CD44-SLC1A2 gene fusions in gastric cancer

Science Translational Medicine

Volumn 3, Issue 77, 2011, Pages

  Tao, Jiong ^a,b   Deng, Nian Tao ^b   Ramnarayanan, Kalpana ^c   Huang, Baohua ^a   Oh, Hue Kian ^c   Leong, Siew Hong ^c   Lim, Seong Soo ^d   Tan, Iain Beehuat ^b,c   Ooi, Chia Huey ^b   Wu, Jeanie ^c   Lee, Minghui ^c   Zhang, Shenli ^b   Rha, Sun Young ^e   Chung, Hyun Cheol ^e   Smoot, Duane T ^f   Ashktorab, Hassan ^f   Kon, Oi Lian ^c   Cacheux, Valere ^d   Yap, Celestial ^a   Palanisamy, Nallasivam ^d,h   Tan, Patrick ^a,b,c,d,g   more..

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^d GENOME INSTITUTE OF SINGAPORE   (Singapore)

^e Yonsei University College of Medicine   (South Korea)

^f HOWARD UNIVERSITY CANCER CENTER   (United States)

^g NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^h UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; CISPLATIN; EXCITATORY AMINO ACID TRANSPORTER 2; GLUTAMIC ACID; HERMES ANTIGEN; GLUTAMATE TRANSPORTER; HYBRID PROTEIN; SLC1A2 PROTEIN, HUMAN;

ARTICLE; CD44 GENE; CELL PROLIFERATION; CHROMOSOME INVERSION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; COPY NUMBER VARIATION; CYTOGENETICS; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE FUSION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENE SEQUENCE; GENE SILENCING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC TRAIT; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SLC1A2 GENE; STOMACH CANCER; TUMOR GROWTH; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH TUMOR; TUMOR CELL CULTURE; TUMOR CELL LINE; WESTERN BLOTTING;

ANTIGENS, CD44; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE FUSION; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 79953869996     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3001423     Document Type: Article

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47. Funding: Supported by grants BMRC 05/1/31/19/423, NMRC TCR/001/2007, and institutional funding from Duke-NUS and Cancer Sciences Institute of Singapore. Author contributions: J.T. designed and performed the experiments. N.T.D., I.B.T., and C.H.O. analyzed the data. K.R., B.H., H.K.O., S.H.L., S.S.L., and V.C. performed additional experiments. J.W., M.L., and S.Z. performed microarray profiling and sequencing. S.Y.R., H.C.C., D.T.S., and H.A. contributed cell lines and other reagents. O.L.K., C.Y., and N.P. supervised the research. P.T. provided funding and wrote the paper. Competing interests: The authors declare that they have no competing interests. As required for research projects funded by the Singapore government, the current work is being evaluated by Exploit Technologies Pte Ltd., the intellectual property armof the Agency for Science Technology and Research, Singapore, for the possibility of filing a patent.