Supersaturated polymeric micelles for oral cyclosporine A delivery

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART B, 2013, Pages 1325-1336

  Yu, Hongzhen ^a   Xia, Dengning ^a   Zhu, Quanlei ^a   Zhu, Chunliu ^a   Chen, Dan ^a   Gan, Yong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cellular uptake and transport; Cyclosporine A; Oral bioavailability; Soluplus ; Supersaturated polymeric micelle; Supersaturation degree

Indexed keywords

COUMARIN; COUMARIN 6; CYCLOSPORIN A; CYCLOSPORIN D; POLYMER; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MICELLE; NONHUMAN; RAT; SUPERSATURATED POLYMERIC MICELLE; TIME TO MAXIMUM PLASMA CONCENTRATION;

2-(4-AMIDINOPHENYL)-6-INDOLECARBAMIDINE DIHYDROCHLORIDE; AP; APICAL; AREA UNDER THE BLOOD DRUG CONCENTRATION-TIME CURVE; AUC(0-24H); BASOLATERAL; BL; C(MAX); CELLULAR UPTAKE AND TRANSPORT; COUMARIN-6 REFERENCE SOLUTION; COUMARIN-6-LOADED CREMOPHOR RH40 MICELLES; CR; CS; CSA; CSD; CYCLOSPORINE A; CYCLOSPORINE D; DAPI; EE; ENTRAPMENT EFFICIENCY; HANK'S BALANCED SALT SOLUTION; HBSS; HIGH SOLUPLUS® CONCENTRATION; HPMC-AS; HS; HYDROXYPROPYL METHYLCELLULOSE ACETATE SUCCINATE; LC; LIMIT OF DETECTION; LIMIT OF QUANTIFICATION; LOADING CONTENT; LOD; LOQ; LOW SOLUPLUS® CONCENTRATION; LS; MAXIMAL BLOOD CONCENTRATION OF THE DRUG; ORAL BIOAVAILABILITY; P-GLYCOPROTEIN; P-GP; PCS; PHOTON CORRELATION SPECTROSCOPY; PMS; POLYMERIC MICELLES; RBA; RELATIVE ORAL BIOAVAILABILITY; RH123; RHODAMINE 123; SOLUPLUS®; SUPERSATURATED POLYMERIC MICELLE; SUPERSATURATION DEGREE; T(MAX); TEM; TF; TIME TAKEN TO REACH THE MAXIMUM BLOOD CONCENTRATION; TRANSMISSION ELECTRON MICROSCOPY; TRANSPORT FLUX; VERAP; VERAPAMIL;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CHEMISTRY, PHARMACEUTICAL; COUMARINS; CYCLOSPORINE; DRUG DELIVERY SYSTEMS; FLOW CYTOMETRY; FLUORESCENT DYES; HUMANS; INTESTINAL ABSORPTION; MALE; MICELLES; MICROSCOPY, CONFOCAL; PARTICLE SIZE; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; WATER;

EID: 84889096450     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.08.003     Document Type: Article

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