Enhanced oral paclitaxel absorption with vitamin E-TPGS: Effect on solubility and permeability in vitro, in situ and in vivo

European Journal of Pharmaceutical Sciences

Volumn 25, Issue 4-5, 2005, Pages 445-453

  Varma, Manthena V S ^a   Panchagnula, Ramesh ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Oral absorption; P glycoprotein; Pharmacokinetics; Vitamin E TPGS

Indexed keywords

ALPHA TOCOPHEROL DERIVATIVE; CARBON 14; DEXTRO ALPHA TOCOPHERYLPOLYETHYLENE GLYCOL 1000 SUCCINATE; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; IMIPRAMINE; MACROGOL DERIVATIVE; PACLITAXEL; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG INHIBITION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG TRANSPORT; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE ABSORPTION; STATISTICAL SIGNIFICANCE;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; ILEUM; INJECTIONS, INTRAVENOUS; MEMBRANES, ARTIFICIAL; P-GLYCOPROTEIN; PACLITAXEL; PERMEABILITY; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; TIME FACTORS; VERAPAMIL; VITAMIN E;

EID: 20744447950     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2005.04.003     Document Type: Article

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