Concordant repression and aberrant methylation of transforming growth factor-beta signaling pathway genes occurs early in gastric cardia adenocarcinoma

Molecular Biology Reports

Volumn 39, Issue 10, 2012, Pages 9453-9462

  Guo, Wei ^a   Dong, Zhiming ^a   Guo, Yanli ^a   Kuang, Gang ^a   Yang, Zhibin ^a   Shan, Baoen ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Gastric cardia adenocarcinoma; Methylation; Smad4; TGFBR1; TGFBR2

Indexed keywords

MESSENGER RNA; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ADULT; AGED; ARTICLE; CANCER GRADING; CARDIA CARCINOMA; FEMALE; GASTROINTESTINAL DYSPLASIA; GENE; GENE FREQUENCY; GENE FUNCTION; GENE INACTIVATION; GENE LOSS; GENE REPRESSION; GENE SILENCING; GENETIC CORRELATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; METHYLATION; MOLECULAR PATHOLOGY; ONCOGENE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD4 GENE; STOMACH ADENOCARCINOMA; STOMACH CARCINOGENESIS; TRANSFORMING GROWTH FACTOR BETA GENE;

ADENOCARCINOMA; ADULT; AGED; BASE SEQUENCE; CARDIA; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MALE; MIDDLE AGED; PRECANCEROUS CONDITIONS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; STOMACH NEOPLASMS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84868591599     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1810-x     Document Type: Article

References (33)

1. Attisano L, Wrana JL (2002) Signal transduction by the TGF-β superfamily. Science 296(5573):1646-1647
2. Shi Y, Massague J (2003) Mechanisms of TGF-βeta signaling from cell membrane to the nucleus. Cell 113(6):685-700
3. Derynck R, Akhurst RJ, Balmain A (2001) TGF-βeta signaling in tumor suppression and cancer progression. Nat Genet 29(2):117-129
4. Chen T, Triplett J, Dehner B et al (2001) Transforming growth factor-β receptor type I gene is frequently mutated in ovarian carcinomas. Cancer Res 61(12):4679-4682
5. Myeroff LL, Parsons R, Kim SJ et al (1995) A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 55(23):5545-5547
6. Seijo ER, Song H, Lynch MA et al (2001) Identification of genetic alterations in the TGFβ type II receptor gene promoter. Mutat Res 483(1-2):19-26
7. Bhattacharyya N, Tao J, Klein EA et al (2004) Alterations of transforming growth factor beta receptor II, insulin growth factor receptor II genes in microsatellite unstable prostate carcinomas. Oncol Rep 11(1):231-236
8. Miyaki M, Kuroki T (2003) Role of Smad4(DPC4) inactivation in human cancer. Biochem Biophys Res Commun 306 (4):799-804
9. Iacobuzio-Donahue CA, Song J, Parmiagiani G et al (2004) Missense mutation of MADH4: characterization of the mutational hot spot and functional consequences in human tumors. Clin Cancer Res 10(5):1597-1604
10. Schutte M, Hruban RH, Hedrick L et al (1996) DPC4 gene in various tumor types. Cancer Res 56(11):2527-2530
11. Lei J, Zou TT, Shi YQ et al (1996) Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms. Oncogene 13(11):2459-2462
12. Esteller M, Corn PG, Baylin SB et al (2001) A gene hypermethylation profile of human cancer. Cancer Res 61(8):3225-3229
13. Pinto M, Oliveira C, Cirnes L et al (2003) Promoter methylation of TGF beta receptor I and mutation of TGF beta receptor II are frequent events in MSI sporadic gastric carcinomas. J Pathol 200(1):32-38
14. Periyasamy S, Ammanamanchi S, Tillekeratne MP et al (2000) Repression of transforming growth factor-beta receptor type I promoter expression by Sp1 deficiency. Oncogene 19(40):4660-4667
15. Zhang Q, Rubenstein JN, Jang TL et al (2005) Insensitivity to transforming growth factor-beta results from promoter methylation of cognate receptors in human prostate cancer cells (LNCaP). Mol Endocrinol 19(9):2390-2399
16. Zhang HT, Chen XF, Wang MH et al (2004) Defective expression of transforming growth factor beta receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer. Clin Cancer Res 10(7):2359-2367
17. Chen G, Ghosh P, Osawa H et al (2007) Resistance to TGF-βeta 1 correlates with aberrant expression of TGF-βeta receptor II in human B-cell lymphoma cell lines. Blood 109(12):5301-5307
18. Onwuegbusi BA, Aitchison A, Chin SF et al (2006) Impaired transforming growth factor[beta]signalling in Barrett's carcinogenesis due to frequent SMAD4 inactivation. Gut 55(6):764-774
19. Wang LH, Kim SH, Lee JH et al (2007) Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression. Clin Cancer Res 13(1):102-110
20. Li JY, Ershow AG, Chen ZJ et al (1989) A case-control study of cancer of the esophageal and gastric cardia in Linxian. Int J Cancer 43(5):755-761
21. Siewert JR, Stein HJ (1998) Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg 85(11):1457-1459
22. Guo W, Dong Z, Chen Z et al (2009) Aberrant CpG Island hypermethylation of RASSF1A in gastric cardia adenocarcinoma. Cancer Invest 27:459-465
23. Baylin SB, Herman JG (2000) DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16(4):168-174
24. Muñoz-Antonia T, Torrellas-Ruiz M, Clavell J (2009) Aberrant methylation inactivates transforming growth factor Beta receptor I in head and neck squamous cell carcinoma. Int J Otolaryngol 2009:848695
25. de Carvalho F, Colleoni GW, Almeida MS et al (2009) TGFbetaR2 aberrant methylation is a potential prognostic marker and therapeutic target in multiple myeloma. Int J Cancer 125(8):1985-1991
26. Ammanamanchi S, Brattain MG (2004) Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells. J Biol Chem 279(31):32620-32625
27. Hinshelwood RA, Huschtscha LI, Melki J et al (2007) Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis. Cancer Res 67(24):11517-11527
28. Osada H, Tatematsu Y, Sugito N et al (2005) Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines. Mol Carcinog 44(4):233-241
29. Sakaguchi J, Kyo S, Kanaya T et al (2005) Aberrant expression and mutations of TGF-βeta receptor type II gene in endometrial cancer. Gynecol Oncol 98(3):427-433
30. Hahn SA, Schutte M, Hoque AT et al (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271(5247):350-353
31. Fukuchi M, Masuda N, Miyazaki T et al (2002) Decreased Smad4 expression in the transforming growth factor-β signaling pathway during progression of esophageal squamous cell carcinoma. Cancer 95(4):737-743
32. Xiangming C, Natsugoe S, Takao S et al (2001) Preserved Smad4 expression in the transforming growth factor-β signaling pathway is a favorable prognostic factor in patients with advanced gastric cancer. Clin Cancer Res 7(2):277-282
33. Aitchison AA, Veerakumarasivam A, Vias M et al (2008) Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer. Prostate 68(6):661-674