Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death

Journal of Biological Chemistry

Volumn 289, Issue 43, 2014, Pages 29994-30004

  Humphrey, Rohan K ^a   Ray, Anamika ^a   Gonuguntla, Sumati ^a   Hao, Ergeng ^a   Jhala, Ulupi S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CHEMICAL ACTIVATION; PHOSPHORYLATION;

DEFENSE MECHANISM; FEEDFORWARD LOOPS; FUNCTIONAL COMPONENTS; JNK ACTIVATION; PANCREATIC BETA CELLS; PROTEASOMAL DEGRADATION; STEADY-STATE LEVEL; UBIQUITINATION;

CELL SIGNALING;

CYTOKINE; INSULIN; LYSINE; MIXED LINEAGE KINASE 3; PEPTIDES AND PROTEINS; PROTEASOME; PROTEIN KINASE B; PROTEIN TRB3; STRESS ACTIVATED PROTEIN KINASE; THREONINE; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11; PHOSPHOTHREONINE; POLYUBIQUITIN; TRB3 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; ENZYME STABILITY; GENE DELETION; INFLAMMATION; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MUTATION; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

ANIMALS; CELL CYCLE PROTEINS; CELL DEATH; CELL LINE, TUMOR; CYTOKINES; ENZYME ACTIVATION; ENZYME STABILITY; HUMANS; INSULIN; INSULIN-SECRETING CELLS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYSINE; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MUTATION; PHOSPHORYLATION; PHOSPHOTHREONINE; POLYUBIQUITIN; PROTO-ONCOGENE PROTEINS C-AKT; UBIQUITINATION;

EID: 84908199075     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.575613     Document Type: Article

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