HMLH1 gene mutation in gastric cancer patients and their kindred

World Journal of Gastroenterology

Volumn 11, Issue 20, 2005, Pages 3144-3146

  Li, Jian Hua ^a   Shi, Xian Zhe ^b   Lü, Shen ^a   Liu, Min ^a   Cui, Wan Ming ^a   Liu, Li Na ^a   Jiang, Jing ^c   Xu, Guo Wang ^b  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^c DALIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Gastric cancer kindred; HNPCC; Mismatch repair; Mutation

Indexed keywords

PROTEIN MLH1;

AMINO ACID SUBSTITUTION; ARTICLE; BLOOD SAMPLING; CHINA; CODON; COLORECTAL CANCER; CONTROLLED STUDY; DNA EXTRACTION; DNA SEQUENCE; GENE MUTATION; GENETIC PREDISPOSITION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; POINT MUTATION; POLYMERASE CHAIN REACTION; POPULATION RESEARCH; SINGLE STRAND CONFORMATION POLYMORPHISM; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STOMACH CANCER;

EID: 20344364194     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v11.i20.3144     Document Type: Article

References (13)

1. Park JG, Vasen HF, Park KJ, Peltomaki P, Ponz de Leon M, Rodriguez-Bigas MA, Lubinski J, Beck NE, Bisgaard ML, Miyaki M, Wijnen JT, Baba S, Lynch HT. Suspected hereditary nonpolyposis colorectal cancer: International collaborative group on hereditary non-polyposis colorectal cancer (ICG-HNPCC) criteria and results of genetic diagnosis. Dis Colon Rectum 1999; 42: 710-715
2. Lynch HT, Watson P, Shaw TG, Lynch JF, Harty AE, Franklin BA, Kapler CR, Tinley ST, Liu B, Lerman C. Clinical impact of molecular genetic diagnosis, genetic counseling, and management of hereditary cancer. Part II: Hereditary nonpolyposis colorectal carcinoma as a model. Cancer 1999; 86 (11 Suppl): 2457-2463
3. Dieumegard B, Grandjouan S, Sabourin JC, Le Bihan ML, Lefrere I, Bellefqih, Pignon JP, Rougier P, Lasser P, Benard J, Couturier D, Bressac-de Paillerets B. Extensive molecular screening for hereditary non-polyposis colorectal cancer. Br J Cancer 2000; 82: 871-880
4. Wang Q, Lasset C, Desseigne F, Saurin JC, Maugard C, Navarro C, Ruano E, Descos L, Trillet-Lenoir V, Bosset JF, Puisieux A. Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer. Hum Genet 1999; 105: 79-85
5. Peltomaki P, Vasen HF. Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The international collaborative group on hereditary nonpolyposis colorectal cancer. Gastroenterology 1997; 113: 1146-1158
6. Peltomaki P. Deficient DNA mismatch repair: A common etiologic factor for colon cancer. Hum Mol Genet 2001; 10: 735-740
7. Jacob S, Praz F. DNA mismatch repair defects: Role in colorectal carcinogenesis. J Biochimie 2002; 84: 27-47
8. Duval A, Hamelin R. Genetic instability in human mismatch repair deficient cancers. Ann Genet 2002; 45: 71-75
9. Loukola A, Eklin K, Laiho P, Salovaara R, Kristo P, Jarvinen H, Mecklin JP, Launonen V, Aaltonen LA. Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC). Cancer Res 2001; 61: 4545-4549
10. Han HJ, Maruyama M, Baba S, Park JG, Nakamura Y. Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary nonpolyposis colorectal cancer (HNPCC). Hum Mol Genet 1995; 4: 237-242
11. Hutter P, Couturier A, Membrez V, Joris F, Sappino AP, Chappuis PO. Excess of hMLH1 germline mutations in Swiss families with hereditary non-polyposis colorectal cancer. Int J Cancer 1998; 78: 680-684
12. La Vecchia C, Negri E, Franceschi S, Gentile A. Family history and the risk of stomach and colorectal cancer. Cancer 1992; 70: 50-55
13. Zanghieri G, Di Gregorio C, Sacchetti C, Fante R, Sassatelli R, Cannizzo G, Carriero A, Ponz de Leon M. Familial occurrence of gastric cancer in the two year experience of a population-based registry. Cancer 1990; 66: 2047-2051