Is nanotechnology a boon for oral drug delivery?

Drug Discovery Today

Volumn 19, Issue 10, 2014, Pages 1530-1546

  Agrawal, Udita ^a   Sharma, Rajeev ^a   Gupta, Madhu ^a   Vyas, Suresh P ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; ANTINEOPLASTIC AGENT; BRACHYSPIRA AALBORGI VACCINE; CELECOXIB; COUMARIN; CYCLOSPORIN A; DICLOFENAC; DOCETAXEL; INDOMETACIN; INSULIN; KETOCONAZOLE; MICROSPHERE; NANOCARRIER; NANOPARTICLE; PACLITAXEL; PEPTIDE; POLYMER; PSORALEN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SOLID LIPID NANOPARTICLE; TACROLIMUS; TALINOLOL; TARIQUIDAR; TOCOFERSOLAN; UNCLASSIFIED DRUG; VACCINE; VANCOMYCIN; DRUG CARRIER; MICELLE;

BIOCOMPATIBILITY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; EMULSION; EX VIVO STUDY; GASTROINTESTINAL SYMPTOM; GENE TARGETING; HUMAN; IN VITRO STUDY; MICELLE; MUCOSA INFLAMMATION; NANOTECHNOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; PATIENT COMPLIANCE; REVIEW; TRANSDERMAL DRUG ADMINISTRATION; ULCER; ANIMAL; GENE TRANSFER;

ADMINISTRATION, ORAL; ANIMALS; DRUG CARRIERS; GENE TRANSFER TECHNIQUES; HUMANS; MICELLES; NANOPARTICLES; NANOTECHNOLOGY; POLYMERS;

EID: 84908641920     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2014.04.011     Document Type: Review

References (114)

1. Banker, G.S. and Rhodes, C.T., eds) (2005) Modern Pharmaceutics, Marcel Dekker Inc, New York
2. Cheng, Y. et al. (2008) Dendrimers as drug carriers: applications in different routes of drug administration. J. Pharm. Sci. 97, 123-143
3. Daugherty, A.L. and Mrsny, R.J. (1999) Transcellular uptake mechanisms of the intestinal epithelial barrier. Pharm. Sci. Technol. Today 2, 144-151
4. Shugarts, S. and Benet, L.Z. (2009) The role of transporters in the pharmacokinetics of orally administered drugs. Pharm. Res. 26, 2039-2054
5. Biju, S.S. et al. (2006) Vesicular systems: an overview. Int. J. Pharm. Sci. 68, 141-153
6. Singh, R. et al. (2008) Past, present, and future technologies for oral delivery of herapeutic proteins. J. Pharm. Sci. 97, 2497-2523
7. Farokhzad, O.C. and Langer, R. (2009) Impact of nanotechnology on drug delivery. ACS Nano 3, 16-20
8. Jong, W.H.D. and Borm, P.J. (2008) Drug delivery and nanoparticles: applications and hazards. Int. J. Nanomed. 3, 133-149
9. Ling, G. et al. (2010) Development of novel self-assembled DS-PLGA hybrid nanoparticles for improving oral bioavailability of vincristine sulphate by P-gp inhibition. J. Control. Release 148, 241-248
10. Mishra, N. et al. (2011) Lectin anchored PLGA nanoparticles for oral mucosal immunization against hepatitis B. J. Drug Target. 19, 67-78
11. Jain, S. et al. (2012) Folate-decorated PLGA nano-particles as a rationally designed vehicle for the oral delivery of insulin. Nanomedicine 7, 1311-1337
12. Garinot, M. et al. (2007) PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination. J. Control. Release 120, 195-204
13. Samstein, R.M. et al. (2008) The use of deoxycholic acid to enhance the oral bioavailability of biodegradable nanoparticles. Biomaterials 29, 703-708
14. Varma, M.V.S. and Panchagnula, R. (2005) Enhanced oral paclitaxel absorption with vitamins E-TPGS: effect on solubility and permeability in vitro, in situ and in vivo. Eur. J. Pharm. Sci. 25, 445-453
15. Norris, D.A. et al. (1998) The effect of physical barriers and properties on the oral absorption of particulates. Adv. Drug Deliv. Rev. 34, 135-154
16. Lee, C.M. et al. (2012) Optical imaging to trace near infrared fluorescent zinc oxide nanoparticles following oral exposure. Int. J. Nanomed. 7, 3203-3209
17. Davaran, S. et al. (2008) Preparation and in vitro evaluation of linear and star-branched PLGA nanoparticles for insulin delivery. J. Bioact. Compat. Polym. 23, 115-131
18. Nassar, T. et al. (2009) A novel double coated nanocapsules for intestinal delivery and enhanced oral bioavailability of tacrolimus, a P-gp substrate drug. J. Control. Release 133, 77-84
19. Nassar, T. et al. (2008) A novel nanocapsule based delivery system approach to enhance intestinal transport and absorption of lipophilic P-glycoprotein substrate drugs. Pharm. Res. 25, 2019-2029
20. Bansal, T. et al. (2009) Novel formulation approaches for optimizing delivery of anticancer drugs based on P-glycoprotein modulation. Drug Discov. Today 14, 1067-1074
21. Feng, S. et al. (2009) Poly(lactide)-vitamins E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel. Biomaterials 30, 3297-3306
22. Bogman, K. et al. (2005) P-glycoprotein and surfactants: effect on intestinal talinolol absorption. Clin. Pharmacol. Ther. 77, 24-32
23. Fischer, J. et al. (2002) Concurrent administration of water-soluble vitamins E can increase the oral bioavailability of cyclosporine A in healthy dogs. Vet. Ther. 3, 465-473
24. Prasad, Y.V.R. et al. (2003) Enhanced intestinal absorption of vancomycin with labrasol and D-alphatocopheryl PEG 1000 succinate in rats. Int. J. Pharm. 250, 181-190
25. Lopes, J.C.M. et al. (2010) Nanoparticulate carriers (NPC) for oral pharmaceutics and nutraceutics. Pharmazie 65, 75-82
26. Swarnakar, N.K. et al. (2011) Oral bioavailability, therapeutic efficacy and reactive oxygen species scavenging properties of coenzyme Q10-loaded polymeric nanoparticles. Biomaterials 32, 6860-6874
27. Wu, Z.M. et al. (2012) HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin. Int. J. Pharm. 425, 1-8
28. Hao, S. et al. (2013) Rapid preparation of pH-sensitive polymeric nanoparticle with high loading capacity using electrospray for oral drug delivery. Mat. Sci. Eng. C: Mater. Biol. Appl. 33, 4562-4567
29. Yu, H. et al. (2013) Supersaturated polymeric micelles for oral cyclosporine A delivery. Eur. J. Pharm. Biopharm. 85, 1325-1336
30. Du, W. et al. (2013) Transferrin receptor specific nanocarriers conjugated with functional 7 peptide for oral drug delivery. Biomaterials 34, 794-806
31. McMahon, H.T. and Boucrot, E. (2011) Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Nat. Rev. Mol. Cell Biol. 2, 517-533
32. Gaucher, G. et al. (2010) Polymeric micelles for oral drug delivery. Eur. J. Pharm. Biopharm. 76, 147-158
33. Mathot, F. et al. (2006) Intestinal uptake and biodistribution of novel polymeric micelles after oral administration. J. Control. Release 111, 47-55
34. Sadoqi, M. et al. (2009) Investigation of the micellar properties of the tocopheryl polyethylene glycol succinate surfactants TPGS 400 and TPGS 1000 by steady state fluorometry. J. Colloid. Interface Sci. 333, 585-589
35. Yao, H.J. et al. (2011) The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery. Biomaterials 32, 3285-3302
36. Moa, R. et al. (2011) The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles. Biomaterials 32, 4609-4620
37. Li, N. et al. (2012) The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier. Biomaterials 33, 8881-8892
38. Zohra, F. et al. (2012) Enhanced oral bioavailability of paclitaxel in pluronic/LHR mixed polymeric micelles: preparation, in vitro and in vivo evaluation. Eur. J. Pharm. Sci. 47, 179-189
39. Huang, X. et al. (2012) Micelles/sodium-alginate composite gel beads: a new matrix for oral drug delivery of indomethacin. Carbohyd. Polym. 87, 790-798
40. Ain, Q. et al. (2003) Ginate based oral drug delivery system for tuberculosis: pharmacokinetics and therapeutic effects. J. Antimicrob. Chemother. 51, 931-938
41. Ismailos, G. et al. (1991) Unusual solubility behavior of cyclosporin A in aqueous media. J. Pharm. Pharmacol. 43, 287-289
42. Furtado, S. et al. (2008) Oral delivery of insulin loaded poly(fumaric-co-sebacic) anhydride microspheres. Int. J. Pharm. Sci. 347, 149-155
43. He, P. et al. (2013) Polyester amide: blend microspheres for oral insulin delivery. Int. J. Pharm. 455, 259-266
44. Ke, W. et al. (2008) Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system. J. Pharm. Sci. 97, 2208-2216
45. Kolhatkar, R.B. et al. (2007) Surface acetylation of polyamidoamine (PAMAM) dendrimers decreases cytotoxicity while maintaining membrane permeability. Bioconj. Chem. 18, 2054-2060
46. Najlah, M. et al. (2007) In vitro evaluation of dendrimer prodrugs for oral drug delivery. Int. J. Pharm. Sci. 336, 183-190
47. Najlah, M. et al. (2006) Synthesis, characterization and stability of dendrimer prodrugs. Int. J. Pharm. Sci. 308, 175-182
48. Najlah, M. et al. (2007) Synthesis and assessment of first-generation polyamidoamine dendrimer prodrugs to enhance the cellular permeability of P-gp substrates. Bioconjug. Chem. 18, 937-946
49. Lin, Y. et al. (2011) Polyamidoamine dendrimers as novel potential absorption enhancers for improving the small intestinal absorption of poorly absorbable drugs in rats. J. Control. Release 149, 21-28
50. Yandrapu, S.K. et al. (2013) Development and optimization of thiolated dendrimer as a viable mucoadhesive excipient for the controlled drug delivery: an acyclovir model formulation. Nanomed. Nanotechnol. Biol. Med. 9, 514-522
51. Cohen, S. et al. (2012) Bioreducible poly(amidoamine)s as carriers for intracellular protein delivery to intestinal cells. Biomaterials 33, 614-623
52. Teow, H.M. et al. (2013) Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier. Int. J. Pharm. 441, 701-711
53. Sadekar, S. et al. (2013) Poly(amido amine) dendrimers as absorption enhancers for oral delivery of camptothecin. Int. J. Pharm. 456, 175-185
54. Thiagarajan, G. et al. (2013) Evidence of oral translocation of anionic G6.5 dendrimers in mice. Mol. Pharm. 10, 988-998
55. Thiagarajan, G. et al. (2013) Charge affects the oral toxicity of poly(amidoamine) dendrimers. Eur. J. Pharm. Biopharm. 84, 330-334
56. Roger, E. et al. (2009) Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis. J. Control. Release 140, 174-181
57. Silva, A.C. et al. (2012) Long-term stability, biocompatibility and oral delivery potential of risperidone-loaded solid lipid nanoparticles. Int. J. Pharm. 436, 798-805
58. Zhang, Z. et al. (2013) Solid lipid nanoparticles loading candesartan cilexetil enhance oral bioavailability: in vitro characteristics and absorption mechanism in rats. Nanomed. Nanotech. Bio. Med. 8, 740-747
59. Singh, R. et al. (2013) Past, present, and future technologies for oral delivery of therapeutic proteins. J. Pharm. Sci. 97, 2497-2523
60. Zhang, Z. et al. (2013) A self-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor. J. Control. Release 166, 30-37
61. Müller, R.H. et al. (2006) Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN®) versus drug nanocrystals. Int. J. Pharm. 317, 82-89
62. Abdul, B.M. et al. (2014) Solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of glimepiride: development and antidiabetic activity in albino rabbits. Drug Deliv. http://dx.doi.org/10.3109/10717544.2013.879753
63. Cai, S. et al. (2014) Self-microemulsifying drug-delivery system for improved oral bioavailability of 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol: preparation and evaluation. Int. J. Nanomed. 9, 913-920
64. Duc, H. et al. (2013) Development of phyllanthin-loaded self-microemulsifying drug delivery system for oral bioavailability enhancement. Drug Dev. Ind. Pharm. http://dx.doi.org/10.3109/03639045.2013.858732
65. Sermkaew, N. et al. (2013) Liquid and solid self-microemulsifying drug delivery systems for improving the oral bioavailability of andrographolide from crude extract of Andrographis paniculata. Eur. J. Pharm. Sci. 50, 459-466
66. Sha, X. et al. (2014) Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: preparation and evaluation. Int. J. Nanomed. 7, 705-712
67. David, T. et al. (2001) Innovations in oral gene delivery: challenges and potentials. Drug Discov. Today 6, 92-101
68. Castanotto, D. et al. (2009) The promises and pitfalls of RNA-interference-based therapeutics. Nature 457, 426-433
69. Han, L. et al. (2014) Oral delivery of shRNA and siRNA via multifunctional polymeric nanoparticles for synergistic cancer therapy. Biomaterials 35, 4589-4600
70. He, C. et al. (2013) Multifunctional polymeric nanoparticles for oral delivery of TNF-a siRNA to macrophages. Biomaterials 34, 2843-2854
71. Bowman, K. et al. (2008) Gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles. J. Control. Release 132, 252-259
72. Zhang, J. et al. (2008) Ternary polymeric nanoparticles for oral siRNA delivery. Pharma. Res. 30, 1228-1239
73. Stevanovi, M. et al. (2009) Poly(lactide-co-glycolide)-based micro and nanoparticles for the controlled drug delivery of vitamins. Curr. Nanosci. 5, 1-15
74. Jani, P.U. et al. (1990) Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmacol. 42, 821-826
75. Curtis, J. et al. (2006) Nanotechnology and nanotoxicology: a primer for clinicians. Toxicol. Sci. 25, 245-260
76. Alexander, K. et al. (1998) Polymeric carriers for oral uptake of microparticulates. Adv. Drug Deliv. Rev. 34, 155-170
77. Nam, H.Y. et al. (2009) Cellular uptake mechanism and intracellular fate of hydrophobically modified glycol chitosan nanoparticles. J. Control. Release 135, 259-267
78. Brayden, D.J. et al. (2001) Intestinal Peyer's patch M cells and oral vaccine targeting. Drug Discov. Today 10, 45-57
79. Li, S.D. and Huang, L. (2008) Pharmacokinetics and biodistribution of nanoparticles. Mol. Pharm. 5, 496-504
80. Mittal, G. et al. (2011) Development and evaluation of polymer nanoparticles for oral delivery of estradiol to rat brain in a model of Alzheimer's pathology. J. Control. Release 150, 220-228
81. Lin, Y.H. et al. (2008) Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs. J. Control. Release 132, 141-149
82. Sahana, D.K. et al. (2008) PLGA nanoparticles for oral delivery of hydrophobic drugs: influence of organic solvent on nanoparticle formation and release behavior in vitro and in vivo using estradiol as a model drug. J. Pharm. Sci. 97, 1530-1542
83. Italia, J.L. et al. (2007) PLGA nanoparticles for oral delivery of cyclosporine: nephrotoxicity and pharmacokinetic studies in comparison to Sandimmune Neoral®. J. Control. Release 119, 197-206
84. McClean, S. et al. (1998) Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia. Eur. J. Pharm. Sci. 6, 153-163
85. Mahler, G.J. et al. (2009) Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability. J. Nutr. Biochem. 20, 494-502
86. Gullberg, E. et al. (2000) Expression of specific markers and particle transport in a new human intestinal M-cell model. Biochem. Biophys. Res. Commun. 279, 808-813
87. Kernéis, S. et al. (1997) Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria. Science 277, 949-952
88. Sezgin, Z. et al. (2007) Investigation of pluronic and PEG-PE micelles as carriers of meso-tetraphenyl porphine for oral administration. Int. J. Pharm. 332, 161-167
89. Lee, E.S. et al. (2005) Super pH-sensitive multifunctional polymeric micelle. Nano Lett. 12, 325-329
90. Goodman, K. et al. (2010) Assessing gastrointestinal motility and disintegration profiles of magnetic tablets by a novel magnetic imaging device and gamma scintigraphy. Eur. J. Pharm. Biopharm. 74, 84-92
91. Garnett, M.C. and Kallinteri, P. (2006) Nanomedicines and nanotoxicology: some physiological principles. Occup. Med. 56, 307-311
92. Hagens, W.I. et al. (2007) What do we (need to) know about the kinetic properties of nanoparticles in the body? Regul. Toxicol. Pharmacol. 49, 217-219
93. Dong, Y.C. and Feng, S.S. (2005) Nanoparticles of montmorillonite (MMT)/Poly (D,L-lactide-co-glycolide) (PLGA) for oral delivery of anticancer drugs. Biomaterials 26, 6068-6076
94. Arora, S. et al. (2012) Nanotoxicology and in vitro studies: the need of the hour. Toxicol. App. Pharmacol. 258, 151-165
95. Miller, J. (2003) Beyond biotechnology: FDA regulation of nanomedicine. Columbia Sci. Technol. Rev. 5, 1-29
96. Moghimi, S.M. et al. (2005) Nanomedicine: current status and future prospects. FASEB J. 19, 311-330
97. Lanone, S. and Boczkowski, J. (2006) Biomedical applications and potential health risks of nanomaterials: molecular mechanisms. Curr. Mol. Med. 6, 651-663
98. Yoncheva, K. et al. (2012) Stabilized micelles as delivery vehicles for paclitaxel. Int. J. Pharm. 436, 258-264
99. Ran, M. et al. (2011) The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles. Biomaterials 32, 4609-4620
100. Dahmani, F.Z. et al. (2012) Enhanced oral bioavailability of paclitaxel in pluronic/LHR mixed polymeric micelles: preparation, in vitro and in vivo evaluation. Eur. J. Pharm. Sci. 47, 179-189
101. Bachar, M. et al. (2012) Development and characterization of a novel drug nanocarrier for oral delivery, based on self-assembled b-casein micelles. J. Control. Release 160, 164-171
102. Wenwen, D. et al. (2013) Transferrin receptor specific nanocarriers conjugated with functional 7 peptide for oral drug delivery. Biomaterials 34, 794-806
103. Goldberg, D.S. et al. (2011) G3.5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity. J. Control. Release 150, 318-325
104. Sadekar, S. et al. (2013) Polyamido amine: dendrimers as absorption enhancers for oral delivery of camptothecin. Int. J. Pharm. 456, 175-185
105. Liu, X. et al. (2011) Dendrimer-delivered short hairpin RNA targeting hTERT inhibits oral cancer cell growth in vitro and in vivo. Biochem. Pharmacol. 82, 17-23
106. Jose, S. et al. (2012) Cross-linked chitosan microspheres for oral delivery of insulin: Taguchi design and in vivo testing. Colloid Surf. B: Biointer. 92, 175-179
107. Banerjee, S. et al. (2012) Interpenetrating polymer network (IPN) hydrogel microspheres or oral controlled release application. Int. J. Biomacromol. 50, 198-206
108. Liu, Y. et al. (2011) Preparation and evaluation of glyceryl monooleate-coated hollow-bioadhesive microspheres for gastroretentive drug delivery. Int. J. Pharm. 413, 103-109
109. Zhang, Y. et al. (2011) Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin. Eur. J. Pharm. Biopharm. 77, 11-19
110. Jiang, T. et al. (2014) Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan. Biomaterials 35, 2365-2373
111. Jianfeng, G. et al. (2013) Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: in vitro investigations. Int. J. Pharm. 447, 150-157
112. Duhem, N. et al. (2012) Tocol modified glycol chitosan for the oral delivery of poorly soluble drugs. Int. J. Pharm. 423, 452-460
113. Du, W. et al. (2013) Transferrin receptor specific nanocarriers conjugated with functional 7peptide for oral drug delivery. Biomaterials 34, 794-806
114. Xiang, Y. et al. (2013) Pluronic P85/poly(lactic acid) vesicles as novel carrier for oral insulin delivery. Colloids Surf. B: Biointer. 111, 282-288