-
1
-
-
0032960181
-
Cancer epigenetics comes of age
-
Jones PA, Laird PW: Cancer epigenetics comes of age. Nat Genet 1999, 21:163-167.
-
(1999)
Nat Genet
, vol.21
, pp. 163-167
-
-
Jones, P.A.1
Laird, P.W.2
-
2
-
-
0035870248
-
A gene hypermethylation profile of human cancer
-
Esteller M, Corn PG, Baylin SB, et al.: A gene hypermethylation profile of human cancer. Cancer Res 2001, 61:3225-3229.
-
(2001)
Cancer Res
, vol.61
, pp. 3225-3229
-
-
Esteller, M.1
Corn, P.G.2
Baylin, S.B.3
-
3
-
-
0037068312
-
CpG island hypermethylation and tumor suppressor genes: A booming present, a brighter future
-
Esteller M: CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 2002, 21:5427-5440.
-
(2002)
Oncogene
, vol.21
, pp. 5427-5440
-
-
Esteller, M.1
-
4
-
-
0345357773
-
Gene silencing in cancer in association with promoter hypermethylation
-
Herman JG, Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003, 349:2042-2054.
-
(2003)
N Engl J Med
, vol.349
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
5
-
-
1042278765
-
The history of cancer epigenetics
-
Feinberg AP, Tycko B: The history of cancer epigenetics. Nat Rev Cancer 2004, 4:143-153.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 143-153
-
-
Feinberg, A.P.1
Tycko, B.2
-
6
-
-
0037068353
-
DNA methylation in cancer: Too much, but also too little
-
Ehrlich M: DNA methylation in cancer: too much, but also too little. Oncogene 2002, 21:5400-5413.
-
(2002)
Oncogene
, vol.21
, pp. 5400-5413
-
-
Ehrlich, M.1
-
7
-
-
0032480226
-
DNA hypomethylation leads to elevated mutation rates
-
Chen RZ, Pettersson U, Beard C, et al.: DNA hypomethylation leads to elevated mutation rates. Nature 1998, 395:199889-199893.
-
(1998)
Nature
, vol.395
, pp. 199889-199893
-
-
Chen, R.Z.1
Pettersson, U.2
Beard, C.3
-
8
-
-
0242584454
-
Chromosomal instability and tumors promoted by DNA hypomethylation
-
Eden A, Gaudet F, Waghmare A, et al.: Chromosomal instability and tumors promoted by DNA hypomethylation. Science 2003, 300:455. In a mouse model, the presence of hypomorphic alleles of DNMT1 is associated with the development of lymphomas and chromosomal instability.
-
(2003)
Science
, vol.300
, pp. 455
-
-
Eden, A.1
Gaudet, F.2
Waghmare, A.3
-
9
-
-
4344705509
-
Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern
-
Jun 25
-
Espada J, Ballestar E, Fraga MF, et al.: Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern. J Biol Chem 2004, Jun 25. This article shows that cancer cells deficient in DNMT1 present aberrant nuclear structures.
-
(2004)
J Biol Chem
-
-
Espada, J.1
Ballestar, E.2
Fraga, M.F.3
-
10
-
-
0142216208
-
Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS
-
Leone G, Voso MT, Teofili L, et al.: Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS. Clin Immunol 2003, 109:89-102.
-
(2003)
Clin Immunol
, vol.109
, pp. 89-102
-
-
Leone, G.1
Voso, M.T.2
Teofili, L.3
-
11
-
-
0037303184
-
DNA demethylating agents and chromatin-remodelling drugs: Which, how and why?
-
Villar-Garea A, Esteller M: DNA demethylating agents and chromatin-remodelling drugs: which, how and why? Curr Drug Metab 2003, 4:11-31.
-
(2003)
Curr Drug Metab
, vol.4
, pp. 11-31
-
-
Villar-Garea, A.1
Esteller, M.2
-
12
-
-
18344390653
-
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
-
Rhee I, Bachman KE, Park BH, et al.: DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 2002, 416:552-556.
-
(2002)
Nature
, vol.416
, pp. 552-556
-
-
Rhee, I.1
Bachman, K.E.2
Park, B.H.3
-
13
-
-
0041779528
-
Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases
-
Paz MF, Wei S, Cigudosa JC, et al.: Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases. Hum Mol Genet 2003, 12:2209-2219. This article demonstrates that the double inactivation of DNMT1 and DNMT3b induces a massive reactivation of previously dormant methylated tumor-suppressor genes.
-
(2003)
Hum Mol Genet
, vol.12
, pp. 2209-2219
-
-
Paz, M.F.1
Wei, S.2
Cigudosa, J.C.3
-
14
-
-
0018860957
-
Cellular differentiation, cytidine analogs and DNA methylation
-
Jones PA, Taylor SM: Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980, 20:85-93.
-
(1980)
Cell
, vol.20
, pp. 85-93
-
-
Jones, P.A.1
Taylor, S.M.2
-
15
-
-
0014872738
-
Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia
-
Li LH, Olin EJ, Buskirk HH, et al.: Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res 1970, 30:2760-2769.
-
(1970)
Cancer Res
, vol.30
, pp. 2760-2769
-
-
Li, L.H.1
Olin, E.J.2
Buskirk, H.H.3
-
16
-
-
0015692518
-
Distribution of kinase and deaminase of 1-beta-D-arabinofuranosylcytosine in tissues of man and mouse
-
Ho DH: Distribution of kinase and deaminase of 1-beta-D- arabinofuranosylcytosine in tissues of man and mouse. Cancer Res 1973, 33:2816-2820.
-
(1973)
Cancer Res
, vol.33
, pp. 2816-2820
-
-
Ho, D.H.1
-
17
-
-
0019857236
-
Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia
-
Rivard GE, Momparler RL, Demers J, et al.: Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia. Leuk Res 1981, 5:453-462.
-
(1981)
Leuk Res
, vol.5
, pp. 453-462
-
-
Rivard, G.E.1
Momparler, R.L.2
Demers, J.3
-
18
-
-
0026323307
-
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues
-
Driscoll JS, Marquez VE, Plowman J, et al.: Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues. J Med Chem 1991, 34:3280-3284.
-
(1991)
J Med Chem
, vol.34
, pp. 3280-3284
-
-
Driscoll, J.S.1
Marquez, V.E.2
Plowman, J.3
-
19
-
-
0036965821
-
Zebularine: A novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases
-
Zhou L, Cheng X, Connolly BA, et al.: Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J Mol Biol 2002, 321:591-599.
-
(2002)
J Mol Biol
, vol.321
, pp. 591-599
-
-
Zhou, L.1
Cheng, X.2
Connolly, B.A.3
-
20
-
-
1642499364
-
Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells
-
Cheng JC, Weisenberger DJ, Gonzales FA, et al.: Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol Cell Biol 2004, 24:1270-1278. It shows that the combination of 5-aza-2′-deoxycytidine and zebularine is highly effective in maintaining the demethylation status of a tumor-suppressor gene.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 1270-1278
-
-
Cheng, J.C.1
Weisenberger, D.J.2
Gonzales, F.A.3
-
21
-
-
0037420191
-
Inhibition of DNA methylation and reactivation of silenced genes by zebularine
-
Cheng JC, Matsen CB, Gonzales FA, et al.: Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst 2003, 95:399-409. The first study showing the use of an oral DNA demethylating agent that restores the methylation of a tumor-suppressor gene and has antitumoral effects.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 399-409
-
-
Cheng, J.C.1
Matsen, C.B.2
Gonzales, F.A.3
-
22
-
-
0023936754
-
Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
-
Cornacchia E, Golbus J, Maybaum J, et al.: Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 1988, 140:2197-2200.
-
(1988)
J Immunol
, vol.140
, pp. 2197-2200
-
-
Cornacchia, E.1
Golbus, J.2
Maybaum, J.3
-
23
-
-
0035893767
-
Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide
-
Lin X, Asgari K, Putzi MJ, et al.: Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide. Cancer Res 2001, 61:8611-8616.
-
(2001)
Cancer Res
, vol.61
, pp. 8611-8616
-
-
Lin, X.1
Asgari, K.2
Putzi, M.J.3
-
24
-
-
0022541497
-
Effects of lupus-inducing drugs on the B to Z transition of synthetic DNA
-
Thomas TJ, Messner RP: Effects of lupus-inducing drugs on the B to Z transition of synthetic DNA. Arthritis Rheum 1986, 29:638-645.
-
(1986)
Arthritis Rheum
, vol.29
, pp. 638-645
-
-
Thomas, T.J.1
Messner, R.P.2
-
25
-
-
0041939756
-
Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells
-
Villar-Garea A, Fraga MF, Espada J, et al.: Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res 2003, 63:4984-4989. The first demonstration that the local anesthetic drug procaine also has DNA demethylation and antitumoral activities.
-
(2003)
Cancer Res
, vol.63
, pp. 4984-4989
-
-
Villar-Garea, A.1
Fraga, M.F.2
Espada, J.3
-
26
-
-
10744225448
-
Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy
-
Segura-Pacheco B, Trejo-Becerril C, Perez-Cardenas E, et al.: Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy. Clin Cancer Res 2003, 9:1596-1603. A new study pinpoints the DNA demethylating capacity of the old drug hydralazine.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1596-1603
-
-
Segura-Pacheco, B.1
Trejo-Becerril, C.2
Perez-Cardenas, E.3
-
27
-
-
0345275879
-
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
-
Fang MZ, Wang Y, Ai N, et al.: Tea polyphenol (-)-epigallocatechin-3- gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res 2003, 63:7563-7570. The first demonstration that these compounds may be able to reactivate hypermethylated tumor-suppressor genes.
-
(2003)
Cancer Res
, vol.63
, pp. 7563-7570
-
-
Fang, M.Z.1
Wang, Y.2
Ai, N.3
-
28
-
-
0038627550
-
Psammaplins from the sponge Pseudoceratina purpurea: Inhibition of both histone deacetylase and DNA methyltransferase
-
Pina IC, Gautschi JT, Wang GY, et al.: Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase. J Org Chem 2003, 68:3866-3873. The first evidence of the DNA demethylation capacity of these compounds.
-
(2003)
J Org Chem
, vol.68
, pp. 3866-3873
-
-
Pina, I.C.1
Gautschi, J.T.2
Wang, G.Y.3
-
29
-
-
18244388241
-
DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis
-
Esteller M, Fraga MF, Guo M, et al.: DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet 2001, 10:3001-3007.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 3001-3007
-
-
Esteller, M.1
Fraga, M.F.2
Guo, M.3
-
30
-
-
0035932396
-
E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma
-
Machado JC, Oliveira C, Carvalho R, et al.: E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma. Oncogene 2001, 20:1525-1528.
-
(2001)
Oncogene
, vol.20
, pp. 1525-1528
-
-
Machado, J.C.1
Oliveira, C.2
Carvalho, R.3
-
31
-
-
13144266670
-
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
-
Herman JG, Umar A, Polyak K, et al.: Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 1998, 95:6870-6875.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6870-6875
-
-
Herman, J.G.1
Umar, A.2
Polyak, K.3
-
32
-
-
0035297539
-
p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2
-
Esteller M, Cordon-Cardo C, Corn PG, et al.: p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2. Cancer Res 2001, 61:2816-2821.
-
(2001)
Cancer Res
, vol.61
, pp. 2816-2821
-
-
Esteller, M.1
Cordon-Cardo, C.2
Corn, P.G.3
-
33
-
-
0037373891
-
A systematic profile of DNA methylation in human cancer cell lines
-
Paz MF, Fraga MF, Avila S, et al.: A systematic profile of DNA methylation in human cancer cell lines. Cancer Res 2003, 63:1114-1121. A study that shows that all cancer cell lines are sensitive to the DNA-demethylating effect of 5-aza-2′-deoxycytidine.
-
(2003)
Cancer Res
, vol.63
, pp. 1114-1121
-
-
Paz, M.F.1
Fraga, M.F.2
Avila, S.3
-
34
-
-
1242272932
-
The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine
-
Nieto M, Samper E, Fraga MF, et al.: The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine. Oncogene 2004, 23:735-743.
-
(2004)
Oncogene
, vol.23
, pp. 735-743
-
-
Nieto, M.1
Samper, E.2
Fraga, M.F.3
-
35
-
-
0029001154
-
Suppression of intestinal neoplasia by DNA hypomethylation
-
Laird PW, Jackson-Grusby L, Fazeli A, et al.: Suppression of intestinal neoplasia by DNA hypomethylation. Cell 1995, 81:197-205.
-
(1995)
Cell
, vol.81
, pp. 197-205
-
-
Laird, P.W.1
Jackson-Grusby, L.2
Fazeli, A.3
-
36
-
-
0642275161
-
Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation"
-
Yang AS, Estecio MR, Garcia-Manero G, et al.: Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation". Science 2003, 302:1153.
-
(2003)
Science
, vol.302
, pp. 1153
-
-
Yang, A.S.1
Estecio, M.R.2
Garcia-Manero, G.3
-
37
-
-
0034883005
-
Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2"- deoxycytidine
-
Lubbert M, Wijermans P, Kunzmann R, et al.: Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2"-deoxycytidine. Br J Haematol 2001, 114:349-357.
-
(2001)
Br J Haematol
, vol.114
, pp. 349-357
-
-
Lubbert, M.1
Wijermans, P.2
Kunzmann, R.3
-
38
-
-
4143140030
-
A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors
-
Fraga MF, Herranz M, Espada J, et al.: A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer Res 2004, 64:5527-5534. The first demonstration that there is a progressive loss of 5-methylcytosine DNA content in tumorigenesis.
-
(2004)
Cancer Res
, vol.64
, pp. 5527-5534
-
-
Fraga, M.F.1
Herranz, M.2
Espada, J.3
-
39
-
-
0041347519
-
Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target?
-
Johnstone RW, Licht JD: Histone deacetylase inhibitors in cancer therapy: is transcription the primary target? Cancer Cell 2003, 4:13-18.
-
(2003)
Cancer Cell
, vol.4
, pp. 13-18
-
-
Johnstone, R.W.1
Licht, J.D.2
-
40
-
-
1042276984
-
Histone deacetylase inhibitors: Assays to assess effectiveness in vitro and in vivo
-
Richon VM, Zhou X, Secrist JP, et al.: Histone deacetylase inhibitors: assays to assess effectiveness in vitro and in vivo. Methods Enzymol 2004, 376:199-205.
-
(2004)
Methods Enzymol
, vol.376
, pp. 199-205
-
-
Richon, V.M.1
Zhou, X.2
Secrist, J.P.3
-
41
-
-
4544323749
-
Histone deacetylase inhibitors: Understanding a new wave of anticancer agents
-
in press
-
Villar-Garea A, Esteller M: Histone deacetylase inhibitors: understanding a new wave of anticancer agents. Int J Cancer, in press.
-
Int J Cancer
-
-
Villar-Garea, A.1
Esteller, M.2
-
42
-
-
0032948005
-
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
-
Cameron EE, Bachman KE, Myohanen S, et al.: Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 1999, 21:103-107.
-
(1999)
Nat Genet
, vol.21
, pp. 103-107
-
-
Cameron, E.E.1
Bachman, K.E.2
Myohanen, S.3
-
43
-
-
0035843169
-
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
-
Soengas MS, Capodieci P, Polsky D, et al.: Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 2001, 409:207-211.
-
(2001)
Nature
, vol.409
, pp. 207-211
-
-
Soengas, M.S.1
Capodieci, P.2
Polsky, D.3
-
44
-
-
0035935980
-
Increased expression of unmethylated CDKN2D by 5-aza-2′- deoxycytidine in human lung cancer cells
-
Zhu WG, Dai Z, Ding H, et al.: Increased expression of unmethylated CDKN2D by 5-aza-2′-deoxycytidine in human lung cancer cells. Oncogene 2001, 20:7787-7796.
-
(2001)
Oncogene
, vol.20
, pp. 7787-7796
-
-
Zhu, W.G.1
Dai, Z.2
Ding, H.3
-
45
-
-
3543056463
-
Biological functions of melanoma-associated antigens
-
Xiao J, Chen HS: Biological functions of melanoma-associated antigens. World J Gastroenterol 2004, 10:1849-1853.
-
(2004)
World J Gastroenterol
, vol.10
, pp. 1849-1853
-
-
Xiao, J.1
Chen, H.S.2
-
46
-
-
0037283924
-
DNA methylation in systemic lupus erythematosus
-
Sekigawa I, Okada M, Ogasawara H, et al.: DNA methylation in systemic lupus erythematosus. Lupus 2003, 12:79-85.
-
(2003)
Lupus
, vol.12
, pp. 79-85
-
-
Sekigawa, I.1
Okada, M.2
Ogasawara, H.3
-
47
-
-
0030974771
-
Pilot phase I-II study on 5-aza-2"-deoxycytidine (Decitabine) in patients with metastatic lung cancer
-
Momparler RL, Bouffard DY, Momparler LF, et al.: Pilot phase I-II study on 5-aza-2"-deoxycytidine (Decitabine) in patients with metastatic lung cancer. Anticancer Drugs 1997, 8:358-368.
-
(1997)
Anticancer Drugs
, vol.8
, pp. 358-368
-
-
Momparler, R.L.1
Bouffard, D.Y.2
Momparler, L.F.3
-
48
-
-
0036794950
-
Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix
-
Pohlmann P, DiLeone LP, Cancella AI, et al.: Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix. Am J Clin Oncol 2002, 25:496-501.
-
(2002)
Am J Clin Oncol
, vol.25
, pp. 496-501
-
-
Pohlmann, P.1
DiLeone, L.P.2
Cancella, A.I.3
-
49
-
-
0024956889
-
5-Aza-2′-deoxycytidine as a differentiation inducer in acute myeloid leukaemias and myelodysplastic syndromes of the elderly
-
Pinto A, Zagonel V, Attadia V, et al.: 5-Aza-2′-deoxycytidine as a differentiation inducer in acute myeloid leukaemias and myelodysplastic syndromes of the elderly. Bone Marrow Transplant 1989, 4(suppl 3):28-32.
-
(1989)
Bone Marrow Transplant
, vol.4
, Issue.3 SUPPL.
, pp. 28-32
-
-
Pinto, A.1
Zagonel, V.2
Attadia, V.3
-
50
-
-
17444452612
-
Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients
-
Wijermans P, Lubbert M, Verhoef G, et al.: Low-dose 5-aza-2′- deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J Clin Oncol 2000, 18:956-962.
-
(2000)
J Clin Oncol
, vol.18
, pp. 956-962
-
-
Wijermans, P.1
Lubbert, M.2
Verhoef, G.3
-
51
-
-
0037654500
-
Low dose decitabine for elderly high risk MDS patients: Who will respond?
-
Wijermans PW, Luebbert M, Verhoef G: Low dose decitabine for elderly high risk MDS patients: who will respond? Blood 2002, 100:96a.
-
(2002)
Blood
, vol.100
-
-
Wijermans, P.W.1
Luebbert, M.2
Verhoef, G.3
-
52
-
-
10744233452
-
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
-
Issa JP, Garcia-Manero G, Giles FJ, et al.: Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′- deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004, 103:1635-1640. A study that proves that low doses of 5-aza-2′- deoxycytidine are effective in myeloid malignancies.
-
(2004)
Blood
, vol.103
, pp. 1635-1640
-
-
Issa, J.P.1
Garcia-Manero, G.2
Giles, F.J.3
-
53
-
-
2942594292
-
The effects of 5-aza-2′-deoxycytidine (Decitabine) on the platelet count in patients with intermediate and high-risk myelodysplastic syndromes
-
van den Bosch J, Lubbert M, Verhoef G, et al.: The effects of 5-aza-2′-deoxycytidine (Decitabine) on the platelet count in patients with intermediate and high-risk myelodysplastic syndromes. Leuk Res 2004, 28:785-790. 5-aza-2′-deoxycytidine affects platelet response and overall survival in myelodysplastic syndrome.
-
(2004)
Leuk Res
, vol.28
, pp. 785-790
-
-
Van Den Bosch, J.1
Lubbert, M.2
Verhoef, G.3
-
54
-
-
0027154222
-
Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes
-
Silverman LR, Holland JF, Weinberg RS, et al.: Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes. Leukemia 1993, 7(suppl 1):21-29.
-
(1993)
Leukemia
, vol.7
, Issue.1 SUPPL.
, pp. 21-29
-
-
Silverman, L.R.1
Holland, J.F.2
Weinberg, R.S.3
-
55
-
-
0037093195
-
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B
-
Silverman LR, Demakos EP, Peterson BL, et al.: Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 2002, 20:2429-2440.
-
(2002)
J Clin Oncol
, vol.20
, pp. 2429-2440
-
-
Silverman, L.R.1
Demakos, E.P.2
Peterson, B.L.3
-
56
-
-
79960971189
-
Transcription modulation: A pilot study of sodium phenylbutyrate plus 5-azacytidine
-
Camacho LH, Ryan HJ, Chanel P, et al.: Transcription modulation: a pilot study of sodium phenylbutyrate plus 5-azacytidine. Blood 2001, 98(suppl 1):460.
-
(2001)
Blood
, vol.98
, Issue.1 SUPPL.
, pp. 460
-
-
Camacho, L.H.1
Ryan, H.J.2
Chanel, P.3
-
57
-
-
0037108309
-
Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment
-
Daskalakis M, Nguyen TT, Nguyen C, et al.: Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment. Blood 2002, 100:2957-2964.
-
(2002)
Blood
, vol.100
, pp. 2957-2964
-
-
Daskalakis, M.1
Nguyen, T.T.2
Nguyen, C.3
-
58
-
-
0036301150
-
High-performance capillary electrophoretic method for the quantification of 5-methyl 2′-deoxycytidine in genomic DNA: Application to plant, animal and human cancer tissues
-
Fraga MF, Uriol E, Borja Diego L, et al.: High-performance capillary electrophoretic method for the quantification of 5-methyl 2′-deoxycytidine in genomic DNA: application to plant, animal and human cancer tissues. Electrophoresis 2002, 23:1677-1681.
-
(2002)
Electrophoresis
, vol.23
, pp. 1677-1681
-
-
Fraga, M.F.1
Uriol, E.2
Borja Diego, L.3
-
59
-
-
0036682379
-
Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors
-
Paz MF, Avila S, Fraga MF, et al.: Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer Res 2002, 62:4519-4524.
-
(2002)
Cancer Res
, vol.62
, pp. 4519-4524
-
-
Paz, M.F.1
Avila, S.2
Fraga, M.F.3
|