메뉴 건너뛰기




Volumn 84, Issue 2, 2006, Pages 101-114

A network model for the control of the differentiation process in Th cells

Author keywords

Discrete dynamical system; Feedback loop; Logical modeling; Regulatory network; Th lymphocytes

Indexed keywords

BETA INTERFERON; BETA INTERFERON RECEPTOR; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; STAT1 PROTEIN; STAT4 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET;

EID: 33646345600     PISSN: 03032647     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biosystems.2005.10.004     Document Type: Article
Times cited : (145)

References (60)
  • 2
    • 0242416575 scopus 로고    scopus 로고
    • Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights
    • Agnello D., Lankford C.S.R., Bream J., Morinobu A., Gadina M., O'Shea J., and Frucht D.M. Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J. Clin. Immunol. 23 (2003) 147-161
    • (2003) J. Clin. Immunol. , vol.23 , pp. 147-161
    • Agnello, D.1    Lankford, C.S.R.2    Bream, J.3    Morinobu, A.4    Gadina, M.5    O'Shea, J.6    Frucht, D.M.7
  • 3
    • 0033952638 scopus 로고    scopus 로고
    • The role of IL-18 in innate immunity
    • Akira S. The role of IL-18 in innate immunity. Curr. Opin. Immunol. 12 (2000) 59-63
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 59-63
    • Akira, S.1
  • 4
    • 0034974036 scopus 로고    scopus 로고
    • Th1 or Th1: how an appropriate T helper response can be made
    • Bergmann C., and van Hemmen J.L. Th1 or Th1: how an appropriate T helper response can be made. Bull. Math. Biol. 63 (2001) 405-430
    • (2001) Bull. Math. Biol. , vol.63 , pp. 405-430
    • Bergmann, C.1    van Hemmen, J.L.2
  • 5
    • 0036560601 scopus 로고    scopus 로고
    • How instruction and feedback can select the appropriate T helper response
    • Bergmann C., van Hemmen J.L., and Segel L.A. How instruction and feedback can select the appropriate T helper response. Bull. Math. Biol. 64 (2002) 425-446
    • (2002) Bull. Math. Biol. , vol.64 , pp. 425-446
    • Bergmann, C.1    van Hemmen, J.L.2    Segel, L.A.3
  • 7
    • 0034002472 scopus 로고    scopus 로고
    • The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit
    • Chang J.T., Segal B.M., Nakanishi K., Okamura H., and Shevach E.M. The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit. Eur. J. Immunol. 30 (2000) 1113-1119
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1113-1119
    • Chang, J.T.1    Segal, B.M.2    Nakanishi, K.3    Okamura, H.4    Shevach, E.M.5
  • 8
    • 0033662322 scopus 로고    scopus 로고
    • SOCS proteins, regulators of intracellular signaling
    • Chen X.P., Losman J.A., and Rothman P. SOCS proteins, regulators of intracellular signaling. Immunity 13 (2000) 287-290
    • (2000) Immunity , vol.13 , pp. 287-290
    • Chen, X.P.1    Losman, J.A.2    Rothman, P.3
  • 9
    • 0036721797 scopus 로고    scopus 로고
    • Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines
    • Cousins D.J., Lee T.H., and Staynov D.Z. Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines. J. Immunol. 169 (2002) 2498-2506
    • (2002) J. Immunol. , vol.169 , pp. 2498-2506
    • Cousins, D.J.1    Lee, T.H.2    Staynov, D.Z.3
  • 11
    • 0036533474 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for the Th cell lineage commitment and maintenance
    • Egwuagu C.E., Yu C.R., Zhang M., Mahdi R.M., Kim S.J., and Gery I. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for the Th cell lineage commitment and maintenance. J. Immunol. 168 (2002) 3181-3187
    • (2002) J. Immunol. , vol.168 , pp. 3181-3187
    • Egwuagu, C.E.1    Yu, C.R.2    Zhang, M.3    Mahdi, R.M.4    Kim, S.J.5    Gery, I.6
  • 13
    • 0038759100 scopus 로고    scopus 로고
    • The role of interleukin-12 in human infectious diseases: only a faint signature
    • Fieschi C., and Casanova J.L. The role of interleukin-12 in human infectious diseases: only a faint signature. Eur. J. Immunol. 33 (2003) 1461-1464
    • (2003) Eur. J. Immunol. , vol.33 , pp. 1461-1464
    • Fieschi, C.1    Casanova, J.L.2
  • 14
    • 0034661356 scopus 로고    scopus 로고
    • Lineage commitment in the immune system: the T helper lymphocyte grows up
    • Glimcher L.H., and Murphy K.M. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14 (2000) 1693-1711
    • (2000) Genes Dev. , vol.14 , pp. 1693-1711
    • Glimcher, L.H.1    Murphy, K.M.2
  • 15
    • 0033795196 scopus 로고    scopus 로고
    • Interferons: cell signalling, immune modulation, antiviral responses and virus countermeasures
    • Goodbourn S., Didcock L., and Randal R.E. Interferons: cell signalling, immune modulation, antiviral responses and virus countermeasures. J. Gen. Virol. 81 (2000) 2341-2364
    • (2000) J. Gen. Virol. , vol.81 , pp. 2341-2364
    • Goodbourn, S.1    Didcock, L.2    Randal, R.E.3
  • 16
    • 0035224492 scopus 로고    scopus 로고
    • Distinct gene expression profiles of human type 1 and type 2 T helper cells
    • research 0022.1-0022.11
    • Hamalainen H., Zhou H., Chou W., Hashizume H., Heller R., and Lahesmaa R. Distinct gene expression profiles of human type 1 and type 2 T helper cells. Genome Biol. 2 (2001) research 0022.1-0022.11
    • (2001) Genome Biol. , vol.2
    • Hamalainen, H.1    Zhou, H.2    Chou, W.3    Hashizume, H.4    Heller, R.5    Lahesmaa, R.6
  • 17
    • 0034653418 scopus 로고    scopus 로고
    • Cutting edge: ectopic expression of the IL-12 receptor-β2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-γ
    • Heat V.L., Showe L., Crain C., Barrat F.J., Trinchieri G., and O'Garra A.O. Cutting edge: ectopic expression of the IL-12 receptor-β2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-γ. J. Immunol. 164 (2000) 2861-2865
    • (2000) J. Immunol. , vol.164 , pp. 2861-2865
    • Heat, V.L.1    Showe, L.2    Crain, C.3    Barrat, F.J.4    Trinchieri, G.5    O'Garra, A.O.6
  • 18
    • 0033526110 scopus 로고    scopus 로고
    • Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 response in IL-1 receptor-associated kinase (IRAK)-deficient mice
    • Kanakaraj P., Ngo K., Wu Y., Angulo A., Ghazal P., Harris C.A., Siekierka J.J., Peterson P.A., and Fung-Leung W.P. Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 response in IL-1 receptor-associated kinase (IRAK)-deficient mice. J. Exp. Med. 189 (1999) 1129-1138
    • (1999) J. Exp. Med. , vol.189 , pp. 1129-1138
    • Kanakaraj, P.1    Ngo, K.2    Wu, Y.3    Angulo, A.4    Ghazal, P.5    Harris, C.A.6    Siekierka, J.J.7    Peterson, P.A.8    Fung-Leung, W.P.9
  • 19
    • 0022376616 scopus 로고
    • Towards a logical analysis of the immune response
    • Kaufman M., Urbain J., and Thomas R. Towards a logical analysis of the immune response. J. Theor. Biol. 114 (1985) 527-561
    • (1985) J. Theor. Biol. , vol.114 , pp. 527-561
    • Kaufman, M.1    Urbain, J.2    Thomas, R.3
  • 20
    • 0033616563 scopus 로고    scopus 로고
    • A logical analysis of T cell activation and anergy
    • Kaufman M., Andris F., and Leo O. A logical analysis of T cell activation and anergy. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 3894-3899
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 3894-3899
    • Kaufman, M.1    Andris, F.2    Leo, O.3
  • 21
    • 0034658583 scopus 로고    scopus 로고
    • Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes
    • Kotenko S.V., and Pestka S. Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes. Oncogene 19 (2000) 2557-2565
    • (2000) Oncogene , vol.19 , pp. 2557-2565
    • Kotenko, S.V.1    Pestka, S.2
  • 23
    • 0033120880 scopus 로고    scopus 로고
    • Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction
    • Losman J.A., Chen X.P., Hilton D., and Rothman P. Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction. J. Immunol. 162 (1999) 3770-3774
    • (1999) J. Immunol. , vol.162 , pp. 3770-3774
    • Losman, J.A.1    Chen, X.P.2    Hilton, D.3    Rothman, P.4
  • 24
    • 3242706926 scopus 로고    scopus 로고
    • Transcriptional control networks of cell differentiation: insights from helper T lymphocytes
    • Mariani L., Löhning M., Radbruch A., and Höfer T. Transcriptional control networks of cell differentiation: insights from helper T lymphocytes. Prog. Biophys. Mol. Biol. 86 (2004) 45-76
    • (2004) Prog. Biophys. Mol. Biol. , vol.86 , pp. 45-76
    • Mariani, L.1    Löhning, M.2    Radbruch, A.3    Höfer, T.4
  • 25
    • 0032879544 scopus 로고    scopus 로고
    • Genetic control of flower morphogenesis in Arabidopsis thaliana: a logical analysis
    • Mendoza L., Thieffry D., and Alvarez-Buylla E.R. Genetic control of flower morphogenesis in Arabidopsis thaliana: a logical analysis. Bioinformatics 15 (1999) 593-606
    • (1999) Bioinformatics , vol.15 , pp. 593-606
    • Mendoza, L.1    Thieffry, D.2    Alvarez-Buylla, E.R.3
  • 26
    • 0032055197 scopus 로고    scopus 로고
    • Activation of STAT proteins and cytokine genes in human Th1 and Th2 cells generated in the absence of IL-12 and IL-4
    • Moriggl R., Kristofic C., Kinzel B., Volarevic S., Groner B., and Brinkmann V. Activation of STAT proteins and cytokine genes in human Th1 and Th2 cells generated in the absence of IL-12 and IL-4. J. Immunol. 160 (1998) 3385-3392
    • (1998) J. Immunol. , vol.160 , pp. 3385-3392
    • Moriggl, R.1    Kristofic, C.2    Kinzel, B.3    Volarevic, S.4    Groner, B.5    Brinkmann, V.6
  • 28
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions on helper T cells
    • Murphy K.M., and Reiner S.L. The lineage decisions on helper T cells. Nat. Rev. Immunol. 2 (2002) 933-944
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 31
    • 0031308702 scopus 로고    scopus 로고
    • IL-4-induced STAT6 suppresses IFN-gamma-stimulated STAT1-dependent transcription in mouse macrophages
    • Ohmori Y., and Hamilton T.A. IL-4-induced STAT6 suppresses IFN-gamma-stimulated STAT1-dependent transcription in mouse macrophages. J. Immunol. 159 (1997) 5474-5482
    • (1997) J. Immunol. , vol.159 , pp. 5474-5482
    • Ohmori, Y.1    Hamilton, T.A.2
  • 32
  • 33
    • 0035076179 scopus 로고    scopus 로고
    • Structure and specificity of GATA proteins in Th2 development
    • Ranganath S., and Murphy K.M. Structure and specificity of GATA proteins in Th2 development. Mol. Cell. Biol. 21 (2001) 2716-2725
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 2716-2725
    • Ranganath, S.1    Murphy, K.M.2
  • 34
    • 85194530403 scopus 로고    scopus 로고
    • Remy, E., Ruet, P., Mendoza, L., Thieffry, D., Chaouiya, C., in press. From logical regulatory graphs to standard Petri nets: dynamical roles and functionality of feedback circuits. Trans. Comput. Systems Biol.
  • 36
    • 0034120709 scopus 로고    scopus 로고
    • IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-γ
    • Saito H., Morita Y., Fujimoto M., Narazaki M., Naka T., and Kishimoto T. IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-γ. J. Immunol. 164 (2000) 5833-5843
    • (2000) J. Immunol. , vol.164 , pp. 5833-5843
    • Saito, H.1    Morita, Y.2    Fujimoto, M.3    Narazaki, M.4    Naka, T.5    Kishimoto, T.6
  • 37
    • 0041381349 scopus 로고    scopus 로고
    • Segmenting the fly embryo: a logical analysis of the pair-rule cross-regulatory module
    • Sánchez L., and Thieffry D. Segmenting the fly embryo: a logical analysis of the pair-rule cross-regulatory module. J. Theor. Biol. 224 (2003) 517-537
    • (2003) J. Theor. Biol. , vol.224 , pp. 517-537
    • Sánchez, L.1    Thieffry, D.2
  • 38
    • 0842326617 scopus 로고    scopus 로고
    • A logical analysis of the process of T cell activation: different consequences depending on the state of CD28 engagement
    • Sarkar A., and Franza B.R. A logical analysis of the process of T cell activation: different consequences depending on the state of CD28 engagement. J. Theor. Biol. 226 (2004) 455-466
    • (2004) J. Theor. Biol. , vol.226 , pp. 455-466
    • Sarkar, A.1    Franza, B.R.2
  • 40
    • 0034176741 scopus 로고    scopus 로고
    • Ligand-independent down-regulation of IFN-γ receptor 1 following TCR engagement
    • Skrenta H., Yang Y., Pestka S., and Fathman C.G. Ligand-independent down-regulation of IFN-γ receptor 1 following TCR engagement. J. Immunol. 164 (2000) 3506-3511
    • (2000) J. Immunol. , vol.164 , pp. 3506-3511
    • Skrenta, H.1    Yang, Y.2    Pestka, S.3    Fathman, C.G.4
  • 41
    • 0035898446 scopus 로고    scopus 로고
    • Regulation of interleukin (IL)-18 receptor α chain expression on CD4+ T cells during T helper (Th)1/Th2 differentiation: critical downregulatory role of IL-4
    • Smeltz R.B., Chen J., Hu-Li J., and Shevach E.M. Regulation of interleukin (IL)-18 receptor α chain expression on CD4+ T cells during T helper (Th)1/Th2 differentiation: critical downregulatory role of IL-4. J. Exp. Med. 194 (2001) 143-153
    • (2001) J. Exp. Med. , vol.194 , pp. 143-153
    • Smeltz, R.B.1    Chen, J.2    Hu-Li, J.3    Shevach, E.M.4
  • 42
    • 0035062386 scopus 로고    scopus 로고
    • IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression
    • Smits H.H., van Rietschoten J.G., Hilkens C.M., Sayilir R., Stiekema F., Kapsenberg M.L., and Wierenga E.A. IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression. Eur. J. Immunol. 31 (2001) 1055-1065
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1055-1065
    • Smits, H.H.1    van Rietschoten, J.G.2    Hilkens, C.M.3    Sayilir, R.4    Stiekema, F.5    Kapsenberg, M.L.6    Wierenga, E.A.7
  • 43
    • 0035817331 scopus 로고    scopus 로고
    • Interleukin 18: tipping the balance towards a T helper cell 1 response
    • Swain S.L. Interleukin 18: tipping the balance towards a T helper cell 1 response. J. Exp. Med. 194 (2001) F11-F14
    • (2001) J. Exp. Med. , vol.194
    • Swain, S.L.1
  • 44
    • 0029071483 scopus 로고
    • Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
    • Szabo S.J., Jacobson N.G., Dighe A.S., Gubler U., and Murphy K.M. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2 (1995) 665-675
    • (1995) Immunity , vol.2 , pp. 665-675
    • Szabo, S.J.1    Jacobson, N.G.2    Dighe, A.S.3    Gubler, U.4    Murphy, K.M.5
  • 45
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo S.J., Dighe A.S., Gubler U., and Murphy K.M. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185 (1997) 817-824
    • (1997) J. Exp. Med. , vol.185 , pp. 817-824
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 46
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., and Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 (2000) 655-669
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1    Kim, S.T.2    Costa, G.L.3    Zhang, X.4    Fathman, C.G.5    Glimcher, L.H.6
  • 48
    • 0032524966 scopus 로고    scopus 로고
    • IFN-γ-deficient mice develop severe granulomatous experimental autoimmune thyroiditis with eosinophil infiltration in thyroids
    • Tang H., Sharp G.C., Peterson K.P., and Braley-Mullen H. IFN-γ-deficient mice develop severe granulomatous experimental autoimmune thyroiditis with eosinophil infiltration in thyroids. J. Immunol. 160 (1998) 5105-5112
    • (1998) J. Immunol. , vol.160 , pp. 5105-5112
    • Tang, H.1    Sharp, G.C.2    Peterson, K.P.3    Braley-Mullen, H.4
  • 50
    • 0036962769 scopus 로고    scopus 로고
    • Alternative epigenetic states understood in terms of specific regulatory structures
    • Thieffry D., and Sánchez L. Alternative epigenetic states understood in terms of specific regulatory structures. Ann. N.Y. Acad. Sci. 981 (2002) 135-153
    • (2002) Ann. N.Y. Acad. Sci. , vol.981 , pp. 135-153
    • Thieffry, D.1    Sánchez, L.2
  • 52
    • 0025948178 scopus 로고
    • Regulatory networks seen as asynchronous automata: a logical description
    • Thomas R. Regulatory networks seen as asynchronous automata: a logical description. J. Theor. Biol. 153 (1991) 1-23
    • (1991) J. Theor. Biol. , vol.153 , pp. 1-23
    • Thomas, R.1
  • 53
    • 0029267491 scopus 로고
    • Dynamical behaviour of biological regulatory networks-I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state
    • Thomas R., Thieffry D., and Kaufman M. Dynamical behaviour of biological regulatory networks-I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state. Bull. Math. Biol. 57 (1995) 247-276
    • (1995) Bull. Math. Biol. , vol.57 , pp. 247-276
    • Thomas, R.1    Thieffry, D.2    Kaufman, M.3
  • 54
    • 0007712725 scopus 로고    scopus 로고
    • Multistationarity, the basis of cell differentiation and memory. I. Structural conditions of multistationarity and other nontrivial behavior
    • Thomas R., and Kaufman M. Multistationarity, the basis of cell differentiation and memory. I. Structural conditions of multistationarity and other nontrivial behavior. Chaos 11 (2001) 170-179
    • (2001) Chaos , vol.11 , pp. 170-179
    • Thomas, R.1    Kaufman, M.2
  • 55
    • 0028970060 scopus 로고
    • Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13 (1995) 251-276
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 56
    • 0037342749 scopus 로고    scopus 로고
    • GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rβ2 chain or T-bet
    • Usui T., Nishikomori R., Kitani A., and Strober W. GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rβ2 chain or T-bet. Immunity 18 (2003) 415-428
    • (2003) Immunity , vol.18 , pp. 415-428
    • Usui, T.1    Nishikomori, R.2    Kitani, A.3    Strober, W.4
  • 57
    • 0035261399 scopus 로고    scopus 로고
    • IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production
    • Yang J., Zhu H., Murphy T.L., Ouyang W., and Murphy K.M. IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production. Nat. Immunol. 2 (2001) 157-164
    • (2001) Nat. Immunol. , vol.2 , pp. 157-164
    • Yang, J.1    Zhu, H.2    Murphy, T.L.3    Ouyang, W.4    Murphy, K.M.5
  • 58
    • 4544379632 scopus 로고    scopus 로고
    • Combining cytokine signalling with T-bet and GATA-3 regulation in Th1 and Th2 differentiation: a model for cellular decision-making
    • Yates A., Callard R., and Stark J. Combining cytokine signalling with T-bet and GATA-3 regulation in Th1 and Th2 differentiation: a model for cellular decision-making. J. Theor. Biol. 231 (2004) 181-196
    • (2004) J. Theor. Biol. , vol.231 , pp. 181-196
    • Yates, A.1    Callard, R.2    Stark, J.3
  • 60
    • 0041374389 scopus 로고    scopus 로고
    • The function role of GATA-3 in Th1 and Th2 differentiation
    • Zhou M., and Ouyang W. The function role of GATA-3 in Th1 and Th2 differentiation. Immunol. Res. 28 (2003) 25-37
    • (2003) Immunol. Res. , vol.28 , pp. 25-37
    • Zhou, M.1    Ouyang, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.