopus 로고
    • The cell-cell adhesion molecule E-cadherin
    • PMID: 18726070
    • van Roy F, Berx G. The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci 2008; 65: 3756-3788 [PMID: 18726070 DOI: 10.1007/s00018-008-8281-1]
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3756-3788
    • Van Roy, F.1    Berx, G.2
  • 101
    • 0033822499 scopus 로고    scopus 로고
    • Mechanism of homophilic cadherin adhesion
    • PMID: 10978894
    • Leckband D, Sivasankar S. Mechanism of homophilic cadherin adhesion. Curr Opin Cell Biol 2000; 12: 587-592 [PMID: 10978894]
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 587-592
    • Leckband, D.1    Sivasankar, S.2
  • 102
    • 84866165478 scopus 로고    scopus 로고
    • Familial gastric cancer and germline mutations of E-cadherin
    • PMID: 22595728
    • Corso G, Marrelli D, Roviello F. Familial gastric cancer and germline mutations of E-cadherin. Ann Ital Chir 2012; 83: 177-182 [PMID: 22595728]
    • (2012) Ann Ital Chir , vol.83 , pp. 177-182
    • Corso, G.1    Marrelli, D.2    Roviello, F.3
  • 103
    • 84866144479 scopus 로고    scopus 로고
    • Gastric cancer carcinogenesis and tumor progression
    • PMID: 22595727
    • Corso G, Seruca R, Roviello F. Gastric cancer carcinogenesis and tumor progression. Ann Ital Chir 2012; 83: 172-176 [PMID: 22595727]
    • (2012) Ann Ital Chir , vol.83 , pp. 172-176
    • Corso, G.1    Seruca, R.2    Roviello, F.3
  • 105
    • 34250648916 scopus 로고    scopus 로고
    • Promoter hypermethylation of CDH1, FHIT, MTAP and PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil
    • PMID: 17552003
    • Leal M, Lima E, Silva P, Assumpc¸ão P, Calcagno D, Payão S, Burbano RR, Smith M. Promoter hypermethylation of CDH1, FHIT, MTAP and PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil. World J Gastroenterol 2007; 13: 2568-2574 [PMID: 17552003]
    • (2007) World J Gastroenterol , vol.13 , pp. 2568-2574
    • Leal, M.1    Lima, E.2    Silva, P.3    Assumpc¸ão, P.4    Calcagno, D.5    Payão, S.6    Burbano, R.R.7    Smith, M.8
  • 107
    • 33845352215 scopus 로고    scopus 로고
    • Wnt signaling and gastrointestinal tumorigenesis in mouse models
    • PMID: 17143296
    • Taketo MM. Wnt signaling and gastrointestinal tumorigenesis in mouse models. Oncogene 2006; 25: 7522-7530 [PMID: 17143296 DOI: 10.1038/sj.onc.1210058]
    • (2006) Oncogene , vol.25 , pp. 7522-7530
    • Taketo, M.M.1
  • 108
    • 38549084327 scopus 로고    scopus 로고
    • DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis
    • PMID: 18158559
    • Kang GH, Lee S, Cho NY, Gandamihardja T, Long TI, Weisenberger DJ, Campan M, Laird PW. DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis. Lab Invest 2008; 88: 161-170 [PMID: 18158559 DOI: 10.1038/labinvest.3700707]
    • (2008) Lab Invest , vol.88 , pp. 161-170
    • Kang, G.H.1    Lee, S.2    Cho, N.Y.3    Gandamihardja, T.4    Long, T.I.5    Weisenberger, D.J.6    Campan, M.7    Laird, P.W.8
  • 110
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
    • PMID: 19116625
    • Baud V, Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 2009; 8: 33-40 [PMID: 19116625 DOI: 10.1038/nrd2781]
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 112
    • 0028986193 scopus 로고
    • NF-kappa B: A lesson in family values
    • PMID: 7867060
    • Thanos D, Maniatis T. NF-kappa B: a lesson in family values. Cell 1995; 80: 529-532 [PMID: 7867060]
    • (1995) Cell , vol.80 , pp. 529-532
    • Thanos, D.1    Maniatis, T.2
  • 114
    • 33745852665 scopus 로고    scopus 로고
    • Alternative pathways of NF-kappaB activation: A double-edged sword in health and disease
    • PMID: 16793322
    • Xiao G, Rabson AB, Young W, Qing G, Qu Z. Alternative pathways of NF-kappaB activation: a double-edged sword in health and disease. Cytokine Growth Factor Rev 2006; 17: 281-293 [PMID: 16793322 DOI: 10.1016/j.cytogfr.2006.04.005]
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 281-293
    • Xiao, G.1    Rabson, A.B.2    Young, W.3    Qing, G.4    Qu, Z.5
  • 117
    • 0036006811 scopus 로고    scopus 로고
    • The ever-increasing complexity of TGF-beta signaling
    • PMID: 11750874
    • Roberts AB. The ever-increasing complexity of TGF-beta signaling. Cytokine Growth Factor Rev 2002; 13: 3-5 [PMID: 11750874]
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 3-5
    • Roberts, A.B.1
  • 118
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • PMID: 12809600
    • Shi Y, Massagué J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003; 113: 685-700 [PMID: 12809600]
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 119
    • 77954027650 scopus 로고    scopus 로고
    • Dysregulation of cellular signaling in gastric cancer
    • PMID: 20488613
    • Wu WK, Cho CH, Lee CW, Fan D, Wu K, Yu J, Sung JJ. Dysregulation of cellular signaling in gastric cancer. Cancer Lett 2010; 295: 144-153 [PMID: 20488613 DOI: 10.1016/j.canlet.2010.04.025]
    • (2010) Cancer Lett , vol.295 , pp. 144-153
    • Wu, W.K.1    Cho, C.H.2    Lee, C.W.3    Fan, D.4    Wu, K.5    Yu, J.6    Sung, J.J.7
  • 120
    • 84868591599 scopus 로고    scopus 로고
    • Concordant repression and aberrant methylation of transforming growth factor-beta signaling pathway genes occurs early in gastric cardia adenocarcinoma
    • PMID: 22722999
    • Guo W, Dong Z, Guo Y, Kuang G, Yang Z, Shan B. Concordant repression and aberrant methylation of transforming growth factor-beta signaling pathway genes occurs early in gastric cardia adenocarcinoma. Mol Biol Rep 2012; 39: 9453-9462 [PMID: 22722999 DOI: 10.1007/s11033-012-1810-x]
    • (2012) Mol Biol Rep , vol.39 , pp. 9453-9462
    • Guo, W.1    Dong, Z.2    Guo, Y.3    Kuang, G.4    Yang, Z.5    Shan, B.6
  • 122
    • 84868193092 scopus 로고    scopus 로고
    • Stepwise cumulation of RUNX3 methylation mediated by Helicobacter pylori infection contributes to gastric carcinoma progression
    • PMID: 22576578
    • Lu XX, Yu JL, Ying LS, Han J, Wang S, Yu QM, Wang XB, Fang XH, Ling ZQ. Stepwise cumulation of RUNX3 methylation mediated by Helicobacter pylori infection contributes to gastric carcinoma progression. Cancer 2012; 118: 5507-5517 [PMID: 22576578 DOI: 10.1002/cncr.27604]
    • (2012) Cancer , vol.118 , pp. 5507-5517
    • Lu, X.X.1    Yu, J.L.2    Ying, L.S.3    Han, J.4    Wang, S.5    Yu, Q.M.6    Wang, X.B.7    Fang, X.H.8    Ling, Z.Q.9
  • 123
    • 58249123443 scopus 로고    scopus 로고
    • Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells
    • PMID: 18850007
    • Lee SH, Kim J, Kim WH, Lee YM. Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. Oncogene 2009; 28: 184-194 [PMID: 18850007 DOI: 10.1038/onc.2008.377]
    • (2009) Oncogene , vol.28 , pp. 184-194
    • Lee, S.H.1    Kim, J.2    Kim, W.H.3    Lee, Y.M.4
  • 124
    • 38449110073 scopus 로고    scopus 로고
    • Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3
    • PMID: 17914577
    • Tan SH, Ida H, Lau QC, Goh BC, Chieng WS, Loh M, Ito Y. Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3. Oncol Rep 2007; 18: 1225-1230 [PMID: 17914577]
    • (2007) Oncol Rep , vol.18 , pp. 1225-1230
    • Tan, S.H.1    Ida, H.2    Lau, Q.C.3    Goh, B.C.4    Chieng, W.S.5    Loh, M.6    Ito, Y.7
  • 125
    • 0033590207 scopus 로고    scopus 로고
    • The role of cyclooxygenases in inflammation, cancer, and development
    • PMID: 10630643
    • Williams CS, Mann M, DuBois RN. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 1999; 18: 7908-7916 [PMID: 10630643 DOI: 10.1038/sj.onc.1203286]
    • (1999) Oncogene , vol.18 , pp. 7908-7916
    • Williams, C.S.1    Mann, M.2    DuBois, R.N.3
  • 126
    • 0037442171 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma
    • PMID: 12532441
    • Xue YW, Zhang QF, Zhu ZB, Wang Q, Fu SB. Expression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma. World J Gastroenterol 2003; 9: 250-253 [PMID: 12532441]
    • (2003) World J Gastroenterol , vol.9 , pp. 250-253
    • Xue, Y.W.1    Zhang, Q.F.2    Zhu, Z.B.3    Wang, Q.4    Fu, S.B.5
  • 127
    • 0043066734 scopus 로고    scopus 로고
    • Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma
    • PMID: 12854133
    • Shi H, Xu JM, Hu NZ, Xie HJ. Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma. World J Gastroenterol 2003; 9: 1421-1426 [PMID: 12854133]
    • (2003) World J Gastroenterol , vol.9 , pp. 1421-1426
    • Shi, H.1    Xu, J.M.2    Hu, N.Z.3    Xie, H.J.4
  • 128
    • 70349584124 scopus 로고    scopus 로고
    • Prostaglandin E2, Wnt, and BMP in gastric tumor mouse models
    • PMID: 19622104
    • Oshima H, Oguma K, Du YC, Oshima M. Prostaglandin E2, Wnt, and BMP in gastric tumor mouse models. Cancer Sci 2009; 100: 1779-1785 [PMID: 19622104 DOI: 10.1111/j.1349-7006.2009.01258.x]
    • (2009) Cancer Sci , vol.100 , pp. 1779-1785
    • Oshima, H.1    Oguma, K.2    Du, Y.C.3    Oshima, M.4
  • 129
    • 0034692689 scopus 로고    scopus 로고
    • Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2
    • PMID: 10869354
    • Murakami M, Naraba H, Tanioka T, Semmyo N, Nakatani Y, Kojima F, Ikeda T, Fueki M, Ueno A, Oh S, Kudo I. Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem 2000; 275: 32783-32792 [PMID: 10869354 DOI: 10.1074/jbc.M003505200]
    • (2000) J Biol Chem , vol.275 , pp. 32783-32792
    • Murakami, M.1    Naraba, H.2    Tanioka, T.3    Semmyo, N.4    Nakatani, Y.5    Kojima, F.6    Ikeda, T.7    Fueki, M.8    Ueno, A.9    Oh, S.10    Kudo, I.11
  • 131
    • 78651347917 scopus 로고    scopus 로고
    • Cigarette smoking, cyclooxygenase-2 pathway and cancer
    • PMID: 21147199
    • Huang RY, Chen GG. Cigarette smoking, cyclooxygenase-2 pathway and cancer. Biochim Biophys Acta 2011; 1815: 158-169 [PMID: 21147199 DOI: 10.1016/j.bbcan.2010.11.005]
    • (2011) Biochim Biophys Acta , vol.1815 , pp. 158-169
    • Huang, R.Y.1    Chen, G.G.2
  • 132
    • 78649417608 scopus 로고    scopus 로고
    • Rb family proteins in gastric cancer (review)
    • PMID: 21042734
    • Cito L, Pentimalli F, Forte I, Mattioli E, Giordano A. Rb family proteins in gastric cancer (review). Oncol Rep 2010; 24: 1411-1418 [PMID: 21042734]
    • (2010) Oncol Rep , vol.24 , pp. 1411-1418
    • Cito, L.1    Pentimalli, F.2    Forte, I.3    Mattioli, E.4    Giordano, A.5
  • 133
    • 84864682940 scopus 로고    scopus 로고
    • Cell cycle-related kinase in carcinogenesis
    • PMID: 23205069
    • Tian Y, Wan H, Tan G. Cell cycle-related kinase in carcinogenesis. Oncol Lett 2012; 4: 601-606 [PMID: 23205069 DOI: 10.3892/ol.2012.828]
    • (2012) Oncol Lett , vol.4 , pp. 601-606
    • Tian, Y.1    Wan, H.2    Tan, G.3
  • 134
    • 0029054399 scopus 로고
    • Retinoblastoma-protein-dependent cellcycle inhibition by the tumour suppressor p16
    • PMID: 7777060
    • Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J. Retinoblastoma-protein-dependent cellcycle inhibition by the tumour suppressor p16. Nature 1995; 375: 503-506 [PMID: 7777060 DOI: 10.1038/375503a0]
    • (1995) Nature , vol.375 , pp. 503-506
    • Lukas, J.1    Parry, D.2    Aagaard, L.3    Mann, D.J.4    Bartkova, J.5    Strauss, M.6    Peters, G.7    Bartek, J.8
  • 135
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • PMID: 7736585
    • Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995; 81: 323-330 [PMID: 7736585]
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 136
    • 0034882417 scopus 로고    scopus 로고
    • Expression, deletion [was deleton] and mutation of p16 gene in human gastric cancer
    • PMID: 11819820
    • He XS, Su Q, Chen ZC, He XT, Long ZF, Ling H, Zhang LR. Expression, deletion [was deleton] and mutation of p16 gene in human gastric cancer. World J Gastroenterol 2001; 7: 515-521 [PMID: 11819820]
    • (2001) World J Gastroenterol , vol.7 , pp. 515-521
    • He, X.S.1    Su, Q.2    Chen, Z.C.3    He, X.T.4    Long, Z.F.5    Ling, H.6    Zhang, L.R.7
  • 137
    • 36348951021 scopus 로고    scopus 로고
    • Aberrant methylation of p16 predicts candidates for 5-fluorouracil-based adjuvant therapy in gastric cancer patients
    • PMID: 18008030
    • Mitsuno M, Kitajima Y, Ide T, Ohtaka K, Tanaka M, Satoh S, Miyazaki K. Aberrant methylation of p16 predicts candidates for 5-fluorouracil-based adjuvant therapy in gastric cancer patients. J Gastroenterol 2007; 42: 866-873 [PMID: 18008030 DOI: 10.1007/s00535-007-2113-1]
    • (2007) J Gastroenterol , vol.42 , pp. 866-873
    • Mitsuno, M.1    Kitajima, Y.2    Ide, T.3    Ohtaka, K.4    Tanaka, M.5    Satoh, S.6    Miyazaki, K.7
  • 139
    • 0036284631 scopus 로고    scopus 로고
    • Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma
    • PMID: 12060614
    • Lee TL, Leung WK, Chan MW, Ng EK, Tong JH, Lo KW, Chung SC, Sung JJ, To KF. Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma. Clin Cancer Res 2002; 8: 1761-1766 [PMID: 12060614]
    • (2002) Clin Cancer Res , vol.8 , pp. 1761-1766
    • Lee, T.L.1    Leung, W.K.2    Chan, M.W.3    Ng, E.K.4    Tong, J.H.5    Lo, K.W.6    Chung, S.C.7    Sung, J.J.8    To, K.F.9
  • 140
    • 84861089134 scopus 로고    scopus 로고
    • Genetic aspects of gastric cancer instability
    • PMID: 22606061
    • Hudler P. Genetic aspects of gastric cancer instability. ScientificWorldJournal 2012; 2012: 761909 [PMID: 22606061 DOI: 10.1100/2012/761909]
    • (2012) ScientificWorldJournal , vol.2012 , pp. 761909
    • Hudler, P.1
  • 143
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • PMID: 17320506
    • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128: 683-692 [PMID: 17320506 DOI: 10.1016/j.cell.2007.01.029]
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 144
    • 67649305191 scopus 로고    scopus 로고
    • Epigenetics in cancer: Targeting chromatin modifications
    • PMID: 19509247
    • Ellis L, Atadja PW, Johnstone RW. Epigenetics in cancer: targeting chromatin modifications. Mol Cancer Ther 2009; 8: 1409-1420 [PMID: 19509247 DOI: 10.1158/1535-7163.mct-08-0860]
    • (2009) Mol Cancer Ther , vol.8 , pp. 1409-1420
    • Ellis, L.1    Atadja, P.W.2    Johnstone, R.W.3
  • 145
    • 13144251125 scopus 로고    scopus 로고
    • DNA methylation and cancer therapy: New developments and expectations
    • PMID: 15608514
    • Esteller M. DNA methylation and cancer therapy: new developments and expectations. Curr Opin Oncol 2005; 17: 55-60 [PMID: 15608514]
    • (2005) Curr Opin Oncol , vol.17 , pp. 55-60
    • Esteller, M.1
  • 148
    • 84858295994 scopus 로고    scopus 로고
    • Epigenetic modifications in cancer
    • PMID: 22082348
    • Kanwal R, Gupta S. Epigenetic modifications in cancer. Clin Genet 2012; 81: 303-311 [PMID: 22082348 DOI: 10.1111/j.1399-0004.2011.01809.x]
    • (2012) Clin Genet , vol.81 , pp. 303-311
    • Kanwal, R.1    Gupta, S.2
  • 149
    • 74049141478 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • PMID: 19752007
    • Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis 2010; 31: 27-36 [PMID: 19752007 DOI: 10.1093/carcin/bgp220]
    • (2010) Carcinogenesis , vol.31 , pp. 27-36
    • Sharma, S.1    Kelly, T.K.2    Jones, P.A.3
  • 150
    • 46149100720 scopus 로고    scopus 로고
    • The global histone modification pattern correlates with cancer recurrence and overall survival in gastric adenocarcinoma
    • PMID: 18470569
    • Park YS, Jin MY, Kim YJ, Yook JH, Kim BS, Jang SJ. The global histone modification pattern correlates with cancer recurrence and overall survival in gastric adenocarcinoma. Ann Surg Oncol 2008; 15: 1968-1976 [PMID: 18470569 DOI: 10.1245/s10434-008-9927-9]
    • (2008) Ann Surg Oncol , vol.15 , pp. 1968-1976
    • Park, Y.S.1    Jin, M.Y.2    Kim, Y.J.3    Yook, J.H.4    Kim, B.S.5    Jang, S.J.6
  • 151
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, openlabel, randomised controlled trial
    • PMID: 20728210
    • Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, Aprile G, Kulikov E, Hill J, Lehle M, Rüschoff J, Kang YK. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, openlabel, randomised controlled trial. Lancet 2010; 376: 687-697 [PMID: 20728210 DOI: 10.1016/s0140-6736(10)61121-x]
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3    Chung, H.C.4    Shen, L.5    Sawaki, A.6    Lordick, F.7    Ohtsu, A.8    Omuro, Y.9    Satoh, T.10    Aprile, G.11    Kulikov, E.12    Hill, J.13    Lehle, M.14    Rüschoff, J.15    Kang, Y.K.16
  • 152
    • 84880315269 scopus 로고    scopus 로고
    • Chemotherapy for advanced gastric cancer: Review and update of current practices
    • PMID: 23898376
    • Park SC, Chun HJ. Chemotherapy for advanced gastric cancer: review and update of current practices. Gut Liver 2013; 7: 385-393 [PMID: 23898376 DOI: 10.5009/gnl.2013.7.4.385]
    • (2013) Gut Liver , vol.7 , pp. 385-393
    • Park, S.C.1    Chun, H.J.2
  • 153
    • 0033817725 scopus 로고    scopus 로고
    • Vascular invasion and potential for tumor angiogenesis and metastasis in gastric carcinoma
    • PMID: 10965312
    • Maehara Y, Kabashima A, Koga T, Tokunaga E, Takeuchi H, Kakeji Y, Sugimachi K. Vascular invasion and potential for tumor angiogenesis and metastasis in gastric carcinoma. Surgery 2000; 128: 408-416 [PMID: 10965312 DOI: 10.1067/msy.2000.107265]
    • (2000) Surgery , vol.128 , pp. 408-416
    • Maehara, Y.1    Kabashima, A.2    Koga, T.3    Tokunaga, E.4    Takeuchi, H.5    Kakeji, Y.6    Sugimachi, K.7
  • 155
    • 80053573446 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A randomized, double-blind, placebo-controlled phase III study
    • PMID: 21844504
    • Ohtsu A, Shah MA, Van Cutsem E, Rha SY, Sawaki A, Park SR, Lim HY, Yamada Y, Wu J, Langer B, Starnawski M, Kang YK. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study. J Clin Oncol 2011; 29: 3968-3976 [PMID: 21844504 DOI: 10.1200/jco.2011.36.2236]
    • (2011) J Clin Oncol , vol.29 , pp. 3968-3976
    • Ohtsu, A.1    Shah, M.A.2    Van Cutsem, E.3    Rha, S.Y.4    Sawaki, A.5    Park, S.R.6    Lim, H.Y.7    Yamada, Y.8    Wu, J.9    Langer, B.10    Starnawski, M.11    Kang, Y.K.12
  • 157
    • 84862256003 scopus 로고    scopus 로고
    • Novel targeted agents for gastric cancer
    • PMID: 22709792
    • Liu L, Wu N, Li J. Novel targeted agents for gastric cancer. J Hematol Oncol 2012; 5: 31 [PMID: 22709792 DOI: 10.1186/1756-8722-5-31]
    • (2012) J Hematol Oncol , vol.5 , pp. 31
    • Liu, L.1    Wu, N.2    Li, J.3
  • 159
    • 84887187698 scopus 로고    scopus 로고
    • Phase I study evaluating the combination of lapatinib (a Her2/Neu and EGFR inhibitor) and everolimus (an mTOR inhibitor) in patients with advanced cancers: South West Oncology Group (SWOG) Study S0528
    • PMID: 24057042
    • Gadgeel SM, Lew DL, Synold TW, LoRusso P, Chung V, Christensen SD, Smith DC, Kingsbury L, Hoering A, Kurzrock R. Phase I study evaluating the combination of lapatinib (a Her2/Neu and EGFR inhibitor) and everolimus (an mTOR inhibitor) in patients with advanced cancers: South West Oncology Group (SWOG) Study S0528. Cancer Chemother Pharmacol 2013; 72: 1089-1096 [PMID: 24057042 DOI: 10.1007/s00280-013-2297-4]
    • (2013) Cancer Chemother Pharmacol , vol.72 , pp. 1089-1096
    • Gadgeel, S.M.1    Lew, D.L.2    Synold, T.W.3    LoRusso, P.4    Chung, V.5    Christensen, S.D.6    Smith, D.C.7    Kingsbury, L.8    Hoering, A.9    Kurzrock, R.10
  • 160
    • 80054057131 scopus 로고    scopus 로고
    • Southwest Oncology Group study S0413: A phase II trial of lapatinib (GW572016) as first-line therapy in patients with advanced or metastatic gastric cancer
    • PMID: 21415234
    • Iqbal S, Goldman B, Fenoglio-Preiser CM, Lenz HJ, Zhang W, Danenberg KD, Shibata SI, Blanke CD. Southwest Oncology Group study S0413: a phase II trial of lapatinib (GW572016) as first-line therapy in patients with advanced or metastatic gastric cancer. Ann Oncol 2011; 22: 2610-2615 [PMID: 21415234 DOI: 10.1093/annonc/mdr021]
    • (2011) Ann Oncol , vol.22 , pp. 2610-2615
    • Iqbal, S.1    Goldman, B.2    Fenoglio-Preiser, C.M.3    Lenz, H.J.4    Zhang, W.5    Danenberg, K.D.6    Shibata, S.I.7    Blanke, C.D.8
  • 161
    • 84859399146 scopus 로고    scopus 로고
    • Targeted therapy in the management of advanced gastric cancer: Are we making progress in the era of personalized medicine?
    • PMID: 22334453
    • Wong H, Yau T. Targeted therapy in the management of advanced gastric cancer: are we making progress in the era of personalized medicine? Oncologist 2012; 17: 346-358 [PMID: 22334453 DOI: 10.1634/theoncologist.2011-0311]
    • (2012) Oncologist , vol.17 , pp. 346-358
    • Wong, H.1    Yau, T.2
  • 165
    • 49749093093 scopus 로고    scopus 로고
    • Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer
    • PMID: 18270704
    • Ku GY, Ilson DH, Schwartz LH, Capanu M, O'Reilly E, Shah MA, Kelsen DP, Schwartz GK. Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer. Cancer Chemother Pharmacol 2008; 62: 875-880 [PMID: 18270704 DOI: 10.1007/s00280-008-0677-y]
    • (2008) Cancer Chemother Pharmacol , vol.62 , pp. 875-880
    • Ku, G.Y.1    Ilson, D.H.2    Schwartz, L.H.3    Capanu, M.4    O'Reilly, E.5    Shah, M.A.6    Kelsen, D.P.7    Schwartz, G.K.8
  • 166
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • PMID: 6156004
    • Jones PA, Taylor SM. Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980; 20: 85-93 [PMID: 6156004]
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 167
    • 46949098033 scopus 로고    scopus 로고
    • Current status of epigenetic treatment in myelodysplastic syndromes
    • PMID: 18392623
    • Kuendgen A, Lübbert M. Current status of epigenetic treatment in myelodysplastic syndromes. Ann Hematol 2008; 87: 601-611 [PMID: 18392623 DOI: 10.1007/s00277-008-0477-9]
    • (2008) Ann Hematol , vol.87 , pp. 601-611
    • Kuendgen, A.1    Lübbert, M.2
  • 168
    • 67449138841 scopus 로고    scopus 로고
    • Epigenetic modifiers: Basic understanding and clinical development
    • PMID: 19509169
    • Piekarz RL, Bates SE. Epigenetic modifiers: basic understanding and clinical development. Clin Cancer Res 2009; 15: 3918-3926 [PMID: 19509169 DOI: 10.1158/1078-0432.ccr-08-2788]
    • (2009) Clin Cancer Res , vol.15 , pp. 3918-3926
    • Piekarz, R.L.1    Bates, S.E.2
  • 170
    • 34447123203 scopus 로고    scopus 로고
    • Delivery of 5-aza-2′-deoxycytidine to cells using oligodeoxynucleotides
    • PMID: 17616700
    • Yoo CB, Jeong S, Egger G, Liang G, Phiasivongsa P, Tang C, Redkar S, Jones PA. Delivery of 5-aza-2′-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res 2007; 67: 6400-6408 [PMID: 17616700 DOI: 10.1158/0008-5472.can-07-0251]
    • (2007) Cancer Res , vol.67 , pp. 6400-6408
    • Yoo, C.B.1    Jeong, S.2    Egger, G.3    Liang, G.4    Phiasivongsa, P.5    Tang, C.6    Redkar, S.7    Jones, P.A.8
  • 171
    • 77952203695 scopus 로고    scopus 로고
    • S110, a 5-Aza-2′ -deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth
    • PMID: 20442312
    • Chuang JC, Warner SL, Vollmer D, Vankayalapati H, Redkar S, Bearss DJ, Qiu X, Yoo CB, Jones PA. S110, a 5-Aza-2′ -deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth. Mol Cancer Ther 2010; 9: 1443-1450 [PMID: 20442312 DOI: 10.1158/1535-7163.mct-09-1048]
    • (2010) Mol Cancer Ther , vol.9 , pp. 1443-1450
    • Chuang, J.C.1    Warner, S.L.2    Vollmer, D.3    Vankayalapati, H.4    Redkar, S.5    Bearss, D.J.6    Qiu, X.7    Yoo, C.B.8    Jones, P.A.9
  • 172
    • 67649449180 scopus 로고    scopus 로고
    • Cancer prevention by tea: Animal studies, molecular mechanisms and human relevance
    • PMID: 19472429
    • Yang CS, Wang X, Lu G, Picinich SC. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 2009; 9: 429-439 [PMID: 19472429 DOI: 10.1038/nrc2641]
    • (2009) Nat Rev Cancer , vol.9 , pp. 429-439
    • Yang, C.S.1    Wang, X.2    Lu, G.3    Picinich, S.C.4
  • 173
    • 25144507259 scopus 로고    scopus 로고
    • Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids
    • PMID: 16037419
    • Lee WJ, Shim JY, Zhu BT. Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol Pharmacol 2005; 68: 1018-1030 [PMID: 16037419 DOI: 10.1124/mol.104.008367]
    • (2005) Mol Pharmacol , vol.68 , pp. 1018-1030
    • Lee, W.J.1    Shim, J.Y.2    Zhu, B.T.3
  • 174
    • 0023936754 scopus 로고
    • Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
    • PMID: 3258330
    • Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S, Richardson B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 1988; 140: 2197-2200 [PMID: 3258330]
    • (1988) J Immunol , vol.140 , pp. 2197-2200
    • Cornacchia, E.1    Golbus, J.2    Maybaum, J.3    Strahler, J.4    Hanash, S.5    Richardson, B.6
  • 175
  • 176
    • 35548988945 scopus 로고    scopus 로고
    • Vorinostat in cutaneous T-cell lymphoma
    • PMID: 17940636
    • Duvic M, Vu J. Vorinostat in cutaneous T-cell lymphoma. Drugs Today (Barc) 2007; 43: 585-599 [PMID: 17940636 DOI: 10.1358/dot.2007.43.9.1112980]
    • (2007) Drugs Today (Barc) , vol.43 , pp. 585-599
    • Duvic, M.1    Vu, J.2
  • 177
    • 80052576073 scopus 로고    scopus 로고
    • Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer
    • PMID: 21931799
    • Claerhout S, Lim JY, Choi W, Park YY, Kim K, Kim SB, Lee JS, Mills GB, Cho JY. Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer. PLoS One 2011; 6: e24662 [PMID: 21931799 DOI: 10.1371/journal.pone.0024662]
    • (2011) PLoS One , vol.6 , pp. e24662
    • Claerhout, S.1    Lim, J.Y.2    Choi, W.3    Park, Y.Y.4    Kim, K.5    Kim, S.B.6    Lee, J.S.7    Mills, G.B.8    Cho, J.Y.9
  • 178
    • 84896393741 scopus 로고    scopus 로고
    • Phase I and pharmacodynamic study of vorinostat combined with capecitabine and cisplatin as first-line chemotherapy in advanced gastric cancer
    • PMID: 23712440
    • Yoo C, Ryu MH, Na YS, Ryoo BY, Lee CW, Maeng J, Kim SY, Koo DH, Park I, Kang YK. Phase I and pharmacodynamic study of vorinostat combined with capecitabine and cisplatin as first-line chemotherapy in advanced gastric cancer. Invest New Drugs 2014; 32: 271-278 [PMID: 23712440 DOI: 10.1007/s10637-013-9983-2]
    • (2014) Invest New Drugs , vol.32 , pp. 271-278
    • Yoo, C.1    Ryu, M.H.2    Na, Y.S.3    Ryoo, B.Y.4    Lee, C.W.5    Maeng, J.6    Kim, S.Y.7    Koo, D.H.8    Park, I.9    Kang, Y.K.10
  • 179
    • 79959309141 scopus 로고    scopus 로고
    • Deep sequencing of patient genomes for disease diagnosis: When will it become routine?
    • PMID: 21677196
    • Kingsmore SF, Saunders CJ. Deep sequencing of patient genomes for disease diagnosis: when will it become routine? Sci Transl Med 2011; 3: 87ps23 [PMID: 21677196 DOI: 10.1126/scitranslmed.3002695]
    • (2011) Sci Transl Med , vol.3 , pp. 87ps23
    • Kingsmore, S.F.1    Saunders, C.J.2
  • 180
    • 84860588781 scopus 로고    scopus 로고
    • Circulating DNA and next-generation sequencing
    • PMID: 22527501
    • Cooke S, Campbell P. Circulating DNA and next-generation sequencing. Recent Results Cancer Res 2012; 195: 143-149 [PMID: 22527501 DOI: 10.1007/978-3-642-28160-0-12]
    • (2012) Recent Results Cancer Res , vol.195 , pp. 143-149
    • Cooke, S.1    Campbell, P.2
  • 181
    • 77952982353 scopus 로고    scopus 로고
    • The role of surgery in the treatment of gastric cancer
    • PMID: 20512944
    • Shi Y, Zhou Y. The role of surgery in the treatment of gastric cancer. J Surg Oncol 2010; 101: 687-692 [PMID: 20512944 DOI: 10.1002/jso.21455]
    • (2010) J Surg Oncol , vol.101 , pp. 687-692
    • Shi, Y.1    Zhou, Y.2
  • 182
    • 0142092681 scopus 로고    scopus 로고
    • Prognostic significance of Bcl-2 and p53 expression in gastric cancer
    • PMID: 12811476
    • Lee HK, Lee HS, Yang HK, Kim WH, Lee KU, Choe KJ, Kim JP. Prognostic significance of Bcl-2 and p53 expression in gastric cancer. Int J Colorectal Dis 2003; 18: 518-525 [PMID: 12811476 DOI: 10.1007/s00384-003-0491-2]
    • (2003) Int J Colorectal Dis , vol.18 , pp. 518-525
    • Lee, H.K.1    Lee, H.S.2    Yang, H.K.3    Kim, W.H.4    Lee, K.U.5    Choe, K.J.6    Kim, J.P.7
  • 184
    • 84875753760 scopus 로고    scopus 로고
    • Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer
    • PMID: 23341533
    • Corso G, Carvalho J, Marrelli D, Vindigni C, Carvalho B, Seruca R, Roviello F, Oliveira C. Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer. J Clin Oncol 2013; 31: 868-875 [PMID: 23341533 DOI: 10.1200/jco.2012.44.4612]
    • (2013) J Clin Oncol , vol.31 , pp. 868-875
    • Corso, G.1    Carvalho, J.2    Marrelli, D.3    Vindigni, C.4    Carvalho, B.5    Seruca, R.6    Roviello, F.7    Oliveira, C.8
  • 187
    • 0031945061 scopus 로고    scopus 로고
    • Overexpression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: With respect to histological subtypes and stages
    • PMID: 9570245
    • Wu MS, Shun CT, Sheu JC, Wang HP, Wang JT, Lee WJ, Chen CJ, Wang TH, Lin JT. Overexpression of mutant p53 and c-erbB-2 proteins and mutations of the p15 and p16 genes in human gastric carcinoma: with respect to histological subtypes and stages. J Gastroenterol Hepatol 1998; 13: 305-310 [PMID: 9570245]
    • (1998) J Gastroenterol Hepatol , vol.13 , pp. 305-310
    • Wu, M.S.1    Shun, C.T.2    Sheu, J.C.3    Wang, H.P.4    Wang, J.T.5    Lee, W.J.6    Chen, C.J.7    Wang, T.H.8    Lin, J.T.9
  • 188
  • 189
    • 0034283031 scopus 로고    scopus 로고
    • Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability
    • PMID: 10987271
    • Piao Z, Fang W, Malkhosyan S, Kim H, Horii A, Perucho M, Huang S. Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability. Cancer Res 2000; 60: 4701-4704 [PMID: 10987271]
    • (2000) Cancer Res , vol.60 , pp. 4701-4704
    • Piao, Z.1    Fang, W.2    Malkhosyan, S.3    Kim, H.4    Horii, A.5    Perucho, M.6    Huang, S.7
  • 190
    • 4544341573 scopus 로고    scopus 로고
    • Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability
    • PMID: 15309726
    • Pan KF, Lu YY, Liu WG, Zhang L, You WC. Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability. World J Gastroenterol 2004; 10: 2719-2722 [PMID: 15309726]
    • (2004) World J Gastroenterol , vol.10 , pp. 2719-2722
    • Pan, K.F.1    Lu, Y.Y.2    Liu, W.G.3    Zhang, L.4    You, W.C.5
  • 191
    • 0035503171 scopus 로고    scopus 로고
    • Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability
    • PMID: 11691784
    • Menoyo A, Alazzouzi H, Espín E, Armengol M, Yamamoto H, Schwartz S. Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability. Cancer Res 2001; 61: 7727-7730 [PMID: 11691784]
    • (2001) Cancer Res , vol.61 , pp. 7727-7730
    • Menoyo, A.1    Alazzouzi, H.2    Espín, E.3    Armengol, M.4    Yamamoto, H.5    Schwartz, S.6
  • 192
    • 0035844994 scopus 로고    scopus 로고
    • Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype
    • PMID: 11470537
    • Ohmiya N, Matsumoto S, Yamamoto H, Baranovskaya S, Malkhosyan SR, Perucho M. Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype. Gene 2001; 272: 301-313 [PMID: 11470537]
    • (2001) Gene , vol.272 , pp. 301-313
    • Ohmiya, N.1    Matsumoto, S.2    Yamamoto, H.3    Baranovskaya, S.4    Malkhosyan, S.R.5    Perucho, M.6
  • 193
    • 68049111679 scopus 로고    scopus 로고
    • Allelic loss of the PTEN gene and mutation of the TP53 gene in choriocarcinoma arising from gastric adenocarcinoma: Analysis of loss of heterozygosity in two male patients with extragonadal choriocarcinoma
    • PMID: 19665071
    • Tate G, Suzuki T, Nemoto H, Kishimoto K, Hibi K, Mitsuya T. Allelic loss of the PTEN gene and mutation of the TP53 gene in choriocarcinoma arising from gastric adenocarcinoma: analysis of loss of heterozygosity in two male patients with extragonadal choriocarcinoma. Cancer Genet Cytogenet 2009; 193: 104-108 [PMID: 19665071 DOI: 10.1016/j.cancergencyto.2009.04.005]
    • (2009) Cancer Genet Cytogenet , vol.193 , pp. 104-108
    • Tate, G.1    Suzuki, T.2    Nemoto, H.3    Kishimoto, K.4    Hibi, K.5    Mitsuya, T.6
  • 195
    • 0028357022 scopus 로고
    • Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas
    • PMID: 8063611
    • Ayhan A, Yasui W, Yokozaki H, Seto M, Ueda R, Tahara E. Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas. Jpn J Cancer Res 1994; 85: 584-591 [PMID: 8063611]
    • (1994) Jpn J Cancer Res , vol.85 , pp. 584-591
    • Ayhan, A.1    Yasui, W.2    Yokozaki, H.3    Seto, M.4    Ueda, R.5    Tahara, E.6
  • 196
    • 0036240762 scopus 로고    scopus 로고
    • Loss of heterozygosity at 18q21 region in gastric cancer involves a number of cancer-related genes and correlates with stage and histology, but lacks independent prognostic value
    • PMID: 12081203
    • Candusso ME, Luinetti O, Villani L, Alberizzi P, Klersy C, Fiocca R, Ranzani GN, Solcia E. Loss of heterozygosity at 18q21 region in gastric cancer involves a number of cancer-related genes and correlates with stage and histology, but lacks independent prognostic value. J Pathol 2002; 197: 44-50 [PMID: 12081203 DOI: 10.1002/path.1105]
    • (2002) J Pathol , vol.197 , pp. 44-50
    • Candusso, M.E.1    Luinetti, O.2    Villani, L.3    Alberizzi, P.4    Klersy, C.5    Fiocca, R.6    Ranzani, G.N.7    Solcia, E.8
  • 198
    • 0037532411 scopus 로고    scopus 로고
    • Basic and translational advances in cancer metastasis: Nm23
    • PMID: 12848344
    • Ouatas T, Salerno M, Palmieri D, Steeg PS. Basic and translational advances in cancer metastasis: Nm23. J Bioenerg Biomembr 2003; 35: 73-79 [PMID: 12848344]
    • (2003) J Bioenerg Biomembr , vol.35 , pp. 73-79
    • Ouatas, T.1    Salerno, M.2    Palmieri, D.3    Steeg, P.S.4
  • 200
    • 33745456167 scopus 로고    scopus 로고
    • Loss of heterozygosity and microsatellite instabilities of fragile histidine triad gene in gastric carcinoma
    • PMID: 16773697
    • Xiao YP, Wu DY, Xu L, Xin Y. Loss of heterozygosity and microsatellite instabilities of fragile histidine triad gene in gastric carcinoma. World J Gastroenterol 2006; 12: 3766-3769 [PMID: 16773697]
    • (2006) World J Gastroenterol , vol.12 , pp. 3766-3769
    • Xiao, Y.P.1    Wu, D.Y.2    Xu, L.3    Xin, Y.4
  • 201
    • 84875594162 scopus 로고    scopus 로고
    • Loss of BRCA1 expression leads to worse survival in patients with gastric carcinoma
    • PMID: 23569343
    • Zhang ZZ, Liu YJ, Yin XL, Zhan P, Gu Y, Ni XZ. Loss of BRCA1 expression leads to worse survival in patients with gastric carcinoma. World J Gastroenterol 2013; 19: 1968-1974 [PMID: 23569343 DOI: 10.3748/wjg.v19.i12.1968]
    • (2013) World J Gastroenterol , vol.19 , pp. 1968-1974
    • Zhang, Z.Z.1    Liu, Y.J.2    Yin, X.L.3    Zhan, P.4    Gu, Y.5    Ni, X.Z.6
  • 202
    • 84880615002 scopus 로고    scopus 로고
    • Prognostic significance of BRCA1 expression in gastric cancer
    • PMID: 23292835
    • Chen W, Wang J, Li X, Li J, Zhou L, Qiu T, Zhang M, Liu P. Prognostic significance of BRCA1 expression in gastric cancer. Med Oncol 2013; 30: 423 [PMID: 23292835 DOI: 10.1007/s12032-012-0423-5]
    • (2013) Med Oncol , vol.30 , pp. 423
    • Chen, W.1    Wang, J.2    Li, X.3    Li, J.4    Zhou, L.5    Qiu, T.6    Zhang, M.7    Liu, P.8
  • 203
    • 0842263902 scopus 로고    scopus 로고
    • Mutational analysis of BRAF and K-ras in gastric cancers: Absence of BRAF mutations in gastric cancers
    • PMID: 14513361
    • Kim IJ, Park JH, Kang HC, Shin Y, Park HW, Park HR, Ku JL, Lim SB, Park JG. Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers. Hum Genet 2003; 114: 118-120 [PMID: 14513361 DOI: 10.1007/s00439-003-1027-0]
    • (2003) Hum Genet , vol.114 , pp. 118-120
    • Kim, I.J.1    Park, J.H.2    Kang, H.C.3    Shin, Y.4    Park, H.W.5    Park, H.R.6    Ku, J.L.7    Lim, S.B.8    Park, J.G.9
  • 205
    • 84903709778 scopus 로고    scopus 로고
    • Prognostic implications of EGFR and HER-2 alteration assessed by immunohistochemistry and silver in situ hybridization in gastric cancer patients following curative resection
    • PMID: 23955257
    • Oh HS, Eom DW, Kang GH, Ahn YC, Lee SJ, Kim JH, Jang HJ, Kim EJ, Oh KH, Ahn HJ. Prognostic implications of EGFR and HER-2 alteration assessed by immunohistochemistry and silver in situ hybridization in gastric cancer patients following curative resection. Gastric Cancer 2014; 17: 402-411 [PMID: 23955257 DOI: 10.1007/s10120-013-0288-0]
    • (2014) Gastric Cancer , vol.17 , pp. 402-411
    • Oh, H.S.1    Eom, D.W.2    Kang, G.H.3    Ahn, Y.C.4    Lee, S.J.5    Kim, J.H.6    Jang, H.J.7    Kim, E.J.8    Oh, K.H.9    Ahn, H.J.10
  • 206
    • 0034789096 scopus 로고    scopus 로고
    • Overexpression of the c-met protooncogene in human gastric carcinoma - correlation to clinical features
    • PMID: 11669338
    • Huang TJ, Wang JY, Lin SR, Lian ST, Hsieh JS. Overexpression of the c-met protooncogene in human gastric carcinoma - correlation to clinical features. Acta Oncol 2001; 40: 638-643 [PMID: 11669338]
    • (2001) Acta Oncol , vol.40 , pp. 638-643
    • Huang, T.J.1    Wang, J.Y.2    Lin, S.R.3    Lian, S.T.4    Hsieh, J.S.5
  • 207
    • 67449094284 scopus 로고    scopus 로고
    • Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma
    • PMID: 19287982
    • Toyokawa T, Yashiro M, Hirakawa K. Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma. Oncol Rep 2009; 21: 875-880 [PMID: 19287982]
    • (2009) Oncol Rep , vol.21 , pp. 875-880
    • Toyokawa, T.1    Yashiro, M.2    Hirakawa, K.3
  • 208
    • 18544362183 scopus 로고    scopus 로고
    • Molecular-pathological prognostic factors of gastric cancer: A review
    • PMID: 15864715
    • Yasui W, Oue N, Aung PP, Matsumura S, Shutoh M, Nakayama H. Molecular-pathological prognostic factors of gastric cancer: a review. Gastric Cancer 2005; 8: 86-94 [PMID: 15864715 DOI: 10.1007/s10120-005-0320-0]
    • (2005) Gastric Cancer , vol.8 , pp. 86-94
    • Yasui, W.1    Oue, N.2    Aung, P.P.3    Matsumura, S.4    Shutoh, M.5    Nakayama, H.6
  • 209
    • 0036207684 scopus 로고    scopus 로고
    • Expression of CD44v6 in advanced gastric cancer and its relationship to hematogenous metastasis and long-term prognosis
    • PMID: 11920780
    • Yamaguchi A, Goi T, Yu J, Hirono Y, Ishida M, Iida A, Kimura T, Takeuchi K, Katayama K, Hirose K. Expression of CD44v6 in advanced gastric cancer and its relationship to hematogenous metastasis and long-term prognosis. J Surg Oncol 2002; 79: 230-235 [PMID: 11920780 DOI: 10.1002/jso.10082]
    • (2002) J Surg Oncol , vol.79 , pp. 230-235
    • Yamaguchi, A.1    Goi, T.2    Yu, J.3    Hirono, Y.4    Ishida, M.5    Iida, A.6    Kimura, T.7    Takeuchi, K.8    Katayama, K.9    Hirose, K.10
  • 210
    • 43049131055 scopus 로고    scopus 로고
    • PRL PTPs: Mediators and markers of cancer progression
    • PMID: 18224294
    • Bessette DC, Qiu D, Pallen CJ. PRL PTPs: mediators and markers of cancer progression. Cancer Metastasis Rev 2008; 27: 231-252 [PMID: 18224294 DOI: 10.1007/s10555-008-9121-3]
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 231-252
    • Bessette, D.C.1    Qiu, D.2    Pallen, C.J.3
  • 211
    • 65549142646 scopus 로고    scopus 로고
    • Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer
    • PMID: 19322925
    • Dai N, Lu AP, Shou CC, Li JY. Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer. World J Gastroenterol 2009; 15: 1499-1505 [PMID: 19322925]
    • (2009) World J Gastroenterol , vol.15 , pp. 1499-1505
    • Dai, N.1    Lu, A.P.2    Shou, C.C.3    Li, J.Y.4
  • 212
    • 0033996667 scopus 로고    scopus 로고
    • Comparative study of tumor angiogenesis and immunohistochemistry for p53, c-ErbB2, c-myc and EGFr as prognostic factors in gastric cancer
    • PMID: 10809364
    • Sanz-Ortega J, Steinberg SM, Moro E, Saez M, Lopez JA, Sierra E, Sanz-Esponera J, Merino MJ. Comparative study of tumor angiogenesis and immunohistochemistry for p53, c-ErbB2, c-myc and EGFr as prognostic factors in gastric cancer. Histol Histopathol 2000; 15: 455-462 [PMID: 10809364]
    • (2000) Histol Histopathol , vol.15 , pp. 455-462
    • Sanz-Ortega, J.1    Steinberg, S.M.2    Moro, E.3    Saez, M.4    Lopez, J.A.5    Sierra, E.6    Sanz-Esponera, J.7    Merino, M.J.8
  • 213
    • 0033203307 scopus 로고    scopus 로고
    • c-Myc expression is related with cell proliferation and associated with poor clinical outcome in human gastric cancer
    • PMID: 10576148
    • Han S, Kim HY, Park K, Cho HJ, Lee MS, Kim HJ, Kim YD. c-Myc expression is related with cell proliferation and associated with poor clinical outcome in human gastric cancer. J Korean Med Sci 1999; 14: 526-530 [PMID: 10576148]
    • (1999) J Korean Med Sci , vol.14 , pp. 526-530
    • Han, S.1    Kim, H.Y.2    Park, K.3    Cho, H.J.4    Lee, M.S.5    Kim, H.J.6    Kim, Y.D.7
  • 216
    • 22044441872 scopus 로고    scopus 로고
    • Potential diagnostic and prognostic values of detecting promoter hypermethylation in the serum of patients with gastric cancer
    • PMID: 15942635
    • Leung WK, To KF, Chu ES, Chan MW, Bai AH, Ng EK, Chan FK, Sung JJ. Potential diagnostic and prognostic values of detecting promoter hypermethylation in the serum of patients with gastric cancer. Br J Cancer 2005; 92: 2190-2194 [PMID: 15942635 DOI: 10.1038/sj.bjc.6602636]
    • (2005) Br J Cancer , vol.92 , pp. 2190-2194
    • Leung, W.K.1    To, K.F.2    Chu, E.S.3    Chan, M.W.4    Bai, A.H.5    Ng, E.K.6    Chan, F.K.7    Sung, J.J.8
  • 219
    • 84855495604 scopus 로고    scopus 로고
    • High CpG island methylator phenotype is associated with lymph node metastasis and prognosis in gastric cancer
    • PMID: 22017425
    • Chen HY, Zhu BH, Zhang CH, Yang DJ, Peng JJ, Chen JH, Liu FK, He YL. High CpG island methylator phenotype is associated with lymph node metastasis and prognosis in gastric cancer. Cancer Sci 2012; 103: 73-79 [PMID: 22017425 DOI: 10.1111/j.1349-7006.2011.02129.x]
    • (2012) Cancer Sci , vol.103 , pp. 73-79
    • Chen, H.Y.1    Zhu, B.H.2    Zhang, C.H.3    Yang, D.J.4    Peng, J.J.5    Chen, J.H.6    Liu, F.K.7    He, Y.L.8
  • 220
    • 85027940278 scopus 로고    scopus 로고
    • Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer
    • PMID: 20300977
    • Hu SL, Huang DB, Sun YB, Wu L, Xu WP, Yin S, Chen J, Jiang XD, Shen G. Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer. Med Oncol 2011; 28: 447-454 [PMID: 20300977 DOI: 10.1007/s12032-010-9467-6]
    • (2011) Med Oncol , vol.28 , pp. 447-454
    • Hu, S.L.1    Huang, D.B.2    Sun, Y.B.3    Wu, L.4    Xu, W.P.5    Yin, S.6    Chen, J.7    Jiang, X.D.8    Shen, G.9
  • 221
    • 0035876138 scopus 로고    scopus 로고
    • Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues
    • PMID: 11413518
    • Leung WK, Yu J, Ng EK, To KF, Ma PK, Lee TL, Go MY, Chung SC, Sung JJ. Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues. Cancer 2001; 91: 2294-2301 [PMID: 11413518]
    • (2001) Cancer , vol.91 , pp. 2294-2301
    • Leung, W.K.1    Yu, J.2    Ng, E.K.3    To, K.F.4    Ma, P.K.5    Lee, T.L.6    Go, M.Y.7    Chung, S.C.8    Sung, J.J.9
  • 222
    • 28544438198 scopus 로고    scopus 로고
    • ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation
    • PMID: 16103878
    • Takada H, Imoto I, Tsuda H, Nakanishi Y, Ichikura T, Mochizuki H, Mitsufuji S, Hosoda F, Hirohashi S, Ohki M, Inazawa J. ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation. Oncogene 2005; 24: 8051-8060 [PMID: 16103878 DOI: 10.1038/sj.onc.1208952]
    • (2005) Oncogene , vol.24 , pp. 8051-8060
    • Takada, H.1    Imoto, I.2    Tsuda, H.3    Nakanishi, Y.4    Ichikura, T.5    Mochizuki, H.6    Mitsufuji, S.7    Hosoda, F.8    Hirohashi, S.9    Ohki, M.10    Inazawa, J.11
  • 225
    • 84876664395 scopus 로고    scopus 로고
    • DNA methylation of NDRG2 in gastric cancer and its clinical significance
    • PMID: 23010743
    • Chang X, Li Z, Ma J, Deng P, Zhang S, Zhi Y, Chen J, Dai D. DNA methylation of NDRG2 in gastric cancer and its clinical significance. Dig Dis Sci 2013; 58: 715-723 [PMID: 23010743 DOI: 10.1007/s10620-012-2393-z]
    • (2013) Dig Dis Sci , vol.58 , pp. 715-723
    • Chang, X.1    Li, Z.2    Ma, J.3    Deng, P.4    Zhang, S.5    Zhi, Y.6    Chen, J.7    Dai, D.8
  • 228
    • 37349022478 scopus 로고    scopus 로고
    • Methylated TMS1 and DAPK genes predict prognosis and response to chemotherapy in gastric cancer
    • PMID: 17943730
    • Kato K, Iida S, Uetake H, Takagi Y, Yamashita T, Inokuchi M, Yamada H, Kojima K, Sugihara K. Methylated TMS1 and DAPK genes predict prognosis and response to chemotherapy in gastric cancer. Int J Cancer 2008; 122: 603-608 [PMID: 17943730 DOI: 10.1002/ijc.23143]
    • (2008) Int J Cancer , vol.122 , pp. 603-608
    • Kato, K.1    Iida, S.2    Uetake, H.3    Takagi, Y.4    Yamashita, T.5    Inokuchi, M.6    Yamada, H.7    Kojima, K.8    Sugihara, K.9
  • 229
    • 0036121312 scopus 로고    scopus 로고
    • Epstein-barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma
    • PMID: 11891177
    • Kang GH, Lee S, Kim WH, Lee HW, Kim JC, Rhyu MG, Ro JY. Epstein-barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol 2002; 160: 787-794 [PMID: 11891177 DOI: 10.1016/s0002-9440(10)64901-2]
    • (2002) Am J Pathol , vol.160 , pp. 787-794
    • Kang, G.H.1    Lee, S.2    Kim, W.H.3    Lee, H.W.4    Kim, J.C.5    Rhyu, M.G.6    Ro, J.Y.7
  • 230
    • 84876918167 scopus 로고    scopus 로고
    • Zinc-finger protein 545 is a novel tumour suppressor that acts by inhibiting ribosomal RNA transcription in gastric cancer
    • PMID: 22580414
    • Wang S, Cheng Y, Du W, Lu L, Zhou L, Wang H, Kang W, Li X, Tao Q, Sung JJ, Yu J. Zinc-finger protein 545 is a novel tumour suppressor that acts by inhibiting ribosomal RNA transcription in gastric cancer. Gut 2013; 62: 833-841 [PMID: 22580414 DOI: 10.1136/gutjnl-2011-301776]
    • (2013) Gut , vol.62 , pp. 833-841
    • Wang, S.1    Cheng, Y.2    Du, W.3    Lu, L.4    Zhou, L.5    Wang, H.6    Kang, W.7    Li, X.8    Tao, Q.9    Sung, J.J.10    Yu, J.11
  • 231
    • 80051631578 scopus 로고    scopus 로고
    • Decreased expression and aberrant hypermethylation of the SFRP genes in human gastric cancer
    • PMID: 21830441
    • Kinoshita T, Nomoto S, Kodera Y, Koike M, Fujiwara M, Nakao A. Decreased expression and aberrant hypermethylation of the SFRP genes in human gastric cancer. Hepatogastroenterology 2011; 58: 1051-1056 [PMID: 21830441]
    • (2011) Hepatogastroenterology , vol.58 , pp. 1051-1056
    • Kinoshita, T.1    Nomoto, S.2    Kodera, Y.3    Koike, M.4    Fujiwara, M.5    Nakao, A.6
  • 234
    • 53949090314 scopus 로고    scopus 로고
    • Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
    • PMID: 18803879
    • Ji Q, Hao X, Meng Y, Zhang M, Desano J, Fan D, Xu L. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer 2008; 8: 266 [PMID: 18803879 DOI: 10.1186/1471-2407-8-266]
    • (2008) BMC Cancer , vol.8 , pp. 266
    • Ji, Q.1    Hao, X.2    Meng, Y.3    Zhang, M.4    Desano, J.5    Fan, D.6    Xu, L.7
  • 235
    • 77649312099 scopus 로고    scopus 로고
    • Regulation of the transcription factor NF-kappaB1 by microRNA-9 in human gastric adenocarcinoma
    • PMID: 20102618
    • Wan HY, Guo LM, Liu T, Liu M, Li X, Tang H. Regulation of the transcription factor NF-kappaB1 by microRNA-9 in human gastric adenocarcinoma. Mol Cancer 2010; 9: 16 [PMID: 20102618 DOI: 10.1186/1476-4598-9-16]
    • (2010) Mol Cancer , vol.9 , pp. 16
    • Wan, H.Y.1    Guo, L.M.2    Liu, T.3    Liu, M.4    Li, X.5    Tang, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.