A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration

FASEB Journal

Volumn 27, Issue 5, 2013, Pages 1820-1829

  Lu, Boxun ^a,b   Palacino, James ^a  

^a FUDAN UNIVERSITY   (China)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Aggregation; High throughput imaging

Indexed keywords

COMPLEMENTARY DNA; HUNTINGTIN; MONOMER; MUTANT PROTEIN; OLIGOMER; PROTEIN; TEXON 1; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; EXON; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MOLECULAR MECHANICS; MOLECULAR MODEL; NERVE DEGENERATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; STABLE TRANSFECTION; WILD TYPE;

CELL LINE; EMBRYONIC STEM CELLS; GENE KNOCKDOWN TECHNIQUES; GTP-BINDING PROTEINS; HUMANS; HUNTINGTON DISEASE; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEURONS; TRANSFECTION;

EID: 84877139837     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-219220     Document Type: Article

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