Stochastic effects and bistability in T cell receptor signaling

Journal of Theoretical Biology

Volumn 254, Issue 1, 2008, Pages 110-122

  Lipniacki, Tomasz ^a   Hat, Beata ^a   Faeder, James R ^b   Hlavacek, William S ^c  

^a INSTITUTE OF FUNDAMENTAL TECHNOLOGICAL RESEARCH   (Poland)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

Hysteresis; Kinetic proofreading; Mathematical model; Ordinary differential equations; Stochastic simulations; T cell activation

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN TYROSINE PHOSPHATASE SHP 1; T LYMPHOCYTE RECEPTOR;

CYTOLOGY; ENZYME ACTIVITY; HYSTERESIS; KINETICS; NUMERICAL MODEL; PROTEIN; SIGNALING; STOCHASTICITY;

ANTIGEN PRESENTING CELL; ARTICLE; CELL ACTIVITY; CELL FATE; DISSOCIATION; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; NEGATIVE FEEDBACK; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; QUALITATIVE ANALYSIS; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STATISTICS;

ANTIGEN-PRESENTING CELLS; ANTIGENIC VARIATION; HUMANS; MODELS, IMMUNOLOGICAL; MODELS, STATISTICAL; PROTEIN BINDING; RECEPTOR CROSS-TALK; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 49049088099     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2008.05.001     Document Type: Article

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