Development and optimization of thiolated dendrimer as a viable mucoadhesive excipient for the controlled drug delivery: An acyclovir model formulation

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 9, Issue 4, 2013, Pages 514-522

  Yandrapu, Sarath K ^a   Kanujia, Parijat ^b   Chalasani, Kishore B ^c   Mangamoori, Lakshminarasu ^d   Kolapalli, Ramanamurthy V ^a   Chauhan, Abhay ^e  

^a ANDHRA UNIVERSITY   (India)

^b INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^c Merrion Pharmaceuticals   (Ireland)

^d JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^e Department of Pharmaceutical Sciences   (United States)

Author keywords

Acyclovir formulations; Dendrimers; Drug delivery; Muco adhesion; Thiol polymers

Indexed keywords

ACYCLOVIR FORMULATIONS; DRUG LOADING; DRUG-CONJUGATES; MODEL FORMULATION; MUCOADHESION; MUCOADHESIVE CARRIERS; PAMAM DENDRIMER; SUSTAINED RELEASE;

CONTROLLED DRUG DELIVERY; DRUG DELIVERY; DRUG PRODUCTS; LOADING; VIRUSES;

DENDRIMERS;

ACICLOVIR; DENDRIMER; EXCIPIENT; MERCAPTAMINE; POLYAMIDOAMINE; THIOL;

ARTICLE; CONJUGATE; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; IN VITRO STUDY; MUCOADHESION; PROCESS OPTIMIZATION;

ACYCLOVIR; ADHESIVES; ANTIVIRAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DENDRIMERS; DRUG DELIVERY SYSTEMS; EXCIPIENTS; MODELS, CHEMICAL; MUCOUS MEMBRANE; SULFHYDRYL COMPOUNDS;

EID: 84876740494     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2012.10.005     Document Type: Article

References (35)

1. Haas J., Lehr C.M. Developments in the area of bioadhesive drug delivery systems. Expert Opin Biol Ther 2002, 2(3):287-298.
2. Akiyama Y., Nagahara N., Nara E., Kitano M., Iwasa S., Yamamoto I., et al. Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites. J Pharm Pharmacol. 1998, 50(2):159-166.
3. Borchard G. Chitosans for gene delivery. Adv Drug Deliv Rev. 2001, 52(2):145-150.
4. Ayensu I., Mitchell J.C., Boateng J.S. Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa. Colloids Surf B Biointerfaces 2012, 91:258-265.
5. Bernkop-Schnurch A., Kast C.E., Richter M.F. Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine. J Control Release 2001, 71(3):277-285.
6. Paliwal R., Paliwal S.R., Agrawal G.P., Vyas S.P. Chitosan nanoconstructs for improved oral delivery of low molecular weight heparin: In vitro and in vivo evaluation. Int J Pharm. 2012, 422(1-2):179-184.
7. Bernkop-Schnurch A., Walker G. Multifunctional matrices for oral peptide delivery. Crit Rev Ther Drug Carrier Syst 2001, 18(5):459-501.
8. Lehr C.M., Bouwstra J.A., Kok W., De Boer A.G., Tukker J.J., Verhoef J.C., et al. Effects of the mucoadhesive polymer polycarbophil on the intestinal absorption of a peptide drug in the rat. J Pharm Pharmacol 1992, 44(5):402-407.
9. Bernkop-Schnurch A. Thiomers: a new generation of mucoadhesive polymers. Adv Drug Deliv Rev. 2005, 57(11):1569-1582.
10. Makhlof A., Werle M., Tozuka Y., Takeuchi H. Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin. Int J Pharm. 2010, 397(1-2):92-95.
11. Kast C.E., Bernkop-Schnurch A. Thiolated polymers-thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates. Biomaterials. 2001, 22(17):2345-2352.
12. Roldo M., Hornof M., Caliceti P., Bernkop-Schnurch A. Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation. Eur J Pharm Biopharm. 2004, 57(1):115-121.
13. Bilicic M.B., Filipovic-Grcic J., Martinac A., Barbaric M., Zorc B., Cetina-Cizmek B., et al. Synthesis and characterization of thiomers of polyaspartamide type. Int J Pharm 2005, 291(1-2):211-219.
14. Sarti F., Staaf A., Sakloetsakun D., Bernkop-Schnurch A. Thiolated hydroxyethylcellulose: synthesis and in vitro evaluation. Eur J Pharm Biopharm. 2010, 76(3):421-427.
15. Chauhan A.S., Sridevi S., Chalasani K.B., Jain A.K., Jain S.K., Jain N.K., et al. Dendrimer-mediated transdermal delivery: enhanced bioavailability of indomethacin. J Control Release 2003, 90(3):335-343.
16. Svenson S., Chauhan A.S. Dendrimers for enhanced drug solubilization. Nanomedicine (Lond). 2008, 3(5):679-702.
17. Vandamme T.F., Brobeck L. Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide. J Control Release 2005, 102(1):23-38.
18. Yao W.J., Sun K.X., Liu Y., Liang N., Mu H.J., Yao C., et al. Effect of poly(amidoamine) dendrimers on corneal penetration of puerarin. Biol Pharm Bull. 2010, 33(8):1371-1377.
19. Jwala J., Boddu S.H., Shah S., Sirimulla S., Pal D., Mitra A.K. Ocular sustained release nanoparticles containing stereoisomeric dipeptide prodrugs of acyclovir. J Ocul Pharmacol Ther 2011, 27(2):163-172.
20. Law S.L., Huang K.J., Chiang C.H. Acyclovir-containing liposomes for potential ocular delivery. Corneal penetration and absorption. J Control Release. 2000, 63(1-2):135-140.
21. Giannavola C., Bucolo C., Maltese A., Paolino D., Vandelli M.A., Puglisi G., et al. Influence of preparation conditions on acyclovir-loaded poly-d, l-lactic acid nanospheres and effect of PEG coating on ocular drug bioavailability. Pharm Res. 2003, 20(4):584-590.
22. Wisher A.C., Bronstein I., Chechik V. Thiolated PAMAM dendrimer-coated CdSe/ZnSe nanoparticles as protein transfection agents. Chem Commun (Camb). 2006, 21(15):1637-1639.
23. Algarra M., Campos B.B., Alonso B., Miranda M.S., Martinez A.M., Casado C.M., et al. Thiolated DAB dendrimers and CdSe quantum dots nanocomposites for Cd(II) or Pb(II) sensing. Talanta. 2012, 88:403-407.
24. Chechik V.C. R.M. Monolayers of Thiol-Terminated Dendrimers on the Surface of Planar and Colloidal Gold. Langmuir. 1999, 15(19):6364-6369.
25. Day B.S., Fiegland L.R., Vint E.S., Shen W., Morris J.R., Norton M.L. Thiolated dendrimers as multi-point binding headgroups for DNA immobilization on gold. Langmuir. 2011, 27(20):12434-12442.
26. Kast C.E., Bernkop-Schnurch A. Polymer-cysteamine conjugates: new mucoadhesive excipients for drug delivery?. Int J Pharm. 2002, 234(1-2):91-99.
27. Ellman G. A colorometric method for determining low concentrations of mercaptians. ArchBiochemBiophys 1958, 74(2):443-450.
28. Habeeb A.F. A sensitive method for localization of disulfide containing peptides in column effluents. Anal Biochem. 1973, 56(1):60-65.
29. Fresta M., Panico A.M., Bucolo C., Giannavola C., Puglisi G. Characterization and in-vivo ocular absorption of liposome-encapsulated acyclovir. J Pharm Pharmacol. 1999, 51(5):565-576.
30. Ranga Rao K, Buri, P. A novel in situ method to test polymers and coated microparticles for bioadhesion International Journal of Pharmaceutics. 1989;52(3):265-70.
31. Iqbal J., Shahnaz G., Dunnhaupt S., Muller C., Hintzen F., Bernkop-Schnurch A. Preactivated thiomers as mucoadhesive polymers for drug delivery. Biomaterials. 2012, 33(5):1528-1535.
32. Bernkop-Schnurch A., Hornof M., Zoidl T. Thiolated polymers-thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates. Int J Pharm. 2003, 260(2):229-237.
33. Neerman M.F., Zhang W., Parrish A.R., Simanek E.E. In vitro and in vivo evaluation of a melamine dendrimer as a vehicle for drug delivery. Int J Pharm. 2004, 281(1-2):129-132.
34. Fischer D., Li Y., Ahlemeyer B., Krieglstein J., Kissel T. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials. 2003, 24(7):1121-1131.
35. Marano R.J., Toth I., Wimmer N., Brankov M., Rakoczy P.E. Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: a long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity. Gene Ther. 2005, 12(21):1544-1550.