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Volumn 42, Issue 4, 1997, Pages 604-612

Huntingtin localization in brains of normal and Huntington's disease patients

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; HUNTINGTIN; MUTANT PROTEIN;

EID: 0030771894     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410420411     Document Type: Article
Times cited : (306)

References (45)
  • 2
    • 0015801439 scopus 로고
    • Huntington's disease in children. Neuropathological study of four cases
    • Byers RK, Gilles FH, Fung C. Huntington's disease in children. Neuropathological study of four cases. Neurology 1973;23:561-569
    • (1973) Neurology , vol.23 , pp. 561-569
    • Byers, R.K.1    Gilles, F.H.2    Fung, C.3
  • 3
    • 0021982117 scopus 로고
    • Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease
    • Graveland GA, Williams RS, DiFiglia M. Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease. Science 1985;227:770-773
    • (1985) Science , vol.227 , pp. 770-773
    • Graveland, G.A.1    Williams, R.S.2    DiFiglia, M.3
  • 4
    • 0025239753 scopus 로고
    • Degeneration of pyramidal projection neurons in Huntington's disease cortex
    • Cudkowicz M, Kowall NS. Degeneration of pyramidal projection neurons in Huntington's disease cortex. Ann Neurol 1990;27:200-204
    • (1990) Ann Neurol , vol.27 , pp. 200-204
    • Cudkowicz, M.1    Kowall, N.S.2
  • 5
    • 0023750525 scopus 로고
    • Morphometric demonstration of atrophic changes in the cerebral cortex, white matter, and neostriatum in Huntington's disease
    • De La Monte SM, Vonsattel J-P, Richardson EP Jr. Morphometric demonstration of atrophic changes in the cerebral cortex, white matter, and neostriatum in Huntington's disease. J Neuropathol Exp Neurol 1988;47:516-525
    • (1988) J Neuropathol Exp Neurol , vol.47 , pp. 516-525
    • De La Monte, S.M.1    Vonsattel, J.-P.2    Richardson Jr., E.P.3
  • 6
    • 0025993794 scopus 로고
    • Decreased neuronal and increased oligodendroglial densities in Huntington's disease caudate nucleus
    • Myers RH, Vonsattel JP, Paskevich PA, et al. Decreased neuronal and increased oligodendroglial densities in Huntington's disease caudate nucleus. J Neuropathol Exp Neurol 1991;50:729-742
    • (1991) J Neuropathol Exp Neurol , vol.50 , pp. 729-742
    • Myers, R.H.1    Vonsattel, J.P.2    Paskevich, P.A.3
  • 8
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993;72:971-983
    • (1993) Cell , vol.72 , pp. 971-983
  • 9
    • 0027240431 scopus 로고
    • Trinucleotide repeat length instability and age of onset in Huntington's disease
    • Duyao M, Ambrose C, Myers R, et al. Trinucleotide repeat length instability and age of onset in Huntington's disease. Nat Genet 1993;4:387-392
    • (1993) Nat Genet , vol.4 , pp. 387-392
    • Duyao, M.1    Ambrose, C.2    Myers, R.3
  • 10
    • 0027377151 scopus 로고
    • Correlations between the onset age of Huntington's disease and length of the trinucleotide repeat in IT15
    • Stine OC, Pleasant N, Franz ML, et al. Correlations between the onset age of Huntington's disease and length of the trinucleotide repeat in IT15. Hum Mol Genet 1993;2:1547-1549
    • (1993) Hum Mol Genet , vol.2 , pp. 1547-1549
    • Stine, O.C.1    Pleasant, N.2    Franz, M.L.3
  • 11
    • 0028829596 scopus 로고
    • CAG expansion affects the expression of mutant huntingtin in the Huntington's disease brain
    • Aronin N, Chase K, Young C, et al. CAG expansion affects the expression of mutant huntingtin in the Huntington's disease brain. Neuron 1995;15:1193-1201
    • (1995) Neuron , vol.15 , pp. 1193-1201
    • Aronin, N.1    Chase, K.2    Young, C.3
  • 12
    • 0029022840 scopus 로고
    • Abnormal gene product identified in Huntington's disease lymphocytes and brain
    • Ide K, Nukina H, Masuda N, et al. Abnormal gene product identified in Huntington's disease lymphocytes and brain. Biochem Biophys Res Commun 1995;209:1119-1125
    • (1995) Biochem Biophys Res Commun , vol.209 , pp. 1119-1125
    • Ide, K.1    Nukina, H.2    Masuda, N.3
  • 13
    • 0028972448 scopus 로고
    • Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias
    • Trottier Y, Lutz Y, Stevanin F, et al. Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias. Nature 1995;378:403-406
    • (1995) Nature , vol.378 , pp. 403-406
    • Trottier, Y.1    Lutz, Y.2    Stevanin, F.3
  • 14
    • 0028989602 scopus 로고
    • Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
    • DiFiglia M, Sapp E, Chase K, et al. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 1995;14:1075-1081
    • (1995) Neuron , vol.14 , pp. 1075-1081
    • DiFiglia, M.1    Sapp, E.2    Chase, K.3
  • 15
    • 0029152808 scopus 로고
    • Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies
    • Gutekunst CA, Levey AI, Heilman DJ, et al. Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. Proc Natl Acad Sci USA 1995;92:8710-8714
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8710-8714
    • Gutekunst, C.A.1    Levey, A.I.2    Heilman, D.J.3
  • 16
    • 0029034511 scopus 로고
    • Widespread expression of Huntington's disease gene (IT15) protein product
    • Sharp AH, Loev SJ, Schilling G, et al. Widespread expression of Huntington's disease gene (IT15) protein product. Neuron 1995;14:1065-1074
    • (1995) Neuron , vol.14 , pp. 1065-1074
    • Sharp, A.H.1    Loev, S.J.2    Schilling, G.3
  • 17
    • 1842335293 scopus 로고    scopus 로고
    • Altered neuronal expression and intracellular trafficking of huntingtin in the Huntington's disease brain
    • Abstract
    • Sapp E, Schwarz C, Chase K, et al. Altered neuronal expression and intracellular trafficking of huntingtin in the Huntington's disease brain. Soc Neurosci Abstr 1996;22:226 (Abstract)
    • (1996) Soc Neurosci Abstr , vol.22 , pp. 226
    • Sapp, E.1    Schwarz, C.2    Chase, K.3
  • 18
    • 0028873186 scopus 로고
    • Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis
    • Sapp E, Ge P, Aizawa H, et al. Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis. Neuroscience 1995;64:397-404
    • (1995) Neuroscience , vol.64 , pp. 397-404
    • Sapp, E.1    Ge, P.2    Aizawa, H.3
  • 19
    • 0025293685 scopus 로고
    • Neurotransmitters and neuromodulators in the basal ganglia
    • Graybiel AM. Neurotransmitters and neuromodulators in the basal ganglia. Trends Neurosci 1990;13:245-254
    • (1990) Trends Neurosci , vol.13 , pp. 245-254
    • Graybiel, A.M.1
  • 20
    • 0028947294 scopus 로고
    • Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
    • Cataldo AM, Barnett JL, Berman SA, et al. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron 1995;14:671-680
    • (1995) Neuron , vol.14 , pp. 671-680
    • Cataldo, A.M.1    Barnett, J.L.2    Berman, S.A.3
  • 21
    • 9444286388 scopus 로고    scopus 로고
    • Expression of normal and mutant huntingtin in the developing brain
    • Bhide PJ, Day M, Sapp E, et al. Expression of normal and mutant huntingtin in the developing brain. J Neurosci 1996;16:5523-5535
    • (1996) J Neurosci , vol.16 , pp. 5523-5535
    • Bhide, P.J.1    Day, M.2    Sapp, E.3
  • 22
    • 0023080626 scopus 로고
    • Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease
    • Ferrante RJ, Kowall NW, Beal MF, et al. Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease. J Neuropathol Exp Neurol 1987; 46:12-27
    • (1987) J Neuropathol Exp Neurol , vol.46 , pp. 12-27
    • Ferrante, R.J.1    Kowall, N.W.2    Beal, M.F.3
  • 23
    • 0022343684 scopus 로고
    • Selective sparing of a class of striatal neurons in Huntington's disease
    • Ferrante RJ, Kowall NW, Beal MF, et al. Selective sparing of a class of striatal neurons in Huntington's disease. Science 1985;230:561-563
    • (1985) Science , vol.230 , pp. 561-563
    • Ferrante, R.J.1    Kowall, N.W.2    Beal, M.F.3
  • 24
    • 0028803757 scopus 로고
    • A huntingtin-associated protein enriched in brain with implications for pathology
    • Li X-J, Li S-H, Sharp AH, et al. A huntingtin-associated protein enriched in brain with implications for pathology. Nature 1995;378:398-402
    • (1995) Nature , vol.378 , pp. 398-402
    • Li, X.-J.1    Li, S.-H.2    Sharp, A.H.3
  • 25
    • 0029899868 scopus 로고    scopus 로고
    • Huntingtin-associated protein (HAP1): Discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase
    • Li X-J, Sharp AH, Li SH, et al. Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase. Proc Natl Acad Sci USA 1996;93:4839-4844
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4839-4844
    • Li, X.-J.1    Sharp, A.H.2    Li, S.H.3
  • 26
    • 0028891145 scopus 로고
    • Huntington's disease gene: Regional and cellular expression in brain of normal and affected individuals
    • Landwehrmeyer GB, McNeil SM, Dure LS, et al. Huntington's disease gene: regional and cellular expression in brain of normal and affected individuals. Ann Neurol 1995;37:218-230
    • (1995) Ann Neurol , vol.37 , pp. 218-230
    • Landwehrmeyer, G.B.1    McNeil, S.M.2    Dure, L.S.3
  • 27
    • 0026717486 scopus 로고
    • Preferential loss of striato-external pallidal and striato-nigral projection neurons in presymptomatic Huntington's disease
    • Albin RL, Reiner A, Anderson K, et al. Preferential loss of striato-external pallidal and striato-nigral projection neurons in presymptomatic Huntington's disease. Ann Neurol 1992;31:425-430
    • (1992) Ann Neurol , vol.31 , pp. 425-430
    • Albin, R.L.1    Reiner, A.2    Anderson, K.3
  • 28
    • 0001589776 scopus 로고
    • Differential loss of striatal projection neurons in Huntington disease
    • Reiner A, Albin RL, Anderson KD, et al. Differential loss of striatal projection neurons in Huntington disease. Proc Natl Acad Sci USA 1988;85:5733-5737
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 5733-5737
    • Reiner, A.1    Albin, R.L.2    Anderson, K.D.3
  • 29
    • 0028957560 scopus 로고
    • Reduced expression of preproenkephalin in striatal neurons from Huntington's disease patients
    • Richfield EK, Maguire-Zeiss KA, Cox C, et al. Reduced expression of preproenkephalin in striatal neurons from Huntington's disease patients. Ann Neurol 1995;37:335-343
    • (1995) Ann Neurol , vol.37 , pp. 335-343
    • Richfield, E.K.1    Maguire-Zeiss, K.A.2    Cox, C.3
  • 30
    • 0016282331 scopus 로고
    • The retrograde intraaxonal transport of horseradish peroxidase in the chick visual system: A light and electron microscopic study
    • LaVail JH, LaVail MM. The retrograde intraaxonal transport of horseradish peroxidase in the chick visual system: a light and electron microscopic study. J Comp Neurol 1974;157:303-358
    • (1974) J Comp Neurol , vol.157 , pp. 303-358
    • LaVail, J.H.1    LaVail, M.M.2
  • 31
    • 0025359062 scopus 로고
    • Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body
    • Felder S, Miller K, Moehren G, et al. Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body. Cell 1990;61:623-634
    • (1990) Cell , vol.61 , pp. 623-634
    • Felder, S.1    Miller, K.2    Moehren, G.3
  • 32
    • 0027419879 scopus 로고
    • Products of endocytosis and autophagy are retrieved from axons by regulated retrograde organelle transport
    • Hollenbeck RJ. Products of endocytosis and autophagy are retrieved from axons by regulated retrograde organelle transport. J Cell Biol 1993;121:305-315
    • (1993) J Cell Biol , vol.121 , pp. 305-315
    • Hollenbeck, R.J.1
  • 33
    • 1842336432 scopus 로고    scopus 로고
    • Wild-type and mutant huntingtin localize to the Golgi complex and to vesicles in the peripheral cytoplasm in fibroblasts of control and HD patients
    • Abstract
    • Velier J, Schwarz C, Young C, et al. Wild-type and mutant huntingtin localize to the Golgi complex and to vesicles in the peripheral cytoplasm in fibroblasts of control and HD patients. Soc Neurosci Abstr 1996;22:226 (Abstract)
    • (1996) Soc Neurosci Abstr , vol.22 , pp. 226
    • Velier, J.1    Schwarz, C.2    Young, C.3
  • 34
    • 0028806557 scopus 로고
    • The endosomal-lysosomal system of neurons: New roles
    • Nixon RA, Cataldo AM. The endosomal-lysosomal system of neurons: new roles. Trends Neurosci 1995;18:489-496
    • (1995) Trends Neurosci , vol.18 , pp. 489-496
    • Nixon, R.A.1    Cataldo, A.M.2
  • 35
    • 0027477946 scopus 로고
    • Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
    • Beal MF, Hyman BT, Koroshetz W. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci 1993;16:125-131
    • (1993) Trends Neurosci , vol.16 , pp. 125-131
    • Beal, M.F.1    Hyman, B.T.2    Koroshetz, W.3
  • 36
    • 0025363346 scopus 로고
    • Excitotoxicity model of Huntington's disease
    • DiFiglia M. Excitotoxicity model of Huntington's disease. Trends Neurosci 1990;13:286-289
    • (1990) Trends Neurosci , vol.13 , pp. 286-289
    • DiFiglia, M.1
  • 37
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle JT, Puttfarcken PP. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993;262:689-695
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.P.2
  • 39
    • 0023137252 scopus 로고
    • Ionic dependence of glutamate neurotoxicity
    • Choi D. Ionic dependence of glutamate neurotoxicity. J Neurosci 1987;7:369-379
    • (1987) J Neurosci , vol.7 , pp. 369-379
    • Choi, D.1
  • 40
    • 0028831934 scopus 로고
    • Quinolinic acid-induced increases in calbindin D28k immunoreactivity in rat striatal neurons in vivo and in vitro mimic the pattern seen in Huntington's disease
    • Huang Q, Zhou D, Sapp E, et al. Quinolinic acid-induced increases in calbindin D28k immunoreactivity in rat striatal neurons in vivo and in vitro mimic the pattern seen in Huntington's disease. Neuroscience 1995;65:397-407
    • (1995) Neuroscience , vol.65 , pp. 397-407
    • Huang, Q.1    Zhou, D.2    Sapp, E.3
  • 41
    • 0027942574 scopus 로고
    • Functional and morphological changes induced by transient in vivo ischemia
    • Hori N, Carpenter DO. Functional and morphological changes induced by transient in vivo ischemia. Exp Neurol 1994;129:279-289
    • (1994) Exp Neurol , vol.129 , pp. 279-289
    • Hori, N.1    Carpenter, D.O.2
  • 42
    • 0028087618 scopus 로고
    • Microtubule-associated protein 2 as an early indicator of ischemia-induced neurodegeneration in the gerbil forebrain
    • Matesic DF, Lin RCS. Microtubule-associated protein 2 as an early indicator of ischemia-induced neurodegeneration in the gerbil forebrain. J Neurochem 1994;63:1012-1020
    • (1994) J Neurochem , vol.63 , pp. 1012-1020
    • Matesic, D.F.1    Lin, R.C.S.2
  • 43
    • 0028838282 scopus 로고
    • Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons
    • Bindokas VP, Miller RJ. Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons. J Neurosci 1995;15:6999-7011
    • (1995) J Neurosci , vol.15 , pp. 6999-7011
    • Bindokas, V.P.1    Miller, R.J.2
  • 44
    • 0025885733 scopus 로고
    • Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease
    • Hedreen JC, Peyser CE, Folstein SE, et al. Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease. Neurosci Lett 1991;133:257-261
    • (1991) Neurosci Lett , vol.133 , pp. 257-261
    • Hedreen, J.C.1    Peyser, C.E.2    Folstein, S.E.3
  • 45
    • 1842409148 scopus 로고
    • 3H]AMPA binding in layer VI of frontal cortex in Huntington's disease
    • 3H]AMPA binding in layer VI of frontal cortex in Huntington's disease. Exp Neurol 1994;126:1-6
    • (1994) Exp Neurol , vol.126 , pp. 1-6
    • Wagster, M.V.1    Hedreen, J.C.2    Peyser, C.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.