Allelic loss of the PTEN gene and mutation of the TP53 gene in choriocarcinoma arising from gastric adenocarcinoma: analysis of loss of heterozygosity in two male patients with extragonadal choriocarcinoma

Cancer Genetics and Cytogenetics

Volumn 193, Issue 2, 2009, Pages 104-108

  Tate, Genshu ^a   Suzuki, Takao ^a   Nemoto, Hiroshi ^a   Kishimoto, Koji ^a   Hibi, Kenji ^a   Mitsuya, Toshiyuki ^a  

^a SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CHORIONIC GONADOTROPIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53;

ADULT; AGED; ARTICLE; CASE REPORT; CHORIOCARCINOMA; COMPUTER ASSISTED TOMOGRAPHY; GASTRECTOMY; GENE DELETION; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; LUNG METASTASIS; MALE; MICROSATELLITE MARKER; POINT MUTATION; PRIORITY JOURNAL; RETROPERITONEAL TUMOR; RISK FACTOR; STOMACH ADENOCARCINOMA;

ADENOCARCINOMA; ADULT; AGED; ALLELES; CHORIOCARCINOMA; CHROMOSOME DELETION; FEMALE; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; MALE; MUTATION; PTEN PHOSPHOHYDROLASE; STOMACH NEOPLASMS;

EID: 68049111679     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2009.04.005     Document Type: Article

References (23)

1. Kobayashi A., Hasebe T., Endo Y., Sasaki S., Konishi M., Sugito M., Kinoshita T., Saito N., and Ochiai A. Primary gastric choriocarcinoma: two case reports and a pooled analysis of 53 cases. Gastric Cancer 8 (2005) 178-185
2. Liu A.Y., Chan W.Y., Ng E.K., Zhang X., Li B.C., Chow J.H., and Chung S.C. Gastric choriocarcinoma shows characteristics of adenocarcinoma and gestational choriocarcinoma: a comparative genomic hybridization and fluorescence in situ hybridization study. Diagn Mol Pathol 2001 (2001) 161-165
3. Di Cristofano A., and Pandolfi P.P. The multiple roles of PTEN in tumor suppression. Cell 100 (2000) 387-390
4. Yamada K.M., and Araki M. Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J Cell Sci 114 (2001) 2375-2382
5. Eng C. PTEN: One gene, many syndromes. Hum Mutat 22 (2003) 183-198
6. Li J., Yen C., Liaw D., Podsypanina K., Bose S., Wang S.I., Puc J., Miliaresis C., Rodgers L., McCombie R., Bigner S.H., Giovanella B.C., Ittmann M., Tycko B., Hibshoosh H., Wigler M.H., and Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275 (1997) 1943-1947
7. Healy E., Belgaid C., Takata M., Harrison D., Zhu N.W., Burd D.A.R., Rigby H.S., Matthews J.N.S., and Rees J.L. Prognostic significance of allelic losses in primary melanoma. Oncogene 16 (1998) 2213-2218
8. Kimura T., Suzuki A., Fujita Y., Yomogida K., Lomeli H., Asada N., Ikeuchi M., Nagy A., Mak T.W., and Nakano T. Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development 130 (2003) 1691-1700
9. Boldajipour B., Mahabaleshwar H., Kardash E., Reichman-Fried M., Blaser H., Minina S., Wilson D., Xu Q., and Raz E. Control of chemokine-guided cell migration by ligand sequestration. Cell 132 (2008) 463-473
10. Suzuki T., Tate G., Ikeda K., and Mitsuya T. A novel multicolor immunofluorescence method using heat treatment. Acta Med Okayama 59 (2005) 145-151
11. Tate G., Suzuki T., and Mitsuya T. Mutation of the PTEN gene in a human hepatic angiosarcoma. Cancer Genet Cytogenet 178 (2007) 160-162
12. Tate G., Suzuki T., Endo Y., and Mitsuya T. A novel mutation of the PTEN gene in a Japanese patient with Cowden syndrome and bilateral breast cancer. Cancer Genet Cytogenet 184 (2008) 67-71
13. Abdel-Rahman M.H., Yang Y., Zhou X.P., Craig E.L., Davidorf F.H., and Eng C. High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma. J Clin Oncol 24 (2006) 288-295
14. Kernek K.M., Ulbright T.M., Zhang S., Billings S.D., Cummings O.W., Henley J.D., Michael H., Brunelli M., Martignoni G., Foster R.S., Eble J.N., and Cheng L. Identical allelic losses in mature teratoma and other histologic components of malignant mixed germ cell tumors of the testis. Am J Pathol 163 (2003) 2477-2484
15. Kokkola A., Monni O., Puolakkainen P., Larramendy M.L., Victorzon M., Nordling S., Haapiainen R., Kivilaakso E., and Knuutila S. 17q12-21 amplicon, a novel recurrent genetic change in intestinal type of gastric carcinoma: a comparative genomic hybridization study. Genes Chromosomes Cancer 20 (1997) 38-43
16. Nessling M., Solinas-Toldo S., Wilgenbus K., Borchard F., and Lichter P. Mapping of chromosomal imbalances in gastric adenocarcinoma revealed amplified protooncogenes MYCN, MET, WNT2 and ERBB2. Genes Chromosomes Cancer 23 (1998) 307-316
17. Sakakura C., Mori T., Sakabe T., Ariyama Y., Shinomiya T., Date K., Hagiwara A., Yamaguchi T., Takahashi T., Nakamura Y., Abe T., and Inazawa J. Gains, losses and amplification of genomic materials in primary gastric cancers analyzed by comparative genomic hybridization. Genes Chromosomes Cancer 24 (1999) 299-305
18. Kobayashi M., Nagata S., Iwasaki T., Yanagihara K., Saitoh I., Karouji Y., Ihara S., and Fukui Y. Dedifferentiation of adenocarcinomas by activation of phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 96 (1999) 4874-4879
19. Oki E., Tokunaga E., Nakamura T., Ueda N., Futatsugi M., Mashino K., Yamamoto M., Watanabe M., Ikebe M., Kakeji Y., Baba H., and Maehara Y. Genetic mutual relationship between PTEN and p53 in gastric cancer. Cancer Lett 227 (2005) 33-38
20. Yaginuma Y., Yamashita T., Takuma N., Katayama H., and Ishikawa M. Analysis of the p53 gene in human choriocarcinoma cell lines. Br J Cancer 71 (1995) 9-12
21. Stambolic V., MacPherson D., Sas D., Lin Y., Snow B., Jang Y., Benchimol S., and Mak T.W. Regulation of PTEN transcription by p53. Mol Cell 8 (2001) 317-325
22. Tokyol C., Aktepe F., Hüsniye Dilek F., and Yilmazer M. Comparison of placental PTEN and β1 integrin expression in early spontaneous abortion, early and late normal pregnancy. Ups J Med Sci 113 (2008) 235-242
23. Chen H., Ye D., Xie X., Lu W., Zhu C., and Chen X. PTEN promoter methylation and protein expression in normal early placentas and hydatidiform moles. J Soc Gynecol Investig 12 (2005) 214-217