Promoter hypermethylation od CDH1, FHIT, MTAP AND PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil

World Journal of Gastroenterology

Volumn 13, Issue 18, 2007, Pages 2568-2574

  Leal, Mariana Ferreira ^a   Lima, Eleonidas Moura ^b   Silva, Patrícia Natátia Oliveira ^a   Pimentel, Assumpção Paulo ^c   Calcagno, Danielle Queiroz ^c   Payão, Spencer Luiz Marques ^d   Burbano, Rommel Rodríguez ^c   de Arruda Cardoso Smith, Marília ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

^c FEDERAL UNIVERSITY OF PARÁ   (Brazil)

^d Faculty of Medicine of Marilia   (Brazil)

Author keywords

CDH1; DNA hypermethylation; FHIT; Gastric adenocarcinoma; MTAP; PLAGL1

Indexed keywords

5' METHYLTHIOADENOSINE PHOSPHORYLASE; FRAGILE HISTIDINE TRIAD PROTEIN; PROTEIN PLAGL 1; UNCLASSIFIED DRUG; UVOMORULIN; ZINC FINGER PROTEIN; ACID ANHYDRIDE HYDROLASE; CADHERIN; CDH1 PROTEIN, HUMAN; CELL CYCLE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; PLAGL1 PROTEIN, HUMAN; PROTEIN; TRANSCRIPTION FACTOR; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; ARTICLE; BRAZIL; CELL ADHESION; CHI SQUARE TEST; CLINICAL ASSESSMENT; CONTROLLED STUDY; DATA ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA METHYLATION; FEMALE; FISHER EXACT TEST; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE SEQUENCE; GENETIC PREDISPOSITION; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PROGNOSIS; PROMOTER REGION; PROTEIN METABOLISM; SEX DETERMINATION; STOMACH ADENOCARCINOMA; STOMACH CARCINOGENESIS; UPREGULATION; ADENOCARCINOMA; GENETICS; METABOLISM; MIDDLE AGED; PHYSIOLOGY; STOMACH TUMOR;

ACID ANHYDRIDE HYDROLASES; ADENOCARCINOMA; ADULT; AGED; BRAZIL; CADHERINS; CELL CYCLE PROTEINS; DNA METHYLATION; FEMALE; HUMANS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); PROTEINS; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 34250648916     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i18.2568     Document Type: Article

References (46)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108
2. Cancer Databases and Other Resourcess. International Agency for Research on Cancer (IARC) page. Available from URL: http://www.iarc.fr
3. Pereira LP, Waisberg J, Andre EA, Zanoto A, Mendes Junior JP, Soares HP. Detection of Helicobacter pylori in gastric cancer. Arq Gastroenterol 2001; 38: 240-246
4. Lauren P. The Two Histological Main Types of Gastric Carcinoma: Diffuse and So-Called Intestinal-Type Carcinoma. an Attempt at a Histo-Clinical Classification. Acta Pathol Microbiol Scand 1965; 64: 31-49
5. Huntsman DG, Carneiro F, Lewis FR, MacLeod PM, Hayashi A, Monaghan KG, Maung R, Seruca R, Jackson CE, Caldas C. Early gastric cancer in young, asymptomatic carriers of germline E-cadherin mutations. N Engl J Med 2001; 344: 1904-1909
6. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002; 16: 6-21
7. Birchmeier W, Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1994; 1198: 11-26
8. Chan AO. E-cadherin in gastric cancer. World J Gastroenterol 2006; 12: 199-203
9. Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, Croce CM, Huebner K. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 1996; 84: 587-597
10. Pekarsky Y, Palamarchuk A, Huebner K, Croce CM. FHIT as tumor suppressor: mechanisms and therapeutic opportunities. Cancer Biol Ther 2002; 1: 232-236
11. Hori H, Tran P, Carrera CJ, Hori Y, Rosenbach MD, Carson DA, Nobori T. Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells. Cancer Res 1996; 56: 5653-5658
12. Subhi AL, Diegelman P, Porter CW, Tang B, Lu ZJ, Markham GD, Kruger WD. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. J Biol Chem 2003; 278: 49868-49873
13. Okuzumi J, Yamane T, Kitao Y, Tokiwa K, Yamaguchi T, Fujita Y, Nishino H, Iwashima A, Takahashi T. Increased mucosal ornithine decarboxylase activity in human gastric cancer. Cancer Res 1991; 51: 1448-1451
14. Wild PJ, Meyer S, Bataille F, Woenckhaus M, Ameres M, Vogt T, Landthaler M, Pauer A, Klinkhammer-Schalke M, Hofstaedter F, Bosserhoff AK. Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors. Arch Dermatol 2006; 142: 471-476
15. Spengler D, Villalba M, Hoffmann A, Pantaloni C, Houssami S, Bockaert J, Journot L. Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J 1997; 16: 2814-2825
16. Hoffmann A, Ciani E, Boeckardt J, Holsboer F, Journot L, Spengler D. Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding. Mol Cell Biol 2003; 23: 988-1003
17. Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. J Biol Chem 1998; 273: 23026-23032
18. Sobin LH, Wittekind CH. TNM classification of malignant tumours. 6th ed. New York: Wiley-Liss, 2002
19. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996; 93: 9821-9826
20. Oue N, Mitani Y, Motoshita J, Matsumura S, Yoshida K, Kuniyasu H, Nakayama H, Yasui W. Accumulation of DNA methylation is associated with tumor stage in gastric cancer. Cancer 2006; 106: 1250-1259
21. Tanaka H, Shimada Y, Harada H, Shinoda M, Hatooka S, Imamura M, Ishizaki K. Methylation of the 5′ CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas. Cancer Res 1998; 58: 3429-3434
22. Behrmann I, Wallner S, Komyod W, Heinrich PC, Schuierer M, Buettner R, Bosserhoff AK. Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma. Am J Pathol 2003; 163: 683-690
23. Yamashita S, Tsujino Y, Moniguchi K, Tatematsu M, Ushijima T. Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2′-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci 2006; 97: 64-71
24. Li LC, Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics 2002; 18: 1427-1431
25. Etoh T, Kanai Y, Ushijima S, Nakagawa T, Nakanishi Y, Sasako M, Kitano S, Hirohashi S. Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am J Pathol 2004; 164: 689-699
26. Esteller M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 2002; 21: 5427-5440
27. Leung WK, Yu J, Ng EK, To KF, Ma PK, Lee TL, Go MY, Chung SC, Sung JJ. Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues. Cancer 2001; 91: 2294-2301
28. Zheng ZH, Sun XJ, Ma MC, Hao DM, Liu YH, Sun KL. Studies of promoter methylation status and protein expression of E-cadherin gene in associated progression stages of gastric cancer. Yichuan Xuebao 2003; 30: 103-108
29. Zazula M, Ferreira AM, Czopek JP, Kolodziejczyk P, Sinczak-Kuta A, Klimkowska A, Wojcik P, Okon K, Bialas M, Kulig J, Stachura J. CDH1 gene promoter hypermethylation in gastric cancer: relationship to Goseki grading, microsatellite instability status, and EBV invasion. Diagn Mol Pathol 2006; 15: 24-29
30. Waki T, Tamura G, Tsuchiya T, Sato K, Nishizuka S, Motoyama T. Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia. Am J Pathol 2002; 161: 399-403
31. Chan AO, Lam SK, Wong BC, Wong WM, Yuen MF, Yeung YH, Hui WM, Rashid A, Kwong YL. Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut 2003; 52: 502-506
32. Liu YC, Shen CY, Wu HS, Chan DC, Chen CJ, Yu JC, Yu CP, Ham HJ, Shyu RY, Shih YL, Hsieh CB, Hsu HM. Helicobacter pylori infection in relation to E-cadherin gene promoter polymorphism and hypermethylation in sporadic gastric carcinomas. World J Gastroenterol 2005; 11: 5174-5179
33. Leung WK, Man EP, Yu J, Go MY, To KF, Yamaoka Y, Cheng VY, Ng EK, Sung JJ. Effects of Helicobacter pylori eradication on methylation status of E-cadherin gene in noncancerous stomach. Clin Cancer Res 2006; 12: 3216-3221
34. Roa JC, Anabalon L, Roa I, Tapia O, Melo A, Villaseca M, Araya JC. Promoter methylation profile in gastric cancer. Rev Med Chil 2005; 133: 874-880
35. Schildhaus HU, Krockel I, Lippert H, Malfertheiner P, Roessner A, Schneider-Stock R. Promoter hypermethylation of p16INK4a, E-cadherin, O6-MGMT, DAPK and FHIT in adenocarcinomas of the esophagus, esophagogastric junction and proximal stomach. Int J Oncol 2005; 26: 1493-1500
36. Sozzi G, Pastorino U, Moiraghi L, Tagliabue E, Pezzella F, Ghirelli C, Tornielli S, Sard L, Huebner K, Pierotti MA, Croce CM, Pilotti S. Loss of FHIT function in lung cancer and preinvasive bronchial lesions. Cancer Res 1998; 58: 5032-5037
37. Berasain C, Hevia H, Fernandez-Irigoyen J, Larrea E, Caballeria J, Mato JM, Prieto J, Corrales FJ, Garcia-Trevijano ER, Avila MA. Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma. Biochim Biophys Acta 2004; 1690: 276-284
38. Furuta J, Umebayashi Y, Miyamoto K, Kikuchi K, Otsuka F, Sugimura T, Ushijima T. Promoter methylation profiling of 30 genes in human malignant melanoma. Cancer Sci 2004; 95: 962-968
39. Hellerbrand C, Muhlbauer M, Wallner S, Schuierer M, Behrmann I, Bataille F, Weiss T, Scholmerich J, Bosserhoff AK. Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma. Carcinogenesis 2006; 27: 64-72
40. Wang Y, Yu Q, Cho AH, Rondeau G, Welsh J, Adamson E, Mercola D, McClelland M. Survey of differentially methylated promoters in prostate cancer cell lines. Neoplasia 2005; 7: 748-760
41. Abdollahi A. LOT1 (ZAC1/PLAGL1) and its family members: mechanisms and functions. J Cell Physiol 2007; 210: 16-25
42. El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, Herrera J, Lissowska J, Yuan CC, Rothman N, Lanyon G, Martin M, Fraumeni JF Jr, Rabkin CS. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404: 398-402
43. El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, Stanford JL, Mayne ST, Goedert J, Blot WJ, Fraumeni JF Jr, Chow WH. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003; 124: 1193-1201
44. Hmadcha A, Bedoya FJ, Sobrino F, Pintado E. Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production. J Exp Med 1999; 190: 1595-1604
45. Vauhkonen M, Vauhkonen H, Sipponen P. Pathology and molecular biology of gastric cancer. Best Pract Res Clin Gastroenterol 2006; 20: 651-674
46. Yuasa Y. Control of gut differentiation and intestinal-type gastric carcinogenesis. Nat Rev Cancer 2003; 3: 592-600