-
1
-
-
0026540751
-
Multichain immune recognition receptors: Similarities in structure and signaling pathways
-
Keegan, A. D. & Paul, W. E. Multichain immune recognition receptors: similarities in structure and signaling pathways. Immunol. Today 13, 63-68 (1992).
-
(1992)
Immunol. Today
, vol.13
, pp. 63-68
-
-
Keegan, A.D.1
Paul, W.E.2
-
2
-
-
0024980981
-
Antigen receptor tail clue
-
Reth, M. Antigen receptor tail clue. Nature 338, 383-334 (1989).
-
(1989)
Nature
, vol.338
, pp. 383-334
-
-
Reth, M.1
-
3
-
-
0029082078
-
Antigen and Fc receptor signaling: The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM)
-
Cambier, J. C. Antigen and Fc receptor signaling: the awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J. Immunol. 155, 3281-3285 (1995).
-
(1995)
J. Immunol.
, vol.155
, pp. 3281-3285
-
-
Cambier, J.C.1
-
4
-
-
0030929805
-
Fc receptor biology
-
Daeron, M. Fc receptor biology. Annu. Rev. Immunol. 15, 203-234 (1997).
-
(1997)
Annu. Rev. Immunol.
, vol.15
, pp. 203-234
-
-
Daeron, M.1
-
5
-
-
0032192469
-
Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands
-
Boniface, J. J. et al. Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands. Immunity 9, 459-466 (1998).
-
(1998)
Immunity
, vol.9
, pp. 459-466
-
-
Boniface, J.J.1
-
6
-
-
0033710093
-
The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers
-
Cochran, J., Cameron, T. & Stern, L. The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers. Immunity 12, 241-250 (2000).
-
(2000)
Immunity
, vol.12
, pp. 241-250
-
-
Cochran, J.1
Cameron, T.2
Stern, L.3
-
7
-
-
0026675654
-
Transmembrane signaling: The joy of aggregation
-
Metzger, H. Transmembrane signaling: the joy of aggregation. J. Immunol. 149, 1477-1487 (1992).
-
(1992)
J. Immunol.
, vol.149
, pp. 1477-1487
-
-
Metzger, H.1
-
8
-
-
0019350386
-
The magnitude of signal amplification by ligand-induced receptor clustering
-
Delisi, C. The magnitude of signal amplification by ligand-induced receptor clustering. Nature 289, 322-323 (1981).
-
(1981)
Nature
, vol.289
, pp. 322-323
-
-
Delisi, C.1
-
9
-
-
0027399703
-
Functional characterization of a signal transducing motif present in the T cell antigen receptor ζ chain
-
Irving, B. A., Chan, A. C. & Weiss, A. Functional characterization of a signal transducing motif present in the T cell antigen receptor ζ chain. J. Exp. Med. 177, 1093-1103 (1993).
-
(1993)
J. Exp. Med.
, vol.177
, pp. 1093-1103
-
-
Irving, B.A.1
Chan, A.C.2
Weiss, A.3
-
10
-
-
0027328526
-
Tandem SH2 domains of ZAP-70 bind to TCRζ and CD3ε from activated Jurkat T cells
-
Wange, R. L., Malek, S. N., Desidedo, S. & Samelson, L. E. Tandem SH2 domains of ZAP-70 bind to TCRζ and CD3ε from activated Jurkat T cells. J. Biol. Chem. 268, 19797-19801 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 19797-19801
-
-
Wange, R.L.1
Malek, S.N.2
Desidedo, S.3
Samelson, L.E.4
-
11
-
-
0027998631
-
Src homology-2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high-affinity IgE receptor
-
Kihara, H. & Siraganian, R. P. Src homology-2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high-affinity IgE receptor. J. Biol. Chem. 269, 22427-22432 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 22427-22432
-
-
Kihara, H.1
Siraganian, R.P.2
-
12
-
-
0029063151
-
Analysis of the interaction of Zap-70 and Syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance
-
Bu, J.-Y., Shaw, A. S. & Chan, A. C. Analysis of the interaction of Zap-70 and Syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance. Proc. Natl Acad. Sci. USA 92, 5106-5110 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 5106-5110
-
-
Bu, J.-Y.1
Shaw, A.S.2
Chan, A.C.3
-
13
-
-
0344304434
-
The tandem Src homology 2 domain of the Syk kinase: A molecular device that adapts to interphosphotyrosine distances
-
Kumaran, S., Grucza, R. A. & Waksman, G. The tandem Src homology 2 domain of the Syk kinase: a molecular device that adapts to interphosphotyrosine distances. Proc. Natl Acad. Sci. USA 100, 14828-14833 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 14828-14833
-
-
Kumaran, S.1
Grucza, R.A.2
Waksman, G.3
-
14
-
-
0037144842
-
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
-
Bunnell, S. C. et al. T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J. Cell Biol. 158, 1263-1275 (2002).
-
(2002)
J. Cell Biol.
, vol.158
, pp. 1263-1275
-
-
Bunnell, S.C.1
-
15
-
-
0032562995
-
An unusual mechanism for ligand antagonism
-
Torigoe, C., Inman, J. K. & Metzger, H. An unusual mechanism for ligand antagonism. Science 281, 568-572 (1998). Showed that the FcεRI-initiated signalling cascade is subject to kinetic proofreading, and proposed a mechanism for ligand antagonism, in which antagonists bind receptors and sequester the crucial initiating kinase, LYN.
-
(1998)
Science
, vol.281
, pp. 568-572
-
-
Torigoe, C.1
Inman, J.K.2
Metzger, H.3
-
16
-
-
0033199986
-
Cross-antagonism of a T cell clone expressing two distinct T cell receptors
-
Dittel, B. N., Stefanova, I., Germain, R. N. & Janeway, C. A. Cross-antagonism of a T cell clone expressing two distinct T cell receptors. Immunity 11, 289-298 (1999).
-
(1999)
Immunity
, vol.11
, pp. 289-298
-
-
Dittel, B.N.1
Stefanova, I.2
Germain, R.N.3
Janeway, C.A.4
-
17
-
-
0033566824
-
+ T cells with dual antigen specificities
-
+ T cells with dual antigen specificities. J. Immunol. 163, 1750-1754 (1999).
-
(1999)
J. Immunol.
, vol.163
, pp. 1750-1754
-
-
Robertson, J.M.1
Evavold, B.D.2
-
18
-
-
0037338890
-
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
-
Stefanova, I. et al. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nature Immunol. 4, 248-254 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 248-254
-
-
Stefanova, I.1
-
19
-
-
0031573523
-
Exploiting the difference between intrinsic and extrinsic kinases: Implications for regulation of signaling by immunoreceptors
-
Wofsy C., Torigoe, C., Kent, U. M., Metzger, H. & Goldstein, B. Exploiting the difference between intrinsic and extrinsic kinases: implications for regulation of signaling by immunoreceptors. J. Immunol. 159, 5984-5992 (1997).
-
(1997)
J. Immunol.
, vol.159
, pp. 5984-5992
-
-
Wofsy, C.1
Torigoe, C.2
Kent, U.M.3
Metzger, H.4
Goldstein, B.5
-
20
-
-
0034009390
-
Signal transduction: Hanging on a scaffold
-
Burack, W. R. & Shaw, A. S. Signal transduction: hanging on a scaffold. Curr. Opin. Cell Biol. 12, 211-216 (2000).
-
(2000)
Curr. Opin. Cell Biol.
, vol.12
, pp. 211-216
-
-
Burack, W.R.1
Shaw, A.S.2
-
21
-
-
0034705227
-
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties
-
Levchenko, A., Bruck, J. & Sternberg, P. W. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc. Natl Acad. Sci. USA 97, 5818-5823 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 5818-5823
-
-
Levchenko, A.1
Bruck, J.2
Sternberg, P.W.3
-
22
-
-
0037378771
-
Investigation of early events in FcεRI-mediated signaling using a detailed mathematical model
-
Faeder, J. R. et al. Investigation of early events in FcεRI-mediated signaling using a detailed mathematical model. J. Immunol. 170, 3769-3781 (2003). Presented a detailed model of the network of early phosphorylation events that occur during signalling through FcεRI and lead to SYK activation, and used this model to analyse various data on the phosphorylation of the β- and γ-receptor subunit ITAMs.
-
(2003)
J. Immunol.
, vol.170
, pp. 3769-3781
-
-
Faeder, J.R.1
-
23
-
-
0842288229
-
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
-
Markevich, N. I., Hoek, J. B. & Kholodenko, B. N. Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J. Cell Biol. 164, 353-359 (2004).
-
(2004)
J. Cell Biol.
, vol.164
, pp. 353-359
-
-
Markevich, N.I.1
Hoek, J.B.2
Kholodenko, B.N.3
-
24
-
-
0030949124
-
Functional rafts in cell membranes
-
Simons, K. & Ikonen, E. Functional rafts in cell membranes. Nature 387, 569-572 (1997).
-
(1997)
Nature
, vol.387
, pp. 569-572
-
-
Simons, K.1
Ikonen, E.2
-
25
-
-
0035811008
-
Synaptic pattern formation during cellular recognition
-
Qi, S. Y., Groves, J. T. & Chakraborty, A. K. Synaptic pattern formation during cellular recognition. Proc. Natl. Acad. Sci. USA 98, 6548-6553 (2001). Used a spatial-kinetic model of immunological-synapse formation to show that receptor proteins at the synapse have a strong tendency to self-organize in the presence of a stimulating ligand, which might be reinforced by active cellular processes but does not require them.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 6548-6553
-
-
Qi, S.Y.1
Groves, J.T.2
Chakraborty, A.K.3
-
26
-
-
0036789459
-
Differential segregation in a cell-cell contact interface: The dynamics of the immunological synapse
-
Burroughs, N. J. & Wulfing, C. Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse. Biophys. J. 83, 1784-1796 (2002).
-
(2002)
Biophys. J.
, vol.83
, pp. 1784-1796
-
-
Burroughs, N.J.1
Wulfing, C.2
-
27
-
-
0036795530
-
Activated TCRs remain marked for internalization after dissociation from pMHC
-
Coombs, D., Kalergis, A. M., Nathenson, S. G., Wofsy, C. & Goldstein, B. Activated TCRs remain marked for internalization after dissociation from pMHC. Nature Immunol. 3, 926-931 (2002).
-
(2002)
Nature Immunol.
, vol.3
, pp. 926-931
-
-
Coombs, D.1
Kalergis, A.M.2
Nathenson, S.G.3
Wofsy, C.4
Goldstein, B.5
-
28
-
-
0242497659
-
The immunological synapse balances T cell receptor signaling and degradation
-
Lee, K. H. et al. The immunological synapse balances T cell receptor signaling and degradation. Science 302, 1218-1222 (2003). Combined modelling and experimental study of the role of the cSMAC in T-cell activation. Showed that enhanced TCR signalling occurs at the cSMAC initially, but later it becomes the site of rapid TCR degradation and diminution of signalling.
-
(2003)
Science
, vol.302
, pp. 1218-1222
-
-
Lee, K.H.1
-
29
-
-
0029037210
-
Serial triggering of many T-cell receptors by a few peptide-MHC complexes
-
Valitutti, S., Muller, S., Cella, M., Padovan, E. & Lanzavecchia, A. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148-151 (1995). Introduced the idea of serial triggering of TCRs. This paper and reference 31 present data showing that when there are only a few cognate peptide-MHC complexes on an APC, a single peptide-MHC complex can trigger the downregulation of numerous TCRs.
-
(1995)
Nature
, vol.375
, pp. 148-151
-
-
Valitutti, S.1
Muller, S.2
Cella, M.3
Padovan, E.4
Lanzavecchia, A.5
-
30
-
-
0031172162
-
Serial triggering of TCRs: A basis for the sensitivity and specificity of antigen recognition
-
Valitutti, S. & Lanzavecchia, A. Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition. Immunol. Today 18, 299-304 (1997).
-
(1997)
Immunol. Today
, vol.18
, pp. 299-304
-
-
Valitutti, S.1
Lanzavecchia, A.2
-
31
-
-
0033558278
-
Serial TCR engagement and down-modulation by peptide-MHC molecule ligands: Relationship to the quality of individual TCR signaling events
-
Itoh, Y., Hemmer, B., Martin, R. & Germain, R. N. Serial TCR engagement and down-modulation by peptide-MHC molecule ligands: relationship to the quality of individual TCR signaling events. J. Immunol. 162, 2073-2080 (1999).
-
(1999)
J. Immunol.
, vol.162
, pp. 2073-2080
-
-
Itoh, Y.1
Hemmer, B.2
Martin, R.3
Germain, R.N.4
-
32
-
-
0034288890
-
Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism
-
San José, E., Borroto, A., Niedergang, F., Alcover, A. & Alarcon, B. Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism. Immunity 12, 161-170 (2000).
-
(2000)
Immunity
, vol.12
, pp. 161-170
-
-
San José, E.1
Borroto, A.2
Niedergang, F.3
Alcover, A.4
Alarcon, B.5
-
33
-
-
0035146577
-
Calculations show substantial serial engagement of T cell receptors
-
Wofsy, C., Coombs, D. & Goldstein, B. Calculations show substantial serial engagement of T cell receptors. Biophys. J. 80, 606-612 (2001).
-
(2001)
Biophys. J.
, vol.80
, pp. 606-612
-
-
Wofsy, C.1
Coombs, D.2
Goldstein, B.3
-
34
-
-
0036231339
-
Retention of antigen on follicular dendritic cells and B lymphocytes through complement-mediated multivalent ligand-receptor interactions: Theory and application to HIV treatment
-
Hlavacek, W. S., Percus, J. K., Percus, O. E., Perelson, A. S. & Wofsy, C. Retention of antigen on follicular dendritic cells and B lymphocytes through complement-mediated multivalent ligand-receptor interactions: theory and application to HIV treatment. Math. Biosci. 176, 185-202 (2002).
-
(2002)
Math. Biosci.
, vol.176
, pp. 185-202
-
-
Hlavacek, W.S.1
Percus, J.K.2
Percus, O.E.3
Perelson, A.S.4
Wofsy, C.5
-
35
-
-
0029063148
-
Kinetic proofreading in T-cell receptor signal-transduction
-
McKeithan, T. W. Kinetic proofreading in T-cell receptor signal-transduction. Proc. Natl Acad. Sci. USA 92, 5042-5046 (1995). Introduced the idea of kinetic proofreading in the context of receptor signalling and presented a mathematical model of kinetic proofreading to explain how T cells can discriminate between ligands with moderately different dissociation rates.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 5042-5046
-
-
McKeithan, T.W.1
-
37
-
-
0003104975
-
A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists
-
Lyons, D. S. et al. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5, 53-61 (1996).
-
(1996)
Immunity
, vol.5
, pp. 53-61
-
-
Lyons, D.S.1
-
38
-
-
0032438551
-
High- and low-potency ligands with similar affinities for the TCR: The importance of kinetics in TCR signaling
-
Kersh, G. J., Kersh, E. N., Fremont, D. H. & Allen, P. M. High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. Immunity 9, 817-826 (1998).
-
(1998)
Immunity
, vol.9
, pp. 817-826
-
-
Kersh, G.J.1
Kersh, E.N.2
Fremont, D.H.3
Allen, P.M.4
-
39
-
-
0033165928
-
Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are ready identical
-
Ding, Y. H., Baker, B. M., Garboczi, D. N., Biddison, W. E. & Wiley, D. C. Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are ready identical. Immunity 11, 45-56 (1999).
-
(1999)
Immunity
, vol.11
, pp. 45-56
-
-
Ding, Y.H.1
Baker, B.M.2
Garboczi, D.N.3
Biddison, W.E.4
Wiley, D.C.5
-
40
-
-
0037331525
-
Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation
-
Holler, P. D. & Kranz, D. M. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity 18, 255-264 (2003).
-
(2003)
Immunity
, vol.18
, pp. 255-264
-
-
Holler, P.D.1
Kranz, D.M.2
-
41
-
-
0032192366
-
Peptide antagonism and T cell receptor interactions with peptide-MHC complexes
-
Sykulev, Y., Vugmeyster, Y., Brunmark, A., Ploegh, H. L. & Eisen, H. N. Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. Immunity 9, 475-483 (1998).
-
(1998)
Immunity
, vol.9
, pp. 475-483
-
-
Sykulev, Y.1
Vugmeyster, Y.2
Brunmark, A.3
Ploegh, H.L.4
Eisen, H.N.5
-
42
-
-
0030014002
-
T-cell-receptor affinity and thymocyte positive selection
-
Alam, S. M. et al. T-cell-receptor affinity and thymocyte positive selection. Nature 381, 616-620 (1996).
-
(1996)
Nature
, vol.381
, pp. 616-620
-
-
Alam, S.M.1
-
43
-
-
0033711639
-
Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: Implications for TCR signaling
-
Baker, B. M., Gagnon, S. J., Biddison, W. E. & Wiley, D. C. Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling. Immunity 13, 475-484 (2000).
-
(2000)
Immunity
, vol.13
, pp. 475-484
-
-
Baker, B.M.1
Gagnon, S.J.2
Biddison, W.E.3
Wiley, D.C.4
-
44
-
-
0348047600
-
Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation
-
Krogsgaard, M. et al. Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol. Cell 12, 1367-1378 (2003).
-
(2003)
Mol. Cell
, vol.12
, pp. 1367-1378
-
-
Krogsgaard, M.1
-
45
-
-
0032563231
-
Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation
-
Kersh, E. N., Shaw, A. S. & Allen, P. M. Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science 281, 572-575 (1998).
-
(1998)
Science
, vol.281
, pp. 572-575
-
-
Kersh, E.N.1
Shaw, A.S.2
Allen, P.M.3
-
46
-
-
0029926145
-
Kinetic discrimination in T-cell activation
-
Rabinowitz, J. D., Beeson, C., Lyons, D. S., Davis, M. M. & McConnell, H. M. Kinetic discrimination in T-cell activation. Proc. Natl Acad. Sci. USA 93, 1401-1405 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 1401-1405
-
-
Rabinowitz, J.D.1
Beeson, C.2
Lyons, D.S.3
Davis, M.M.4
McConnell, H.M.5
-
47
-
-
0032977676
-
A kinetic differentiation model for the action of altered TCR ligands
-
Lord, G. M., Lechler, R. I. & George, A. J. T. A kinetic differentiation model for the action of altered TCR ligands, Immunol. Today 20, 33-39 (1999).
-
(1999)
Immunol. Today
, vol.20
, pp. 33-39
-
-
Lord, G.M.1
Lechler, R.I.2
George, A.J.T.3
-
48
-
-
0042853581
-
T cell sensitivity and specificity - Kinetic proofreading revisited
-
Chan, C., George, A. J. T. & Stark, J. T cell sensitivity and specificity - kinetic proofreading revisited. Discrete Contin. Dyn. Syst. Ser. B 3, 343-360 (2003).
-
(2003)
Discrete Contin. Dyn. Syst. Ser. B
, vol.3
, pp. 343-360
-
-
Chan, C.1
George, A.J.T.2
Stark, J.3
-
49
-
-
0035826696
-
Cooperative enhancement of specificity in a lattice of T cell receptors
-
Chan, C., George, A. J. T. & Stark, J. Cooperative enhancement of specificity in a lattice of T cell receptors. Proc. Natl Acad. Sci. USA 98, 5758-5763 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 5758-5763
-
-
Chan, C.1
George, A.J.T.2
Stark, J.3
-
50
-
-
0035912716
-
Unexpected signals in a system subject to kinetic proofreading
-
Liu, Z. J., Haleem-Smith, H., Chen, H. X. & Metzger, H. Unexpected signals in a system subject to kinetic proofreading. Proc. Natl Acad. Sci. USA 98, 7289-7294 (2001). Showed that many FcεRI-mediated mast-cell responses follow kinetic proofreading, as described in reference 15, but also found an exception - a rapidly dissociating ligand that activated a late response but failed to activate earlier responses, similar to the findings for T cells in reference 54.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 7289-7294
-
-
Liu, Z.J.1
Haleem-Smith, H.2
Chen, H.X.3
Metzger, H.4
-
51
-
-
0037369685
-
Synthesis and secretion of monocyte chemotactic protein-1 stimulated by the high affinity receptor for IgE
-
Eglite, S., Morin, J. M. & Metzger, H. Synthesis and secretion of monocyte chemotactic protein-1 stimulated by the high affinity receptor for IgE. J. Immunol. 170, 2680-2687 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 2680-2687
-
-
Eglite, S.1
Morin, J.M.2
Metzger, H.3
-
52
-
-
0035912821
-
Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading
-
Hlavacek, W. S., Redondo, A., Metzger, H., Wofsy, C. & Goldstein, B. Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading. Proc. Natl Acad. Sci. USA 98, 7295-7300 (2001). Extended McKeithan's kinetic proofreading model to aggregating receptor systems and to receptor systems in which signalling depends on an external initiating kinase. Considered the kinetics of signalling molecules that are generated by aggregated receptors but do not remain associated with the receptor complex.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 7295-7300
-
-
Hlavacek, W.S.1
Redondo, A.2
Metzger, H.3
Wofsy, C.4
Goldstein, B.5
-
53
-
-
0036739732
-
Kinetic proofreading in receptor-mediated transduction of cellular signals: Receptor aggregation, partially activated receptors, and cytosolic messengers
-
Hlavacek, W. S., Redondo, A., Wofsy, C. & Goldstein, B. Kinetic proofreading in receptor-mediated transduction of cellular signals: receptor aggregation, partially activated receptors, and cytosolic messengers. Bull. Math. Biol. 64, 887-911 (2002).
-
(2002)
Bull. Math. Biol.
, vol.64
, pp. 887-911
-
-
Hlavacek, W.S.1
Redondo, A.2
Wofsy, C.3
Goldstein, B.4
-
54
-
-
0034903068
-
The impact of duration versus extent of TCR occupancy on T cell activation: A revision of the kinetic proofreading model
-
Rosette, C. et al. The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model. Immunity 15, 59-70 (2001). Showed that a low-affinity tetrameric peptide-MHC complex generated a late T-cell response but not early responses. Proposed that T-cell responses are triggered by a cumulative signal.
-
(2001)
Immunity
, vol.15
, pp. 59-70
-
-
Rosette, C.1
-
55
-
-
0042847271
-
Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling
-
Faroudi, M., Zaru, R., Paulet, P., Muller, S. & Valitutti, S. Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling. J. Immunol. 171, 1128-1132 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 1128-1132
-
-
Faroudi, M.1
Zaru, R.2
Paulet, P.3
Muller, S.4
Valitutti, S.5
-
56
-
-
0033058187
-
Kinetics and extent of protein tyrosine kinase activation in individual T cells upon antigenic stimulation
-
Muller, S., Demotz, S., Bulliard, C. & Valitutti, S. Kinetics and extent of protein tyrosine kinase activation in individual T cells upon antigenic stimulation. Immunology 97, 287-293 (1999).
-
(1999)
Immunology
, vol.97
, pp. 287-293
-
-
Muller, S.1
Demotz, S.2
Bulliard, C.3
Valitutti, S.4
-
57
-
-
0037077280
-
Serial triggering of T cell receptors results in incremental accumulation of signaling intermediates
-
Borovsky, Z., Mishan-Eisenberg, G., Yaniv, E. & Rachmilewitz, J. Serial triggering of T cell receptors results in incremental accumulation of signaling intermediates. J. Biol. Chem. 277, 21529-21536 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 21529-21536
-
-
Borovsky, Z.1
Mishan-Eisenberg, G.2
Yaniv, E.3
Rachmilewitz, J.4
-
58
-
-
0036898764
-
A temporal and spatial summation model for T-cell activation: Signal integration and antigen decoding
-
Rachmilewitz, J. & Lanzavecchia, A. A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding. Trends Immunol. 23, 592-595 (2002).
-
(2002)
Trends Immunol.
, vol.23
, pp. 592-595
-
-
Rachmilewitz, J.1
Lanzavecchia, A.2
-
59
-
-
0030176270
-
Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response
-
Sykulev, Y., Joo, M., Vurina, I., Tsomides, T. J. & Eisen, H. N. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity 4, 565-571 (1996).
-
(1996)
Immunity
, vol.4
, pp. 565-571
-
-
Sykulev, Y.1
Joo, M.2
Vurina, I.3
Tsomides, T.J.4
Eisen, H.N.5
-
60
-
-
0037167816
-
Direct observation of ligand recognition by T cells
-
Irvine, D. J., Purbhoo, M. A., Krogsgaard, M. & Davis, M. M. Direct observation of ligand recognition by T cells. Nature 419, 845-849 (2002).
-
(2002)
Nature
, vol.419
, pp. 845-849
-
-
Irvine, D.J.1
Purbhoo, M.A.2
Krogsgaard, M.3
Davis, M.M.4
-
61
-
-
0033534678
-
From TCR engagement to T cell activation: A kinetic view of T cell behavior
-
Lanzavecchia, A., Iezzi, G. & Viola, A. From TCR engagement to T cell activation: a kinetic view of T cell behavior. Cell 96, 1-4 (1999).
-
(1999)
Cell
, vol.96
, pp. 1-4
-
-
Lanzavecchia, A.1
Iezzi, G.2
Viola, A.3
-
62
-
-
0035925931
-
A reliable and safe T cell repertoire based on low-affinity T cell receptors
-
Van Den Berg, H. A., Rand, D. A. & Burroughs, N. J. A reliable and safe T cell repertoire based on low-affinity T cell receptors. J. Theor. Biol. 209, 465-486 (2001).
-
(2001)
J. Theor. Biol.
, vol.209
, pp. 465-486
-
-
Van Den Berg, H.A.1
Rand, D.A.2
Burroughs, N.J.3
-
63
-
-
0035286588
-
Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex
-
Kalergis, A. M. et al. Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nature Immunol. 2, 229-234 (2001). Showed that TCR activation increases to a maximum value and then declines as a function of dwell-time, as predicted by competition between serial engagement and kinetic proofreading.
-
(2001)
Nature Immunol.
, vol.2
, pp. 229-234
-
-
Kalergis, A.M.1
-
64
-
-
0033737310
-
A mathematical analysis of TCR senal triggering and down-regulation
-
Sousa, J. & Carneiro, J. A mathematical analysis of TCR senal triggering and down-regulation. Eur. J. Immunol. 30, 3219-3227 (2000).
-
(2000)
Eur. J. Immunol.
, vol.30
, pp. 3219-3227
-
-
Sousa, J.1
Carneiro, J.2
-
65
-
-
0036034789
-
Modeling the early signaling events mediated by FcεRI
-
Goldstein, B. et al. Modeling the early signaling events mediated by FcεRI. Mol. Immunol. 38, 1213-1219 (2002).
-
(2002)
Mol. Immunol.
, vol.38
, pp. 1213-1219
-
-
Goldstein, B.1
-
66
-
-
0346502078
-
The complexity of complexes in signal transduction
-
Hlavacek, W. S., Faeder, J. R., Blinov, M. L., Perelson, A. S. & Goldstein, B. The complexity of complexes in signal transduction. Biotechnol. Bioeng. 84, 783-794 (2003).
-
(2003)
Biotechnol. Bioeng.
, vol.84
, pp. 783-794
-
-
Hlavacek, W.S.1
Faeder, J.R.2
Blinov, M.L.3
Perelson, A.S.4
Goldstein, B.5
-
67
-
-
0029154906
-
Kinetics of tyrosine phosphorylation when IgE dimers bind to Fcε receptors on rat basophilic leukemia cells
-
Wofsy, C., Kent, U. M., Mao, S. Y., Metzger, H. & Goldstein, B. Kinetics of tyrosine phosphorylation when IgE dimers bind to Fcε receptors on rat basophilic leukemia cells. J. Biol. Chem. 270, 20264-20272 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 20264-20272
-
-
Wofsy, C.1
Kent, U.M.2
Mao, S.Y.3
Metzger, H.4
Goldstein, B.5
-
68
-
-
0031030037
-
Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response
-
Toringoe, C., Goldstein, B., Wofsy, C. & Metzger, H. Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response. Proc. Natl Acad. Sci. USA 94, 1372-1377 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 1372-1377
-
-
Toringoe, C.1
Goldstein, B.2
Wofsy, C.3
Metzger, H.4
-
69
-
-
0033587769
-
One Lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors
-
Wofsy, C., Vonakis, B. M., Metzger, H. & Goldstein, B. One Lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors. Proc. Natl Acad. Sci. USA 96, 8615-8620 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 8615-8620
-
-
Wofsy, C.1
Vonakis, B.M.2
Metzger, H.3
Goldstein, B.4
-
70
-
-
0038827018
-
A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation
-
Young, R. M., Holowka, D. & Baird, B. A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation. J. Biol. Chem. 278, 20746-20752 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20746-20752
-
-
Young, R.M.1
Holowka, D.2
Baird, B.3
-
71
-
-
0031832471
-
Stimulation of the high-affinity 19E receptor results in the tyrosine phosphorylation of a 60 kD protein which is associated with the protein-tyrosine kinase Csk
-
Rafnar, T. et al. Stimulation of the high-affinity 19E receptor results in the tyrosine phosphorylation of a 60 kD protein which is associated with the protein-tyrosine kinase Csk. Mol. Immunol. 35, 249-257 (1998).
-
(1998)
Mol. Immunol.
, vol.35
, pp. 249-257
-
-
Rafnar, T.1
-
72
-
-
0036498594
-
Cutting edge: Transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through the FcεRI
-
Ohtake, H., Ichikawa, N., Okada, M. & Yamashita, T. Cutting edge: Transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through the FcεRI. J. Immunol. 168, 2087-2090 (2002).
-
(2002)
J. Immunol.
, vol.168
, pp. 2087-2090
-
-
Ohtake, H.1
Ichikawa, N.2
Okada, M.3
Yamashita, T.4
-
73
-
-
0242659390
-
Mast cell signal transduction from the high-affinity IgE receptor
-
Siraganian, R. P. Mast cell signal transduction from the high-affinity IgE receptor. Curr. Opin. Immunol. 15, 639-646 (2003).
-
(2003)
Curr. Opin. Immunol.
, vol.15
, pp. 639-646
-
-
Siraganian, R.P.1
-
74
-
-
0030944680
-
Characterization of protein-tyrosine phosphatases that dephosphorylate the high affinity IgE receptor
-
Mao, S. Y. & Metzger, H. Characterization of protein-tyrosine phosphatases that dephosphorylate the high affinity IgE receptor. J. Biol. Chem. 272, 14067-14073 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14067-14073
-
-
Mao, S.Y.1
Metzger, H.2
-
75
-
-
0036774231
-
The synapse assembly model
-
Lee, S. J., Hon, Y., Groves, J. T., Dustin, M. L. & Chakraborty, A. K. The synapse assembly model. Trends Immunol. 23, 500-502 (2002).
-
(2002)
Trends Immunol.
, vol.23
, pp. 500-502
-
-
Lee, S.J.1
Hon, Y.2
Groves, J.T.3
Dustin, M.L.4
Chakraborty, A.K.5
-
76
-
-
1542375362
-
Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs
-
Coombs, D., Dembo, M., Wofsy, C. & Goldstein, B. Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs. Biophys. J. 86, 1408-1423 (2004).
-
(2004)
Biophys. J.
, vol.86
, pp. 1408-1423
-
-
Coombs, D.1
Dembo, M.2
Wofsy, C.3
Goldstein, B.4
-
77
-
-
0142092630
-
In silico models for cellular and molecular immunology: Successes, promises and challenges
-
Chakraborty, A. K., Dustin, M. L. & Shaw, A. S. In silico models for cellular and molecular immunology: successes, promises and challenges. Nature Immunol. 4, 933-936 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 933-936
-
-
Chakraborty, A.K.1
Dustin, M.L.2
Shaw, A.S.3
-
78
-
-
0032483559
-
A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts
-
Dustin, M. L. et al. A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell 94, 667-677 (1998).
-
(1998)
Cell
, vol.94
, pp. 667-677
-
-
Dustin, M.L.1
-
79
-
-
0000359208
-
Kinetic proofreading: A new mechanism for reducing errors in biosynthetic processes requiring high specificity
-
Hopfield, J. J. Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. Proc. Natl Acad. Sci. USA 71, 4135-4139 (1974).
-
(1974)
Proc. Natl Acad. Sci. USA
, vol.71
, pp. 4135-4139
-
-
Hopfield, J.J.1
-
80
-
-
0017030517
-
A general method for numerically simulating the stochastic time evolution of coupled chemical reactions
-
Gillespie, D. T. A general method for numerically simulating the stochastic time evolution of coupled chemical reactions. J. Comp. Phys. 22, 403-434 (1976).
-
(1976)
J. Comp. Phys.
, vol.22
, pp. 403-434
-
-
Gillespie, D.T.1
-
81
-
-
0001144902
-
Efficient exact stochastic simulation of chemical systems with many species and many channels
-
Gibson, M. A. & Bruck, J. Efficient exact stochastic simulation of chemical systems with many species and many channels. J. Phys. Chem. A 104, 1876-1889 (2000).
-
(2000)
J. Phys. Chem. A
, vol.104
, pp. 1876-1889
-
-
Gibson, M.A.1
Bruck, J.2
-
82
-
-
0142219725
-
Quantitative cell biology with the virtual cell
-
Slepchenko, B. M., Schaff, J. C., Macara, I. & Loew, L. M. Quantitative cell biology with the virtual cell. Trends Cell Biol. 13, 570-576 (2003).
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 570-576
-
-
Slepchenko, B.M.1
Schaff, J.C.2
Macara, I.3
Loew, L.M.4
-
83
-
-
0028176193
-
Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-α
-
Pleiman, C. M. et al. Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-α. Proc. Natl Acad. Sci. USA 91, 4268-4272 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 4268-4272
-
-
Pleiman, C.M.1
-
84
-
-
0030849446
-
The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE
-
Vonakis, B. M., Chen, H. X., Haleemsmith, H. & Metzger, H. The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE. J. Biol. Chem. 272, 24072-24080 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24072-24080
-
-
Vonakis, B.M.1
Chen, H.X.2
Haleemsmith, H.3
Metzger, H.4
-
85
-
-
0033604543
-
Signalling through the high-affinity IgE receptor FcεRI
-
Turner, H. & Kinet, J. P. Signalling through the high-affinity IgE receptor FcεRI. Nature 402, B24-B30 (1999).
-
(1999)
Nature
, vol.402
-
-
Turner, H.1
Kinet, J.P.2
-
86
-
-
0030795735
-
Molecular mechanisms in B cell antigen receptor signaling
-
Kurosaki, T. Molecular mechanisms in B cell antigen receptor signaling. Curr. Opin. Immunol. 9, 309-318 (1997).
-
(1997)
Curr. Opin. Immunol.
, vol.9
, pp. 309-318
-
-
Kurosaki, T.1
-
87
-
-
0034093737
-
Signal transduction by the TCR for antigen
-
Kane, L. P., Lin, J. & Weiss, A. Signal transduction by the TCR for antigen. Curr. Opin. Immunol. 12, 242-249 (2000).
-
(2000)
Curr. Opin. Immunol.
, vol.12
, pp. 242-249
-
-
Kane, L.P.1
Lin, J.2
Weiss, A.3
-
88
-
-
0037340388
-
The nature of molecular recognition by T cells
-
Davis, S. J. et al. The nature of molecular recognition by T cells. Nature Immunol. 4, 217-224 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 217-224
-
-
Davis, S.J.1
|