Oral delivery of insulin loaded poly(fumaric-co-sebacic) anhydride microspheres

International Journal of Pharmaceutics

Volumn 347, Issue 1-2, 2008, Pages 149-155

  Furtado, Stacia ^a   Abramson, Danielle ^a   Burrill, Roxanne ^a   Olivier, Gloria ^a   Gourd, Celinda ^a   Bubbers, Emily ^a   Mathiowitz, Edith ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Insulin; Microsphere; Oral delivery; Polyanhydride

Indexed keywords

INSULIN ZINC SUSPENSION; MICROSPHERE; POLY(FUMARIC CO SEBACIC)ANHYDRIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; FEMALE; INSULIN DEPENDENT DIABETES MELLITUS; LASER DIFFRACTION; MALE; NANOENCAPSULATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; DECANOIC ACIDS; DIABETES MELLITUS, TYPE 1; DOGS; FEMALE; FUMARATES; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYMERS; RATS; RATS, INBRED BB;

EID: 36549049905     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.06.039     Document Type: Article

References (18)

1. Agarwal V., Reddy I., and Khan M. Polymethyacrylate based microparticulates of insulin for oral delivery: preparation and in vitro dissolution stability in the presence of enzyme inhibitors. Int. J. Pharm. 225 (2001) 31-39
2. Carino G., Jacob J., and Mathiowitz E. Nanosphere based oral insulin delivery. J. Control. Release 65 (2000) 261-269
3. Carr K., Hazzard R., Reid S., and Hodges G. The effect of size on uptake of orally administered latex microparticles in the small intestine and transport to mesenteric lymph nodes. Pharm. Res. 13 (1996) 1205-1209
4. Chickering D., Jacob J., Desai T., Harrison M., Harris W., Morrell C., Chaturvedi P., and Mathiowitz E. Bioadhesive microspheres: III. An in vivo transit and bioavailability study of drug-loaded alginate and poly(fumaric-co-sebacic anhydride) microspheres. J. Control. Release 48 (1997) 35-46
5. Damge C., Maincent P., and Ubrich N. Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J. Control. Release 117 (2007) 163-170
6. Del Prato S. Loss of early insulin secretion leads to postprandial hyperglycemia. Diabetologia 46 (2003) M2-M8
7. Desai M., Labhasetwar V., Amidon G., and Levy R. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res. 13 (1996) 1838-1845
8. Florence A., Hillery A., Hussain N., and Jani P. Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence. J. Drug Target 3 (1995) 65-70
9. Furtado S., Abramson D., Simhkay L., Wobbekind D., and Mathiowitz E. Subcutaneous delivery of insulin loaded poly(fumaric-co-sebacic anhydride) microspheres to type 1 diabetic rats. Eur. J. Pharm. Biopharm. 63 (2006) 229-236
10. Jacobs J.J., and Mathiowitz E.M. In: Svenson S. (Ed). A Novel Mechanism for Spontaneous Encapsulation of Active Agents: Phase Inversion Nanoencapsulation. Carrier-based Drug Delivery (2004), American Chemical Society, Washington, DC 214-223
11. Katsuma M., Watanabe S., Kawai H., Takemura S., and Sako K. Effects of absorption promoters on insulin absorption through colon-targeted delivery. Int. J. Pharm. 307 (2006) 156-162
12. Lee V., and Yamamoto A. Penetration and enzymatic barriers to peptide and protein absorption. Adv. Drug Deliv. Rev. 4 (1989) 171-207
13. Ma E., Ma H., Liu Z., Zheng C., and Duan M. In vitro and in vivo evaluation of a novel oral insulin formulation. Acta Pharmacol. Sin. 10 (2006) 1382-1388
14. Ma Z., Lim T., and Lim L. Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats. Int. J. Pharm. 293 (2005) 271-280
15. Mathiowitz E., Jacob J., Jong Y., Carino G., Chickering D., Chaturvedi P., Santos C., Vijayaraghavan K., Montgomery S., Bassett M., and Morrell C. Biologically erodable microspheres as potential oral drug delivery systems. Nature 386 (1997) 410-414
16. Morishita M., Goto T., Nakamura K., Lowman A., Takayama K., and Peppas N. Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats. J. Control. Release 110 (2006) 587-594
17. Toorisaka E., Hashida M., Kamiya N., Ono H., Kokazu Y., and Goto M. An enteric-coated dry emulsion formulation for oral insulin delivery. J. Control. Release 107 (2005) 91-96
18. Zhang N., Ping Q., Huang G., Xu W., Cheng Y., and Han X. Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin. Int. J. Pharm. 327 (2006) 153-159