Nanomedicines and nanotoxicology: Some physiological principles

Occupational Medicine

Volumn 56, Issue 5, 2006, Pages 307-311

  Garnett, M C ^a   Kallinteri, P ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Biodistribution; Nanomedicines; Nanoparticles; Physiological barriers; Toxicology

Indexed keywords

ADIPIC ACID DERIVATIVE; CYANOACRYLATE DERIVATIVE; DENDRIMER; DEXTRAN; DNA; MACROGOL; NANOPARTICLE; POLYBUTYL CYANOACRYLATE; POLYELECTROLYTE; POLYGLYCEROL ADIPATE; POLYMER; POLYSORBATE 80; QUANTUM DOT; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG;

BIOCOMPATIBILITY; BIODEGRADABILITY; DRUG DISTRIBUTION; DRUG EXTRAVASATION; DRUG PENETRATION; DRUG STABILITY; DRUG TRANSPORT; DRUG UPTAKE; ENCAPSULATION; ENDOCYTOSIS; HUMAN; MOLECULAR WEIGHT; NONVIRAL GENE DELIVERY SYSTEM; OPSONIZATION; PHAGOCYTOSIS; PHARMACEUTICAL CARE; PRIORITY JOURNAL; REVIEW; SURFACE PROPERTY; TOXICITY TESTING; TOXICOLOGY;

EXTRAVASATION OF DIAGNOSTIC AND THERAPEUTIC MATERIALS; HUMANS; NANOMEDICINE; NANOPARTICLES; PHAGOCYTOSIS; TISSUE DISTRIBUTION;

EID: 33748118294     PISSN: 09627480     EISSN: 14718405     Source Type: Journal    
DOI: 10.1093/occmed/kql052     Document Type: Review

References (14)

1. Stolnik S, Illum L, Davis SS. Long circulating microparticulate drug carriers. Adv Drug Deliv Rev 1995; 16:195-214.
2. Schnitzer JE. Caveolae: From basic trafficking mechanisms to targeting transcytosis for tissue specific drug and gene delivery in vivo. Adv Drug Deliv Rev 2001;49:265-280.
3. Maeda H, Matsumura Y. Tumoritropic and lymphotropic principles of macromolecular drugs. Grit Rev Ther Drug Carrier Syst 1989;6:193-210.
4. Van Deurs B, Peterson OW, Olsnes S, Sandvig K. The ways of endocytosis. Int Rev Cytol 1989;117:131-177.
5. Porter CJ, Moghimi SM, Illum L, Davis SS. The polyoxy-ethylene/ polyoxypropylene block copolymer-407 selectively redirects intravenously injected microspheres to sinusoidal endothelial cells of rabbit bone marrow. FEBS Lett 1992;305:63-66.
6. Kruth HS, Chang J, Ifrim I, Zhang W-Y. Characterisation of patocytosis: endocytosis into macrophage surface-connected compartments. Eur J Cell Biol 1999;78:91-99.
7. Geiser M, Rothe-Rutishauser B, Kapp N et al. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 2005;113:1555-1560.
8. Hong S, Bielinska AU, Mecke A et al. Interaction of poly (amidoamine) dendrimers with supported lipid bilayers and cells: Hole formation and the relation to transport. Bioconjug Chem 2004;15:774-782.
9. Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev 2001;47:65-81.
10. Lind K, Kresse M, Debus NP, Müller RH. A novel formulation for superparamagnetic iron oxide (SPIO) particle enhancing MR lymphography: comparison of physicochemical properties and the in vivo behaviour. J Drug Target 2002;10:221-230.
11. Hawley AE, Davis SS, Illum L. Targeting of colloids to lymph nodes: influence of lymphatic physiology and colloidal characteristics. Adv Drug Deliv Rev 1995;17:129-148.
12. Brightman MW. The distribution within the brain of ferritin injected into cerebrospinal fluid compartments. II. Parenchymal distribution. Am J Anat 1966;117: 193-220.
13. Kallinteri P, Higgins S, Hutcheon GA, St Pourçain CB, Garnett MC. Novel functionalized biodegradable polymers for nanoparticle drug delivery systems. Biomacromolecules 2005;6:1885-1894.
14. Villodi A. Lysosomal storage disorders. Br J Haematol 2004;128:413-431.