Multifunctional polymeric nanoparticles for oral delivery of TNF-α siRNA to macrophages

Biomaterials

Volumn 34, Issue 11, 2013, Pages 2843-2854

  He, Chunbai ^a   Yin, Lichen ^a,b   Tang, Cui ^a   Yin, Chunhua ^a  

^a FUDAN UNIVERSITY   (China)

^b University of Illinois at Urbana Champaign   (United States)

Author keywords

Gene therapy; Oral delivery; Polymeric nanoparticles; Targeting gene delivery; TNF siRNA

Indexed keywords

EXTRACELLULAR; GENE DELIVERY; GENE SILENCING; HEPATIC INJURY; IN-VITRO; IN-VIVO; INFLAMMATORY DISEASE; INTESTINAL EPITHELIUM; LIVER DAMAGE; ORAL DELIVERY; PHYSIOLOGICAL ENVIRONMENT; POLYMERIC NANOPARTICLES; RATIONAL DESIGN; SIRNA DELIVERY; TARGET CELLS; TRIMETHYL;

AMINO ACIDS; CHITOSAN; CYTOLOGY; DISEASES; ENZYME ACTIVITY; GELATION; GENE THERAPY; GENE TRANSFER; MACROPHAGES; MOLECULAR BIOLOGY; NANOPARTICLES;

POLYMERS;

CHITOSAN; CLATHRIN; LIPOFECTAMINE; NANOPARTICLE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; HEPATITIS; HUMAN; HUMAN CELL; IN VIVO GENE TRANSFER; LETHALITY; LIVER INJURY; MACROPHAGE; MALE; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL;

ACUTE DISEASE; ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; CHITOSAN; CYSTEINE; GENE SILENCING; HUMANS; INFLAMMATION; LIVER; LIVER DISEASES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NANOCONJUGATES; NANOPARTICLES; POLYMERS; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84873095720     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.01.033     Document Type: Article

References (37)

1. Pecot C.V., Calin G.A., Coleman R.L., Lopez-Berestein G., Sood A.K. RNA interference in the clinic: challenges and future directions. Nat Rev Cancer 2011, 11:59-67.
2. Tahara K., Samura S., Tsuji K., Yamamoto H., Tsukad Y., Bando Y., et al. Oral nuclear factor-κB decoy oligonucleotides delivery system with chitosan modified poly(D, L-lactide-co-glycolide) nanospheres for inflammatory bowel disease. Biomaterials 2011, 32:870-878.
3. Whitehead K.A., Langer R., Anderson D.G. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov 2009, 9:129-138.
4. Mohanan D., Slutter B., Henriksen-Lacey M., Jiskoot W., Bouwstra J.A., Perrie Y., et al. Administration routes affect the quality of immune responses: a cross-sectional evaluation of particulate antigen-delivery systems. J Control Release 2010, 147:342-349.
5. Akhtar S. Oral delivery of siRNA and antisense oligonucleotides. J Drug Target 2009, 17:491-495.
6. O'Neill M.J., Bourre L., Melgar S., O'Driscoll C.M. Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models. Drug Discov Today 2011, 16:203-218.
7. Juliano R., Bauman J., Kang H., Ming X. Biological barriers to therapy with antisense and siRNA oligonucleotides. Mol Pharmaceut 2009, 6:686-695.
8. Aouadi M., Tesz G.J., Nicoloro S.M., Wang M.X., Chouinard M., Soto E., et al. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature 2009, 458:1180-1184.
9. Troiber C., Wagner E. Nucleic acid carriers based on precise polymer conjugates. Bioconjug Chem 2011, 22:1737-1752.
10. Tesz G.J., Aouadi M., Prot M., Nicoloro S.M., Boutet E., Amano S.U., et al. Glucan particles for selective delivery of siRNA to phagocytic cells in mice. Biochem J 2011, 436:351-362.
11. Wagner E. Polymers for siRNA delivery: inspired by viruses to be targeted, dynamic, and precise. Acc Chem Res 2012, 45:1005-1013.
12. van der Merwei S.M., Verhoef J.C., Verheijden J.H.M., Kotze A.F., Junginger H.E. Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs. Eur J Pharm Biopharm 2004, 58:225-235.
13. Jiang H.L., Kang M.L., Quan J.S., Kang S.G., Akaike T., Yoo H.S., et al. The potential of mannosylated chitosan microspheres to target macrophage mannose receptors in an adjuvant-delivery system for intranasal immunization. Biomaterials 2008, 29:1931-1939.
14. Marschütz M.K., Bernkop-Schnürch A. Thiolated conjugates: self-crosslinking properties of thiolated 450 kDa poly(acrylic acid) and their influence on mucoadhesion. Eur J Pharm Sci 2002, 15:387-394.
15. Gullberg E., Leonard M., Karlsson J., Hopkins A.M., Brayden D., Baird A.W., et al. Expression of specific markers and particle transport in a new human intestinal M-cell model. Biochem Biophys Res Commun 2000, 279:808-813.
16. Gratton S.E.A., Ropp P.A., Pohlhaus P.D., Luft J.C., Madden V.J., Napier M.E., et al. The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci U S A 2008, 105:11613-11618.
17. Akinc A., Thomas M., Klibanov A.M., Langer R. Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med 2005, 7:657-663.
18. Howard K.A., Rahbek U.L., Liu X., Damgaard C.K., Glud S.Z., Andersen M.O., et al. RNA interference in vitro and in vivo using a chitosan/siRNA nanoparticle system. Mol Ther 2006, 14:476-484.
19. Patil M.L., Zhang M., Minko T. Multifunctional triblock nanocarrier (PAMAM-PEG-PLL) for the efficient intracellular siRNA delivery and gene silencing. ACS Nano 2011, 5:1877-1887.
20. Mao S.R., Sun W., Kissel T. Chitosan-based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev 2010, 62:12-27.
21. Katas H., Alpar H.O. Development and characterization of chitosan nanoparticles for siRNA delivery. J Control Release 2006, 115:216-225.
22. Suma T., Miyata K., Ishii T., Uchida S., Uchida H., Itaka K., et al. Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain. Biomaterials 2012, 33:2770-2779.
23. Liu X.D., Howard K.A., Dong M.D., Anderson M.O., Rahbek U.L., Johnsen M.G., et al. The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. Biomaterials 2007, 28:1280-1288.
24. Ack D.W., Hoffman A.S., Pun S., Stayton P.S. Design and development of polymers for gene delivery. Nat Rev Drug Discov 2005, 4:581-593.
25. Howard K.A., Paludan S.R., Behlke M.A., Besenbacher F., Deleuran B., Kjems J. Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. Mol Ther 2009, 17:162-168.
26. Fievez V., Plapied L., des Rieux A., Pourcelle V., Freichels H., Wascote V., et al. Targeting nanoparticles to M cells with non-peptidic ligands for oral vaccination. Eur J Pharm Biopharm 2009, 73:16-24.
27. Yin L.C., Ding J.Y., He C.B., Cui L.M., Tang C., Yin C.H. Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials 2009, 30:5691-5700.
28. Nuhn L., Hirsch M., Krieg B., Koynov K., Fischer K., Schmidt M., et al. Cationic nanohydrogel particles as potential siRNA carriers for cellular delivery. ACS Nano 2012, 6:2198-2214.
29. Khalil I.A., Kogure K., Akita H., Harashima H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol Rev 2006, 58:32-45.
30. Contreras J., Xie J.S., Chen Y.J., Pei H., Zhang G.Q., Fraser C.L., et al. Intracellular uptake and trafficking of difluoroboron dibenzoylmethane polylactide nanoparticles in HeLa cells. ACS Nano 2010, 4:2735-2747.
31. Kommareddy S., Amiji M. Preparation and evaluation of thiol-modified gelatin nanoparticles for intracellular DNA delivery in response to glutathione. Bioconjug Chem 2005, 16:1423-1432.
32. Lin J., Ziring D., Desai S., Kim S., Wong M., Korin Y., et al. TNFα blockade in human diseases: an overview of efficacy and safety. Clin Immunol 2008, 126:13-30.
33. Duffield J.S. The inflammatory macrophage: a story of Jekyll and Hyde. Clin Sci 2003, 104:260-266.
34. Lee S., Yang S.C., Kao C.Y., Pierce R.H., Murthy N. Solid polymeric microparticles enhance the delivery of siRNA to macrophages in vivo. Nucl Acids Res 2009, 37:e145.
35. Kim S.S., Ye C.T., Kumar P., Chiu I., Subramanya S., Wu H.Q., et al. Targeted delivery of siRNA to macrophages for anti-inflammatory treatment. Mol Ther 2010, 18:993-1001.
36. Marques J.T., Devosse T., Wang D., Zamanian-Daryoush M., Serbinowski P., Hartmann R., et al. A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nat Biotechnol 2006, 24:559-565.
37. Judge A.D., Bola G., Lee A.C., Maclachlan I. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol Ther 2006, 13:494-505.