-
1
-
-
78650510609
-
mTOR: From growth signal integration to cancer, diabetes and ageing
-
doi:10.1038/nrm3025. PubMed: 21157483
-
Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21-35. doi:10.1038/nrm3025. PubMed: 21157483.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
2
-
-
33750155593
-
Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase
-
DOI 10.1038/sj.onc.1209882, PII 1209882
-
Avruch J, Hara K, Lin Y, Liu M, Long X et al. (2006) Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene 25: 6361-6372. doi:10.1038/sj.onc.1209882. PubMed: 17041622. (Pubitemid 44596154)
-
(2006)
Oncogene
, vol.25
, Issue.48
, pp. 6361-6372
-
-
Avruch, J.1
Hara, K.2
Lin, Y.3
Liu, M.4
Long, X.5
Ortiz-Vega, S.6
Yonezawa, K.7
-
3
-
-
67349217986
-
Molecular mechanisms of mTOR-mediated translational control
-
doi:10.1038/nrm2672. PubMed: 19339977
-
Ma XM, Blenis J (2009) Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10: 307-318. doi:10.1038/nrm2672. PubMed: 19339977.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 307-318
-
-
Ma, X.M.1
Blenis, J.2
-
4
-
-
77952967459
-
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
-
Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD et al. (2011) mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science 328: 1172-1176.
-
(2011)
Science
, vol.328
, pp. 1172-1176
-
-
Dowling, R.J.1
Topisirovic, I.2
Alain, T.3
Bidinosti, M.4
Fonseca, B.D.5
-
5
-
-
0038643484
-
Rheb promotes cell growth as a component of the insulin/TOR signalling network
-
DOI 10.1038/ncb996
-
Saucedo LJ, Gao X, Chiarelli DA, Li L, Pan D et al. (2003) Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol 5: 566-571. doi:10.1038/ncb996. PubMed: 12766776. (Pubitemid 36781092)
-
(2003)
Nature Cell Biology
, vol.5
, Issue.6
, pp. 566-571
-
-
Saucedo, L.J.1
Gao, X.2
Chiarelli, D.A.3
Li, L.4
Pan, D.5
Edgar, B.A.6
-
6
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
DOI 10.1038/ncb995
-
Stocker H, Radimerski T, Schindelholz B, Wittwer F, Belawat P et al. (2003) Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol 5: 559-565. doi:10.1038/ncb995. PubMed: 12766775. (Pubitemid 36781091)
-
(2003)
Nature Cell Biology
, vol.5
, Issue.6
, pp. 559-565
-
-
Stocker, H.1
Radimerski, T.2
Schindelholz, B.3
Wittwer, F.4
Belawat, P.5
Daram, P.6
Breuer, S.7
Thomas, G.8
Hafen, E.9
-
7
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway
-
DOI 10.1016/S1097-2765(02)00568-3
-
Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC (2002) Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10: 151-162. doi:10.1016/S1097-2765(02)00568-3. PubMed: 12150915. (Pubitemid 34876569)
-
(2002)
Molecular Cell
, vol.10
, Issue.1
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon M.Nicole3
Blenis, J.4
Cantley, L.C.5
-
8
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
DOI 10.1038/ncb839
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4: 648-657. doi:10.1038/ncb839. PubMed: 12172553. (Pubitemid 34993700)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.9
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.-L.5
-
9
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
DOI 10.1101/gad.1199104
-
Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL (2004) Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 18: 1533-1538. doi:10.1101/gad.1199104. PubMed: 15231735. (Pubitemid 38868905)
-
(2004)
Genes and Development
, vol.18
, Issue.13
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
DePinho, R.A.4
Guan, K.-L.5
-
10
-
-
27744588780
-
Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways
-
PubMed: 16244323
-
Kwiatkowski DJ, Manning BD (2005) Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet 14 spec No. 2: R251-R258. PubMed: 16244323.
-
(2005)
Hum Mol Genet
, vol.14
, Issue.SPEC NO. 2
-
-
Kwiatkowski, D.J.1
Manning, B.D.2
-
11
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
DOI 10.1016/S1097-2765(03)00220-X
-
Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M et al. (2003) Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 11: 1457-1466. doi:10.1016/S1097-2765(03)00220-X. PubMed: 12820960. (Pubitemid 36776533)
-
(2003)
Molecular Cell
, vol.11
, Issue.6
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.T.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.C.7
Hafen, E.8
Bos, J.L.9
Thomas, G.10
-
12
-
-
0037117409
-
Identification of a conserved motif required for mTOR signaling
-
DOI 10.1016/S0960-9822(02)00762-5, PII S0960982202007625
-
Schalm SS, Blenis J (2002) Identification of a conserved motif required for mTOR signaling. Curr Biol 12: 632-639. doi:10.1016/S0960-9822(02)00762-5. PubMed: 11967149. (Pubitemid 34315846)
-
(2002)
Current Biology
, vol.12
, Issue.8
, pp. 632-639
-
-
Schalm, S.S.1
Blenis, J.2
-
13
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
DOI 10.1016/S0092-8674(02)00808-5
-
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR et al. (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110: 163-175. doi:10.1016/S0092-8674(02)00808-5. PubMed: 12150925. (Pubitemid 34876545)
-
(2002)
Cell
, vol.110
, Issue.2
, pp. 163-175
-
-
Kim, D.-H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
14
-
-
42949139481
-
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
-
DOI 10.1016/j.molcel.2008.03.003, PII S109727650800169X
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30: 214-226. doi:10.1016/j.molcel.2008.03.003. PubMed: 18439900. (Pubitemid 351626684)
-
(2008)
Molecular Cell
, vol.30
, Issue.2
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
15
-
-
51049083138
-
Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation
-
doi:10.1016/j.cub.2008.07.078. PubMed: 18722121
-
Carrière A, Cargnello M, Julien LA, Gao H, Bonneil E et al. (2008) Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. Curr Biol 18: 1269-1277. doi:10.1016/j.cub.2008.07.078. PubMed: 18722121.
-
(2008)
Curr Biol
, vol.18
, pp. 1269-1277
-
-
Carrière, A.1
Cargnello, M.2
Julien, L.A.3
Gao, H.4
Bonneil, E.5
-
16
-
-
78650943298
-
ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)
-
doi:10.1074/jbc.M110.159046. PubMed: 21071439
-
Carriere A, Romeo Y, Acosta-Jaquez HA, Moreau J, Bonneil E et al. (2011) ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1). J Biol Chem 286: 567-577. doi:10.1074/jbc.M110.159046. PubMed: 21071439.
-
(2011)
J Biol Chem
, vol.286
, pp. 567-577
-
-
Carriere, A.1
Romeo, Y.2
Acosta-Jaquez, H.A.3
Moreau, J.4
Bonneil, E.5
-
17
-
-
67649344456
-
Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR
-
doi:10.1074/jbc.C109.002907. PubMed: 19346248
-
Wang L, Lawrence JC Jr., Sturgill TW, Harris TE (2009) Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR. J Biol Chem 284: 14693-14697. doi:10.1074/jbc.C109.002907. PubMed: 19346248.
-
(2009)
J Biol Chem
, vol.284
, pp. 14693-14697
-
-
Wang, L.1
Lawrence Jr., J.C.2
Sturgill, T.W.3
Harris, T.E.4
-
18
-
-
73649098283
-
Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation
-
PubMed: 19864431
-
Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA et al. (2010) Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. J Biol Chem 285: 80-94. PubMed: 19864431.
-
(2010)
J Biol Chem
, vol.285
, pp. 80-94
-
-
Foster, K.G.1
Acosta-Jaquez, H.A.2
Romeo, Y.3
Ekim, B.4
Soliman, G.A.5
-
19
-
-
33847397874
-
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
-
DOI 10.1038/ncb1547, PII NCB1547
-
Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH (2007) Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 9: 316-323. doi:10.1038/ncb1547. PubMed: 17277771. (Pubitemid 46344611)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.3
, pp. 316-323
-
-
Haar, E.V.1
Lee, S.2
Bandhakavi, S.3
Griffin, T.J.4
Kim, D.-H.5
-
20
-
-
33947264077
-
PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase
-
DOI 10.1016/j.molcel.2007.03.003, PII S1097276507001487
-
Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA et al. (2007) PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 25: 903-915. doi:10.1016/j.molcel.2007.03.003. PubMed: 17386266. (Pubitemid 46436534)
-
(2007)
Molecular Cell
, vol.25
, Issue.6
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.C.2
Peterson, T.R.3
Lindquist, R.A.4
Kang, S.A.5
Spooner, E.6
Carr, S.A.7
Sabatini, D.M.8
-
21
-
-
34547133519
-
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
-
DOI 10.1074/jbc.M702636200
-
Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A et al. (2007) The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem 282: 20329-20339. doi:10.1074/jbc.M702636200. PubMed: 17517883. (Pubitemid 47100038)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.28
, pp. 20329-20339
-
-
Oshiro, N.1
Takahashi, R.2
Yoshino, K.-I.3
Tanimura, K.4
Nakashima, A.5
Eguchi, S.6
Miyamoto, T.7
Hara, K.8
Takehana, K.9
Avruch, J.10
Kikkawa, U.11
Yonezawa, K.12
-
22
-
-
0032486268
-
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
-
DOI 10.1074/jbc.273.23.14484
-
Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C et al. (1998) Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 273: 14484-14494. doi:10.1074/jbc.273.23.14484. PubMed: 9603962. (Pubitemid 28319170)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.23
, pp. 14484-14494
-
-
Hara, K.1
Yonezawa, K.2
Weng, Q.-P.3
Kozlowski, M.T.4
Belham, C.5
Avruch, J.6
-
23
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
DOI 10.1073/pnas.0506925102
-
Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY et al. (2005) Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A 102: 14238-14243. doi:10.1073/pnas.0506925102. PubMed: 16176982. (Pubitemid 41429682)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.40
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
Byfield, M.P.7
Backer, J.M.8
Natt, F.9
Bos, J.L.10
Zwartkruis, F.J.T.11
Thomas, G.12
-
24
-
-
48649085816
-
Regulation of TORC1 by Rag GTPases in nutrient response
-
doi:10.1038/ncb1753. PubMed: 18604198
-
Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL (2008) Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol 10: 935-945. doi:10.1038/ncb1753. PubMed: 18604198.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 935-945
-
-
Kim, E.1
Goraksha-Hicks, P.2
Li, L.3
Neufeld, T.P.4
Guan, K.L.5
-
25
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
doi:10.1126/science.1157535. PubMed: 18497260
-
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC et al. (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320: 1496-1501. doi:10.1126/science.1157535. PubMed: 18497260.
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
-
26
-
-
84856351274
-
Evolution of the TOR Pathway
-
PubMed: 22057117
-
van Dam TJ, Zwartkruis FJ, Bos JL, Snel B (2011) Evolution of the TOR Pathway. J Mol Evol, 73: 209-20. PubMed: 22057117.
-
(2011)
J Mol Evol
, vol.73
, pp. 209-220
-
-
Van Dam, T.J.1
Zwartkruis, F.J.2
Bos, J.L.3
Snel, B.4
-
27
-
-
70549112921
-
TOR signaling in invertebrates
-
doi:10.1016/j.ceb.2009.08.007. PubMed: 19767189
-
Soulard A, Cohen A, Hall MN (2009) TOR signaling in invertebrates. Curr Opin Cell Biol 21: 825-836. doi:10.1016/j.ceb.2009.08.007. PubMed: 19767189.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 825-836
-
-
Soulard, A.1
Cohen, A.2
Hall, M.N.3
-
28
-
-
34249697628
-
S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase
-
DOI 10.1016/j.cmet.2007.05.006, PII S1550413107001337
-
Aguilar V, Alliouachene S, Sotiropoulos A, Sobering A, Athea Y et al. (2007) S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. Cell Metab 5: 476-487. doi:10.1016/j.cmet.2007.05.006. PubMed: 17550782. (Pubitemid 46825498)
-
(2007)
Cell Metabolism
, vol.5
, Issue.6
, pp. 476-487
-
-
Aguilar, V.1
Alliouachene, S.2
Sotiropoulos, A.3
Sobering, A.4
Athea, Y.5
Djouadi, F.6
Miraux, S.7
Thiaudiere, E.8
Foretz, M.9
Viollet, B.10
Diolez, P.11
Bastin, J.12
Benit, P.13
Rustin, P.14
Carling, D.15
Sandri, M.16
Ventura-Clapier, R.17
Pende, M.18
-
29
-
-
78650848337
-
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
-
doi:10.1038/nature09584. PubMed: 21179166
-
Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM (2010) mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468: 1100-1104. doi:10.1038/nature09584. PubMed: 21179166.
-
(2010)
Nature
, vol.468
, pp. 1100-1104
-
-
Sengupta, S.1
Peterson, T.R.2
Laplante, M.3
Oh, S.4
Sabatini, D.M.5
-
30
-
-
54849431380
-
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
-
doi:10.1016/j.cmet.2008.09.003. PubMed: 19046571
-
Polak P, Cybulski N, Feige JN, Auwerx J, Rüegg MA et al. (2008) Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab 8: 399-410. doi:10.1016/j.cmet.2008.09. 003. PubMed: 19046571.
-
(2008)
Cell Metab
, vol.8
, pp. 399-410
-
-
Polak, P.1
Cybulski, N.2
Feige, J.N.3
Auwerx, J.4
Rüegg, M.A.5
-
31
-
-
6344245674
-
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
-
DOI 10.1128/MCB.24.21.9508-9516.2004
-
Gangloff YG, Mueller M, Dann SG, Svoboda P, Sticker M et al. (2004) Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol 24: 9508-9516. doi:10.1128/MCB.24.21.9508-9516.2004. PubMed: 15485918. (Pubitemid 39391687)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.21
, pp. 9508-9516
-
-
Gangloff, Y.-G.1
Mueller, M.2
Dann, S.G.3
Svoboda, P.4
Sticker, M.5
Spetz, J.-F.6
Sung, H.U.7
Brown, E.J.8
Cereghini, S.9
Thomas, G.10
Kozma, S.C.11
-
32
-
-
3242721268
-
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
-
DOI 10.1128/MCB.24.15.6710-6718.2004
-
Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K et al. (2004) mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol 24: 6710-6718. doi:10.1128/MCB.24.15.6710-6718.2004. PubMed: 15254238. (Pubitemid 38944350)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.15
, pp. 6710-6718
-
-
Murakami, M.1
Ichisaka, T.2
Maeda, M.3
Oshiro, N.4
Hara, K.5
Edenhofer, F.6
Kiyama, H.7
Yonezawa, K.8
Yamanaka, S.9
-
33
-
-
33751348056
-
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCalpha, but Not S6K1
-
DOI 10.1016/j.devcel.2006.10.007, PII S153458070600459X
-
Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY et al. (2006) Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 11: 859-871. doi:10.1016/j.devcel.2006.10.007. PubMed: 17141160. (Pubitemid 44804279)
-
(2006)
Developmental Cell
, vol.11
, Issue.6
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
Burds, A.A.4
Kalaany, N.Y.5
Moffat, J.6
Brown, M.7
Fitzgerald, K.J.8
Sabatini, D.M.9
-
34
-
-
79953140523
-
Rheb is essential for murine development
-
doi:10.1128/MCB.00985-10. PubMed: 21321084
-
Goorden SM, Hoogeveen-Westerveld M, Cheng C, van Woerden GM, Mozaffari M et al. (2011) Rheb is essential for murine development. Mol Cell Biol 31: 1672-1678. doi:10.1128/MCB.00985-10. PubMed: 21321084.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 1672-1678
-
-
Goorden, S.M.1
Hoogeveen-Westerveld, M.2
Cheng, C.3
Van Woerden, G.M.4
Mozaffari, M.5
-
35
-
-
78651427865
-
Rheb1 is required for mTORC1 and myelination in postnatal brain development
-
doi:10.1016/j.devcel.2010.11.020. PubMed: 21238928
-
Zou J, Zhou L, Du XX, Ji Y, Xu J et al. (2011) Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell 20: 97-108. doi:10.1016/j.devcel.2010.11.020. PubMed: 21238928.
-
(2011)
Dev Cell
, vol.20
, pp. 97-108
-
-
Zou, J.1
Zhou, L.2
Du, X.X.3
Ji, Y.4
Xu, J.5
-
36
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
DOI 10.1038/nature02866
-
Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M et al. (2004) Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431: 200-205. doi:10.1038/nature02866. PubMed: 15306821. (Pubitemid 39243474)
-
(2004)
Nature
, vol.431
, Issue.7005
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
Thomas, G.11
-
37
-
-
24044442298
-
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1
-
DOI 10.1016/j.febslet.2005.07.054, PII S0014579305009154
-
Tee AR, Blenis J, Proud CG (2005) Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett 579: 4763-4768. doi:10.1016/j.febslet. 2005.07.054. PubMed: 16098514. (Pubitemid 41218660)
-
(2005)
FEBS Letters
, vol.579
, Issue.21
, pp. 4763-4768
-
-
Tee, A.R.1
Blenis, J.2
Proud, C.G.3
-
38
-
-
0033153166
-
Regulation of 4E-BP1 phosphorylation: A novel two step mechanism
-
Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham RT et al. (1999) Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev 13: 1422-1437. doi:10.1101/gad.13.11.1422. PubMed: 10364159. (Pubitemid 29270247)
-
(1999)
Genes and Development
, vol.13
, Issue.11
, pp. 1422-1437
-
-
Gingras, A.-C.1
Gygi, S.P.2
Raught, B.3
Polakiewicz, R.D.4
Abraham, R.T.5
Hoekstra, M.F.6
Aebersold, R.7
Sonenberg, N.8
-
39
-
-
65549145048
-
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
-
doi:10.1074/jbc.M900301200. PubMed: 19150980
-
Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J et al. (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 284: 8023-8032. doi:10.1074/jbc.M900301200. PubMed: 19150980.
-
(2009)
J Biol Chem
, vol.284
, pp. 8023-8032
-
-
Thoreen, C.C.1
Kang, S.A.2
Chang, J.W.3
Liu, Q.4
Zhang, J.5
-
40
-
-
56249147509
-
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
-
doi:10.1073/pnas.0809136105. PubMed: 18955708
-
Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J (2008) Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci U S A 105: 17414-17419. doi:10.1073/pnas.0809136105. PubMed: 18955708.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 17414-17419
-
-
Choo, A.Y.1
Yoon, S.O.2
Kim, S.G.3
Roux, P.P.4
Blenis, J.5
-
41
-
-
15044340650
-
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
-
DOI 10.1128/MCB.25.7.2558-2572.2005
-
Wang X, Beugnet A, Murakami M, Yamanaka S, Proud CG (2005) Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol Cell Biol 25: 2558-2572. doi:10.1128/MCB.25.7.2558-2572.2005. PubMed: 15767663. (Pubitemid 40381622)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.7
, pp. 2558-2572
-
-
Wang, X.1
Beugnet, A.2
Murakami, M.3
Yamanaka, S.4
Proud, C.G.5
-
42
-
-
4544384577
-
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
-
DOI 10.1073/pnas.0405659101
-
Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J (2004) Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A 101: 13489-13494. doi:10.1073/pnas.0405659101. PubMed: 15342917. (Pubitemid 39238430)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.37
, pp. 13489-13494
-
-
Roux, P.P.1
Ballif, B.A.2
Anjum, R.3
Gygi, S.P.4
Blenis, J.5
-
43
-
-
17444431201
-
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
-
DOI 10.1016/j.cell.2005.02.031
-
Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP (2005) Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121: 179-193. doi:10.1016/j.cell.2005.02.031. PubMed: 15851026. (Pubitemid 40546387)
-
(2005)
Cell
, vol.121
, Issue.2
, pp. 179-193
-
-
Ma, L.1
Chen, Z.2
Erdjument-Bromage, H.3
Tempst, P.4
Pandolfi, P.P.5
-
44
-
-
73649098283
-
Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation
-
doi:10.1074/jbc.M109.029637. PubMed: 19864431
-
Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA et al. (2010) Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. J Biol Chem 285: 80-94. doi:10.1074/jbc.M109.029637. PubMed: 19864431.
-
(2010)
J Biol Chem
, vol.285
, pp. 80-94
-
-
Foster, K.G.1
Acosta-Jaquez, H.A.2
Romeo, Y.3
Ekim, B.4
Soliman, G.A.5
-
45
-
-
70349782278
-
Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes
-
doi:10.1016/j.cellsig.2009.09.009. PubMed: 19765648
-
Chen S, Mackintosh C (2009) Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes. Cell Signal 21: 1984-1993. doi:10.1016/j.cellsig.2009.09. 009. PubMed: 19765648.
-
(2009)
Cell Signal
, vol.21
, pp. 1984-1993
-
-
Chen, S.1
Mackintosh, C.2
-
46
-
-
79961011264
-
Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters
-
doi:10.1074/jbc.M111.260794. PubMed: 21659537
-
Fonseca BD, Alain T, Finestone LK, Huang BP, Rolfe M et al. (2011) Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters. J Biol Chem 286: 27111-27122. doi:10.1074/jbc.M111. 260794. PubMed: 21659537.
-
(2011)
J Biol Chem
, vol.286
, pp. 27111-27122
-
-
Fonseca, B.D.1
Alain, T.2
Finestone, L.K.3
Huang, B.P.4
Rolfe, M.5
-
48
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
doi:10.1016/j.molcel.2006.03.029. PubMed: 16603397
-
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP et al. (2006) Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 22: 159-168. doi:10.1016/j.molcel.2006.03.029. PubMed: 16603397.
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
-
49
-
-
18044381192
-
Rheb binds and regulates the mTOR kinase
-
DOI 10.1016/j.cub.2005.02.053
-
Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J (2005) Rheb binds and regulates the mTOR kinase. Curr Biol 15: 702-713. doi:10.1016/j.cub.2005.02.053. PubMed: 15854902. (Pubitemid 40599924)
-
(2005)
Current Biology
, vol.15
, Issue.8
, pp. 702-713
-
-
Long, X.1
Lin, Y.2
Ortiz-Vega, S.3
Yonezawa, K.4
Avruch, J.5
-
50
-
-
64849101452
-
Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition
-
doi:10.1016/j.cellsig.2009.02.024. PubMed: 19272448
-
Dunlop EA, Dodd KM, Seymour LA, Tee AR (2009) Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition. Cell Signal 21: 1073-1084. doi:10.1016/j.cellsig.2009.02. 024. PubMed: 19272448.
-
(2009)
Cell Signal
, vol.21
, pp. 1073-1084
-
-
Dunlop, E.A.1
Dodd, K.M.2
Seymour, L.A.3
Tee, A.R.4
-
51
-
-
33747690458
-
Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1
-
DOI 10.1074/jbc.M603566200
-
Wang L, Rhodes CJ, Lawrence JC Jr. (2006) Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. J Biol Chem 281: 24293-24303. doi:10.1074/jbc. M603566200. PubMed: 16798736. (Pubitemid 44274202)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.34
, pp. 24293-24303
-
-
Wang, L.1
Rhodes, C.J.2
Lawrence Jr., J.C.3
-
52
-
-
80055073635
-
The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling
-
doi:10.1074/jbc.M111.245449. PubMed: 21914810
-
Rapley J, Oshiro N, Ortiz-Vega S, Avruch J (2011) The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling. J Biol Chem 286: 38043-38053. doi:10.1074/jbc.M111.245449. PubMed: 21914810.
-
(2011)
J Biol Chem
, vol.286
, pp. 38043-38053
-
-
Rapley, J.1
Oshiro, N.2
Ortiz-Vega, S.3
Avruch, J.4
-
53
-
-
67649823420
-
Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein
-
doi:10.1074/jbc.M809207200. PubMed: 19299511
-
Sato T, Nakashima A, Guo L, Tamanoi F (2009) Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein. J Biol Chem 284: 12783-12791. doi:10.1074/jbc.M809207200. PubMed: 19299511.
-
(2009)
J Biol Chem
, vol.284
, pp. 12783-12791
-
-
Sato, T.1
Nakashima, A.2
Guo, L.3
Tamanoi, F.4
-
54
-
-
36049043184
-
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38
-
DOI 10.1126/science.1147379
-
Bai X, Ma D, Liu A, Shen X, Wang QJ et al. (2007) Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science 318: 977-980. doi:10.1126/science.1147379. PubMed: 17991864. (Pubitemid 350098994)
-
(2007)
Science
, vol.318
, Issue.5852
, pp. 977-980
-
-
Bai, X.1
Ma, D.2
Liu, A.3
Shen, X.4
Wang, Q.J.5
Liu, Y.6
Jiang, Y.7
-
55
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
doi:10.1016/j.cell.2010.02.024. PubMed: 20381137
-
Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S et al. (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141: 290-303. doi:10.1016/j.cell.2010. 02.024. PubMed: 20381137.
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
-
56
-
-
77649269312
-
PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR
-
doi:10.1016/j.molcel.2010.01.031. PubMed: 20227368
-
Yan L, Mieulet V, Burgess D, Findlay GM, Sully K et al. (2010) PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR. Mol Cell 37: 633-642. doi:10.1016/j.molcel.2010.01.031. PubMed: 20227368.
-
(2010)
Mol Cell
, vol.37
, pp. 633-642
-
-
Yan, L.1
Mieulet, V.2
Burgess, D.3
Findlay, G.M.4
Sully, K.5
-
57
-
-
79960387847
-
Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1)
-
doi:10.1074/jbc.M111.249631. PubMed: 21622984
-
Xu L, Salloum D, Medlin PS, Saqcena M, Yellen P et al. (2011) Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1). J Biol Chem 286: 25477-25486. doi:10.1074/jbc.M111.249631. PubMed: 21622984.
-
(2011)
J Biol Chem
, vol.286
, pp. 25477-25486
-
-
Xu, L.1
Salloum, D.2
Medlin, P.S.3
Saqcena, M.4
Yellen, P.5
-
58
-
-
84855731134
-
Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
-
doi:10.1083/jcb.201107033. PubMed: 22024166
-
Yoon MS, Du G, Backer JM, Frohman MA, Chen J (2011) Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J Cell Biol 195: 435-447. doi:10.1083/jcb.201107033. PubMed: 22024166.
-
(2011)
J Cell Biol
, vol.195
, pp. 435-447
-
-
Yoon, M.S.1
Du, G.2
Backer, J.M.3
Frohman, M.A.4
Chen, J.5
-
59
-
-
84862283776
-
Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart
-
doi:10.4161/auto.19627. PubMed: 22498475
-
Jaber N, Dou Z, Lin RZ, Zhang J, Zong WX (2012) Mammalian PIK3C3/VPS34: the key to autophagic processing in liver and heart. Autophagy 8: 707-708. doi:10.4161/auto.19627. PubMed: 22498475.
-
(2012)
Autophagy
, vol.8
, pp. 707-708
-
-
Jaber, N.1
Dou, Z.2
Lin, R.Z.3
Zhang, J.4
Zong, W.X.5
-
60
-
-
77952562382
-
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
-
doi:10.1016/j.molcel.2010.05.007. PubMed: 20513425
-
Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H et al. (2010) Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol Cell 38: 487-499. doi:10.1016/j.molcel.2010. 05.007. PubMed: 20513425.
-
(2010)
Mol Cell
, vol.38
, pp. 487-499
-
-
Choo, A.Y.1
Kim, S.G.2
Vander Heiden, M.G.3
Mahoney, S.J.4
Vu, H.5
-
61
-
-
0034722888
-
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
-
DOI 10.1038/sj.onc.1204091
-
Hidalgo M, Rowinsky EK (2000) The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 19: 6680-6686. doi:10.1038/sj.onc.1204091. PubMed: 11426655. (Pubitemid 32197708)
-
(2000)
Oncogene
, vol.19
, Issue.56
, pp. 6680-6686
-
-
Hidalgo, M.1
Rowinsky, E.K.2
-
62
-
-
67349123408
-
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
-
doi:10.1038/nature07935. PubMed: 19329995
-
Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N et al. (2009) Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459: 262-265. doi:10.1038/nature07935. PubMed: 19329995.
-
(2009)
Nature
, vol.459
, pp. 262-265
-
-
Sato, T.1
Vries, R.G.2
Snippert, H.J.3
Van De Wetering, M.4
Barker, N.5
|