Does the expression of cyclin E, pRb, and p21 correlate with prognosis in gastric adenocarcinoma?

Digestive Diseases and Sciences

Volumn 54, Issue 5, 2009, Pages 1015-1020

  Kouraklis, Gregory ^a   Katsoulis, Iraklis E ^a   Theocharis, Stamatios ^a   Tsourouflis, Gerasimos ^a   Xipolitas, Nikos ^a   Glinavou, Andromahi ^a   Sioka, Chrysa ^a   Kostakis, Alkiviadis ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Cyclin E; Gastric cancer; P21; PRb

Indexed keywords

CYCLIN E; PROTEIN P21; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER SURGERY; CANCER SURVIVAL; CELL CYCLE; CELL INFILTRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HELICOBACTER PYLORI; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STOMACH ADENOCARCINOMA; STOMACH WALL; SURVIVAL TIME; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; GASTRECTOMY; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; ONCOGENE PROTEINS; PHOSPHORYLATION; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; RETINOBLASTOMA PROTEIN; RISK ASSESSMENT; STOMACH NEOPLASMS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 63949085773     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-008-0464-y     Document Type: Article

References (28)

1. CJ Sherr 1996 Cancer cell cycle Science 274 1672 1677 10.1126/science.274.5293.1672
2. LH Hartwell MB Kastan 1994 Cell cycle control and cancer Science 266 1821 1828 10.1126/science.7997877
3. VK Puduvalli AP Kyritsis KR Hess ML Bondy GN Fuller GP Kouraklis 2000 Patterns of expression of Rb and p16 in astrocytic gliomas, and correlation with survival Int J Oncol 17 5 963 969
4. Y Akama W Yasui H Yokozaki H Kuniyasu K Kitahara T Ishikawa 1995 Frequent amplification of the cyclin E gene in gastric carcinoma Jpn J Cancer Res 86 617 621
5. W Yasui Y Akama H Kuniyasu H Yokozaki S Semba T Shimamoto 1996 Expression of cyclin E in human gastric adenomas and adenocarcinomas: correlation with proliferative activity and p53 status J Exp Ther Oncol 1 88 94
6. W Yasui Y Kudo S Semba H Yokozaki E Tahara 1997 Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is associated with advanced stage and invasiveness of gastric carcinomas Jpn J Cancer Res 88 625 629
7. M Nakamura M Katano K Fujimoto T Morisaki 1997 A new prognostic strategy for gastric carcinoma: mRNA expression of tumour growth-related factors in endoscopic biopsy specimens Ann Surg 226 35 42 10.1097/00000658-199707000-00005
8. Jiaqing L, Hokita S, Xiangming C, et al. Role of cyclin E and p53 expression in progression of early gastric cancer. Gastric Cancer. 1998;1(2):160-165. doi: 10.1007/s101200050011
9. Sakaguchi T, Watanabe A, Sawada H, et al. Prognostic value of cyclin E and p53 expression in gastric carcinoma. Cancer. 1998;82(7):1238-1243. doi:10.1002/(SICI)1097-0142(19980401)82:7<1238::AID-CNCR5>3.0.CO;2-B
10. MJ Ahn BH Kim SJ Jang EK Hong WM Lee HK Baik 1998 Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance J Korean Med Sci 13 5 513 518
11. Jang SJ, Park YW, Park MH, et al. Expression of cell-cycle regulators, cyclin E and p21WAF1/CIP1, potential prognostic markers for gastric cancer. Eur J Surg Oncol. 1999;25(2):157-63. doi: 10.1053/ejso.1998.0619
12. K Aoyagi K Koufuji S Yano N Murakami Y Terasaki Y Yamasaki 2000 Immunohistochemical study on the expression of cyclin D1 and E in gastric cancer Kurume Med J 47 3 199 203
13. KE Bani-Hani NM Almasri YS Khader FM Sheyab HN Karam 2005 Combined evaluation of expressions of cyclin E and p53 proteins as prognostic factors for patients with gastric cancer Clin Cancer Res 11 1447 1453 10.1158/1078-0432. CCR-04-1730
14. M Tenderenda 2005 A study on the prognostic value of cyclins D1 and E expression levels in respectable gastric cancer and on some correlations between cyclins expression, histoclinical parameters and selected protein products of cell-cycle regulatory genes J Exp Clin Cancer Res 24 3 405 414
15. B Liang S Wang X Yang Y Ye Y Yu Z Cui 2003 Expressions of cyclin E cyclin dependent kinase 2 and p57 (KIP2) in human gastric cancer Chin Med J (Engl) 116 20 23
16. Y Takano Y Kato PJ van Diest M Masuda H Mitomi I Okayasu 2000 Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases Am J Pathol 156 585 594
17. W Muller T Noguchi HC Wirtz G Hommel HE Gabbert 1999 Expression of cell-cycle regulatory proteins cyclin D1, cyclin E, and their inhibitor p21 WAF1/CIP1 in gastric cancer J Pathol 189 186 193 10.1002/(SICI)1096-9896(199910) 189:2<186::AID-PATH418>3.0.CO;2-L
18. OJ Kwon HS Kang JS Suh MS Chang JJ Jang JK Chung 1999 The loss of p27 protein has an independent prognostic significance in gastric cancer Anticancer Res 19 4215 4220
19. N Myung MR Kim IP Chung H Kim JJ Jang 2000 Loss of p16 and p27 is associated with progression of human gastric cancer Cancer Lett 153 129 136 10.1016/S0304-3835(00)00359-1
20. R Chetty CW Sitti 2003 Cyclin E immunoexpression in gastric cancer does not correlate with clinicopathological parameters Histopathology 42 66 69 10.1046/j.1365-2559.2003.01519.x
21. Y Gomyo M Ikeda M Osaki S Tatebe S Tsujitani M Ikeguchi 1997 Expression of p21 (waf1/cip1/sdi1), but not p53 protein, is a factor in survival of patients with advanced gastric carcinoma Cancer (Phila) 79 2067 2072 10.1002/(SICI)1097-0142(19970601)79:11<2067::AID-CNCR3>3.0.CO;2-M
22. M Ogawa K Maeda N Onoda YS Chung M Sowa 1997 Loss of p21WAF1/CIP1 expression correlates with disease progression in gastric carcinoma Br J Cancer 75 11 1617 1620
23. Xiangming C, Hokita S, Natsugoe S, et al. p21 expression is a prognostic factor in patients with p53-negative gastric cancer. Cancer Lett. 2000;148(2):181-188. doi: 10.1016/S0304-3835(99)00335-3.
24. Baldus SE, Schneider PM, Monig SP, et al. p21/waf1/cip1 in gastric cancer: associations with histopathological subtypes, lymphonodal metastasis, prognosis and p53 status. Scand J Gastroenterol. 2001;36(9):975-980. doi: 10.1080/003655201750305512.
25. Okuyama T, Maehara Y, Kabashima A, Takahashi I, Kakeji Y, Sugimachi K. Combined evaluation of expressions of p53 and p21 proteins as prognostic factors for patients with gastric carcinoma. Oncology. 2002;63(4):353-361. doi: 10.1159/000066223.
26. Kaye PV, Radebold K, Isaacs S, Dent DM. Expression of p53 and p21waf1/cip1 in gastric carcinoma: lack of inter-relationship or correlation with prognosis. Eur J Surg Oncol. 2000;26(1):39-43. doi: 10.1053/ejso.1999.0738.
27. Feakins RM, Nickols CD, Bidd H, Walton SJ. Abnormal expression of pRb, p16, and cyclin D1 in gastric adenocarcinoma and its lymph node metastases: relationship with pathological features and survival. Hum Pathol. 2003;34(12):1276-1282. doi: 10.1016/j.humpath.2003.07.005.
28. HS Song IH Kim SS Sohn KY Kwon WS Lee 2005 Prognostic significance of immunohistochemical expression of p53 and retinoblastoma gene protein (pRB) in curatively resected gastric cancer Korean J Intern Med 20 1 1 7