Enhanced oral bioavailability of paclitaxel in pluronic/LHR mixed polymeric micelles: Preparation, in vitro and in vivo evaluation

European Journal of Pharmaceutical Sciences

Volumn 47, Issue 1, 2012, Pages 179-189

  Dahmani, Fatima Zohra ^a   Yang, Hui ^a   Zhou, Jianping ^a   Yao, Jing ^a   Zhang, Ting ^a   Zhang, Qiang ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

LHR conjugate; Mixed polymeric micelles; Oral bioavailability; Paclitaxel; Pluronic F127 and P188

Indexed keywords

COPOLYMER; CYTOCHROME P450; GLYCOPROTEIN P; LOW MOLECULAR WEIGHT HEPARIN; PACLITAXEL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; CYTOTOXICITY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MUCOSA PERMEABILITY; MALE; MICELLE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN METABOLISM; RAT; SINGLE DRUG DOSE; SMALL INTESTINE;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BREAST NEOPLASMS; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; INTESTINAL ABSORPTION; INTESTINE, SMALL; MCF-7 CELLS; MICELLES; P-GLYCOPROTEIN; PACLITAXEL; PARTICLE SIZE; POLOXAMER; POLYMERS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84862731507     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.05.015     Document Type: Article

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