Assessing gastrointestinal motility and disintegration profiles of magnetic tablets by a novel magnetic imaging device and gamma scintigraphy

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 74, Issue 1, 2010, Pages 84-92

  Goodman, Kirsteen ^a   Hodges, Lee Ann ^b   Band, Janet ^b   Stevens, Howard N E ^a,b   Weitschies, Werner ^c   Wilson, Clive G ^a,b  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b Bio Images Research Ltd   (United Kingdom)

^c UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Gamma scintigraphy; Gastrointestinal motility; Magnetic imaging; Magnetic tablets

Indexed keywords

EUDRAGIT; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; IRON OXIDE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; PENTETATE TECHNETIUM TC 99M; POVIDONE; STARCH GLYCOLATE SODIUM;

ADULT; ARTICLE; CLINICAL TRIAL; CROSSOVER PROCEDURE; DIET RESTRICTION; DRUG RELEASE; ENTERIC COATED TABLET; GAMMA SCINTIGRAPHY; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MAGNETIC FIELD; MALE; MEAN RESIDENCE TIME; NORMAL HUMAN; PHANTOM; RELIABILITY; SINGLE BLIND PROCEDURE; STOMACH EMPTYING; TABLET DISINTEGRATION; TABLET FORMULATION; TABLET MATRIX; VALIDATION PROCESS;

ADULT; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; DIFFUSION; ELECTROMAGNETIC PHENOMENA; GASTROINTESTINAL MOTILITY; HUMANS; IMAGING, THREE-DIMENSIONAL; MALE; MOLECULAR PROBE TECHNIQUES; MOLECULAR PROBES; PHARMACEUTICAL PREPARATIONS; RADIONUCLIDE IMAGING; SOLUBILITY; TABLETS; TABLETS, ENTERIC-COATED; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS; YOUNG ADULT;

EID: 72149109261     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2009.01.004     Document Type: Article

References (38)

1. Curt N.E., Hardy J.G., and Wilson C.G. Utilisation de la gamma camera pour l'etude du transit en fonction de la formule salenique. Ann. Biol. Clin. (1978) (Abstract only)
2. Hurowitz A., Robinson R.G., Vats T.S., Whittier F.C., and Herrin W.F. Effects of antacids on gastric emptying. Gastroenterology 71 (1976) 268-273
3. Clarke G.M., Newton J.M., and Short M.D. Gastrointestinal transit of pellets of differing size and density. Int. J. Pharm. 100 (1993) 81-92
4. Clarke G.M., Newton J.M., and Short M.D. Comparative gastrointestinal transit of pellet systems of varying density. Int. J. Pharm. 114 (1995) 1-11
5. Coupe A.J., Davis S.S., and Wilding I.R. Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects. Pharm. Res. 8 (1991) 360-364
6. Davis S.S., Norring-Christensen F., Khosla R., and Feely L.C. Gastric emptying of large single unit dosage forms. J. Pharm. Pharmacol. 40 (1988) 205-207
7. Khosla R., Feely L.C., and Davis S.S. Gastrointestinal transit of non-disintegrating tablets in fed subjects. Int. J. Pharm. 53 (1989) 107-117
8. Khosla R., and Davis S.S. Gastric emptying and small and large bowel transit of non-disintegrating tablets in fasted subjects. Int. J. Pharm. 52 (1989) 1-10
9. Maublant J.C., Sournac M., Aiche J.M., and Veyre A. Gastrointestinal scintigraphy with 99m-Tc-DTPA labelled tablets in fed and fasting subjects. Eur. J. Nucl. Med. 15 (1989) 143-145
10. Parker G., Wilson C.G., and Hardy J.G. The effect of capsule size and density on transit through the proximal colon. J. Pharm. Pharmacol. 40 (1988) 376-377
11. Benini L., Sembenini C., Heading R.C., Giorgetti P.G., and Montemezzi S. Simultaneous measurement of gastric emptying of a solid meal by ultrasound and by scintigraphy. Am. J. Gastroenterol. 94 (1999) 2861-2865
12. Punkkinen J., Konkka I., Punkkinen O., Korppi-Tommola T., Farkkila M., and Koskenpato J. Measuring gastric emptying: comparison of 13C-octanic acid breath test and scintigraphy. Dig. Dis. Sci. 51 (2006) 262-267
13. Weitschies W., Karaus M., Cordini D., and Trahms L. Magnetic marker monitoring of disintegrating capsules. Eur. J. Pharm. Sci. 13 (2001) 411-416
14. Weitschies W., Wedemeyer J., Stehr R., and Trahms L. Magnetic markers as a non-invasive tool to monitor gastrointestinal transit. IEEE Trans. Biomed. Eng. 41 (1994) 192-196
15. Weitschies W., Kotitz R., Cordini D., and Trahms L. High-resolution monitoring of the gastrointestinal transit of a magnetically marked capsule. J. Pharm. Sci. 86 (1997) 1218-1222
16. E. Osmanoglou, O. Kosch, V. Hartmann, A. Strenske, L. Trahms, W. Weitschies, B. Wiedenmann, H. Monnikes, Magnetic marker monitoring to characterise effects of exogenous factors on oesophageal transit of solid drug forms, in: Biomag. 2002: 13th Int. Conference on Biomagnetism, 2004, pp. 1099-1101.
17. Weitschies W., Kosch O., Monnikes H., and Trahms L. Magnetic marker monitoring: an application of bio-magnetic measurement instrumentation and principles for the determination of the gastrointestinal behaviour of magnetically marked solid dosage forms. Adv. Drug Deliv. Rev. 57 (2005) 1210-1222
18. Miquelin C.A., Braga F.J.H.N., Dantas R.O., Oliveira R.B., and Baffa O. Pharyngeal clearance and pharyngeal transit time determined by a biomagnetic method in humans. Dysphagia 16 (2001) 308-312
19. Daghastanli N.A., Braga F.J.H.N., Oliveira R.B., and Baffa O. Oesophageal transit time evaluated by a biomagnetic method. Physiol. Meas. 19 (1998) 413-420
20. Miranda J.R.A., Oliveira R.B., Sousa P.L., Braga F.J.H.N., and Baffa O. A novel bio-magnetic method to study gastric antral contractions. Phys. Med. Biol. 42 (1997) 1791-1799
21. Miranda J.R.A., Baffa O., Oliveira R.B., and Matsuda N.M. An AC bio-susceptometer to study gastric emptying. Med. Phys. 19 (1992) 445-448
22. Cora L.A., Americo M.F., Oliveira R.B., Baffa O., Moraes R., Romeiro F.G., and Miranda J.R.A. Disintegration of magnetic tablets in human stomach evaluated by alternate current biosusceptometry. Eur. J. Pharm. Biopharm. 56 (2003) 413-420
23. Cora L.A., Romeiro F.G., Stelzer M., Americo M.F., Oliveira R.B., Baffa O., and Miranda J.R.A. AC biosusceptometry in the study of drug delivery. Adv. Drug Deliv. Rev. 57 (2005) 1223-1241
24. A Cora L., Romeiro F.G., Americo M.F., Oliveira R.B., Baffa O., Stelzer M., and Miranda J.R.A. Gastrointestinal transit and disintegration of enteric coated magnetic tablets assessed by ac biosusceptometry. Eur. J. Pharm. Sci. 27 (2006) 1-8
25. Cora L.A., Romeiro F.G., Paixao F.C., Americo M.F., Oliveira R.B., Baffa O., Ricardo J., and Miranda J.R.A. Enteric coated magnetic HPMC capsules evaluated in human gastrointestinal tract by AC biosusceptometry. Pharm. Res. 23 (2006) 1809-1816
26. Romeiro F.G., Cora L.A., De Andreis U., Americo M.F., Oliveira R.B., Baffa O., and Miranda J.R.A. A novel biomagnetic approach to study caeco-colonic motility in humans. Neurogastroenterol. Motil. 18 (2006) 1078-1083
27. Cordova-Fraga T., Huerta-Franco R., and Guitierrez-Juarez G. The colon transit times in different phases of the menstrual cycle: assessed with bio-magnetic technique. Neurol. Clin. Neurophysiol. 31 (2004) 1-4
28. Schlageter V., Drljaca P., Popovic R.S., and Kucera P. A magnetic tracking system based on highly sensitive integrated hall sensors. JSME Int. J. 45 (2002) 967-973
29. Stathopoulos E., Schlageter V., and Meyrat B. Magnetic pill tracking: a novel non-invasive tool for investigation of human digestive motility. Neurogastroenterol. Motil. 16 (2005) 1-7
30. Wenger J., Jackson R.E., and Norman S. Screening for oesophageal luminal narrowing - a magnetic disc tablet as a bolus challenge: preliminary report. Dig. Dis. Sci. 49 1 (2004) 157-160
31. Andrä W., Danan H., Eitner K., Hocke M., Kramer H.H., Parusel H., Saupe P., Werner C., and Belleman M.E. A novel magnetic method for examination of bowel motility. Med. Phys. 32 (2005) 2942-2944
32. Wilson K., Mahoney B., Lindsay B., Band J., and Wilson C.G. A reproducible, robust meal for gastric emptying studies. J. Pharm. Pharmacol. 57 (2005) S104
33. Abrahamsson B., Albery T., Eriksson A., Gustafsson I., and Sjoberg M. Food effects on tablet disintegration. Eur. J. Pharm. Sci. 22 (2004) 165-172
34. Davis S.S., Hardy J.G., Taylor M.J., Whalley D.R., and Wilson C.G. The effect of food on the gastrointestinal transit of pellets and an osmotic delivery system. Int. J. Pharm. 21 (1984) 331-340
35. Al-Behaisi S., Antal I., Morovjan G., Szunyog J., Drabant S., Marton S., and Klebovich I. In vitro simulation of food effect on dissolution of deramciclane film-coated tablets and correlation with in vivo data in healthy volunteers. Eur. J. Pharm. Sci. 15 (2002) 157-162
36. Anwar S., Fell J.T., and Dickinson P.A. An investigation of the disintegration of tablets in bio-relevant media. Int. J. Pharm. 290 (2005) 121-127
37. Schiller C., Frohlich C.P., Giessmann T., Siegmund W., Monnikess H., Hosten N., and Weitschies W. Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging. Aliment. Pharmacol. Ther. 22 (2005) 971-979
38. Podczeck F., Course N.C., Newton J.M., and Short M.B. The influence of non-disintegrating tablet dimensions and density on their gastric emptying in fasted volunteers. J. Pharm. Pharmacol. 59 (2007) 23-27