Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

Nature Medicine

Volumn 17, Issue 3, 2011, Pages 377-383

  Song, Wenjun ^a   Chen, Jin ^a   Petrilli, Alejandra ^a   Liot, Geraldine ^a   Klinglmayr, Eva ^b   Zhou, Yue ^a   Poquiz, Patrick ^c   Tjong, Jonathan ^c   Pouladi, Mahmoud A ^d   Hayden, Michael R ^d   Masliah, Eliezer ^c   Ellisman, Mark ^c   Rouiller, Isabelle ^e   Schwarzenbacher, Robert ^b   Bossy, Blaise ^a   Perkins, Guy ^c   Bossy Wetzel, Ella ^a  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF SALZBURG   (Austria)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMIN RELATED PROTEIN 1; GUANOSINE TRIPHOSPHATASE; HUNTINGTIN; POLYGLUTAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; FIBROBLAST; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HUNTINGTON CHOREA; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRION; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NONHUMAN; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT;

ANIMALS; DISEASE MODELS, ANIMAL; GTP PHOSPHOHYDROLASES; HUMANS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING;

MUS; RATTUS;

EID: 79952443408     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2313     Document Type: Article

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