High CpG island methylator phenotype is associated with lymph node metastasis and prognosis in gastric cancer

Cancer Science

Volumn 103, Issue 1, 2012, Pages 73-79

  Chen, Hua Yun ^a   Zhu, Bao He ^a   Zhang, Chang Hua ^a   Yang, Dong Jie ^a   Peng, Jian Jun ^a   Chen, Jian Hui ^a   Liu, Fa Keng ^a   He, Yu Long ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ADULT; AGED; ALX4 GENE; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CAPILLARY ELECTROPHORESIS; CHCHD10 GENE; CONTROLLED STUDY; CORRELATION ANALYSIS; CPG ISLAND; DNA METHYLATION; FEMALE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; HELICOBACTER INFECTION; HUMAN; HUMAN TISSUE; IGFBP3 GENE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; NPR1 GENE; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; TMEFF2 GENE; TUMOR CLASSIFICATION;

ADULT; AGED; AGED, 80 AND OVER; CPG ISLANDS; DNA METHYLATION; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; LYMPHATIC METASTASIS; MALE; MEMBRANE PROTEINS; MICROSATELLITE INSTABILITY; MIDDLE AGED; MITOCHONDRIAL PROTEINS; NEOPLASM PROTEINS; NEOPLASM STAGING; PHENOTYPE; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ATRIAL NATRIURETIC FACTOR; RNA, NEOPLASM; STOMACH NEOPLASMS; SURVIVAL RATE; TRANSCRIPTION FACTORS;

EID: 84855495604     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.02129.x     Document Type: Article

References (37)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
2. Toyota M, Ahuja N, Suzuki H et al. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res 1999; 59: 5438-42.
3. Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128: 683-92.
4. Wang XH, Zhang LH, Zhong XY et al. S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer. Am J Pathol 2010; 177: 586-97.
5. Kim J, Min SY, Lee HE, Kim WH. Aberrant DNA methylation and tumor suppressive activity of the EBF3 gene in gastric carcinoma. Int J Cancer 2011; doi: [Epub ahead of print].
6. Yu J, Tao Q, Cheng YY et al. Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer. Cancer 2009; 115: 49-60.
7. Al-Moundhri MS, Al-Nabhani M, Tarantini L, Baccarelli A, Rusiecki JA. The prognostic significance of whole blood global and specific DNA methylation levels in gastric adenocarcinoma. PLoS ONE 2010; 5: e15585.
8. Enomoto S, Maekita T, Tsukamoto T et al. Lack of association between CpG island methylator phenotype in human gastric cancers and methylation in their background non-cancerous gastric mucosae. Cancer Sci 2007; 98: 1853-61.
9. Yasui W, Oue N, Aung PP, Matsumura S, Shutoh M, Nakayama H. Molecular-pathological prognostic factors of gastric cancer: a review. Gastric Cancer 2005; 8: 86-94.
10. Kusano M, Toyota M, Suzuki H et al. Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus. Cancer 2006; 106: 1467-79.
11. Park SY, Kook MC, Kim YW et al. CpG island hypermethylator phenotype in gastric carcinoma and its clinicopathological features. Virchows Arch 2010; 457: 415-22.
12. An C, Choi IS, Yao JC et al. Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma. Clin Cancer Res 2005; 11(2 Pt 1): 656-63.
13. Ebert MP, Model F, Mooney S et al. Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas. Gastroenterology 2006; 131: 1418-30.
14. Suzuki H, Igarashi S, Nojima M et al. IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. Carcinogenesis 2010; 31: 342-9.
15. Young J, Biden KG, Simms LA et al. HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers. Proc Natl Acad Sci USA 2001; 98: 265-70.
16. Gu P, Xing X, Tanzer M et al. Frequent loss of TIMP-3 expression in progression of esophageal and gastric adenocarcinomas. Neoplasia 2008; 10: 563-72.
17. Geddert H, Kiel S, Iskender E et al. Correlation of hMLH1 and HPP1 hypermethylation in gastric, but not in esophageal and cardiac adenocarcinoma. Int J Cancer 2004; 110: 208-11.
18. Brucher BL, Geddert H, Langner C et al. Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel. Int J Cancer 2006; 119: 1298-302.
19. Sabbioni S, Miotto E, Veronese A et al. Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood. Mol Diagn 2003; 7: 201-7.
20. Martherus RS, Sluiter W, Timmer ED, VanHerle SJ, Smeets HJ, Ayoubi TA. Functional annotation of heart enriched mitochondrial genes GBAS and CHCHD10 through guilt by association. Biochem Biophys Res Commun 2010; 402: 203-8.
21. Cavalieri D, Dolara P, Mini E et al. Analysis of gene expression profiles reveals novel correlations with the clinical course of colorectal cancer. Oncol Res 2007; 16: 535-48.
22. Deng YB, Nagae G, Midorikawa Y et al. Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma. Cancer Sci 2010; 101: 1501-10.
23. Giovannucci E. Nutrition, insulin, insulin-like growth factors and cancer. Horm Metab Res 2003; 35: 694-704.
24. Jang TJ, Kim DI, Shin YM, Chang HK, Yang CH. p16(INK4a) Promoter hypermethylation of non-tumorous tissue adjacent to gastric cancer is correlated with glandular atrophy and chronic inflammation. Int J Cancer 2001; 93: 629-34.
25. Torng PL, Lin CW, Chan MW, Yang HW, Huang SC, Lin CT. Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinoma. Mol Cancer 2009; 8: 120.
26. Ogino S, Cantor M, Kawasaki T et al. CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. Gut 2006; 55: 1000-6.
27. Ogino S, Kawasaki T, Brahmandam M et al. Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. J Mol Diagn 2006; 8: 209-17.
28. He Q, Chen HY, Bai EQ et al. Development of a multiplex MethyLight assay for the detection of multigene methylation in human colorectal cancer. Cancer Genet Cytogenet 2010; 202: 1-10.
29. Zhang KL, Sun Y, Li Y et al. Increased frequency of CpG island methylator phenotype and CDH1 methylation in a gastric cancer high-risk region of china. Transl Oncol 2008; 1: 28-35.
30. Boland CR, Thibodeau SN, Hamilton SR et al. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998; 58: 5248-57.
31. Zhang ZW, Newcomb PV, Moorghen M et al. Insulin-like growth factor binding protein-3: relationship to the development of gastric pre-malignancy and gastric adenocarcinoma (United Kingdom). Cancer Causes Control 2004; 15: 211-8.
32. Maekita T, Nakazawa K, Mihara M et al. High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res 2006; 12: 989-95.
33. Tahara T, Arisawa T, Shibata T et al. Increased number of methylated CpG islands correlates with Helicobacter pylori infection, histological and serological severity of chronic gastritis. Eur J Gastroenterol Hepatol 2009; 21: 613-9.
34. Yan J, Zhang M, Zhang J, Chen X, Zhang X. Helicobacter pylori infection promotes methylation of WWOX gene in human gastric cancer. Biochem Biophys Res Commun 2010; 408: 99-102.
35. Niwa T, Tsukamoto T, Toyoda T et al. Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res 2010; 70: 1430-40.
36. Seo HM, Chang YS, Joo SH et al. Clinicopathologic characteristics and outcomes of gastric cancers with the MSI-H phenotype. J Surg Oncol 2009; 99: 143-7.
37. Beghelli S, de Manzoni G, Barbi S et al. Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers. Surgery 2006; 139: 347-56.