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Guarantor of the article: Nicholas J. Talley, M.D., Ph.D. Specific author contributions: Drs. Crane, Locke, Zinsmeister, Melton, Romero, and Talley have been involved in concept, design, and drafting of the manuscript. Mr. Harmsen and Ms. Diehl have done statistical analysis and review of the manuscript. Financial support: American College of Gastroenterology. Potential competing interests: Dr. Romero acknowledges research grants from Astra Zeneca and TAP, and an educational grant with TAP. Dr. Talley has consulted for Astra Zeneca and has research support from TAP. Dr. Locke has research support from TAP and previous research support from Astra Zeneca.
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