T cell responses to antigen: Hasty proposals resolved through long engagements

Current Opinion in Immunology

Volumn 25, Issue 1, 2013, Pages 120-125

  Tkach, Karen ^a   Altan Bonnet, Grégoire ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANTIGEN BINDING; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; BINDING AFFINITY; BINDING COMPETITION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INTERACTION; CELL POPULATION; CELLULAR IMMUNITY; DENDRITIC CELL; INTRACELLULAR SIGNALING; LIGAND BINDING; MOLECULAR INTERACTION; PHAGOCYTOSIS; POPULATION DYNAMICS; POSITIVE FEEDBACK; REVIEW; T LYMPHOCYTE ACTIVATION; TROGOCYTOSIS;

ANTIGENS; BIOPHYSICAL PHENOMENA; COMPUTATIONAL BIOLOGY; FEEDBACK, PHYSIOLOGICAL; HUMANS; IMMUNITY, CELLULAR; LIGANDS; LYMPHOCYTE ACTIVATION; MODELS, THEORETICAL; PROBABILITY; PROTEIN BINDING; RECEPTOR CROSS-TALK; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84875252501     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2012.12.001     Document Type: Review

References (61)

1. Sykulev Y., Vugmeyster Y., Brunmark A., Ploegh H.L., Eisen H.N. Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. Immunity 1998, 9:475-483.
2. Grakoui A., Bromley S.K., Sumen C., Davis M.M., Shaw A.S., Allen P.M., Dustin M.L. The immunological synapse: a molecular machine controlling T cell activation. Science 1999, 285:221-227.
3. Altan-Bonnet G., Germain R.N. Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol 2005, 3:e356.
4. Davis M.M., Krogsgaard M., Huse M., Huppa J., Lillemeier B.F., Li Q.J. T cells as a self-referential, sensory organ. Annu Rev Immunol 2007, 25:681-695.
5. Lewis R.S. Calcium signaling mechanisms in T lymphocytes. Annu Rev Immunol 2001, 19:497-521.
6. Bromley S.K., Burack W.R., Johnson K.G., Somersalo K., Sims T.N., Sumen C., Davis M.M., Shaw A.S., Allen P.M., Dustin M.L. The immunological synapse. Annu Rev Immunol 2001, 19:375-396.
7. Gascoigne N.R., Zal T., Alam S.M. T-cell receptor binding kinetics in T-cell development and activation. Expert Rev Mol Med 2001, 2001:1-17.
8. Gottschalk R.A., Hathorn M.M., Beuneu H., Corse E., Dustin M.L., Altan-Bonnet G., Allison J.P. Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses. Proc Natl Acad Sci U S A 2012, 109:881-886.
9. Huang J., Zarnitsyna V.I., Liu B., Edwards L.J., Jiang N., Evavold B.D., Zhu C. The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness. Nature 2010, 464:932-936.
10. Zarnitsyna V., Zhu C. T cell triggering: insights from 2D kinetics analysis of molecular interactions. Phys Biol 2012, 9:045005.
11. Robert P., Aleksic M., Dushek O., Cerundolo V., Bongrand P., van der Merwe P.A. Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands. Biophys J 2012, 102:248-257.
12. Huppa J.B., Axmann M., Mortelmaier M.A., Lillemeier B.F., Newell E.W., Brameshuber M., Klein L.O., Schutz G.J., Davis M.M. TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature 2010, 463:963-967.
13. + T cells in response to infection is markedly efficient. Science 2009, 325:1265-1269.
14. Zehn D., Lee S.Y., Bevan M.J. Complete but curtailed T-cell response to very low-affinity antigen. Nature 2009, 458:211-214.
15. Das J., Ho M., Zikherman J., Govern C., Yang M., Weiss A., Chakraborty A.K., Roose J.P. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell 2009, 136:337-351.
16. Stefanova I., Hemmer B., Vergelli M., Martin R., Biddison W.E., Germain R.N. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat Immunol 2003, 4:248-254.
17. Xiong W., Ferrell J.E. A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature 2003, 426:460-465.
18. Feinerman O., Veiga J., Dorfman J.R., Germain R.N., Altan-Bonnet G. Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science 2008, 321:1081-1084.
19. Johansen P., Storni T., Rettig L., Qiu Z., Der-Sarkissian A., Smith K.A., Manolova V., Lang K.S., Senti G., Müllhaupt B., et al. Antigen kinetics determines immune reactivity. Proc Natl Acad Sci U S A 2008, 105:5189-5194.
20. Quiel J., Caucheteux S., Laurence A., Singh N.J., Bocharov G., Ben-Sasson S.Z., Grossman Z., Paul W.E. Antigen-stimulated CD4 T-cell expansion is inversely and log-linearly related to precursor number. Proc Natl Acad Sci U S A 2011, 108:3312-3317.
21. Feinerman O., Germain R.N., Altan-Bonnet G. Quantitative challenges in understanding ligand discrimination by alphabeta T cells. Mol Immunol 2008, 45:619-631.
22. Garcia Z., Pradelli E., Celli S., Beuneu H., Simon A., Bousso P. Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion. Proc Natl Acad Sci U S A 2007, 104:4553-4558.
23. Goldsmith M.A., Weiss A. Early signal transduction by the antigen receptor without commitment to T cell activation. Science 1988, 240:1029-1031.
24. Valitutti S., Dessing M., Aktories K., Gallati H., Lanzavecchia A. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J Exp Med 1995, 181:577-584.
25. + T cells. J Exp Med 1997, 186:757-766.
26. Iezzi G., Karjalainen K., Lanzavecchia A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 1998, 8:89-95.
27. Müller S., Demotz S., Bulliard C., Valitutti S. Kinetics and extent of protein tyrosine kinase activation in individual T cells upon antigenic stimulation. Immunology 1999, 97:287-293.
28. van Stipdonk M.J., Lemmens E.E., Schoenberger S.P. Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat Immunol 2001, 2:423-429.
29. Huppa J.B., Gleimer M., Sumen C., Davis M.M. Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat Immunol 2003, 4:749-755.
30. Obst R., van Santen H.-M., Mathis D., Benoist C. Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med 2005, 201:1555-1565.
31. + T cell activation. Immunity 2007, 27:625-634.
32. + T cell response. J Exp Med 2006, 203:2135-2143.
33. + T cell cross-priming. J Immunol (Baltimore, MD: 1950) 2008, 181:3067-3076.
34. Henrickson S.E., Mempel T.R., Mazo I.B., Liu B., Artyomov M.N., Zheng H., Peixoto A., Flynn M.P., Senman B., Junt T., et al. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol 2008, 9:282-291.
35. Zheng H., Jin B., Henrickson S.E., Perelson A.S., von Andrian U.H., Chakraborty A.K. How antigen quantity and quality determine T-cell decisions in lymphoid tissue. Mol Cell Biol 2008, 28:4040-4051.
36. Borovsky Z., Mishan-Eisenberg G., Yaniv E., Rachmilewitz J. Serial triggering of T cell receptors results in incremental accumulation of signaling intermediates. J Biol Chem 2002, 277:21529-21536.
37. Faroudi M., Zaru R., Paulet P., Müller S., Valitutti S. Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling. J Immunol (Baltimore, MD: 1950) 2003, 171:1128-1132.
38. Schrum A.G., Turka L.A., Palmer E. Surface T-cell antigen receptor expression and availability for long-term antigenic signaling. Immunol Rev 2003, 196:7-24.
39. Locasale J.W. Computational investigations into the origins of short-term biochemical memory in T cell activation. PLoS ONE 2007, 2:e627.
40. Davis D.M. Mechanisms and functions for the duration of intercellular contacts made by lymphocytes. Nat Rev Immunol 2009, 9:543-555.
41. Lee I.H., Li W.P., Hisert K.B., Ivashkiv L.B. Inhibition of interleukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell receptor-mediated feedback inhibition of T cell expansion. J Exp Med 1999, 190:1263-1274.
42. + T cells to generate a Th2-inducing cytokine environment. J Exp Med 2005, 202:793-804.
43. Yamane H., Paul W.E. Cytokines of the gamma(c) family control CD4(+) T cell differentiation and function. Nat Immunol 2012, 13:1037-1044.
44. Smith A.L., Wikstrom M.E., Fazekas de St Groth B. Visualizing T cell competition for peptide/MHC complexes: a specific mechanism to minimize the effect of precursor frequency. Immunity 2000, 13:783-794.
45. Foulds K.E., Shen H. Clonal competition inhibits the proliferation and differentiation of adoptively transferred TCR transgenic CD4 T cells in response to infection. J Immunol (Baltimore, MD: 1950) 2006, 176:3037-3043.
46. + T cell precursor frequency determines the quality of the antitumor immune response. J Exp Med 2009, 206:849-866.
47. + T cells in vivo is rapid, transient, and influenced by TCR-specific competition. J Immunol (Baltimore, MD: 1950) 2004, 172:6136-6143.
48. Sarkar S., Teichgräber V., Kalia V., Polley A., Masopust D., Harrington L.E., Ahmed R., Wherry E.J. Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. J Immunol (Baltimore, MD: 1950) 2007, 179:6704-6714.
49. + T cell survival controlled by clonal abundance. Science (New York, NY) 2006, 312:114-116.
50. Blair D.A., Lefrançois L. Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells. Proc Natl Acad Sci U S A 2007, 104:15045-15050.
51. + T cell lineage commitment. Nat Immunol 2005, 6:793-799.
52. + T cell differentiation during viral infection. Immunity 2007, 27:393-405.
53. Willis R.A., Kappler J.W., Marrack P.C. CD8 T cell competition for dendritic cells in vivo is an early event in activation. Proc Natl Acad Sci U S A 2006, 103:12063-12068.
54. + T cells of different antigen/MHC specificity. J Immunol (Baltimore, MD: 1950) 2003, 171:240-246.
55. Huang J.F., Yang Y., Sepulveda H., Shi W., Hwang I., Peterson P.A., Jackson M.R., Sprent J., Cai Z. TCR-mediated internalization of peptide-MHC complexes acquired by T cells. Science 1999, 286:952-954.
56. Martinez-Martin N., Fernandez-Arenas E., Cemerski S., Delgado P., Turner M., Heuser J., Irvine D.J., Huang B., Bustelo X.R., Shaw A., et al. T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis. Immunity 2011, 35:208-222.
57. Helft J., Jacquet A., Joncker N.T., Grandjean I., Dorothée G., Kissenpfennig A., Malissen B., Matzinger P., Lantz O. Antigen-specific T-T interactions regulate CD4 T-cell expansion. Blood 2008, 112:1249-1258.
58. + T cells. J Immunol (Baltimore, MD: 1950) 2012, 189:4728-4739.
59. Joly E., Hudrisier D. What is trogocytosis and what is its purpose?. Nat Immunol 2003, 4:815.
60. Kedl R.M., Schaefer B.C., Kappler J.W., Marrack P. T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat Immunol 2002, 3:27-32.
61. + T cell clones. J Immunol (Baltimore, MD: 1950) 2012, 188:632-640.