Rheb GTPase regulates β-secretase levels and amyloid β generation

Journal of Biological Chemistry

Volumn 289, Issue 9, 2014, Pages 5799-5808

  Shahani, Neelam ^a   Pryor, William ^a   Swarnkar, Supriya ^a   Kholodilov, Nikolai ^b   Thinakaran, Gopal ^c   Burke, Robert E ^b   Subramaniam, Srinivasa ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); MOLECULAR MECHANISM; MTOR SIGNALING; OVER-EXPRESSION; PHYSIOLOGICAL REGULATORS; PROTEIN LEVEL;

ANTIBIOTICS; GLYCOPROTEINS; PHYSIOLOGY;

BRAIN;

AMYLOID BETA PROTEIN; BETA SECRETASE; BETA SECRETASE 1; MAMMALIAN TARGET OF RAPAMYCIN; RHEB PROTEIN;

ADULT; AGED; ANIMAL CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVITY; ENZYME BINDING; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STABILITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LYSOSOME; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; VERY ELDERLY;

AGING; AMYLOID; GTPASE; PROTEIN STABILITY; SECRETASES;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BRAIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEK293 CELLS; HUMANS; MICE; MONOMERIC GTP-BINDING PROTEINS; NEUROPEPTIDES; PROTEIN BINDING; PROTEOLYSIS;

EID: 84896830954     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.532713     Document Type: Article

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