Self-microemulsifying drug-delivery system for improved oral bioavailability of 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol: Preparation and evaluation

International Journal of Nanomedicine

Volumn 9, Issue 1, 2014, Pages 913-920

  Cai, Shuang ^a   Shi, Cai Hong ^b   Zhang, Xiangrong ^b   Tang, Xiaojiao ^b   Suo, Hao ^b   Yang, Li ^b   Zhao, Yuqing ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

25 methoxydammarane 3 ; 12 ; 20 triol (25 OCH3 PPD); 25 OH PPD; Bioavailability; Pharmacokinetics; Self microemulsifying drug delivery system

Indexed keywords

25 METHOXYL DAMMARANE 3 BETA, 12 BETA, 20 TRIOL; COSURFACTANT; CREMOPHOR; GLYCEROL; SAPOGENIN; UNCLASSIFIED DRUG; 25-HYDROXYPROTOPANAXADIOL; EMULSION; GINSENOSIDE; SURFACTANT;

ADULT; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; EMULSION; FEMALE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM; TANDEM MASS SPECTROMETRY; THERMODYNAMICS; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BIOAVAILABILITY; BLOOD; MEDICINAL CHEMISTRY; NANOMEDICINE; ORAL DRUG ADMINISTRATION; RAT; SOLUBILITY; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; FEMALE; GINSENOSIDES; MALE; NANOMEDICINE; RATS; RATS, WISTAR; SAPOGENINS; SOLUBILITY; SURFACE-ACTIVE AGENTS;

EID: 84896888106     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S56894     Document Type: Article

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