A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia

Journal of Visualized Experiments

Volumn , Issue 39, 2010, Pages

  Guyenet, Stephan J ^a   Furrer, Stephanie A ^a   Damian, Vincent M ^a   Baughan, Travis D ^a   la Spada, Albert R ^b   Garden, Gwenn A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

Cerebellar ataxia; Issue 39; Jove neuroscience; Mouse behavior assay; Neurodegeneration; Polyglutamine disease

Indexed keywords

EID: 80055101576     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/1787     Document Type: Article

References (3)

1. Chou, A.H., et al., Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation. Neurobiol Dis, 2008. 31(1): p. 89-101.
2. Thomas, P.S., Jr., et al., Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy. Hum Mol Genet, 2006. 15(14): p. 2225-38.
3. Ditzler, S., J. Stoeck, M. LeBlanc, C. Kooperberg, S. Hansen, L. Coppin, J.M. Olson, A Rapid Neurobehavioral Assessment Reveals that FK506 Delays Symptom Onset in R6/2 Huntington's Disease Mice. Preclinica Research Articles, 2003. 1(3): p. 115-126.