메뉴 건너뛰기




Volumn 41, Issue 5, 2014, Pages 401-413

Modeling the T cell immune response: a fascinating challenge

Author keywords

Immune regulation; Mathematical modeling; Signaling; T cell

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; T LYMPHOCYTE RECEPTOR;

EID: 84910006234     PISSN: 1567567X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/s10928-014-9376-y     Document Type: Review
Times cited : (7)

References (146)
  • 1
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • COI: 1:CAS:528:DC%2BD2cXlt1Cqur0%3D, PID: 15229469
    • Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4:499–511
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 2
    • 0012929728 scopus 로고    scopus 로고
    • Toll-like receptors
    • COI: 1:CAS:528:DC%2BD3sXjtF2isrg%3D, PID: 12524386
    • Takeda K, Kaisho T, Akira S (2003) Toll-like receptors. Annu Rev Immunol 21:335–376. doi:10.1146/annurev.immunol.21.120601.141126
    • (2003) Annu Rev Immunol , vol.21 , pp. 335-376
    • Takeda, K.1    Kaisho, T.2    Akira, S.3
  • 3
    • 79953046719 scopus 로고    scopus 로고
    • The inflammasome NLRs in immunity, inflammation, and associated diseases
    • COI: 1:CAS:528:DC%2BC3MXltlKnsLY%3D, PID: 21219188, 10.1146/annurev-immunol-031210-101405
    • Davis BK, Wen H, Ting JP-Y (2011) The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol 29:707–735 10.1146/annurev-immunol-031210-101405
    • (2011) Annu Rev Immunol , vol.29 , pp. 707-735
    • Davis, B.K.1    Wen, H.2    Ting, J.P.-Y.3
  • 4
    • 84859405717 scopus 로고    scopus 로고
    • Signaling by myeloid C-type lectin receptors in immunity and homeostasis
    • COI: 1:CAS:528:DC%2BC38XmsVKmuro%3D, PID: 22224766, 10.1146/annurev-immunol-031210-101352
    • Sancho D, Reis e Sousa C (2012) Signaling by myeloid C-type lectin receptors in immunity and homeostasis. Annu Rev Immunol 30:491–529 10.1146/annurev-immunol-031210-101352
    • (2012) Annu Rev Immunol , vol.30 , pp. 491-529
    • Sancho, D.1    Reis e Sousa, C.2
  • 5
    • 84880849460 scopus 로고    scopus 로고
    • Adaptive immunity after cell death
    • COI: 1:CAS:528:DC%2BC3sXmt12hsrg%3D, PID: 23608152
    • Zelenay S, Reis e Sousa C (2013) Adaptive immunity after cell death. Trends Immunol 34:329–335. doi:10.1016/j.it.2013.03.005
    • (2013) Trends Immunol , vol.34 , pp. 329-335
    • Zelenay, S.1    Reis e Sousa, C.2
  • 6
    • 17644379940 scopus 로고    scopus 로고
    • Antigen-specific memory B cell development
    • COI: 1:CAS:528:DC%2BD2MXktFOjurk%3D, PID: 15771579
    • McHeyzer-Williams LJ, McHeyzer-Williams MG (2005) Antigen-specific memory B cell development. Annu Rev Immunol 23:487–513. doi:10.1146/annurev.immunol.23.021704.115732
    • (2005) Annu Rev Immunol , vol.23 , pp. 487-513
    • McHeyzer-Williams, L.J.1    McHeyzer-Williams, M.G.2
  • 7
    • 84875493408 scopus 로고    scopus 로고
    • Memory T cell subsets, migration patterns, and tissue residence
    • COI: 1:CAS:528:DC%2BC3sXnsFClsLo%3D, PID: 23215646
    • Mueller SN, Gebhardt T, Carbone FR, Heath WR (2013) Memory T cell subsets, migration patterns, and tissue residence. Annu Rev Immunol 31:137–161. doi:10.1146/annurev-immunol-032712-095954
    • (2013) Annu Rev Immunol , vol.31 , pp. 137-161
    • Mueller, S.N.1    Gebhardt, T.2    Carbone, F.R.3    Heath, W.R.4
  • 8
    • 0034453826 scopus 로고    scopus 로고
    • The effect of antigen presenting cells on the cytokine profiles of stable and reactional lepromatous leprosy patients
    • COI: 1:CAS:528:DC%2BD3MXhsVOnug%3D%3D, PID: 11163869
    • Nath I, Vemuri N, Reddi AL, Jain S, Brooks P, Colston MJ, Misra RS, Ramesh V (2000) The effect of antigen presenting cells on the cytokine profiles of stable and reactional lepromatous leprosy patients. Immunol Lett 75:69–76
    • (2000) Immunol Lett , vol.75 , pp. 69-76
    • Nath, I.1    Vemuri, N.2    Reddi, A.L.3    Jain, S.4    Brooks, P.5    Colston, M.J.6    Misra, R.S.7    Ramesh, V.8
  • 9
    • 0029813545 scopus 로고    scopus 로고
    • Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    • Berg DJ, Davidson N, xFc, hn R, xFc, ller W, Menon S, Holland G, Thompson-Snipes L, Leach MW, Rennick D (1996) Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest 98:1010–1020. doi:10.1172/jci118861
    • (1996) J Clin Invest , vol.98 , pp. 1010-1020
    • Berg, D.J.1    Davidson, N.2    Fc, R.3    Fc, W.4    Menon, S.5    Holland, G.6    Thompson-Snipes, L.7    Leach, M.W.8    Rennick, D.9
  • 10
    • 84870873399 scopus 로고    scopus 로고
    • Interleukin-27: Balancing protective and pathological immunity
    • COI: 1:STN:280:DC%2BC3s3isVGkug%3D%3D, PID: 23244718
    • Hunter Christopher A, Kastelein R (2012) Interleukin-27: balancing protective and pathological immunity. Immunity 37:960–969. doi:10.1016/j.immuni.2012.11.003
    • (2012) Immunity , vol.37 , pp. 960-969
    • Hunter Christopher, A.1    Kastelein, R.2
  • 11
    • 4043102582 scopus 로고    scopus 로고
    • Regulatory cells and infectious agents: Détentes cordiale and contraire
    • COI: 1:CAS:528:DC%2BD2cXmt1Omtbg%3D, PID: 15294929
    • Rouse BT, Suvas S (2004) Regulatory cells and infectious agents: détentes cordiale and contraire. J Immunol 173:2211–2215
    • (2004) J Immunol , vol.173 , pp. 2211-2215
    • Rouse, B.T.1    Suvas, S.2
  • 12
    • 2242423605 scopus 로고    scopus 로고
    • CD4+ CD25 + regulatory T cells control Leishmania major persistence and immunity
    • COI: 1:CAS:528:DC%2BD38Xpt1Whs7w%3D, PID: 12466842
    • Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL (2002) CD4+ CD25 + regulatory T cells control Leishmania major persistence and immunity. Nature 420:502–507
    • (2002) Nature , vol.420 , pp. 502-507
    • Belkaid, Y.1    Piccirillo, C.A.2    Mendez, S.3    Shevach, E.M.4    Sacks, D.L.5
  • 13
    • 0034658617 scopus 로고    scopus 로고
    • IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii
    • COI: 1:CAS:528:DC%2BD3cXjt1Gktbc%3D, PID: 10799901
    • Suzuki Y, Sher A, Yap G, Park D, Neyer LE, Liesenfeld O, Fort M, Kang H, Gufwoli E (2000) IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii. J Immunol 164:5375–5382
    • (2000) J Immunol , vol.164 , pp. 5375-5382
    • Suzuki, Y.1    Sher, A.2    Yap, G.3    Park, D.4    Neyer, L.E.5    Liesenfeld, O.6    Fort, M.7    Kang, H.8    Gufwoli, E.9
  • 14
    • 84866556192 scopus 로고    scopus 로고
    • Maintaining system homeostasis: The third law of Newtonian immunology
    • COI: 1:CAS:528:DC%2BC38XhtlGqtbbL, PID: 22990887
    • Germain RN (2012) Maintaining system homeostasis: the third law of Newtonian immunology. Nat Immunol 13:902–906
    • (2012) Nat Immunol , vol.13 , pp. 902-906
    • Germain, R.N.1
  • 15
    • 0031586018 scopus 로고    scopus 로고
    • Modeling the proliferative response of T cells to IL-2 and IL-4
    • COI: 1:CAS:528:DyaK2sXjvVWls7Y%3D, PID: 9184697
    • Burke MA, Morel BF, Oriss TB, Bray J, McCarthy SA, Morel PA (1997) Modeling the proliferative response of T cells to IL-2 and IL-4. Cell Immunol 178:42–52
    • (1997) Cell Immunol , vol.178 , pp. 42-52
    • Burke, M.A.1    Morel, B.F.2    Oriss, T.B.3    Bray, J.4    McCarthy, S.A.5    Morel, P.A.6
  • 16
    • 0030137663 scopus 로고    scopus 로고
    • Making sense of the combined effect of interleukin-2 and interleukin-4 on lymphocytes using a mathematical model
    • COI: 1:CAS:528:DyaK28XktlChtLc%3D
    • Morel BF, Burke MA, Kalagnanam JR, McCarthy SA, Tweardy DJ, Morel PA (1996) Making sense of the combined effect of interleukin-2 and interleukin-4 on lymphocytes using a mathematical model. Bull Mathemat Biol 58:569–594
    • (1996) Bull Mathemat Biol , vol.58 , pp. 569-594
    • Morel, B.F.1    Burke, M.A.2    Kalagnanam, J.R.3    McCarthy, S.A.4    Tweardy, D.J.5    Morel, P.A.6
  • 17
    • 0000305219 scopus 로고
    • Mathematical modeling of immunological reactions
    • Morel PA (1988) Mathematical modeling of immunological reactions. Frontiers Biosci 3:338–347
    • (1988) Frontiers Biosci , vol.3 , pp. 338-347
    • Morel, P.A.1
  • 18
    • 33947131802 scopus 로고    scopus 로고
    • New insights into mathematical modeling of the immune system
    • COI: 1:CAS:528:DC%2BD2sXisVKntrc%3D, PID: 17337776
    • Morel PA, Ta’asan S, Morel BF, Kirschner DE, Flynn JL (2006) New insights into mathematical modeling of the immune system. Immunol Res 36:157–165. doi:10.1385/IR:36:1:157
    • (2006) Immunol Res , vol.36 , pp. 157-165
    • Morel, P.A.1    Ta’asan, S.2    Morel, B.F.3    Kirschner, D.E.4    Flynn, J.L.5
  • 19
    • 0021271862 scopus 로고
    • The interleukin-2 T-cell system: A new cell growth model
    • COI: 1:CAS:528:DyaL2cXksFejtbc%3D, PID: 6427923
    • Cantrell DA, Smith KA (1984) The interleukin-2 T-cell system: a new cell growth model. Science 224:1312–1316
    • (1984) Science , vol.224 , pp. 1312-1316
    • Cantrell, D.A.1    Smith, K.A.2
  • 20
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • COI: 1:CAS:528:DyaK3MXltlekurY%3D, PID: 1830926
    • Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I (1991) Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352:621–624
    • (1991) Nature , vol.352 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 21
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • COI: 1:CAS:528:DyaK3sXms1yrsL4%3D, PID: 8402910
    • Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253–261. doi:10.1016/0092-8674(93)80067-O
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 22
    • 0348047537 scopus 로고    scopus 로고
    • The main function of IL-2 is to promote the development of T regulatory cells
    • COI: 1:CAS:528:DC%2BD3sXpvFejsbY%3D, PID: 12960253
    • Malek TR (2003) The main function of IL-2 is to promote the development of T regulatory cells. J Leukocyte Biol 74:961–965. doi:10.1189/jlb.0603272
    • (2003) J Leukocyte Biol , vol.74 , pp. 961-965
    • Malek, T.R.1
  • 23
    • 0037120053 scopus 로고    scopus 로고
    • Interleukin 2 signaling is required for CD4(+) regulatory T cell function
    • COI: 1:CAS:528:DC%2BD38Xnt1yhtLg%3D, PID: 12235217
    • Furtado GC, Curotto de Lafaille MA, Kutchukhidze N, Lafaille JJ (2002) Interleukin 2 signaling is required for CD4(+) regulatory T cell function. J Exp Med 196:851–857
    • (2002) J Exp Med , vol.196 , pp. 851-857
    • Furtado, G.C.1    Curotto de Lafaille, M.A.2    Kutchukhidze, N.3    Lafaille, J.J.4
  • 24
    • 77951681944 scopus 로고    scopus 로고
    • Functional motifs in biochemical reaction networks
    • COI: 1:CAS:528:DC%2BC3cXmt1ajsL8%3D, PID: 20055671
    • Tyson JJ, Novak B (2010) Functional motifs in biochemical reaction networks. Annu Rev Phys Chem 61:219–240. doi:10.1146/annurev.physchem.012809.103457
    • (2010) Annu Rev Phys Chem , vol.61 , pp. 219-240
    • Tyson, J.J.1    Novak, B.2
  • 25
    • 0016592141 scopus 로고
    • H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D
    • COI: 1:STN:280:DyaE2M7lt1Kqsg%3D%3D, PID: 47901
    • Zinkernagel RM, Doherty PC (1975) H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D. J Exp Med 141:1427–1436. doi:10.1084/jem.141.6.1427
    • (1975) J Exp Med , vol.141 , pp. 1427-1436
    • Zinkernagel, R.M.1    Doherty, P.C.2
  • 27
    • 0023187442 scopus 로고
    • The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
    • COI: 1:CAS:528:DyaL2sXmtlCguro%3D, PID: 2443855
    • Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC (1987) The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512–518
    • (1987) Nature , vol.329 , pp. 512-518
    • Bjorkman, P.J.1    Saper, M.A.2    Samraoui, B.3    Bennett, W.S.4    Strominger, J.L.5    Wiley, D.C.6
  • 28
    • 18344405559 scopus 로고    scopus 로고
    • Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids
    • COI: 1:CAS:528:DyaK1cXjtVOkt7g%3D, PID: 9586631
    • Ding Y-H, Smith KJ, Garboczi DN, Utz U, Biddison WE, Wiley DC (1998) Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8:403–411. doi:10.1016/S1074-7613(00)80546-4
    • (1998) Immunity , vol.8 , pp. 403-411
    • Ding, Y.-H.1    Smith, K.J.2    Garboczi, D.N.3    Utz, U.4    Biddison, W.E.5    Wiley, D.C.6
  • 29
    • 0032076119 scopus 로고    scopus 로고
    • Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes
    • COI: 1:CAS:528:DyaK1cXjsFCjs78%3D, PID: 9620676
    • Speir JA, Garcia KC, Brunmark A, Degano M, Peterson PA, Teyton L, Wilson IA (1998) Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes. Immunity 8:553–562. doi:10.1016/S1074-7613(00)80560-9
    • (1998) Immunity , vol.8 , pp. 553-562
    • Speir, J.A.1    Garcia, K.C.2    Brunmark, A.3    Degano, M.4    Peterson, P.A.5    Teyton, L.6    Wilson, I.A.7
  • 31
    • 0030022868 scopus 로고    scopus 로고
    • Studying interactions involving the T-cell antigen receptor by surface plasmon resonance
    • COI: 1:CAS:528:DyaK28Xjtl2iu7g%3D, PID: 8725950
    • Margulies DH, Plaksin D, Khilko SN, Jelonek MT (1996) Studying interactions involving the T-cell antigen receptor by surface plasmon resonance. Curr Opin Immunol 8:262–270
    • (1996) Curr Opin Immunol , vol.8 , pp. 262-270
    • Margulies, D.H.1    Plaksin, D.2    Khilko, S.N.3    Jelonek, M.T.4
  • 32
    • 25844526684 scopus 로고    scopus 로고
    • Central tolerance: Learning self-control in the thymus
    • COI: 1:CAS:528:DC%2BD2MXhtVGrurjN, PID: 16200080
    • Hogquist KA, Baldwin TA, Jameson SC (2005) Central tolerance: learning self-control in the thymus. Nat Rev Immunol 5:772–782
    • (2005) Nat Rev Immunol , vol.5 , pp. 772-782
    • Hogquist, K.A.1    Baldwin, T.A.2    Jameson, S.C.3
  • 33
    • 84895552474 scopus 로고    scopus 로고
    • Theories and quantification of thymic selection
    • PID: 24550908
    • Yates AJ (2014) Theories and quantification of thymic selection. Front Immunol 5:13. doi:10.3389/fimmu.2014.00013
    • (2014) Front Immunol , vol.5 , pp. 13
    • Yates, A.J.1
  • 34
    • 84871835297 scopus 로고    scopus 로고
    • Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age
    • COI: 1:CAS:528:DC%2BC3sXoslSmsA%3D%3D, PID: 23236163
    • Johnson PL, Yates AJ, Goronzy JJ, Antia R (2012) Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age. Proc Natl Acad Sci USA 109:21432–21437. doi:10.1073/pnas.1209283110
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 21432-21437
    • Johnson, P.L.1    Yates, A.J.2    Goronzy, J.J.3    Antia, R.4
  • 35
    • 84898777643 scopus 로고    scopus 로고
    • A population biological approach to understanding the maintenance and loss of the T cell repertoire during aging
    • Johnson PL, Goronzy JJ, Antia R (2014) A population biological approach to understanding the maintenance and loss of the T cell repertoire during aging. Immunology. doi:10.1111/imm.12244
    • (2014) Immunology
    • Johnson, P.L.1    Goronzy, J.J.2    Antia, R.3
  • 36
    • 0035925931 scopus 로고    scopus 로고
    • A reliable and safe T cell repertoire based on low-affinity T cell receptors
    • Van Den Berg HA, Rand DA, Burroughs NJ (2001) A reliable and safe T cell repertoire based on low-affinity T cell receptors. J Theor Biol 209:465–486. doi:10.1006/jtbi.2001.2281
    • (2001) J Theor Biol , vol.209 , pp. 465-486
    • Van Den Berg, H.A.1    Rand, D.A.2    Burroughs, N.J.3
  • 37
    • 84890389129 scopus 로고    scopus 로고
    • A mechanistic model for naive CD4 T cell homeostasis in healthy adults and children
    • PID: 24273540
    • Hapuarachchi T, Lewis J, Callard RE (2013) A mechanistic model for naive CD4 T cell homeostasis in healthy adults and children. Front Immunol 4:366. doi:10.3389/fimmu.2013.00366
    • (2013) Front Immunol , vol.4 , pp. 366
    • Hapuarachchi, T.1    Lewis, J.2    Callard, R.E.3
  • 38
    • 84895516392 scopus 로고    scopus 로고
    • From pre-DP, post-DP, SP4, and SP8 thymocyte cell counts to a dynamical model of cortical and medullary selection
    • PID: 24592261
    • Sawicka M, Stritesky GL, Reynolds J, Abourashchi N, Lythe G, Molina-Paris C, Hogquist KA (2014) From pre-DP, post-DP, SP4, and SP8 thymocyte cell counts to a dynamical model of cortical and medullary selection. Front Immunol 5:19. doi:10.3389/fimmu.2014.00019
    • (2014) Front Immunol , vol.5 , pp. 19
    • Sawicka, M.1    Stritesky, G.L.2    Reynolds, J.3    Abourashchi, N.4    Lythe, G.5    Molina-Paris, C.6    Hogquist, K.A.7
  • 39
    • 84881096188 scopus 로고    scopus 로고
    • Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system
    • COI: 1:CAS:528:DC%2BC3sXht12htbvO, PID: 23858460
    • Sinclair C, Bains I, Yates AJ, Seddon B (2013) Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system. Proc Natl Acad Sci USA 110:E2905–E2914. doi:10.1073/pnas.1304859110
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. E2905-E2914
    • Sinclair, C.1    Bains, I.2    Yates, A.J.3    Seddon, B.4
  • 40
    • 0029058023 scopus 로고
    • Modeling positive and negative selection and differentiation processes in the thymus
    • COI: 1:STN:280:DyaK28%2FgslOlug%3D%3D, PID: 7564390
    • Mehr R, Globerson A, Perelson AS (1995) Modeling positive and negative selection and differentiation processes in the thymus. J Theor Biol 175:103–126. doi:10.1006/jtbi.1995.0124
    • (1995) J Theor Biol , vol.175 , pp. 103-126
    • Mehr, R.1    Globerson, A.2    Perelson, A.S.3
  • 41
    • 42149131535 scopus 로고    scopus 로고
    • Comprehensive assessment and mathematical modeling of T cell population dynamics and homeostasis
    • COI: 1:CAS:528:DC%2BD1cXhsVShtbg%3D, PID: 18250431
    • Thomas-Vaslin V, Altes HK, de Boer RJ, Klatzmann D (2008) Comprehensive assessment and mathematical modeling of T cell population dynamics and homeostasis. J Immunol 180:2240–2250
    • (2008) J Immunol , vol.180 , pp. 2240-2250
    • Thomas-Vaslin, V.1    Altes, H.K.2    de Boer, R.J.3    Klatzmann, D.4
  • 43
    • 13944266418 scopus 로고    scopus 로고
    • Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment
    • Bhakta NR, Oh DY, Lewis RS (2005) Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment. Nat Immunol 6:143–151. http://www.nature.com/ni/journal/v6/n2/suppinfo/ni1161_S1.html
    • (2005) Nat Immunol , vol.6 , pp. 143-151
    • Bhakta, N.R.1    Oh, D.Y.2    Lewis, R.S.3
  • 44
    • 1542377327 scopus 로고    scopus 로고
    • Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo
    • COI: 1:CAS:528:DC%2BD2cXhsFeitLo%3D, PID: 14770180
    • Liu X, Bosselut R (2004) Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo. Nat Immunol 5:280–288. doi:10.1038/ni1040
    • (2004) Nat Immunol , vol.5 , pp. 280-288
    • Liu, X.1    Bosselut, R.2
  • 45
    • 61349149901 scopus 로고    scopus 로고
    • Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper
    • COI: 1:CAS:528:DC%2BD1cXhsVWlsLfO, PID: 19151748
    • Palmer E, Naeher D (2009) Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper. Nat Rev Immunol 9:207–213
    • (2009) Nat Rev Immunol , vol.9 , pp. 207-213
    • Palmer, E.1    Naeher, D.2
  • 46
    • 0032171644 scopus 로고    scopus 로고
    • A very high level of crossreactivity is an essential feature of the T-cell receptor
    • COI: 1:CAS:528:DyaK1cXlvVWisL4%3D, PID: 9745202
    • Mason D (1998) A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol Today 19:395–404
    • (1998) Immunol Today , vol.19 , pp. 395-404
    • Mason, D.1
  • 47
    • 84892161760 scopus 로고    scopus 로고
    • Estimating the Diversity, Completeness, and Cross-Reactivity of the T Cell Repertoire
    • PID: 24421780
    • Zarnitsyna VI, Evavold BD, Schoettle LN, Blattman JN, Antia R (2013) Estimating the Diversity, Completeness, and Cross-Reactivity of the T Cell Repertoire. Front Immunol 4:485. doi:10.3389/fimmu.2013.00485
    • (2013) Front Immunol , vol.4 , pp. 485
    • Zarnitsyna, V.I.1    Evavold, B.D.2    Schoettle, L.N.3    Blattman, J.N.4    Antia, R.5
  • 49
    • 23944497170 scopus 로고    scopus 로고
    • Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse
    • Yachi PP, Ampudia J, Gascoigne NRJ, Zal T (2005) Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol 6:785–792. http://www.nature.com/ni/journal/v6/n8/suppinfo/ni1220_S1.html
    • (2005) Nat Immunol , vol.6 , pp. 785-792
    • Yachi, P.P.1    Ampudia, J.2    Gascoigne, N.R.J.3    Zal, T.4
  • 50
    • 84881656591 scopus 로고    scopus 로고
    • Antiviral memory phenotype T cells in unexposed adults
    • PID: 23947350
    • Su LF, Davis MM (2013) Antiviral memory phenotype T cells in unexposed adults. Immunol Rev 255:95–109. doi:10.1111/imr.12095
    • (2013) Immunol Rev , vol.255 , pp. 95-109
    • Su, L.F.1    Davis, M.M.2
  • 51
    • 84874253445 scopus 로고    scopus 로고
    • Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults
    • COI: 1:CAS:528:DC%2BC3sXit1ensLs%3D, PID: 23395677
    • Su LF, Kidd BA, Han A, Kotzin JJ, Davis MM (2013) Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults. Immunity 38:373–383. doi:10.1016/j.immuni.2012.10.021
    • (2013) Immunity , vol.38 , pp. 373-383
    • Su, L.F.1    Kidd, B.A.2    Han, A.3    Kotzin, J.J.4    Davis, M.M.5
  • 52
    • 34548038390 scopus 로고    scopus 로고
    • Naive CD4+ T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude
    • COI: 1:CAS:528:DC%2BD2sXhtVSgtbzF, PID: 17707129
    • Moon JJ, Chu HH, Pepper M, McSorley SJ, Jameson SC, Kedl Ross M, Jenkins MK (2007) Naive CD4+ T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27:203–213. doi:10.1016/j.immuni.2007.07.007
    • (2007) Immunity , vol.27 , pp. 203-213
    • Moon, J.J.1    Chu, H.H.2    Pepper, M.3    McSorley, S.J.4    Jameson, S.C.5    Kedl Ross, M.6    Jenkins, M.K.7
  • 53
    • 84860346184 scopus 로고    scopus 로고
    • The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude
    • COI: 1:CAS:528:DC%2BC38XlvVKju7Y%3D, PID: 22517866
    • Jenkins MK, Moon JJ (2012) The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude. J Immunol 188:4135–4140. doi:10.4049/jimmunol.1102661
    • (2012) J Immunol , vol.188 , pp. 4135-4140
    • Jenkins, M.K.1    Moon, J.J.2
  • 55
    • 0027251463 scopus 로고
    • The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments
    • COI: 1:CAS:528:DyaK3sXktVKrsrY%3D, PID: 8483950
    • Pannetier C, Cochet M, Darche S, Casrouge A, Zoller M, Kourilsky P (1993) The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc Natl Acad Sci USA 90:4319–4323
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4319-4323
    • Pannetier, C.1    Cochet, M.2    Darche, S.3    Casrouge, A.4    Zoller, M.5    Kourilsky, P.6
  • 56
    • 24644447794 scopus 로고    scopus 로고
    • SpA: Web-accessible spectratype analysis: Data management, statistical analysis and visualization
    • COI: 1:CAS:528:DC%2BD2MXpvFGqtrg%3D, PID: 16051675
    • He M, Tomfohr JK, Devlin BH, Sarzotti M, Markert ML, Kepler TB (2005) SpA: web-accessible spectratype analysis: data management, statistical analysis and visualization. Bioinformatics 21:3697–3699. doi:10.1093/bioinformatics/bti600
    • (2005) Bioinformatics , vol.21 , pp. 3697-3699
    • He, M.1    Tomfohr, J.K.2    Devlin, B.H.3    Sarzotti, M.4    Markert, M.L.5    Kepler, T.B.6
  • 57
    • 24044534785 scopus 로고    scopus 로고
    • Statistical analysis of antigen receptor spectratype data
    • COI: 1:CAS:528:DC%2BD2MXovVKqsr8%3D, PID: 15955781
    • Kepler TB, He M, Tomfohr JK, Devlin BH, Sarzotti M, Markert ML (2005) Statistical analysis of antigen receptor spectratype data. Bioinformatics 21:3394–3400. doi:10.1093/bioinformatics/bti539
    • (2005) Bioinformatics , vol.21 , pp. 3394-3400
    • Kepler, T.B.1    He, M.2    Tomfohr, J.K.3    Devlin, B.H.4    Sarzotti, M.5    Markert, M.L.6
  • 58
    • 33748937755 scopus 로고    scopus 로고
    • Statistical analysis of CDR3 length distributions for the assessment of T and B cell repertoire biases
    • COI: 1:CAS:528:DC%2BD28XpvVOgs78%3D, PID: 16930714
    • Miqueu P, Guillet M, Degauque N, Dore JC, Soulillou JP, Brouard S (2007) Statistical analysis of CDR3 length distributions for the assessment of T and B cell repertoire biases. Mol Immunol 44:1057–1064. doi:10.1016/j.molimm.2006.06.026
    • (2007) Mol Immunol , vol.44 , pp. 1057-1064
    • Miqueu, P.1    Guillet, M.2    Degauque, N.3    Dore, J.C.4    Soulillou, J.P.5    Brouard, S.6
  • 59
    • 0033615678 scopus 로고    scopus 로고
    • A direct estimate of the human alphabeta T cell receptor diversity
    • COI: 1:CAS:528:DyaK1MXntFaku7g%3D, PID: 10542151
    • Arstila TP, Casrouge A, Baron V, Even J, Kanellopoulos J, Kourilsky P (1999) A direct estimate of the human alphabeta T cell receptor diversity. Science 286:958–961
    • (1999) Science , vol.286 , pp. 958-961
    • Arstila, T.P.1    Casrouge, A.2    Baron, V.3    Even, J.4    Kanellopoulos, J.5    Kourilsky, P.6
  • 61
    • 84896362591 scopus 로고    scopus 로고
    • Automated analysis of immunoglobulin genes from high-throughput sequencing: Life without a template
    • Michaeli M, Barak M, Hazanov L, Noga H, Mehr R (2013) Automated analysis of immunoglobulin genes from high-throughput sequencing: life without a template. J Clin Bioinform 3:15
    • (2013) J Clin Bioinform , vol.3 , pp. 15
    • Michaeli, M.1    Barak, M.2    Hazanov, L.3    Noga, H.4    Mehr, R.5
  • 62
    • 84882455458 scopus 로고    scopus 로고
    • Single-cell sequencing-based technologies will revolutionize whole-organism science
    • COI: 1:CAS:528:DC%2BC3sXhtFygsL3L, PID: 23897237
    • Shapiro E, Biezuner T, Linnarsson S (2013) Single-cell sequencing-based technologies will revolutionize whole-organism science. Nat Rev Genet 14:618–630. doi:10.1038/nrg3542
    • (2013) Nat Rev Genet , vol.14 , pp. 618-630
    • Shapiro, E.1    Biezuner, T.2    Linnarsson, S.3
  • 63
    • 84893833939 scopus 로고    scopus 로고
    • Beyond model antigens: High-dimensional methods for the analysis of antigen-specific T cells
    • COI: 1:CAS:528:DC%2BC2cXps1Kgsg%3D%3D, PID: 24441473
    • Newell EW, Davis MM (2014) Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells. Nat Biotechnol 32:149–157. doi:10.1038/nbt.2783
    • (2014) Nat Biotechnol , vol.32 , pp. 149-157
    • Newell, E.W.1    Davis, M.M.2
  • 66
    • 80054904029 scopus 로고    scopus 로고
    • TCR diversity and Treg cells, sometimes more is more
    • COI: 1:CAS:528:DC%2BC3MXhtlGktbzP, PID: 22015985
    • Wing JB, Sakaguchi S (2011) TCR diversity and Treg cells, sometimes more is more. Eur J Immunol 41:3097–3100. doi:10.1002/eji.201142115
    • (2011) Eur J Immunol , vol.41 , pp. 3097-3100
    • Wing, J.B.1    Sakaguchi, S.2
  • 67
    • 66249118012 scopus 로고    scopus 로고
    • Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells
    • COI: 1:CAS:528:DC%2BD1MXmvVWmt7Y%3D, PID: 19359477
    • Ferreira C, Singh Y, Furmanski AL, Wong FS, Garden OA, Dyson J (2009) Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells. Proc Natl Acad Sci USA 106:8320–8325. doi:10.1073/pnas.0808493106
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 8320-8325
    • Ferreira, C.1    Singh, Y.2    Furmanski, A.L.3    Wong, F.S.4    Garden, O.A.5    Dyson, J.6
  • 68
    • 84888342216 scopus 로고    scopus 로고
    • The fate of CD4+ T cells under tolerance-inducing stimulation: A modeling perspective
    • COI: 1:CAS:528:DC%2BC3sXhs1yhs7fO, PID: 24145855
    • Caridade M, Oliveira VG, Agua-Doce A, Graca L, Ribeiro RM (2013) The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective. Immunol Cell Biol 91:652–660. doi:10.1038/icb.2013.63
    • (2013) Immunol Cell Biol , vol.91 , pp. 652-660
    • Caridade, M.1    Oliveira, V.G.2    Agua-Doce, A.3    Graca, L.4    Ribeiro, R.M.5
  • 69
    • 0000768235 scopus 로고
    • The route of re-circulation of lymphocytes in the rat
    • COI: 1:STN:280:DyaF2c%2FntFyltA%3D%3D, PID: 14114163
    • Gowans JL, Knight EJ (1964) The route of re-circulation of lymphocytes in the rat. Proc R Soc Lond B 159:257–282
    • (1964) Proc R Soc Lond B , vol.159 , pp. 257-282
    • Gowans, J.L.1    Knight, E.J.2
  • 70
    • 0242551584 scopus 로고    scopus 로고
    • Homing and cellular traffic in lymph nodes
    • von Andrian UH, Mempel TR (2003) Homing and cellular traffic in lymph nodes. Nat Rev Immunol 3:867–878. doi:10.1038/nri1222
    • (2003) Nat Rev Immunol , vol.3 , pp. 867-878
    • von Andrian, U.H.1    Mempel, T.R.2
  • 71
    • 0030775139 scopus 로고    scopus 로고
    • Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules
    • COI: 1:CAS:528:DyaK2sXmvVehtbk%3D, PID: 9334366
    • Kirberg J, Berns A, von Boehmer H (1997) Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J Exp Med 186:1269–1275
    • (1997) J Exp Med , vol.186 , pp. 1269-1275
    • Kirberg, J.1    Berns, A.2    von Boehmer, H.3
  • 72
    • 33745618166 scopus 로고    scopus 로고
    • Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment
    • COI: 1:CAS:528:DC%2BD28XmsVOmurc%3D, PID: 16527889
    • Martin B, Becourt C, Bienvenu B, Lucas B (2006) Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment. Blood 108:270–277. doi:10.1182/blood-2006-01-0017
    • (2006) Blood , vol.108 , pp. 270-277
    • Martin, B.1    Becourt, C.2    Bienvenu, B.3    Lucas, B.4
  • 73
    • 0033136944 scopus 로고    scopus 로고
    • Designing and maintaining the mature TCR repertoire: The continuum of self-peptide: Self-MHC complex recognition
    • COI: 1:CAS:528:DyaK1MXjslamtbc%3D, PID: 10367901
    • Viret C, Wong FS, Janeway CA Jr (1999) Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition. Immunity 10:559–568
    • (1999) Immunity , vol.10 , pp. 559-568
    • Viret, C.1    Wong, F.S.2    Janeway, C.A.3
  • 74
    • 0015608651 scopus 로고
    • Circulating T and B lymphocytes of the mouse. I. Migratory properties
    • COI: 1:STN:280:DyaE3s7ltVWjtg%3D%3D, PID: 4540428
    • Sprent J (1973) Circulating T and B lymphocytes of the mouse. I. Migratory properties. Cell Immunol 7:10–39
    • (1973) Cell Immunol , vol.7 , pp. 10-39
    • Sprent, J.1
  • 75
    • 0020580587 scopus 로고
    • The recirculating lymphocyte pool of the rat: A systematic description of the migratory behaviour of recirculating lymphocytes
    • COI: 1:STN:280:DyaL3s7osVChsg%3D%3D, PID: 6840811
    • Smith ME, Ford WL (1983) The recirculating lymphocyte pool of the rat: a systematic description of the migratory behaviour of recirculating lymphocytes. Immunology 49:83–94
    • (1983) Immunology , vol.49 , pp. 83-94
    • Smith, M.E.1    Ford, W.L.2
  • 76
    • 0030912475 scopus 로고    scopus 로고
    • A model of lymphocyte recirculation
    • COI: 1:CAS:528:DyaK2sXjtFGktLc%3D, PID: 9153952
    • Stekel DJ, Parker CE, Nowak MA (1997) A model of lymphocyte recirculation. Immunol Today 18:216–221
    • (1997) Immunol Today , vol.18 , pp. 216-221
    • Stekel, D.J.1    Parker, C.E.2    Nowak, M.A.3
  • 77
    • 0037036142 scopus 로고    scopus 로고
    • Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
    • COI: 1:CAS:528:DC%2BD38XksVWntLY%3D, PID: 12016203
    • Miller MJ, Wei SH, Parker I, Cahalan MD (2002) Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296:1869–1873. doi:10.1126/science.1070051
    • (2002) Science , vol.296 , pp. 1869-1873
    • Miller, M.J.1    Wei, S.H.2    Parker, I.3    Cahalan, M.D.4
  • 78
    • 4444328615 scopus 로고    scopus 로고
    • Intravital microscopy: Visualizing immunity in context
    • COI: 1:CAS:528:DC%2BD2cXotFakt7s%3D, PID: 15357943
    • Sumen C, Mempel TR, Mazo IB, von Andrian UH (2004) Intravital microscopy: visualizing immunity in context. Immunity 21:315–329. doi:10.1016/j.immuni.2004.08.006
    • (2004) Immunity , vol.21 , pp. 315-329
    • Sumen, C.1    Mempel, T.R.2    Mazo, I.B.3    von Andrian, U.H.4
  • 79
    • 84868156968 scopus 로고    scopus 로고
    • Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naïve CD4+ and CD8+ T cells
    • COI: 1:CAS:528:DC%2BC38Xhsl2ktbbN, PID: 23071319
    • Mandl JN, Liou R, Klauschen F, Vrisekoop N, Monteiro JP, Yates AJ, Huang AY, Germain RN (2012) Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naïve CD4+ and CD8+ T cells. Proc Natl Acad Sci 109:18036–18041. doi:10.1073/pnas.1211717109
    • (2012) Proc Natl Acad Sci , vol.109 , pp. 18036-18041
    • Mandl, J.N.1    Liou, R.2    Klauschen, F.3    Vrisekoop, N.4    Monteiro, J.P.5    Yates, A.J.6    Huang, A.Y.7    Germain, R.N.8
  • 81
    • 84895558372 scopus 로고    scopus 로고
    • Harnessing the heterogeneity of T cell differentiation fate to fine-tune generation of effector and memory T cells
    • PID: 24600448
    • Gong C, Linderman JJ, Kirschner D (2014) Harnessing the heterogeneity of T cell differentiation fate to fine-tune generation of effector and memory T cells. Front Immunol 5:57. doi:10.3389/fimmu.2014.00057
    • (2014) Front Immunol , vol.5 , pp. 57
    • Gong, C.1    Linderman, J.J.2    Kirschner, D.3
  • 82
    • 84865173738 scopus 로고    scopus 로고
    • The race for the prize: T-cell trafficking strategies for optimal surveillance
    • COI: 1:CAS:528:DC%2BC38Xht1Ghs7jO, PID: 22773385
    • Lee M, Mandl JN, Germain RN, Yates AJ (2012) The race for the prize: T-cell trafficking strategies for optimal surveillance. Blood 120:1432–1438. doi:10.1182/blood-2012-04-424655
    • (2012) Blood , vol.120 , pp. 1432-1438
    • Lee, M.1    Mandl, J.N.2    Germain, R.N.3    Yates, A.J.4
  • 84
    • 81155159689 scopus 로고    scopus 로고
    • Systems biology approaches for understanding cellular mechanisms of immunity in lymph nodes during infection
    • PID: 21798267
    • Mirsky HP, Miller MJ, Linderman JJ, Kirschner DE (2011) Systems biology approaches for understanding cellular mechanisms of immunity in lymph nodes during infection. J Theor Biol 287:160–170. doi:10.1016/j.jtbi.2011.06.037
    • (2011) J Theor Biol , vol.287 , pp. 160-170
    • Mirsky, H.P.1    Miller, M.J.2    Linderman, J.J.3    Kirschner, D.E.4
  • 85
    • 78650599246 scopus 로고    scopus 로고
    • Mechanisms for T cell receptor triggering
    • PID: 21127503
    • van der Merwe PA, Dushek O (2011) Mechanisms for T cell receptor triggering. Nat Rev Immunol 11:47–55. doi:10.1038/nri2887
    • (2011) Nat Rev Immunol , vol.11 , pp. 47-55
    • van der Merwe, P.A.1    Dushek, O.2
  • 86
    • 72949108077 scopus 로고    scopus 로고
    • Pairing computation with experimentation: A powerful coupling for understanding T cell signalling
    • COI: 1:CAS:528:DC%2BD1MXhsF2hsL%2FE, PID: 20029448
    • Chakraborty AK, Das J (2010) Pairing computation with experimentation: a powerful coupling for understanding T cell signalling. Nat Rev Immunol 10:59–71. doi:10.1038/nri2688
    • (2010) Nat Rev Immunol , vol.10 , pp. 59-71
    • Chakraborty, A.K.1    Das, J.2
  • 87
    • 0029037210 scopus 로고
    • Serial triggering of many T-cell receptors by a few peptide-MHC complexes
    • COI: 1:CAS:528:DyaK2MXls1Wisrs%3D, PID: 7753171
    • Valitutti S, Muller S, Cella M, Padovan E, Lanzavecchia A (1995) Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148–151. doi:10.1038/375148a0
    • (1995) Nature , vol.375 , pp. 148-151
    • Valitutti, S.1    Muller, S.2    Cella, M.3    Padovan, E.4    Lanzavecchia, A.5
  • 88
    • 2942588906 scopus 로고    scopus 로고
    • Mathematical and computational models of immune-receptor signalling
    • COI: 1:CAS:528:DC%2BD2cXksVaqsbo%3D, PID: 15173833
    • Goldstein B, Faeder JR, Hlavacek WS (2004) Mathematical and computational models of immune-receptor signalling. Nat Rev Immunol 4:445–456
    • (2004) Nat Rev Immunol , vol.4 , pp. 445-456
    • Goldstein, B.1    Faeder, J.R.2    Hlavacek, W.S.3
  • 89
    • 0029063148 scopus 로고
    • Kinetic proofreading in T-cell receptor signal transduction
    • COI: 1:CAS:528:DyaK2MXlvFyit7c%3D, PID: 7761445
    • McKeithan TW (1995) Kinetic proofreading in T-cell receptor signal transduction. Proc Natl Acad Sci USA 92:5042–5046
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5042-5046
    • McKeithan, T.W.1
  • 91
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligand–induced partial T cell activation: Molecular mechanisms and role in T cell biology
    • COI: 1:CAS:528:DyaK28XitlCgt7s%3D, PID: 8717505
    • Sloan-Lancaster J, Allen PM (1996) Altered peptide ligand–induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu Rev Immunol 14:1–27. doi:10.1146/annurev.immunol.14.1.1
    • (1996) Annu Rev Immunol , vol.14 , pp. 1-27
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 92
    • 85012563943 scopus 로고    scopus 로고
    • T-cell receptor binding kinetics in T-cell development and activation
    • PID: 14987373
    • Gascoigne NR, Zal T, Alam SM (2001) T-cell receptor binding kinetics in T-cell development and activation. Expert Rev Mol Med 2001:1–17. doi:10.1017/S1462399401002502
    • (2001) Expert Rev Mol Med , vol.2001 , pp. 1-17
    • Gascoigne, N.R.1    Zal, T.2    Alam, S.M.3
  • 93
    • 84875252501 scopus 로고    scopus 로고
    • T cell responses to antigen: Hasty proposals resolved through long engagements
    • COI: 1:CAS:528:DC%2BC3sXhtVKgtA%3D%3D, PID: 23276422
    • Tkach K, Altan-Bonnet G (2013) T cell responses to antigen: hasty proposals resolved through long engagements. Curr Opin Immunol 25:120–125. doi:10.1016/j.coi.2012.12.001
    • (2013) Curr Opin Immunol , vol.25 , pp. 120-125
    • Tkach, K.1    Altan-Bonnet, G.2
  • 94
    • 27844541328 scopus 로고    scopus 로고
    • Modeling T cell antigen discrimination based on feedback control of digital ERK responses
    • PID: 16231973
    • Altan-Bonnet G, Germain RN (2005) Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol 3:e356. doi:10.1371/journal.pbio.0030356
    • (2005) PLoS Biol , vol.3
    • Altan-Bonnet, G.1    Germain, R.N.2
  • 95
    • 58249092059 scopus 로고    scopus 로고
    • Digital signaling and hysteresis characterize ras activation in lymphoid cells
    • COI: 1:CAS:528:DC%2BD1MXhs1Kiu70%3D, PID: 19167334
    • Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP (2009) Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell 136:337–351. doi:10.1016/j.cell.2008.11.051
    • (2009) Cell , vol.136 , pp. 337-351
    • Das, J.1    Ho, M.2    Zikherman, J.3    Govern, C.4    Yang, M.5    Weiss, A.6    Chakraborty, A.K.7    Roose, J.P.8
  • 96
    • 84886058861 scopus 로고    scopus 로고
    • A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties
    • PID: 24065966
    • Schmeitz C, Hernandez-Vargas EA, Fliegert R, Guse AH, Meyer-Hermann M (2013) A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties. Front Immunol 4:277. doi:10.3389/fimmu.2013.00277
    • (2013) Front Immunol , vol.4 , pp. 277
    • Schmeitz, C.1    Hernandez-Vargas, E.A.2    Fliegert, R.3    Guse, A.H.4    Meyer-Hermann, M.5
  • 97
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular activation clusters in T cells
    • COI: 1:CAS:528:DyaK1cXmtVSlt7c%3D, PID: 9738502
    • Monks CRF, Freiberg BA, Kupfer H, Sciaky N, Kupfer A (1998) Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395:82–86
    • (1998) Nature , vol.395 , pp. 82-86
    • Monks, C.R.F.1    Freiberg, B.A.2    Kupfer, H.3    Sciaky, N.4    Kupfer, A.5
  • 98
    • 84871431712 scopus 로고    scopus 로고
    • How the immune system talks to itself: The varied role of synapses
    • PID: 23278741
    • Xie J, Tato CM, Davis MM (2013) How the immune system talks to itself: the varied role of synapses. Immunol Rev 251:65–79. doi:10.1111/imr.12017
    • (2013) Immunol Rev , vol.251 , pp. 65-79
    • Xie, J.1    Tato, C.M.2    Davis, M.M.3
  • 99
    • 80053130680 scopus 로고    scopus 로고
    • New insights into the T cell synapse from single molecule techniques
    • COI: 1:CAS:528:DC%2BC3MXhtFCnt7%2FE, PID: 21904389
    • Dustin ML, Depoil D (2011) New insights into the T cell synapse from single molecule techniques. Nat Rev Immunol 11:672–684. doi:10.1038/nri3066
    • (2011) Nat Rev Immunol , vol.11 , pp. 672-684
    • Dustin, M.L.1    Depoil, D.2
  • 100
    • 84858728161 scopus 로고    scopus 로고
    • Lessons from mathematically modeling the NF-kappaB pathway
    • PID: 22435558
    • Basak S, Behar M, Hoffmann A (2012) Lessons from mathematically modeling the NF-kappaB pathway. Immunol Rev 246:221–238. doi:10.1111/j.1600-065X.2011.01092.x
    • (2012) Immunol Rev , vol.246 , pp. 221-238
    • Basak, S.1    Behar, M.2    Hoffmann, A.3
  • 101
    • 84885669414 scopus 로고    scopus 로고
    • The dynamics of signaling as a pharmacological target
    • COI: 1:CAS:528:DC%2BC3sXhs1Srsr3E, PID: 24120141
    • Behar M, Barken D, Werner SL, Hoffmann A (2013) The dynamics of signaling as a pharmacological target. Cell 155:448–461. doi:10.1016/j.cell.2013.09.018
    • (2013) Cell , vol.155 , pp. 448-461
    • Behar, M.1    Barken, D.2    Werner, S.L.3    Hoffmann, A.4
  • 102
    • 0018757937 scopus 로고
    • The in vitro induction of T cells which mediate delayed-type hypersensitivity toward horse red blood cells
    • COI: 1:STN:280:DyaE1M7mslKktg%3D%3D, PID: 86387
    • Ramshaw IA, Eidinger D (1979) The in vitro induction of T cells which mediate delayed-type hypersensitivity toward horse red blood cells. Cell Immunol 42:42–47
    • (1979) Cell Immunol , vol.42 , pp. 42-47
    • Ramshaw, I.A.1    Eidinger, D.2
  • 103
    • 0026781801 scopus 로고
    • Establishment of stable, cell-mediated immunity that makes “susceptible” mice resistant to Leishmania major
    • COI: 1:STN:280:DyaK38zkt12mtA%3D%3D, PID: 1636090
    • Bretscher PA, Wei G, Menon JN, Bielefeldt-Ohmann H (1992) Establishment of stable, cell-mediated immunity that makes “susceptible” mice resistant to Leishmania major. Science 257:539–542
    • (1992) Science , vol.257 , pp. 539-542
    • Bretscher, P.A.1    Wei, G.2    Menon, J.N.3    Bielefeldt-Ohmann, H.4
  • 104
    • 0030963614 scopus 로고    scopus 로고
    • + T cell responses: The alternative approaches
    • COI: 1:CAS:528:DyaK2sXisVCnuro%3D, PID: 9143690
    • + T cell responses: the alternative approaches. Annu Rev Immunol 15:297–322
    • (1997) Annu Rev Immunol , vol.15 , pp. 297-322
    • Constant, S.L.1    Bottomly, K.2
  • 105
    • 0028874351 scopus 로고
    • The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model
    • COI: 1:CAS:528:DyaK2MXovFWqsLo%3D, PID: 7595228
    • Hosken NA, Shibuya K, Heath AW, Murphy KM, O’Garra A (1995) The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J Exp Med 182:1579–1584
    • (1995) J Exp Med , vol.182 , pp. 1579-1584
    • Hosken, N.A.1    Shibuya, K.2    Heath, A.W.3    Murphy, K.M.4    O’Garra, A.5
  • 106
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations (*)
    • COI: 1:CAS:528:DC%2BC3cXlsVSmsL4%3D, PID: 20192806
    • Zhu J, Yamane H, Paul WE (2010) Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol 28:445–489. doi:10.1146/annurev-immunol-030409-101212
    • (2010) Annu Rev Immunol , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 107
    • 79960943812 scopus 로고    scopus 로고
    • A mathematical model for the reciprocal differentiation of T helper 17 cells and induced regulatory T cells
    • COI: 1:CAS:528:DC%2BC3MXhtVOrt7nN, PID: 21829337
    • Hong T, Xing J, Li L, Tyson JJ (2011) A mathematical model for the reciprocal differentiation of T helper 17 cells and induced regulatory T cells. PLoS Comput Biol 7:e1002122. doi:10.1371/journal.pcbi.1002122
    • (2011) PLoS Comput Biol , vol.7
    • Hong, T.1    Xing, J.2    Li, L.3    Tyson, J.J.4
  • 108
    • 33646345600 scopus 로고    scopus 로고
    • A network model for the control of the differentiation process in Th cells
    • COI: 1:CAS:528:DC%2BD28Xjs1ahsrk%3D, PID: 16386358
    • Mendoza L (2006) A network model for the control of the differentiation process in Th cells. Biosystems 84:101–114. doi:10.1016/j.biosystems.2005.10.004
    • (2006) Biosystems , vol.84 , pp. 101-114
    • Mendoza, L.1
  • 109
    • 78049424847 scopus 로고    scopus 로고
    • Diversity and plasticity of Th cell types predicted from regulatory network modelling
    • PID: 20824124
    • Naldi A, Carneiro J, Chaouiya C, Thieffry D (2010) Diversity and plasticity of Th cell types predicted from regulatory network modelling. PLoS Comput Biol 6:e1000912. doi:10.1371/journal.pcbi.1000912
    • (2010) PLoS Comput Biol , vol.6
    • Naldi, A.1    Carneiro, J.2    Chaouiya, C.3    Thieffry, D.4
  • 110
    • 84867740388 scopus 로고    scopus 로고
    • Cell division curtails helper phenotype plasticity and expedites helper T-cell differentiation
    • PID: 22565392
    • van den Ham HJ, de Boer RJ (2012) Cell division curtails helper phenotype plasticity and expedites helper T-cell differentiation. Immunol Cell Biol 90:860–868. doi:10.1038/icb.2012.23
    • (2012) Immunol Cell Biol , vol.90 , pp. 860-868
    • van den Ham, H.J.1    de Boer, R.J.2
  • 111
    • 77954104660 scopus 로고    scopus 로고
    • Dominant role of antigen dose in CD4+ Foxp3+ regulatory T cell induction and expansion
    • COI: 1:CAS:528:DC%2BD1MXht1WhsLnO, PID: 19801514
    • Turner MS, Kane LP, Morel PA (2009) Dominant role of antigen dose in CD4+ Foxp3+ regulatory T cell induction and expansion. J Immunol 183:4895–4903. doi:10.4049/jimmunol.0901459
    • (2009) J Immunol , vol.183 , pp. 4895-4903
    • Turner, M.S.1    Kane, L.P.2    Morel, P.A.3
  • 112
    • 79960369940 scopus 로고    scopus 로고
    • Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope
    • COI: 1:CAS:528:DC%2BC3MXovVKhtbY%3D, PID: 21690251
    • Daniel C, Weigmann B, Bronson R, von Boehmer H (2011) Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope. J Exp Med 208:1501–1510. doi:10.1084/jem.20110574
    • (2011) J Exp Med , vol.208 , pp. 1501-1510
    • Daniel, C.1    Weigmann, B.2    Bronson, R.3    von Boehmer, H.4
  • 113
    • 77955391804 scopus 로고    scopus 로고
    • TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
    • COI: 1:CAS:528:DC%2BC3cXhtVejt7bL, PID: 20660617
    • Gottschalk RA, Corse E, Allison JP (2010) TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J Exp Med 207:1701–1711. doi:10.1084/jem.20091999
    • (2010) J Exp Med , vol.207 , pp. 1701-1711
    • Gottschalk, R.A.1    Corse, E.2    Allison, J.P.3
  • 115
    • 41149113441 scopus 로고    scopus 로고
    • The AKT-mTOR axis regulates de novo differentiation of CD4+ Foxp3+ cells
    • COI: 1:CAS:528:DC%2BD1cXjs1ahtbs%3D, PID: 18283119
    • Haxhinasto S, Mathis D, Benoist C (2008) The AKT-mTOR axis regulates de novo differentiation of CD4+ Foxp3+ cells. J Exp Med 205:565–574
    • (2008) J Exp Med , vol.205 , pp. 565-574
    • Haxhinasto, S.1    Mathis, D.2    Benoist, C.3
  • 117
    • 84903527180 scopus 로고    scopus 로고
    • Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes
    • Turner MS, Isse K, Turnquist HR, Morel PA (2014) Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes. Diabetologia 57(7):1428–1436
    • (2014) Diabetologia , vol.57 , Issue.7 , pp. 1428-1436
    • Turner, M.S.1    Isse, K.2    Turnquist, H.R.3    Morel, P.A.4
  • 118
    • 84888180619 scopus 로고    scopus 로고
    • The duration of T cell stimulation is a critical determinant of cell fate and plasticity
    • Miskov-Zivanov N, Turner MS, Kane LP, Morel PA, Faeder JR (2013) The duration of T cell stimulation is a critical determinant of cell fate and plasticity. Sci Signal 6:ra97. doi:10.1126/scisignal.2004217
    • (2013) Sci Signal
    • Miskov-Zivanov, N.1    Turner, M.S.2    Kane, L.P.3    Morel, P.A.4    Faeder, J.R.5
  • 119
    • 84867272347 scopus 로고    scopus 로고
    • Boolean modeling in systems biology: An overview of methodology and applications
    • PID: 23011283
    • Wang RS, Saadatpour A, Albert R (2012) Boolean modeling in systems biology: an overview of methodology and applications. Phys Biol 9:055001. doi:10.1088/1478-3975/9/5/055001
    • (2012) Phys Biol , vol.9 , pp. 055001
    • Wang, R.S.1    Saadatpour, A.2    Albert, R.3
  • 120
    • 50149090966 scopus 로고    scopus 로고
    • Variability and robustness in T cell activation from regulated heterogeneity in protein levels
    • COI: 1:CAS:528:DC%2BD1cXhtVSitrbK, PID: 18719282
    • Feinerman O, Veiga J, Dorfman JR, Germain RN, Altan-Bonnet G (2008) Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science 321:1081–1084. doi:10.1126/science.1158013
    • (2008) Science , vol.321 , pp. 1081-1084
    • Feinerman, O.1    Veiga, J.2    Dorfman, J.R.3    Germain, R.N.4    Altan-Bonnet, G.5
  • 121
    • 84896704750 scopus 로고    scopus 로고
    • Homeostatic control of regulatory T cell diversity
    • COI: 1:CAS:528:DC%2BC2cXhs1Smtb4%3D, PID: 24481337
    • Liston A, Gray DH (2014) Homeostatic control of regulatory T cell diversity. Nat Rev Immunol 14:154–165. doi:10.1038/nri3605
    • (2014) Nat Rev Immunol , vol.14 , pp. 154-165
    • Liston, A.1    Gray, D.H.2
  • 122
    • 43649094708 scopus 로고    scopus 로고
    • The regulatory, inflammatory, and T cell programming roles of interleukin-2 (IL-2)
    • COI: 1:CAS:528:DC%2BD1cXmtlSitbY%3D, PID: 18442895
    • Lan RY, Selmi C, Gershwin ME (2008) The regulatory, inflammatory, and T cell programming roles of interleukin-2 (IL-2). J Autoimmun 31:7–12. doi:10.1016/j.jaut.2008.03.002
    • (2008) J Autoimmun , vol.31 , pp. 7-12
    • Lan, R.Y.1    Selmi, C.2    Gershwin, M.E.3
  • 123
    • 78649875958 scopus 로고    scopus 로고
    • Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response
    • COI: 1:CAS:528:DC%2BC3MXhs1Gmt7s%3D, PID: 21119631
    • Feinerman O, Jentsch G, Tkach KE, Coward JW, Hathorn MM, Sneddon MW, Emonet T, Smith KA, Altan-Bonnet G (2010) Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response. Mol Syst Biol 6:437. doi:10.1038/msb.2010.90
    • (2010) Mol Syst Biol , vol.6 , pp. 437
    • Feinerman, O.1    Jentsch, G.2    Tkach, K.E.3    Coward, J.W.4    Hathorn, M.M.5    Sneddon, M.W.6    Emonet, T.7    Smith, K.A.8    Altan-Bonnet, G.9
  • 124
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • COI: 1:CAS:528:DC%2BD1cXmtlagt7s%3D, PID: 18468463
    • Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, Piccirillo CA, Salomon BL, Bluestone JA (2008) Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 28:687–697. doi:10.1016/j.immuni.2008.03.016
    • (2008) Immunity , vol.28 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3    Melli, K.4    Piaggio, E.5    Sgouroudis, E.6    Piccirillo, C.A.7    Salomon, B.L.8    Bluestone, J.A.9
  • 125
    • 56649095825 scopus 로고    scopus 로고
    • The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice
    • COI: 1:CAS:528:DC%2BD1cXhtl2qu7vJ, PID: 18780166
    • Dendrou CA, Wicker LS (2008) The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice. J Clin Immunol 28:685–696. doi:10.1007/s10875-008-9237-9
    • (2008) J Clin Immunol , vol.28 , pp. 685-696
    • Dendrou, C.A.1    Wicker, L.S.2
  • 126
    • 33845339257 scopus 로고    scopus 로고
    • Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease
    • COI: 1:CAS:528:DC%2BD28Xht1eks7vK, PID: 17223740
    • Boyman O, Surh CD, Sprent J (2006) Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease. Expert opinion on biological therapy 6:1323–1331. doi:10.1517/14712598.6.12.1323
    • (2006) Expert opinion on biological therapy , vol.6 , pp. 1323-1331
    • Boyman, O.1    Surh, C.D.2    Sprent, J.3
  • 127
    • 77649337932 scopus 로고    scopus 로고
    • Modeling the role of IL-2 in the interplay between CD4+ helper and regulatory T cells: Assessing general dynamical properties
    • COI: 1:CAS:528:DC%2BC3cXhs1amsro%3D, PID: 19878686, S0022-5193(09)00506-2 [pii]
    • Garcia-Martinez K, Leon K (2010) Modeling the role of IL-2 in the interplay between CD4+ helper and regulatory T cells: assessing general dynamical properties. J Theor Biol 262:720–732. doi:10.1016/j.jtbi.2009.10.025 S0022-5193(09)00506-2 [pii]
    • (2010) J Theor Biol , vol.262 , pp. 720-732
    • Garcia-Martinez, K.1    Leon, K.2
  • 128
    • 84892140453 scopus 로고    scopus 로고
    • Mathematical models of the impact of IL2 modulation therapies on T Cell dynamics
    • PID: 24376444
    • Leon K, Garcia-Martinez K, Carmenate T (2013) Mathematical models of the impact of IL2 modulation therapies on T Cell dynamics. Front Immunol 4:439. doi:10.3389/fimmu.2013.00439
    • (2013) Front Immunol , vol.4 , pp. 439
    • Leon, K.1    Garcia-Martinez, K.2    Carmenate, T.3
  • 129
    • 84880360732 scopus 로고    scopus 로고
    • Quorum sensing allows T cells to discriminate between self and nonself
    • COI: 1:CAS:528:DC%2BC3sXht1emurvF, PID: 23818603
    • Butler TC, Kardar M, Chakraborty AK (2013) Quorum sensing allows T cells to discriminate between self and nonself. Proc Natl Acad Sci USA 110:11833–11838. doi:10.1073/pnas.1222467110
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 11833-11838
    • Butler, T.C.1    Kardar, M.2    Chakraborty, A.K.3
  • 130
    • 84861908599 scopus 로고    scopus 로고
    • Preexisting autoantibodies predict efficacy of oral insulin to cure autoimmune diabetes in combination with anti-CD3
    • COI: 1:CAS:528:DC%2BC38XotlGqurY%3D, PID: 22362174
    • Mamchak AA, Manenkova Y, Leconet W, Zheng Y, Chan JR, Stokes CL, Shoda LK, von Herrath M, Bresson D (2012) Preexisting autoantibodies predict efficacy of oral insulin to cure autoimmune diabetes in combination with anti-CD3. Diabetes 61:1490–1499. doi:10.2337/db11-1304
    • (2012) Diabetes , vol.61 , pp. 1490-1499
    • Mamchak, A.A.1    Manenkova, Y.2    Leconet, W.3    Zheng, Y.4    Chan, J.R.5    Stokes, C.L.6    Shoda, L.K.7    von Herrath, M.8    Bresson, D.9
  • 131
    • 33646392755 scopus 로고    scopus 로고
    • Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
    • COI: 1:CAS:528:DC%2BD28XksVWns7k%3D, PID: 16628253
    • Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von Herrath M (2006) Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Investig 116:1371–1381. doi:10.1172/jci27191
    • (2006) J Clin Investig , vol.116 , pp. 1371-1381
    • Bresson, D.1    Togher, L.2    Rodrigo, E.3    Chen, Y.4    Bluestone, J.A.5    Herold, K.C.6    von Herrath, M.7
  • 132
    • 0027958044 scopus 로고
    • Anti-CD3 antibody induces long term remission of overt autoimmunity in nonobese diabetic mice
    • COI: 1:CAS:528:DyaK2cXnsFehuw%3D%3D, PID: 8278351
    • Chatenoud L, Thervet E, Primo J, Bach JF (1994) Anti-CD3 antibody induces long term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci USA 91:123–127
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 123-127
    • Chatenoud, L.1    Thervet, E.2    Primo, J.3    Bach, J.F.4
  • 133
    • 84858266814 scopus 로고    scopus 로고
    • Training experimental biologists in bioinformatics
    • PID: 22400026
    • Fernandes P, Jain P, Moita C (2012) Training experimental biologists in bioinformatics. Advances in bioinformatics 2012:672749. doi:10.1155/2012/672749
    • (2012) Advances in bioinformatics , vol.2012
    • Fernandes, P.1    Jain, P.2    Moita, C.3
  • 134
    • 84887479405 scopus 로고    scopus 로고
    • So you want to be a computational biologist?
    • COI: 1:CAS:528:DC%2BC3sXhslCmtr3O, PID: 24213777
    • Loman N, Watson M (2013) So you want to be a computational biologist? Nat Biotechnol 31:996–998. doi:10.1038/nbt.2740
    • (2013) Nat Biotechnol , vol.31 , pp. 996-998
    • Loman, N.1    Watson, M.2
  • 135
    • 0037378771 scopus 로고    scopus 로고
    • Investigation of early events in Fc epsilon RI-mediated signaling using a detailed mathematical model
    • COI: 1:CAS:528:DC%2BD3sXitFKltbw%3D, PID: 12646643
    • Faeder JR, Hlavacek WS, Reischl I, Blinov ML, Metzger H, Redondo A, Wofsy C, Goldstein B (2003) Investigation of early events in Fc epsilon RI-mediated signaling using a detailed mathematical model. J Immunol 170:3769–3781
    • (2003) J Immunol , vol.170 , pp. 3769-3781
    • Faeder, J.R.1    Hlavacek, W.S.2    Reischl, I.3    Blinov, M.L.4    Metzger, H.5    Redondo, A.6    Wofsy, C.7    Goldstein, B.8
  • 136
    • 49049088099 scopus 로고    scopus 로고
    • Stochastic effects and bistability in T cell receptor signaling
    • COI: 1:CAS:528:DC%2BD1cXpvFKgsLY%3D, PID: 18556025
    • Lipniacki T, Hat B, Faeder JR, Hlavacek WS (2008) Stochastic effects and bistability in T cell receptor signaling. J Theor Biol 254:110–122. doi:10.1016/j.jtbi.2008.05.001
    • (2008) J Theor Biol , vol.254 , pp. 110-122
    • Lipniacki, T.1    Hat, B.2    Faeder, J.R.3    Hlavacek, W.S.4
  • 139
    • 33646337667 scopus 로고    scopus 로고
    • A methodology for the structural and functional analysis of signaling and regulatory networks
    • Klamt S, Saez-Rodriguez J, Lindquist JA, Simeoni L, Gilles ED (2006) A methodology for the structural and functional analysis of signaling and regulatory networks. BMC Bioinform 7:56. doi:10.1186/1471-2105-7-56
    • (2006) BMC Bioinform , vol.7 , pp. 56
    • Klamt, S.1    Saez-Rodriguez, J.2    Lindquist, J.A.3    Simeoni, L.4    Gilles, E.D.5
  • 140
    • 84866732828 scopus 로고    scopus 로고
    • Systems immunology: A survey of modeling formalisms, applications and simulation tools
    • COI: 1:CAS:528:DC%2BC38XhtVGhtbjL, PID: 22528121
    • Narang V, Decraene J, Wong SY, Aiswarya BS, Wasem AR, Leong SR, Gouaillard A (2012) Systems immunology: a survey of modeling formalisms, applications and simulation tools. Immunol Res 53:251–265. doi:10.1007/s12026-012-8305-7
    • (2012) Immunol Res , vol.53 , pp. 251-265
    • Narang, V.1    Decraene, J.2    Wong, S.Y.3    Aiswarya, B.S.4    Wasem, A.R.5    Leong, S.R.6    Gouaillard, A.7
  • 141
    • 79953050420 scopus 로고    scopus 로고
    • Systems biology in immunology: A computational modeling perspective
    • COI: 1:CAS:528:DC%2BC3MXltlKnsLo%3D, PID: 21219182
    • Germain RN, Meier-Schellersheim M, Nita-Lazar A, Fraser IDC (2011) Systems biology in immunology: a computational modeling perspective. Annu Rev Immunol 29:527–585. doi:10.1146/annurev-immunol-030409-101317
    • (2011) Annu Rev Immunol , vol.29 , pp. 527-585
    • Germain, R.N.1    Meier-Schellersheim, M.2    Nita-Lazar, A.3    Fraser, I.D.C.4
  • 142
    • 33947236071 scopus 로고    scopus 로고
    • Toward a multiscale model of antigen presentation in immunity
    • COI: 1:CAS:528:DC%2BD2sXltVWltrw%3D, PID: 17367337
    • Kirschner DE, Chang ST, Riggs TW, Perry N, Linderman JJ (2007) Toward a multiscale model of antigen presentation in immunity. Immunol Rev 216:93–118. doi:10.1111/j.1600-065X.2007.00490.x
    • (2007) Immunol Rev , vol.216 , pp. 93-118
    • Kirschner, D.E.1    Chang, S.T.2    Riggs, T.W.3    Perry, N.4    Linderman, J.J.5
  • 143
    • 84875089912 scopus 로고    scopus 로고
    • Information-theoretic analysis of the dynamics of an executable biological model
    • COI: 1:CAS:528:DC%2BC3sXltFSrsb4%3D, PID: 23527156
    • Sadot A, Sarbu S, Kesseli J, Amir-Kroll H, Zhang W, Nykter M, Shmulevich I (2013) Information-theoretic analysis of the dynamics of an executable biological model. PLoS ONE 8:e59303. doi:10.1371/journal.pone.0059303
    • (2013) PLoS ONE , vol.8
    • Sadot, A.1    Sarbu, S.2    Kesseli, J.3    Amir-Kroll, H.4    Zhang, W.5    Nykter, M.6    Shmulevich, I.7
  • 144
    • 65649154507 scopus 로고    scopus 로고
    • Rule-based modeling of biochemical systems with BioNetGen
    • COI: 1:CAS:528:DC%2BD1MXls1Cisb4%3D, PID: 19399430
    • Faeder JR, Blinov ML, Hlavacek WS (2009) Rule-based modeling of biochemical systems with BioNetGen. Methods Mol Biol 500:113–167. doi:10.1007/978-1-59745-525-1_5
    • (2009) Methods Mol Biol , vol.500 , pp. 113-167
    • Faeder, J.R.1    Blinov, M.L.2    Hlavacek, W.S.3
  • 145
    • 84886430663 scopus 로고    scopus 로고
    • The simmune modeler visual interface for creating signaling networks based on bi-molecular interactions
    • PID: 23508970
    • Zhang F, Angermann BR, Meier-Schellersheim M (2013) The simmune modeler visual interface for creating signaling networks based on bi-molecular interactions. Bioinformatics 29:1229–1230. doi:10.1093/bioinformatics/btt134
    • (2013) Bioinformatics , vol.29 , pp. 1229-1230
    • Zhang, F.1    Angermann, B.R.2    Meier-Schellersheim, M.3
  • 146
    • 84873023311 scopus 로고    scopus 로고
    • Harnessing the power of the immune system to target cancer
    • PID: 23092383
    • Lizée G, Overwijk WW, Radvanyi L, Gao J, Sharma P, Hwu P (2013) Harnessing the power of the immune system to target cancer. Annu Rev Med 64:71–90. doi:10.1146/annurev-med-112311-083918
    • (2013) Annu Rev Med , vol.64 , pp. 71-90
    • Lizée, G.1    Overwijk, W.W.2    Radvanyi, L.3    Gao, J.4    Sharma, P.5    Hwu, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.