Cross-linked chitosan microspheres for oral delivery of insulin: Taguchi design and in vivo testing

Colloids and Surfaces B: Biointerfaces

Volumn 92, Issue , 2012, Pages 175-179

  Jose, S ^a   Fangueiro, J F ^b   Smitha, J ^a   Cinu, T A ^a   Chacko, A J ^a   Premaletha, K ^c   Souto, E B ^b,d  

^a MAHATMA GANDHI UNIVERSITY   (India)

^b UNIVERSIDADE FERNANDO PESSOA   (Portugal)

^c Academy of Pharmaceutical Sciences   (India)

^d UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

Author keywords

Chitosan; Cross linking; Factorial design; Insulin; Microspheres; Taguchi design

Indexed keywords

BLOOD GLUCOSE LEVEL; CHITOSAN MICROSPHERES; CROSS LINKED CHITOSAN; CROSSLINKER; DEPENDENT VARIABLES; ENCAPSULATION EFFICIENCY; FACTORIAL DESIGN; GLUTARALDEHYDES; IN-VIVO; INSULIN INJECTIONS; INSULIN THERAPY; MEAN PARTICLE SIZE; OPTIMAL FORMULATION; ORAL DELIVERY; ORTHOGONAL METHOD; PRODUCTION TIME; PROTEIN RELEASE; TAGUCHI; TAGUCHI DESIGN;

ALDEHYDES; CHITOSAN; DESIGN; EMULSIFICATION; ENCAPSULATION; GLUCOSE; MICROSPHERES; OPTIMIZATION;

INSULIN;

CHITOSAN; GLUCOSE; GLUTARALDEHYDE; HUMAN INSULIN; MICROSPHERE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; CROSS LINKING TIME; DIABETES MELLITUS; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DOSAGE FORM COMPARISON; ENCAPSULATION; FACTORIAL DESIGN; GLUCOSE BLOOD LEVEL; IN VIVO STUDY; MALE; MICROSPHERE SIZE; NONHUMAN; ORAL DRUG DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN SECRETION; RAT; TAGUCHI DESIGN; TIME; VISCOSITY; WEIGHT, MASS AND SIZE;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; CROSS-LINKING REAGENTS; HUMANS; INJECTIONS, SUBCUTANEOUS; INSULIN; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; RATS; RATS, WISTAR; TIME FACTORS;

RATTUS;

EID: 84856117022     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2011.11.040     Document Type: Article

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