The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier

Biomaterials

Volumn 33, Issue 34, 2012, Pages 8881-8892

  Li, Na ^a   Li, Xin Ru ^a   Zhou, Yan Xia ^a   Li, Wen Jing ^a   Zhao, Yong ^a   Ma, Shu Jin ^a   Li, Jin Wen ^a   Gao, Ya Jie ^a   Liu, Yan ^a   Wang, Xing Lin ^b   Yin, Dong Dong ^b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Monomethoxy poly(ethylene glycol) grafted alginic acid; Oral drug delivery; Polyion complex micelles; Salmon calcitonin; Transport mechanism

Indexed keywords

MONOMETHOXY POLY(ETHYLENE GLYCOL); ORAL DRUG DELIVERY; POLYION COMPLEX MICELLES; SALMON CALCITONIN; TRANSPORT MECHANISM;

CELLS; CYTOLOGY; DRUG DELIVERY; GRAFTING (CHEMICAL); MOLECULAR BIOLOGY; MONOLAYERS; MOTION PICTURE EXPERTS GROUP STANDARDS; MULTILAYERS; POLYETHYLENE GLYCOLS; PROTEINS;

MICELLES;

DRUG CARRIER; F ACTIN; POLYION COMPLEX; SALCATONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN CACO 2; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; ELECTRIC RESISTANCE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE EPITHELIUM; MEMBRANE PERMEABILITY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; TRANSCYTOSIS;

ADMINISTRATION, ORAL; ALGINATES; ANIMALS; BONE DENSITY CONSERVATION AGENTS; CACO-2 CELLS; CALCITONIN; DRUG CARRIERS; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; INTESTINAL MUCOSA; MALE; MICELLES; PERMEABILITY; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84866854777     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.08.047     Document Type: Article

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