Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability

Cancer Research

Volumn 60, Issue 17, 2000, Pages 4701-4704

  Piao, Z ^a   Fang, W ^a   Malkhosyan, S ^a   Kim, H ^a   Horii, A ^a   Perucho, M ^a   Huang, S ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOBLASTOMA PROTEIN; ZINC FINGER PROTEIN;

ARTICLE; CHROMOSOME 1P; COLORECTAL CANCER; ENDOMETRIUM CARCINOMA; FRAMESHIFT MUTATION; GASTROINTESTINAL CARCINOMA; GENE DELETION; GENE INACTIVATION; GENE LOCUS; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ALLELES; COLORECTAL NEOPLASMS; DNA-BINDING PROTEINS; ENDOMETRIAL NEOPLASMS; FEMALE; FRAMESHIFT MUTATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MICROSATELLITE REPEATS; NUCLEAR PROTEINS; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; ZINC FINGERS;

EID: 0034283031     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Genetic instabilities in human cancers
2. Cancer epigenetics comes of age
3. Microsatellite instability in cancer of the proximal colon
4. Clues to the pathogenesis of familial colorectal cancer
5. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
6. Microsatellite instability in inherited and sporadic neoplasms
7. Mismatch repair in replication fidelity, genetic recombination, and cancer biology
8. The retinoblastoma protein binds to RIZ, a zinc finger protein that shares an epitope with the adenovirus E1A protein
9. The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression
10. The yin-yang of PR-domain family genes in tumorigenesis
11. The retinoblastoma interacting zinc finger gene RIZ produces a PR domain lacking product through an internal promoter
12. The retinoblastoma protein-interacting zinc finger gene RIZ in 1p36-linked cancers
13. 2-M cell cycle arrest and/or apoptosis
14. Decreased RIZ1 expression but not RIZ2 in hepatoma and suppression of hepatoma tumorigenicity by RIZ1
15. Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesis
16. PTEN1 is frequently mutated in primary endometrial carcinomas
17. Frameshift somatic mutations in gastro-intestinal cancer of the microsatellite mutator phenotype
18. Accumulated frameshift mutations at coding nucleotide repeats during the progression of gastric carcinoma with microsatellite instability
19. National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
20. Mapping of a minimal deleted region in human hepatocellular carcinoma to 1p36.13-p36.23 and mutational analysis of the RIZ (PRDM2) gene localized to the region
21. Mutation and cancer: Statistical study of retinoblastoma
22. The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action