Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma

American Journal of Pathology

Volumn 160, Issue 3, 2002, Pages 787-794

  Kang, Gyeong Hoon ^a   Lee, Sun ^a   Kim, Woo Ho ^a   Lee, Hye Won ^b   Kim, Jin Cheon ^b   Rhyu, Mun Gan ^c   Ro, Jae Y ^b  

^a Seoul National University College of Medicine   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GLUTATHIONE TRANSFERASE P1; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN MINT1; PROTEIN MINT2; PROTEIN MINT25; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CPG ISLAND; CROSS LINKING; DNA METHYLATION; EPSTEIN BARR VIRUS; GENE INACTIVATION; GENE LOCUS; GENETIC ANALYSIS; HUMAN; ONCOGENE; PRIORITY JOURNAL; STOMACH CARCINOMA;

EID: 0036121312     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64901-2     Document Type: Article

References (32)

1. Virus particles in cultured lymphoblasts from Burkitt's lymphoma
2. EBV-DNA in biopsies of Burkitt tumors and anaplastic carcinoma of the nasopharynx
3. Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus
4. Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration: Lymphoepithelioma-like carcinoma
5. Gastric carcinoma: Monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein
6. Epstein-Barr virus in gastric carcinoma with lymphoid stroma. Special reference to its detection by the polymerase chain reaction and in situ hybridization in 99 tumors, including a morphologic analysis
7. Epstein-Barr virus infection in non-carcinomatous gastric epithelium
8. Epstein-Barr virus and gastric carcinoma in Western patients: Comparison of pathological parameters and p53 expression in EBV-positive and negative tumors
9. Loss of p16/CDKN2A tumor suppressor protein in gastric adenocarcinoma is associated with Epstein-Barr virus and anatomic location in the body of the stomach
10. Mutation frequency of the p16/CDKN2 gene in primary cancers in the upper digestive tract
11. INK4B genes in gastric carcinomas
12. Correlation of p16 hypermethylation with the p16 protein loss in sporadic gastric carcinomas
13. p16(INK4a) promoter hypermethylation of non-tumorous tissue adjacent to gastric cancer is correlated with glandular atrophy and chronic inflammation
14. CpG island methylator phenotype in colorectal cancer
15. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
16. Hypermethylation of multiple genes in pancreatic adenocarcinoma
17. Insertion of foreign DNA into an established mammalian genome can alter the methylation of cellular DNA sequences
18. Aberrant methylation and simian virus 40 tag sequences in malignant mesothelioma
19. Correlation of methylation of the hMLH1 promoter with lack of expression of hMLH1 in sporadic gastric carcinomas with replication error
20. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
21. Clinicopathologic characteristics of replication error-positive gastric carcinoma
22. Absence of nuclear p16 from Epstein-Barr virus-associated undifferentiated nasopharyngeal carcinomas
23. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes. The international Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
24. Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor gene
25. Epigenetic inactivation of a RAS association domain family protein from the lung tumor suppressor locus 3p21.3
26. Hypermethylation of the CpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers
27. High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma
28. Effect of in vitro promoter methylation and CGG repeat expansion on FMR-1 expression
29. DNA methylation, heterochromatin and epigenetic carcinogens
30. Chromosomal insertion of foreign (adenovirus type 12, plasmid, or bacteriophage lambda) DNA is associated with enhanced methylation of cellular DNA segments
31. Mapping promoter regions that are hypersensitive to methylation-mediated inhibition of transcription: Application of the methylation cassette assay to the Epstein-Barr virus major latency promoter
32. 5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line Rael