Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes

Diabetologia

Volumn 57, Issue 7, 2014, Pages 1428-1436

  Turner, Michael S ^a,b   Isse, Kumiko ^a,c   Fischer, Douglas K ^a   Turnquist, Hěth R ^c   Morel, Penelope A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b BENAROYA RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

NOD mice; Regulatory T cells; TCR signal strength; Type 1 diabetes

Indexed keywords

ANTIGEN; CD3 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 5; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN S6; QUANTUM DOT; STAT1 PROTEIN; STAT5 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; CYTOKINE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL EXPANSION; CELL POPULATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LOW DRUG DOSE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SPLEEN CELL; T CELL CULTURE; TH1 CELL; TH2 CELL; ANIMAL; DIABETES MELLITUS, TYPE 1; IMMUNOLOGY; METABOLISM; PROCEDURES; SCID MOUSE;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DENDRITIC CELLS; DIABETES MELLITUS, TYPE 1; IMMUNOTHERAPY; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; MICE, SCID; T-LYMPHOCYTES, REGULATORY; TH2 CELLS;

EID: 84903527180     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3233-9     Document Type: Article

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