Designing and maintaining the mature TCR repertoire: The continuum of self-peptide:self-MHC complex recognition

Immunity

Volumn 10, Issue 5, 1999, Pages 559-568

  Viret, Christophe ^a   Wong, F Susan ^a   Janeway Jr , Charles A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ARTICLE; CELL SELECTION; CELL SPECIFICITY; CELL SURVIVAL; CONTROLLED STUDY; FETUS; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; THYMUS; TRANSGENIC MOUSE;

EID: 0033136944     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80055-2     Document Type: Article

References (55)

1. Ashton-Rickardt, P.G., Van Kaer, L., Schumacher, T.N.M., Ploegh, H.L., and Tonegawa, S. (1993). Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus. Cell 73, 1041- 1049.
2. Bevan, M.J. (1997). In thymic selection, peptide diversity gives and takes away. Immunity 7, 175-178.
3. Bikoff, E.K., Huang., L.Y., Episkopou, V., van Meerwijk., J., Germain, R.N., and Robertson, E.J. (1993). Defective MHC complex class II assembly, transport, peptide acquisition and CD4+ T cell selection in mice lacking invariant chain expression. J. Exp. Med. 177,1699-1712.
4. Brocker, T. (1997). Survival of mature CD4 T lymphocytes is dependent on MHC class II-expressing dendritic cells. J. Exp. Med. 186, 1223-1232.
5. Bruno, L., Kirberg, J., and von Boehmer, H. (1995). On the cellular basis of immunological T cell memory. Immunity 2, 37-43.
6. Burkly, L., Hession, C., Ogata, L., Reilly, C., Marconi, L.A., Olson, D., Tizard, R., Cate, R., and Lo, D. (1995). Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373, 531-536.
7. Chervonsky, A.V., Medzhitov, R.M., Denzin, L.K., Barlow, A.K., Rudensky, A.Y., and Janeway, C.A., Jr. (1998). Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proc. Natl. Acad. Sci. USA. 95, 10094- 10099.
8. DeKoning, J., DiMolfetto, L., Reilly, C., Wei, Q., Havran, W.L., and Lo, D. (1997). Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice. J. Immunol. 158, 2558-2566.
9. Denzin, L.K., and Cresswell, P. (1995). HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 82, 155-165.
10. Ernst, B., Surh, C.D., and Sprent, J. (1995). Thymic selection and cell division. J. Exp. Med. 182, 961-972.
11. Fung-Leung, W.P., Surh, C.D., Liljedahl, M., Pang, J., Leturcq, D., Peterson, P.A., Webb, S.R., and Karlsson, L. (1996). Antigen presentation and T cell development in H2-M deficient mice. Science 271, 1278-1281.
12. + T cells in mice displaying altered repertoire of MHC class II bound self-peptides. Immunity 7, 197-208.
13. Grusby, M., Johnson, R.S., Papaioannou, V.E., and Glimcher, L.H. (1991). Depletion of CD4+ T cells in major histocompatibility complex class II deficient mice. Science 253, 1417-1420.
14. + T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J. Exp. Med. 177, 1469-1473.
15. Hunt, D.F., Michel, H., Dickinson, T.A., Shabanowitz, J., Cox, A.L., Sakaguchi, K., Apella, E., Greg, H.M., and Sette, A. (1992). Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad. Science 256, 1817-1820.
16. Ignatowicz, L., Kappler, J., and Marrack, P. (1996). The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84, 521-529.
17. Jameson, S.C., Hogquist, K.A., and Bevan, M.J. (1995). Positive selection of thymocytes. Annu. Rev. Immunol. 13, 93-126.
18. Janeway, C.A., Jr., Conrad, P.J., Lerner, E.A., Babich, J., Wettstein, P., and Murphy, D.B. (1984). Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: Possible role of T cell bound Ia antigens as targets of immunoregulatory T cells. J. Immunol. 132, 662-667.
19. Janeway, C.A., Jr., Kupfer, A., Viret, C., Boursalian, T., Goverman, J., Bottomly, K., and Sant'Angelo, D.B. (1998). T cell development, survival and signaling: A new concept of the role of self peptide:self MHC complexes. Immunologist 6, 5-12.
20. Kirberg, J., Berns, A., and von Boehmer, H. (1997). Peripheral T cell survival requires continual ligation of the T cell receptor to MHC-encoded molecules. J. Exp. Med. 186, 1269-1275.
21. Kisielow, P., and von Boehmer, H. (1995). Development and selection of T cells: Facts and puzzles. Adv. Immunol. 58, 87-209.
22. Lam, K.P., Kuhn, R., and Rajewsky, K. (1997). In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90, 1073-1083.
23. Lyons, A.B., and Parish, C.R. (1994). Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171, 131-137.
24. Martin, W.D., Hicks, G.G., Mendiratta, S.K., Leva, H.I., Ruley, E.H., and Van Kaer, L. (1996). H-2M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 84, 543-550.
25. Miyazaki, T., Wolf, P., Tourne, S., Waltzinger, C., Dierich, A., Barois, N., Ploegh, H., Benoist, C., and Mathis, D. (1996). Mice lacking H2-M complexes, enigmatic elements of the MHC class Ii peptide loading pathway. Cell 84, 531-541.
26. Murphy, D.B., Lo, D., Rath, S., Brinster, R.L., Flavell, R.A., Slanetz, A., and Janeway, C.A., Jr. (1989). A novel MHC class II epitope expressed in thymic medulla but not cortex. Nature 338, 765-768.
27. Murphy, D.B., Rath, S., Pizzo, E., Rudensky, A.Y., George, A., Larson, J.K., and Janeway, C.A., Jr. (1992). Monoclonal antibody detection of a major self peptide. MHC class II complex. J. Immunol. 148, 3483-3491.
28. Neuberger, M.S. (1997). Antigen receptor signaling gives lymphocytes a long life. Cell 90, 971-973.
29. Nikolic-Zugic, J., and Bevan, M.J. (1990). Role of self-peptides in positively selecting the T cell receptor repertoire. Nature 344, 65-67.
30. Nossal, G.J.V. (1994). Negative selection of lymphocytes. Cell 76, 229-240.
31. Ozato, K., Mayer, N., and Sachs, D.H. (1980). Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens. J. Immunol. 124, 533-540.
32. Penit, C., and Vasseur, F. (1997). Expansion of mature thymocytes subsets before emigration to the periphery. J. Immunol. 159, 4848-4856.
33. Riberdy, J.M., Newcomb, J.R., Surman, M.J., Barbosa, J.A., and Creswell, P. (1992). HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature 353, 660-662.
34. Robey, E., and Fowlkes, B.J. (1994). Selective events in T cell development. Annu. Rev. Immunol. 12, 675-705.
35. Rocha, B., and von Boehmer, H. (1991). Peripheral selection of the T cell repertoire. Science 251, 1225-1228.
36. Rooke, R., Waltzinger, C., Benoist, C., and Mathis, D. (1997). Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenovirus. Immunity 7, 123-134.
37. Rudensky, A.Y., Rath, S., Preston-Hurlburt, P., Murphy, D.B., and Janeway, C.A., Jr. (1991a). On the complexity of self. Nature 353, 660-662.
38. Rudensky, A.Y., Preston-Hurlburt, P., Hong, S.C., Barlow, A., and Janeway, C.A., Jr. (1991b). Sequence analysis of peptides bound to MHC class II molecules. Nature 353, 622-627.
39. Sant'Angelo, D.B., Waterbury, P.G., Cohen, B.E., Martin, W.D., Van Kaer, L., Hayday, A.C., and Janeway, C.A., Jr. (1997). The imprint of intrathymic self-peptides on the mature T cell receptor repertoire. Immunity 7, 517-524.
40. Sette, A., Ceman, S., Kubo, R.T., Sakaguchi, E., Apella, K., Hunt, D.F., Davis, T.A., Michrel, H., Shabanowitz, J., Rudersdorf, R., et al. (1992). Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant. Science 258, 1801-1804.
41. Sha, W.C., Nelson, C.A., Newberry, R.D., Pullen, J.K., Pease, L.R., Russell, J.H., and Loh, D.Y. (1990). Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding. Proc. Natl. Acad. Sci. USA 87, 6186-6190.
42. Sprent, J., Schaefer, M., Hurd, M., Surh, C.D., and Ron, Y. (1991). Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype. J. Exp. Med. 174, 717-728.
43. Steinman, R.M., Pack, M., and Inaba, K. (1997). Dendritic cells in the T cell areas of lymphoid organs. Immunol. Rev. 156, 25-37.
44. Surh, C.D., Lee, D.S., Fung-Leung, W.P., Karlsson, L., and Sprent, J. (1997). Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells. Immunity 7, 209-219.
45. Takeda, S., Rodewald, H.R., Arakawa, H., Bluethmann, H., and Shimizu, T. (1996). MHC class II molecules are not required for survival of newly generated CD4+ T cells but affect their long-term life span. Immunity 5, 217-228.
46. Tanchot, C., and Rocha, B. (1995). The peripheral T cell repertoire: Independent homeostatic regulation of virgin and activated CD8+ T cell pools. Eur. J. Immunol. 25, 2127-2136.
47. Tanchot, C., and Rocha, B. (1997). Peripheral selection of T cell repertoires: The role of continuous thymus output. J. Exp. Med. 7, 1099-1106.
48. Tanchot, C., Lemonier, F.A., Perarnau, B., Freitas, A.A., and Rocha, B. (1997). Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276, 2057-2062.
49. Tough, D.F., and Sprent, J. (1994). Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179, 1127-1135.
50. o/o mice. Immunity 7, 187-196.
51. Viret, C., and Janeway, C.A., Jr. (1999). MHC and T cell development. Rev. Immunogenet. 1, in press.
52. von Boehmer, H. (1994). Positive selection of lymphocytes. Cell 76, 219-228.
53. von Boehmer, H., and Hafen, K. (1993). The lifespan of naive a/b T cells in secondary lymphoid organs. J. Exp. Med. 177, 891-896.
54. Webb, S.R., Morris, C., and Sprent, J. (1990). Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity. Cell 63, 1249-1256.
55. Zijlstra, M., Bix, M., Simister, N.E., Loring, J.M., Raulet, D.H., and Jaenisch, R. (1990). β2-microglobulin deficient mice lack CD4-CD8+ cytolytic T cells. Nature 344, 742-746.