메뉴 건너뛰기




Volumn 64, Issue , 2013, Pages 71-90

Harnessing the power of the immune system to target cancer

Author keywords

adoptive transfer; immune checkpoint blockade; immunotherapy; T cells; vaccines

Indexed keywords

CANCER VACCINE; CD40 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; DACARBAZINE; IMATINIB; IMIQUIMOD; IMMUNOSTIMULATING AGENT; IPILIMUMAB; NIVOLUMAB; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR AGONIST; VEMURAFENIB;

EID: 84873023311     PISSN: 00664219     EISSN: 1545326X     Source Type: Book Series    
DOI: 10.1146/annurev-med-112311-083918     Document Type: Review
Times cited : (121)

References (105)
  • 1
    • 0023652701 scopus 로고
    • A. Chekhov, M.D., and Coley's toxins
    • Gresser I. 1987. A. Chekhov, M.D., and Coley's toxins. N. Engl. J. Med. 317:457
    • (1987) N. Engl. J. Med. , vol.317 , pp. 457
    • Gresser, I.1
  • 2
    • 0000161413 scopus 로고
    • The treatment of malignant tumors by repeated inoculations of Erysipelas, with a report of ten original cases
    • Coley WB. 1893. The treatment of malignant tumors by repeated inoculations of Erysipelas, with a report of ten original cases. Am. J. Med. Sci. 105:487-511
    • (1893) Am. J. Med. Sci. , vol.105 , pp. 487-511
    • Coley, W.B.1
  • 3
    • 0026004545 scopus 로고
    • A randomized trial of intravesical doxorubicin and immunotherapywith bacille Calmette-Guerin for transitional-cell carcinoma of the bladder
    • Lamm DL, Blumenstein BA, Crawford ED, et al. 1991. A randomized trial of intravesical doxorubicin and immunotherapywith bacille Calmette-Guerin for transitional-cell carcinoma of the bladder. N. Engl. J. Med. 325:1205-9
    • (1991) N. Engl. J. Med. , vol.325 , pp. 1205-1209
    • Lamm, D.L.1    Blumenstein, B.A.2    Crawford, E.D.3
  • 4
    • 0022605668 scopus 로고
    • Cancer immunotherapy using interleukin-2 and interleukin-2-activated lymphocytes
    • Rosenberg SA, Lotze MT. 1986. Cancer immunotherapy using interleukin-2 and interleukin-2-activated lymphocytes. Annu. Rev. Immunol. 4:681-709
    • (1986) Annu. Rev. Immunol. , vol.4 , pp. 681-709
    • Rosenberg, S.A.1    Lotze, M.T.2
  • 5
    • 0028929682 scopus 로고
    • Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
    • Fyfe G, Fisher RI, Rosenberg SA, et al. 1995. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J. Clin. Oncol. 13:688-96
    • (1995) J. Clin. Oncol. , vol.13 , pp. 688-696
    • Fyfe, G.1    Fisher, R.I.2    Rosenberg, S.A.3
  • 6
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
    • Atkins MB, Lotze MT, Dutcher JP, et al. 1999. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J. Clin. Oncol. 17:2105-16
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2105-2116
    • Atkins, M.B.1    Lotze, M.T.2    Dutcher, J.P.3
  • 7
    • 34248326338 scopus 로고    scopus 로고
    • Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
    • Future II Study Group
    • Future II Study Group. 2007. Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions. N. Engl. J. Med. 356:1915-27
    • (2007) N. Engl. J. Med. , vol.356 , pp. 1915-1927
  • 8
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • Rosenberg SA, Yang JC, Restifo NP. 2004. Cancer immunotherapy: moving beyond current vaccines. Nat. Med. 10:909-15
    • (2004) Nat. Med. , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 9
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al. 2010. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N. Engl. J. Med. 363:411-22
    • (2010) N. Engl. J. Med. , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 10
    • 77949895922 scopus 로고    scopus 로고
    • Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
    • Kantoff PW, Schuetz TJ, Blumenstein BA, et al. 2010. Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J. Clin. Oncol. 28:1099-105
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1099-1105
    • Kantoff, P.W.1    Schuetz, T.J.2    Blumenstein, B.A.3
  • 11
    • 79957831345 scopus 로고    scopus 로고
    • Gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma
    • Schwartzentruber DJ, Lawson DH, Richards JM, et al. 2011. gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N. Engl. J. Med. 364:2119-27
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2119-2127
    • Schwartzentruber, D.J.1    Lawson, D.H.2    Richards, J.M.3
  • 12
    • 70350772293 scopus 로고    scopus 로고
    • Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia
    • Kenter GG, WeltersMJ, Valentijn AR, et al. 2009. Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N. Engl. J. Med. 361:1838-47
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1838-1847
    • Kenter, G.G.1    Welters, M.J.2    Valentijn, A.R.3
  • 13
    • 79958264390 scopus 로고    scopus 로고
    • Vaccination with patient-specific tumor-derived antigen in first remission improves disease-free survival in follicular lymphoma
    • Schuster SJ, Neelapu SS, Gause BL, et al. 2011. Vaccination with patient-specific tumor-derived antigen in first remission improves disease-free survival in follicular lymphoma. J. Clin. Oncol. 29:2787-94
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2787-2794
    • Schuster, S.J.1    Neelapu, S.S.2    Gause, B.L.3
  • 14
    • 78049420571 scopus 로고    scopus 로고
    • In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: A phase I/II study
    • Brody JD, Ai WZ, Czerwinski DK, et al. 2010. In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study. J. Clin. Oncol. 28:4324-32
    • (2010) J. Clin. Oncol. , vol.28 , pp. 4324-4332
    • Brody, J.D.1    Ai, W.Z.2    Czerwinski, D.K.3
  • 15
    • 84862907845 scopus 로고    scopus 로고
    • In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: A phase 1/2 study
    • Kim YH, Gratzinger D, Harrison C, et al. 2012. In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study. Blood 119:355-63
    • (2012) Blood , vol.119 , pp. 355-363
    • Kim, Y.H.1    Gratzinger, D.2    Harrison, C.3
  • 16
    • 84862776855 scopus 로고    scopus 로고
    • Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
    • Matsushita H, Vesely MD, Koboldt DC, et al. 2012. Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature 482:400-4
    • (2012) Nature , vol.482 , pp. 400-404
    • Matsushita, H.1    Vesely, M.D.2    Koboldt, D.C.3
  • 17
    • 74549167783 scopus 로고    scopus 로고
    • Regulation of adaptive immunity by the innate immune system
    • Iwasaki A, Medzhitov R. 2010. Regulation of adaptive immunity by the innate immune system. Science 327:291-95
    • (2010) Science , vol.327 , pp. 291-295
    • Iwasaki, A.1    Medzhitov, R.2
  • 18
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. 1998. Dendritic cells and the control of immunity. Nature 392:245-52
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 19
    • 2342473348 scopus 로고    scopus 로고
    • Imiquimod 5%cream for the treatment of superficial basal cell carcinoma: Results from two phase III, randomized, vehicle-controlled studies
    • Geisse J, Caro I, Lindholm J, et al. 2004. Imiquimod 5%cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies. J. Am. Acad. Dermatol. 50:722-33
    • (2004) J. Am. Acad. Dermatol. , vol.50 , pp. 722-733
    • Geisse, J.1    Caro, I.2    Lindholm, J.3
  • 20
    • 18944395052 scopus 로고    scopus 로고
    • Imiquimod 5%cream for the treatment of superficial basal cell carcinoma: Results from a randomized vehicle-controlled phase III study in Europe
    • Schulze HJ, Cribier B, Requena L, et al. 2005. Imiquimod 5%cream for the treatment of superficial basal cell carcinoma: results from a randomized vehicle-controlled phase III study in Europe. Br. J. Dermatol. 152:939-47
    • (2005) Br. J. Dermatol. , vol.152 , pp. 939-947
    • Schulze, H.J.1    Cribier, B.2    Requena, L.3
  • 22
    • 25144522269 scopus 로고    scopus 로고
    • Recurrence rate of superficial basal cell carcinoma following successful treatment with imiquimod 5% cream: Interim 2-year results from an ongoing 5- year follow-up study in Europe
    • Gollnick H, Barona CG, Frank RG, et al. 2005. Recurrence rate of superficial basal cell carcinoma following successful treatment with imiquimod 5% cream: interim 2-year results from an ongoing 5- year follow-up study in Europe. Eur. J. Dermatol. 15:374-81
    • (2005) Eur. J. Dermatol. , vol.15 , pp. 374-381
    • Gollnick, H.1    Barona, C.G.2    Frank, R.G.3
  • 23
    • 38949100471 scopus 로고    scopus 로고
    • An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma
    • Dummer R, Hauschild A, Becker JC, et al. 2008. An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma. Clin. Cancer Res. 14:856-64
    • (2008) Clin. Cancer Res. , vol.14 , pp. 856-864
    • Dummer, R.1    Hauschild, A.2    Becker, J.C.3
  • 24
    • 37249041922 scopus 로고    scopus 로고
    • First in human phase i trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer
    • Dudek AZ, Yunis C, Harrison LI, et al. 2007. First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer. Clin. Cancer Res. 13:7119-25
    • (2007) Clin. Cancer Res. , vol.13 , pp. 7119-7125
    • Dudek, A.Z.1    Yunis, C.2    Harrison, L.I.3
  • 25
    • 34247389227 scopus 로고    scopus 로고
    • Phase II trial of a toll-like receptor 9-activating oligonucleotide in patients with metastatic melanoma
    • PashenkovM, Goess G, Wagner C, et al. 2006. Phase II trial of a toll-like receptor 9-activating oligonucleotide in patients with metastatic melanoma. J. Clin. Oncol. 24:5716-24
    • (2006) J. Clin. Oncol. , vol.24 , pp. 5716-5724
    • Pashenkov, M.1    Goess, G.2    Wagner, C.3
  • 26
    • 70449127697 scopus 로고    scopus 로고
    • Safety and efficacy of PF-3512676 for the treatment of stage IV renal cell carcinoma: An open-label, multicenter phase I/II study
    • Thompson JA, Kuzel T, Drucker BJ, et al. 2009. Safety and efficacy of PF-3512676 for the treatment of stage IV renal cell carcinoma: an open-label, multicenter phase I/II study. Clin. Genitourin. Cancer 7:E58-65
    • (2009) Clin. Genitourin. Cancer , vol.7
    • Thompson, J.A.1    Kuzel, T.2    Drucker, B.J.3
  • 27
    • 55249083982 scopus 로고    scopus 로고
    • Phase 1 evaluation of intralesionally injected TLR9- agonist PF-3512676 in patients with basal cell carcinoma ormetastaticmelanoma
    • Hofmann MA, Kors C, Audring H, et al. 2008. Phase 1 evaluation of intralesionally injected TLR9- agonist PF-3512676 in patients with basal cell carcinoma ormetastaticmelanoma. J. Immunother. 31:520-27
    • (2008) J. Immunother. , vol.31 , pp. 520-527
    • Hofmann, M.A.1    Kors, C.2    Audring, H.3
  • 28
    • 79953050787 scopus 로고    scopus 로고
    • Antitumor activity mediated by CpG: The route of administration is critical
    • Lou Y, Liu C, Lizee G, et al. 2011. Antitumor activity mediated by CpG: the route of administration is critical. J. Immunother. 34:279-88
    • (2011) J. Immunother. , vol.34 , pp. 279-288
    • Lou, Y.1    Liu, C.2    Lizee, G.3
  • 29
    • 0025856680 scopus 로고
    • Phase i trial of intravenously administered endotoxin (Salmonella abortus equi) in cancer patients
    • Engelhardt R, Mackensen A, Galanos C. 1991. Phase I trial of intravenously administered endotoxin (Salmonella abortus equi) in cancer patients. Cancer Res. 51:2524-30
    • (1991) Cancer Res. , vol.51 , pp. 2524-2530
    • Engelhardt, R.1    MacKensen, A.2    Galanos, C.3
  • 30
    • 0029455909 scopus 로고
    • Endotoxin (Salmonella abortus equi) in cancer patients. Clinical and immunological findings
    • Engelhardt R, Otto F, Mackensen A, et al. 1995. Endotoxin (Salmonella abortus equi) in cancer patients. Clinical and immunological findings. Prog. Clin. Biol. Res. 392:253-61
    • (1995) Prog. Clin. Biol. Res. , vol.392 , pp. 253-261
    • Engelhardt, R.1    Otto, F.2    MacKensen, A.3
  • 31
    • 0347414952 scopus 로고
    • Poly I:C immunotherapy in patients with papillomas or superficial carcinomas of the bladder
    • Herr HW, Kemeny N, Yagoda A, et al. 1978. Poly I:C immunotherapy in patients with papillomas or superficial carcinomas of the bladder. Natl. Cancer Inst. Monogr. 325.
    • (1978) Natl. Cancer Inst. Monogr. , vol.325
    • Herr, H.W.1    Kemeny, N.2    Yagoda, A.3
  • 32
    • 0018426924 scopus 로고
    • Initial clinical trials in cancer patients of polyriboinosinicpolyribocytidylic acid stabilized with poly-L-lysine, in carboxymethylcellulose [poly(ICLC)], a highly effective interferon inducer
    • Levine AS, Sivulich M, Wiernik PH, et al. 1979. Initial clinical trials in cancer patients of polyriboinosinicpolyribocytidylic acid stabilized with poly-L-lysine, in carboxymethylcellulose [poly(ICLC)], a highly effective interferon inducer. Cancer Res. 39:1645-50
    • (1979) Cancer Res. , vol.39 , pp. 1645-1650
    • Levine, A.S.1    Sivulich, M.2    Wiernik, P.H.3
  • 33
    • 0019675765 scopus 로고
    • Antitumor effects of interferon and poly ICLC, and their possible utility as anti-neoplastic agents in man
    • Levy HB, Levine AS. 1981. Antitumor effects of interferon and poly ICLC, and their possible utility as anti-neoplastic agents in man. Tex. Rep. Biol. Med. 41:653-62
    • (1981) Tex. Rep. Biol. Med. , vol.41 , pp. 653-662
    • Levy, H.B.1    Levine, A.S.2
  • 34
    • 57349097681 scopus 로고    scopus 로고
    • A North American brain tumor consortium phase II study of poly-ICLC for adult patients with recurrent anaplastic gliomas
    • Butowski N, Lamborn KR, Lee BL, et al. 2009. A North American brain tumor consortium phase II study of poly-ICLC for adult patients with recurrent anaplastic gliomas. J. Neurooncol. 91:183-89
    • (2009) J. Neurooncol. , vol.91 , pp. 183-189
    • Butowski, N.1    Lamborn, K.R.2    Lee, B.L.3
  • 35
    • 57349153494 scopus 로고    scopus 로고
    • A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: A North American Brain Tumor Consortium (NABTC01-05)
    • Butowski N, Chang SM, Junck L, et al. 2009. A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: a North American Brain Tumor Consortium (NABTC01-05). J. Neurooncol. 91:175-82
    • (2009) J. Neurooncol. , vol.91 , pp. 175-182
    • Butowski, N.1    Chang, S.M.2    Junck, L.3
  • 36
    • 14644390867 scopus 로고    scopus 로고
    • Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909
    • Speiser DE, Lienard D, Rufer N, et al. 2005. Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J. Clin. Invest. 115:739-46
    • (2005) J. Clin. Invest. , vol.115 , pp. 739-746
    • Speiser, D.E.1    Lienard, D.2    Rufer, N.3
  • 37
    • 5444251632 scopus 로고    scopus 로고
    • The impact of imiquimod, a Toll-like receptor-7 ligand (TLR7L), on the immunogenicity of melanoma peptide vaccination with adjuvant Flt3 ligand
    • Shackleton M, Davis ID, Hopkins W, et al. 2004. The impact of imiquimod, a Toll-like receptor-7 ligand (TLR7L), on the immunogenicity of melanoma peptide vaccination with adjuvant Flt3 ligand. Cancer Immun. 4:9
    • (2004) Cancer Immun. , vol.4 , pp. 9
    • Shackleton, M.1    Davis, I.D.2    Hopkins, W.3
  • 38
    • 79951849234 scopus 로고    scopus 로고
    • Efficient in vivo priming by vaccination with recombinant NY-ESO-1 protein and CpG in antigen naive prostate cancer patients
    • Karbach J, Neumann A, Atmaca A, et al. 2011. Efficient in vivo priming by vaccination with recombinant NY-ESO-1 protein and CpG in antigen naive prostate cancer patients. Clin. Cancer Res. 17:861-70
    • (2011) Clin. Cancer Res. , vol.17 , pp. 861-870
    • Karbach, J.1    Neumann, A.2    Atmaca, A.3
  • 39
    • 47949129948 scopus 로고    scopus 로고
    • Immunization of malignant melanoma patients with fulllength NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant
    • Adams S, O'Neill DW, Nonaka D, et al. 2008. Immunization of malignant melanoma patients with fulllength NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant. J. Immunol. 181:776-84
    • (2008) J. Immunol. , vol.181 , pp. 776-784
    • Adams, S.1    O'Neill, D.W.2    Nonaka, D.3
  • 40
    • 79952711945 scopus 로고    scopus 로고
    • Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy
    • Prins RM, Soto H, Konkankit V, et al. 2011. Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy. Clin. Cancer Res. 17:1603-15
    • (2011) Clin. Cancer Res. , vol.17 , pp. 1603-1615
    • Prins, R.M.1    Soto, H.2    Konkankit, V.3
  • 41
    • 79957904174 scopus 로고    scopus 로고
    • Therapeutic vaccination with an autologousmRNA electroporated dendritic cell vaccine in patients with advanced melanoma
    • Wilgenhof S, Van Nuffel AM, Corthals J, et al. 2011. Therapeutic vaccination with an autologousmRNA electroporated dendritic cell vaccine in patients with advanced melanoma. J. Immunother. 34:448-56
    • (2011) J. Immunother. , vol.34 , pp. 448-456
    • Wilgenhof, S.1    Van Nuffel, A.M.2    Corthals, J.3
  • 42
    • 84155163266 scopus 로고    scopus 로고
    • A novel dendritic cell-based immunization approach for the induction of durable Th1-polarized anti-HER-2/neu responses in women with early breast cancer
    • Koski GK, Koldovsky U, Xu S, et al. 2012. A novel dendritic cell-based immunization approach for the induction of durable Th1-polarized anti-HER-2/neu responses in women with early breast cancer. J. Immunother. 35:54-65
    • (2012) J. Immunother. , vol.35 , pp. 54-65
    • Koski, G.K.1    Koldovsky, U.2    Xu, S.3
  • 43
    • 36849005123 scopus 로고    scopus 로고
    • Phase i study of tumorAg-loaded IL-12 secreting semi-mature DC for the treatment of pediatric cancer
    • DohnalAM, Witt V, HugelH, et al. 2007. Phase I study of tumorAg-loaded IL-12 secreting semi-mature DC for the treatment of pediatric cancer. Cytotherapy 9:755-70
    • (2007) Cytotherapy , vol.9 , pp. 755-770
    • Dohnal, A.M.1    Witt, V.2    Hugel, H.3
  • 44
    • 33947223664 scopus 로고    scopus 로고
    • Prospect of targeting the CD40 pathway for cancer therapy
    • Vonderheide RH. 2007. Prospect of targeting the CD40 pathway for cancer therapy. Clin. Cancer Res. 13:1083-88
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1083-1088
    • Vonderheide, R.H.1
  • 45
    • 70349334508 scopus 로고    scopus 로고
    • Phase i study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma
    • Advani R, Forero-Torres A, Furman RR, et al. 2009. Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. J. Clin. Oncol. 27:4371-77
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4371-4377
    • Advani, R.1    Forero-Torres, A.2    Furman, R.R.3
  • 46
    • 33947506186 scopus 로고    scopus 로고
    • Clinical activity and immune modulation in cancer patients treated with CP-870, 893, a novel CD40 agonist monoclonal antibody
    • Vonderheide RH, Flaherty KT, Khalil M, et al. 2007. Clinical activity and immune modulation in cancer patients treated with CP-870, 893, a novel CD40 agonist monoclonal antibody. J. Clin. Oncol. 25:876-83
    • (2007) J. Clin. Oncol. , vol.25 , pp. 876-883
    • Vonderheide, R.H.1    Flaherty, K.T.2    Khalil, M.3
  • 47
    • 33750326077 scopus 로고    scopus 로고
    • Intralymphatic dendritic cell vaccination induces tumor antigenspecific, skin-homing T lymphocytes
    • Grover A, Kim GJ, LizeeG, et al. 2006. Intralymphatic dendritic cell vaccination induces tumor antigenspecific, skin-homing T lymphocytes. Clin. Cancer Res. 12:5801-8
    • (2006) Clin. Cancer Res. , vol.12 , pp. 5801-5808
    • Grover, A.1    Kim, G.J.2    Lizee, G.3
  • 48
    • 77955780508 scopus 로고    scopus 로고
    • Optimizing dendritic cell-based immunotherapy in multiple myeloma: Intranodal injections of idiotype-pulsed CD40 ligand-matured vaccines led to induction of type-1 and cytotoxic T-cell immune responses in patients
    • Yi Q, Szmania S, Freeman J, et al. 2010. Optimizing dendritic cell-based immunotherapy in multiple myeloma: intranodal injections of idiotype-pulsed CD40 ligand-matured vaccines led to induction of type-1 and cytotoxic T-cell immune responses in patients. Br. J. Haematol. 150:554-64
    • (2010) Br. J. Haematol. , vol.150 , pp. 554-564
    • Yi, Q.1    Szmania, S.2    Freeman, J.3
  • 49
    • 78349241798 scopus 로고    scopus 로고
    • A randomized trial of ex vivo CD40L activation of a dendritic cell vaccine in colorectal cancer patients: Tumor-specific immune responses are associated with improved survival
    • Barth RJ Jr, Fisher DA, Wallace PK, et al. 2010. A randomized trial of ex vivo CD40L activation of a dendritic cell vaccine in colorectal cancer patients: tumor-specific immune responses are associated with improved survival. Clin. Cancer Res. 16:5548-56
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5548-5556
    • Barth Jr., R.J.1    Fisher, D.A.2    Wallace, P.K.3
  • 50
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty GL, Chiorean EG, FishmanMP, et al. 2011. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 331:1612-16
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1    Chiorean, E.G.2    Fishman, M.P.3
  • 51
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • Dudley ME, Wunderlich JR, Robbins PF, et al. 2002. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 298:850-54
    • (2002) Science , vol.298 , pp. 850-854
    • Dudley, M.E.1    Wunderlich, J.R.2    Robbins, P.F.3
  • 52
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • Rosenberg SA, Yang JC, Sherry RM, et al. 2011. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin. Cancer Res. 17:4550-57
    • (2011) Clin. Cancer Res. , vol.17 , pp. 4550-4557
    • Rosenberg, S.A.1    Yang, J.C.2    Sherry, R.M.3
  • 53
    • 0037058993 scopus 로고    scopus 로고
    • Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells
    • Yee C, Thompson JA, Byrd D, et al. 2002. Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc. Natl. Acad. Sci. USA 99:16168-73
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16168-16173
    • Yee, C.1    Thompson, J.A.2    Byrd, D.3
  • 54
    • 33750940238 scopus 로고    scopus 로고
    • Phase i study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma
    • Mackensen A, Meidenbauer N, Vogl S, et al. 2006. Phase I study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma. J. Clin. Oncol. 24:5060-69
    • (2006) J. Clin. Oncol. , vol.24 , pp. 5060-5069
    • MacKensen, A.1    Meidenbauer, N.2    Vogl, S.3
  • 55
    • 45549099784 scopus 로고    scopus 로고
    • Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1
    • Hunder NN, Wallen H, Cao J, et al. 2008. Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1. N. Engl. J. Med. 358:2698-703
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2698-2703
    • Hunder, N.N.1    Wallen, H.2    Cao, J.3
  • 56
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • Morgan RA, Dudley ME, Wunderlich JR, et al. 2006. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 314:126-29
    • (2006) Science , vol.314 , pp. 126-129
    • Morgan, R.A.1    Dudley, M.E.2    Wunderlich, J.R.3
  • 57
    • 70149114880 scopus 로고    scopus 로고
    • Gene therapy with human andmouseT-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
    • Johnson LA, Morgan RA, Dudley ME, et al. 2009. Gene therapy with human andmouseT-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood 114:535-46
    • (2009) Blood , vol.114 , pp. 535-546
    • Johnson, L.A.1    Morgan, R.A.2    Dudley, M.E.3
  • 58
    • 70349439277 scopus 로고    scopus 로고
    • Immunotherapy ofmetastaticmelanoma using genetically engineered GD2-specific T cells
    • Yvon E, DelVecchio M, Savoldo B, et al. 2009. Immunotherapy ofmetastaticmelanoma using genetically engineered GD2-specific T cells. Clin. Cancer Res. 15:5852-60
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5852-5860
    • Yvon, E.1    Delvecchio, M.2    Savoldo, B.3
  • 59
    • 77951089216 scopus 로고    scopus 로고
    • A high molecular weight melanoma-associated antigenspecific chimeric antigen receptor redirects lymphocytes to target human melanomas
    • Burns WR, Zhao Y, Frankel TL, et al. 2010. A high molecular weight melanoma-associated antigenspecific chimeric antigen receptor redirects lymphocytes to target human melanomas. Cancer Res. 70:3027-33
    • (2010) Cancer Res. , vol.70 , pp. 3027-3033
    • Burns, W.R.1    Zhao, Y.2    Frankel, T.L.3
  • 60
    • 78650316191 scopus 로고    scopus 로고
    • CD8+ enriched "young" tumor infiltrating lymphocytes can mediate regression of metastatic melanoma
    • Dudley ME, Gross CA, Langhan MM, et al. 2010. CD8+ enriched "young" tumor infiltrating lymphocytes can mediate regression of metastatic melanoma. Clin. Cancer Res. 16:6122-31
    • (2010) Clin. Cancer Res. , vol.16 , pp. 6122-6131
    • Dudley, M.E.1    Gross, C.A.2    Langhan, M.M.3
  • 61
    • 20244366111 scopus 로고    scopus 로고
    • Adoptive cell transfer therapy following nonmyeloablative but lymphodepleting chemotherapy for the treatment of patients with refractorymetastatic melanoma
    • Dudley ME, Wunderlich JR, Yang JC, et al. 2005. Adoptive cell transfer therapy following nonmyeloablative but lymphodepleting chemotherapy for the treatment of patients with refractorymetastatic melanoma. J. Clin. Oncol. 23:2346-57
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2346-2357
    • Dudley, M.E.1    Wunderlich, J.R.2    Yang, J.C.3
  • 62
    • 55949125601 scopus 로고    scopus 로고
    • Adoptive cell therapy for patients withmetastaticmelanoma: Evaluation of intensive myeloablative chemoradiation preparative regimens
    • Dudley ME, Yang JC, Sherry R, et al. 2008. Adoptive cell therapy for patients withmetastaticmelanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J. Clin. Oncol. 26:5233-39
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5233-5239
    • Dudley, M.E.1    Yang, J.C.2    Sherry, R.3
  • 63
    • 77951714425 scopus 로고    scopus 로고
    • Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes inmetastaticmelanoma patients
    • Besser MJ, Shapira-Frommer R, Treves AJ, et al. 2010. Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes inmetastaticmelanoma patients. Clin. Cancer Res. 16:2646-55
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2646-2655
    • Besser, M.J.1    Shapira-Frommer, R.2    Treves, A.J.3
  • 64
    • 84859474960 scopus 로고    scopus 로고
    • Adoptive T-cell therapy for metastatic melanoma: The MD Anderson experience
    • Radvanyi LG, Bernatchez C, Zhang M, et al. 2010. Adoptive T-cell therapy for metastatic melanoma: The MD Anderson experience. J. Immunother. 33:863
    • (2010) J. Immunother. , vol.33 , pp. 863
    • Radvanyi, L.G.1    Bernatchez, C.2    Zhang, M.3
  • 65
    • 79952304769 scopus 로고    scopus 로고
    • Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1
    • Robbins PF, Morgan RA, Feldman SA, et al. 2011. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J. Clin. Oncol. 29:917-24
    • (2011) J. Clin. Oncol. , vol.29 , pp. 917-924
    • Robbins, P.F.1    Morgan, R.A.2    Feldman, S.A.3
  • 66
    • 77952361779 scopus 로고    scopus 로고
    • Anti-GD3 chimeric sFv-CD28/T-cell receptor zeta designer T cells for treatment of metastatic melanoma and other neuroectodermal tumors
    • Lo AS, Ma Q, Liu DL, et al. 2010. Anti-GD3 chimeric sFv-CD28/T-cell receptor zeta designer T cells for treatment of metastatic melanoma and other neuroectodermal tumors. Clin. Cancer Res. 16:2769-80
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2769-2780
    • Lo, A.S.1    Ma, Q.2    Liu, D.L.3
  • 67
    • 80051775476 scopus 로고    scopus 로고
    • Tcells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • Kalos M, Levine BL, Porter DL, et al. 2011.Tcells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci. Transl. Med. 3:95ra73
    • (2011) Sci. Transl. Med. , vol.3
    • Kalos, M.1    Levine, B.L.2    Porter, D.L.3
  • 68
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, et al. 2011. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N. Engl. J. Med. 365:725-33
    • (2011) N. Engl. J. Med. , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3
  • 69
    • 84859471907 scopus 로고    scopus 로고
    • Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes for metastatic melanoma: Current status and future outlook
    • Wu R, Forget MA, Chacon J, et al. 2012. Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes for metastatic melanoma: current status and future outlook. Cancer J. 18:160-75
    • (2012) Cancer J. , vol.18 , pp. 160-175
    • Wu, R.1    Forget, M.A.2    Chacon, J.3
  • 70
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: Harnessing the T cell response
    • Restifo NP, Dudley ME, Rosenberg SA. 2012. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat. Rev. Immunol. 12:269-81
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 71
    • 0029669950 scopus 로고    scopus 로고
    • A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes
    • Robbins PF, El-GamilM, Li YF, et al. 1996. A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes. J. Exp. Med. 183:1185-92
    • (1996) J. Exp. Med. , vol.183 , pp. 1185-1192
    • Robbins, P.F.1    El-Gamil, M.2    Li, Y.F.3
  • 72
    • 25844484607 scopus 로고    scopus 로고
    • Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells
    • Gattinoni L, Finkelstein SE, Klebanoff CA, et al. 2005. Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells. J. Exp. Med. 202:907-12
    • (2005) J. Exp. Med. , vol.202 , pp. 907-912
    • Gattinoni, L.1    Finkelstein, S.E.2    Klebanoff, C.A.3
  • 73
    • 67449092903 scopus 로고    scopus 로고
    • Minimally cultured or selected autologous tumor-infiltrating lymphocytes after a lympho-depleting chemotherapy regimen inmetastaticmelanoma patients
    • Besser MJ, Shapira-Frommer R, Treves AJ, et al. 2009. Minimally cultured or selected autologous tumor-infiltrating lymphocytes after a lympho-depleting chemotherapy regimen inmetastaticmelanoma patients. J. Immunother. 32:415-23
    • (2009) J. Immunother. , vol.32 , pp. 415-423
    • Besser, M.J.1    Shapira-Frommer, R.2    Treves, A.J.3
  • 74
    • 0037829421 scopus 로고    scopus 로고
    • Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients
    • Dudley ME, Wunderlich JR, Shelton TE, et al. 2003. Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients. J. Immunother. 26:332-42
    • (2003) J. Immunother. , vol.26 , pp. 332-342
    • Dudley, M.E.1    Wunderlich, J.R.2    Shelton, T.E.3
  • 75
    • 0036909464 scopus 로고    scopus 로고
    • A cell-based artificial antigen-presenting cell coated with anti-CD3 and CD28 antibodies enables rapid expansion and long-term growth of CD4 T lymphocytes
    • Thomas AK, Maus MV, Shalaby WS, et al. 2002. A cell-based artificial antigen-presenting cell coated with anti-CD3 and CD28 antibodies enables rapid expansion and long-term growth of CD4 T lymphocytes. Clin. Immunol. 105:259-72
    • (2002) Clin. Immunol. , vol.105 , pp. 259-272
    • Thomas, A.K.1    Maus, M.V.2    Shalaby, W.S.3
  • 76
    • 79961133788 scopus 로고    scopus 로고
    • Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes
    • Ye Q, Loisiou M, Levine BL, et al. 2011. Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes. J. Transl. Med. 9:131
    • (2011) J. Transl. Med. , vol.9 , pp. 131
    • Ye, Q.1    Loisiou, M.2    Levine, B.L.3
  • 77
    • 80054875641 scopus 로고    scopus 로고
    • Novel cancer immunotherapy agents with survival benefit: Recent successes and next steps
    • Sharma P, Wagner K, Wolchok JD, et al. 2011. Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. Nat. Rev. Cancer 11:805-12
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 805-812
    • Sharma, P.1    Wagner, K.2    Wolchok, J.D.3
  • 78
    • 66849135251 scopus 로고    scopus 로고
    • Cancer immunotherapy: Co-stimulatory agonists and coinhibitory antagonists
    • Peggs KS, Quezada SA, Allison JP. 2009. Cancer immunotherapy: co-stimulatory agonists and coinhibitory antagonists. Clin. Exp. Immunol. 157:9-19
    • (2009) Clin. Exp. Immunol. , vol.157 , pp. 9-19
    • Peggs, K.S.1    Quezada, S.A.2    Allison, J.P.3
  • 79
    • 75649095238 scopus 로고    scopus 로고
    • CTLA-4 suppresses the pathogenicity of self antigenspecific T cells by cell-intrinsic and cell-extrinsic mechanisms
    • Ise W, Kohyama M, Nutsch KM, et al. 2010. CTLA-4 suppresses the pathogenicity of self antigenspecific T cells by cell-intrinsic and cell-extrinsic mechanisms. Nat. Immunol. 11:129-35
    • (2010) Nat. Immunol. , vol.11 , pp. 129-135
    • Ise, W.1    Kohyama, M.2    Nutsch, K.M.3
  • 80
    • 80051944092 scopus 로고    scopus 로고
    • Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation
    • Wing K, Yamaguchi T, Sakaguchi S. 2011. Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation. Trends Immunol. 32:428-33
    • (2011) Trends Immunol. , vol.32 , pp. 428-433
    • Wing, K.1    Yamaguchi, T.2    Sakaguchi, S.3
  • 81
    • 84864128521 scopus 로고    scopus 로고
    • Cutting edge: CTLA-4 on effector T cells inhibits in trans
    • Corse E, Allison JP. 2012. Cutting edge: CTLA-4 on effector T cells inhibits in trans. J. Immunol. 189(3):1123-27
    • (2012) J. Immunol. , vol.189 , Issue.3 , pp. 1123-1127
    • Corse, E.1    Allison, J.P.2
  • 82
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, KrummelMF, Allison JP. 1996. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271:1734-36
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 83
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. 2010. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363:711-23
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 84
    • 78449243490 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibody therapy: Immune monitoring during clinical development of a novel immunotherapy
    • Callahan MK, Wolchok JD, Allison JP. 2010. Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy. Semin. Oncol. 37:473-84
    • (2010) Semin. Oncol. , vol.37 , pp. 473-484
    • Callahan, M.K.1    Wolchok, J.D.2    Allison, J.P.3
  • 85
    • 75249100054 scopus 로고    scopus 로고
    • Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study
    • Wolchok JD, Neyns B, Linette G, et al. 2010. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol. 11:155-64
    • (2010) Lancet Oncol. , vol.11 , pp. 155-164
    • Wolchok, J.D.1    Neyns, B.2    Linette, G.3
  • 86
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. 2011. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364:2517-26
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 87
  • 88
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • NishimuraH, NoseM, Hiai H, et al. 1999. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11:141-51
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3
  • 89
    • 0035846991 scopus 로고    scopus 로고
    • Autoimmune dilated cardiomyopathy in PD-1 receptordeficient mice
    • NishimuraH, OkazakiT, Tanaka Y, et al. 2001. Autoimmune dilated cardiomyopathy in PD-1 receptordeficient mice. Science 291:319-22
    • (2001) Science , vol.291 , pp. 319-322
    • Nishimura, H.1    Okazaki, T.2    Tanaka, Y.3
  • 90
    • 13844294372 scopus 로고    scopus 로고
    • PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells
    • Iwai Y, Terawaki S, Honjo T. 2005. PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells. Int. Immunol. 17:133-44
    • (2005) Int. Immunol. , vol.17 , pp. 133-144
    • Iwai, Y.1    Terawaki, S.2    Honjo, T.3
  • 91
    • 34247532726 scopus 로고    scopus 로고
    • Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
    • Nomi T, Sho M, Akahori T, et al. 2007. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin. Cancer Res. 13:2151-57
    • (2007) Clin. Cancer Res. , vol.13 , pp. 2151-2157
    • Nomi, T.1    Sho, M.2    Akahori, T.3
  • 92
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai Y, Ishida M, Tanaka Y, et al. 2002. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci. USA 99:12293-97
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3
  • 93
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer JR, Drake CG, Wollner I, et al. 2010. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28:3167-75
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 94
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. 2012. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366:2443-54
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 95
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al. 2012. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366:2455-65
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 96
    • 54449091476 scopus 로고    scopus 로고
    • CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients
    • Liakou CI, Kamat A, Tang DN, et al. 2008. CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc. Natl. Acad. Sci. USA 105:14987-92
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 14987-14992
    • Liakou, C.I.1    Kamat, A.2    Tang, D.N.3
  • 97
    • 77952337834 scopus 로고    scopus 로고
    • Preoperative CTLA-4 blockade: Tolerability and immune monitoring in the setting of a presurgical clinical trial
    • Carthon BC, Wolchok JD, Yuan J, et al. 2010. Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial. Clin. Cancer Res. 16:2861-71
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2861-2871
    • Carthon, B.C.1    Wolchok, J.D.2    Yuan, J.3
  • 98
    • 84863116743 scopus 로고    scopus 로고
    • Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
    • Sosman JA, Kim KB, Schuchter L, et al. 2012. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N. Engl. J. Med. 366:707-14
    • (2012) N. Engl. J. Med. , vol.366 , pp. 707-714
    • Sosman, J.A.1    Kim, K.B.2    Schuchter, L.3
  • 99
    • 84859807701 scopus 로고    scopus 로고
    • BRAF(V600) inhibitor GSK2118436 targeted inhibition of mutant BRAF in cancer patients does not impair overall immune competency
    • Hong DS, Vence L, Falchook G, et al. 2012. BRAF(V600) inhibitor GSK2118436 targeted inhibition of mutant BRAF in cancer patients does not impair overall immune competency.Clin. Cancer Res. 18:2326-35
    • (2012) Clin. Cancer Res. , vol.18 , pp. 2326-2335
    • Hong, D.S.1    Vence, L.2    Falchook, G.3
  • 100
    • 84863393623 scopus 로고    scopus 로고
    • Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma
    • Wilmott JS, Long GV, Howle JR, et al. 2012. Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma. Clin. Cancer Res. 18:1386-94
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1386-1394
    • Wilmott, J.S.1    Long, G.V.2    Howle, J.R.3
  • 101
    • 3843119865 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo
    • Dietz AB, Souan L, Knutson GJ, et al. 2004. Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo. Blood 104:1094-99
    • (2004) Blood , vol.104 , pp. 1094-1099
    • Dietz, A.B.1    Souan, L.2    Knutson, G.J.3
  • 102
    • 84866918738 scopus 로고    scopus 로고
    • Oncogenic BRAF(V600E) promotes stromal cellmediated immunosuppression via induction of interleukin-1 in melanoma
    • Khalili JS, Liu S, Rodríguez-Cruz TG, et al. 2012. Oncogenic BRAF(V600E) promotes stromal cellmediated immunosuppression via induction of interleukin-1 in melanoma. Clin. Cancer Res. 18:5329-40
    • (2012) Clin. Cancer Res. , vol.18 , pp. 5329-5340
    • Khalili, J.S.1    Liu, S.2    Rodríguez-Cruz, T.G.3
  • 103
    • 33745859743 scopus 로고    scopus 로고
    • The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells
    • Sumimoto H, Imabayashi F, Iwata T, et al. 2006. The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J. Exp. Med. 203:1651-56
    • (2006) J. Exp. Med. , vol.203 , pp. 1651-1656
    • Sumimoto, H.1    Imabayashi, F.2    Iwata, T.3
  • 104
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • Phan GQ, Yang JC, Sherry RM, et al. 2003. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc. Natl. Acad. Sci. USA 100:8372-77
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8372-8377
    • Phan, G.Q.1    Yang, J.C.2    Sherry, R.M.3
  • 105
    • 58049202334 scopus 로고    scopus 로고
    • Phase I/II study of ipilimumab for patients with metastatic melanoma
    • Weber JS, O'Day S, Urba W, et al. 2008. Phase I/II study of ipilimumab for patients with metastatic melanoma. J. Clin. Oncol. 26:5950-56
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5950-5956
    • Weber, J.S.1    O'Day, S.2    Urba, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.