Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease

Science Signaling

Volumn 7, Issue 349, 2014, Pages

  Pryor, William M ^a   Biagioli, Marta ^b   Shahani, Neelam ^a   Swarnkar, Supriya ^a   Huang, Wen Chin ^a   Page, Damon T ^a   MacDonald, Marcy E ^b   Subramaniam, Srinivasa ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; HUNTINGTIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; TUBERIN; HTT PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MULTIPROTEIN COMPLEX; NERVE PROTEIN; NEUROPEPTIDE; RHEB PROTEIN, HUMAN; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELL SIZING (MEASUREMENT); CELLULAR DISTRIBUTION; COGNITION; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE COURSE; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN CONFORMATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; CELL SIZE; CYTOLOGY; GENE VECTOR; GENETICS; HEK293 CELL LINE; KAPLAN MEIER METHOD; METABOLISM; NONPARAMETRIC TEST; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; ROTAROD TEST; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SIZE; CORPUS STRIATUM; GENETIC VECTORS; HEK293 CELLS; HUMANS; HUNTINGTON DISEASE; KAPLAN-MEIER ESTIMATE; MICE; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; NERVE TISSUE PROTEINS; NEUROPEPTIDES; RNA, SMALL INTERFERING; ROTAROD PERFORMANCE TEST; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; TOR SERINE-THREONINE KINASES;

EID: 84908577656     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005633     Document Type: Article

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