-
1
-
-
0026342401
-
Crystal-structure of the catalytic subunit of cyclic adenosinemonophosphate dependent protein-kinase
-
Knighton D.R., Zheng J.H., Teneyck L.F., Ashford V.A., Xuong N.H., Taylor S.S., Sowadski J.M. Crystal-structure of the catalytic subunit of cyclic adenosinemonophosphate dependent protein-kinase. Science 1991, 253:407-414.
-
(1991)
Science
, vol.253
, pp. 407-414
-
-
Knighton, D.R.1
Zheng, J.H.2
Teneyck, L.F.3
Ashford, V.A.4
Xuong, N.H.5
Taylor, S.S.6
Sowadski, J.M.7
-
2
-
-
0026326821
-
Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
-
Knighton D.R., Zheng J.H., Ten Eyck L.F., Xuong N.H., Taylor S.S., Sowadski J.M. Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 1991, 253:414-420.
-
(1991)
Science
, vol.253
, pp. 414-420
-
-
Knighton, D.R.1
Zheng, J.H.2
Ten Eyck, L.F.3
Xuong, N.H.4
Taylor, S.S.5
Sowadski, J.M.6
-
3
-
-
0023885305
-
The protein-kinase family-conserved features and deduced phylogeny of the catalytic domains
-
Hanks S.K., Quinn A.M., Hunter T. The protein-kinase family-conserved features and deduced phylogeny of the catalytic domains. Science 1988, 241:42-52.
-
(1988)
Science
, vol.241
, pp. 42-52
-
-
Hanks, S.K.1
Quinn, A.M.2
Hunter, T.3
-
4
-
-
0028773477
-
Three protein-kinase structures define a common motif
-
Taylor S.S., Radzio-Andzelm E. Three protein-kinase structures define a common motif. Structure 1994, 2:345-355.
-
(1994)
Structure
, vol.2
, pp. 345-355
-
-
Taylor, S.S.1
Radzio-Andzelm, E.2
-
5
-
-
0029993727
-
Active and inactive protein kinases: structural basis for regulation
-
Johnson L.N., Noble M.E.M., Owen D.J. Active and inactive protein kinases: structural basis for regulation. Cell 1996, 85:149-158.
-
(1996)
Cell
, vol.85
, pp. 149-158
-
-
Johnson, L.N.1
Noble, M.E.M.2
Owen, D.J.3
-
6
-
-
0037013143
-
The conformational plasticity of protein kinases
-
Huse M., Kuriyan J. The conformational plasticity of protein kinases. Cell 2002, 109(3):275-282.
-
(2002)
Cell
, vol.109
, Issue.3
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
7
-
-
4444353636
-
Regulation of protein kinases; controlling activity through activation segment conformation
-
Nolen B., Taylor S., Ghosh G. Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell 2004, 15:661-675.
-
(2004)
Mol Cell
, vol.15
, pp. 661-675
-
-
Nolen, B.1
Taylor, S.2
Ghosh, G.3
-
8
-
-
41849110846
-
Structural evolution of the protein kinase-like superfamily
-
Scheeff E.D., Bourne P.E. Structural evolution of the protein kinase-like superfamily. PLoS Comp Biol 2005, 1:e49.
-
(2005)
PLoS Comp Biol
, vol.1
-
-
Scheeff, E.D.1
Bourne, P.E.2
-
9
-
-
33947226782
-
Structural and functional diversity of the microbial kinome
-
Kannan N., Taylor S.S., Zhai Y., Venter J.C., Manning G. Structural and functional diversity of the microbial kinome. PLoS Biol 2007, 5:e17.
-
(2007)
PLoS Biol
, vol.5
-
-
Kannan, N.1
Taylor, S.S.2
Zhai, Y.3
Venter, J.C.4
Manning, G.5
-
10
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S. The protein kinase complement of the human genome. Science 2002, 298:1912-1934.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
11
-
-
7244245762
-
Finishing the euchromatic sequence of the human genome
-
International Human Genome Sequencing, Consortium
-
Finishing the euchromatic sequence of the human genome. Nature 2004, 431(7011):931-945. International Human Genome Sequencing, Consortium.
-
(2004)
Nature
, vol.431
, Issue.7011
, pp. 931-945
-
-
-
12
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
Lander E.S., Linton L.M., Birren B., Nusbaum C., Zody M.C., Baldwin J., Devon K., Dewar K., Doyle M., FitzHugh W., et al. Initial sequencing and analysis of the human genome. Nature 2001, 409(6822):860-921.
-
(2001)
Nature
, vol.409
, Issue.6822
, pp. 860-921
-
-
Lander, E.S.1
Linton, L.M.2
Birren, B.3
Nusbaum, C.4
Zody, M.C.5
Baldwin, J.6
Devon, K.7
Dewar, K.8
Doyle, M.9
FitzHugh, W.10
-
13
-
-
33747886526
-
Emerging roles of pseudokinases
-
Boudeau J., Miranda-Saavedra D., Barton G.J., Alessi D.R. Emerging roles of pseudokinases. Trends Cell Biol 2006, 16:443-452.
-
(2006)
Trends Cell Biol
, vol.16
, pp. 443-452
-
-
Boudeau, J.1
Miranda-Saavedra, D.2
Barton, G.J.3
Alessi, D.R.4
-
14
-
-
41949103009
-
Rethinking pseudokinases
-
Kannan N., Taylor S.S. Rethinking pseudokinases. Cell 2008, 133(2):204-205.
-
(2008)
Cell
, vol.133
, Issue.2
, pp. 204-205
-
-
Kannan, N.1
Taylor, S.S.2
-
15
-
-
58149186589
-
Pseudokinases: functional insights gleaned from structure
-
Kornev A.P., Taylor S.S. Pseudokinases: functional insights gleaned from structure. Structure 2009, 17(1):5-7.
-
(2009)
Structure
, vol.17
, Issue.1
, pp. 5-7
-
-
Kornev, A.P.1
Taylor, S.S.2
-
16
-
-
77952557301
-
Allosteric protein kinase regulation by pseudokinases: insights from strad
-
Rajakulendran T., Sicheri F. Allosteric protein kinase regulation by pseudokinases: insights from strad. Sci Signal 2010, 3(111):pe8.
-
(2010)
Sci Signal
, vol.3
, Issue.111
-
-
Rajakulendran, T.1
Sicheri, F.2
-
17
-
-
77952415026
-
Yet another äctive" pseudokinase, erb3
-
Taylor S.S., Kornev A.P. Yet another äctive" pseudokinase, erb3. Proc Natl Acad Sci 2010, 107(18):8047-8048.
-
(2010)
Proc Natl Acad Sci
, vol.107
, Issue.18
, pp. 8047-8048
-
-
Taylor, S.S.1
Kornev, A.P.2
-
18
-
-
56349151939
-
The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway
-
Richardson C., Alessi D.R. The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway. J Cell Sci 2008, 121(Pt 20):3293-3304.
-
(2008)
J Cell Sci
, vol.121
, Issue.PT 20
, pp. 3293-3304
-
-
Richardson, C.1
Alessi, D.R.2
-
19
-
-
3142600709
-
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension
-
Min X., Lee B.-H., Cobb M.H., Goldsmith E.J. Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure 2004, 12(7):1303-1311.
-
(2004)
Structure
, vol.12
, Issue.7
, pp. 1303-1311
-
-
Min, X.1
Lee, B.-H.2
Cobb, M.H.3
Goldsmith, E.J.4
-
20
-
-
41949128173
-
CASK Functions as a Mg2+-independent neurexin kinase
-
Mukherjee S.K., Sharma M., Urlaub H., Bourenkov G.P., Jahn R., Sudhof T.C., Wahl M.C. CASK Functions as a Mg2+-independent neurexin kinase. Cell 2008, 133(2):328-339.
-
(2008)
Cell
, vol.133
, Issue.2
, pp. 328-339
-
-
Mukherjee, S.K.1
Sharma, M.2
Urlaub, H.3
Bourenkov, G.P.4
Jahn, R.5
Sudhof, T.C.6
Wahl, M.C.7
-
21
-
-
44049097129
-
Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2
-
Kawagoe T., Sato S., Matsushita K., Kato H., Matsui K., Kumagai Y., Saitoh T., Kawai T., Takeuchi O., Akira S. Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nat Immunol 2008, 9(6):684-691.
-
(2008)
Nat Immunol
, vol.9
, Issue.6
, pp. 684-691
-
-
Kawagoe, T.1
Sato, S.2
Matsushita, K.3
Kato, H.4
Matsui, K.5
Kumagai, Y.6
Saitoh, T.7
Kawai, T.8
Takeuchi, O.9
Akira, S.10
-
22
-
-
77952338791
-
Erbb3/her3 intracellular domain is competent to bind atp and catalyze autophosphorylation
-
Shi F., Telesco S.E., Liu Y., Radhakrishnan R., Lemmon M.A. Erbb3/her3 intracellular domain is competent to bind atp and catalyze autophosphorylation. Proc Natl Acad Sci 2010, 107(17):7692-7697.
-
(2010)
Proc Natl Acad Sci
, vol.107
, Issue.17
, pp. 7692-7697
-
-
Shi, F.1
Telesco, S.E.2
Liu, Y.3
Radhakrishnan, R.4
Lemmon, M.A.5
-
23
-
-
73949140419
-
Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization
-
Villa F., Capasso P., Tortorici M., Forneris F., de Marco A., Mattevi A., Musacchio A. Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization. Proc Natl Acad Sci USA 2009, 106(48):20204-20209.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.48
, pp. 20204-20209
-
-
Villa, F.1
Capasso, P.2
Tortorici, M.3
Forneris, F.4
de Marco, A.5
Mattevi, A.6
Musacchio, A.7
-
24
-
-
0038614742
-
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase
-
Baas A.F., Boudeau J., Sapkota G.P., Smit L., Morrice N.A., Alessi D.R., Clevers H.C. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase. EMBO J 2003, 22:3062-3072.
-
(2003)
EMBO J
, vol.22
, pp. 3062-3072
-
-
Baas, A.F.1
Boudeau, J.2
Sapkota, G.P.3
Smit, L.4
Morrice, N.A.5
Alessi, D.R.6
Clevers, H.C.7
-
26
-
-
0141753981
-
MO25 isoforms interact with STRADα/β enhancing their ability to bind, activate and localise LKB1
-
Boudeau J., Baas A.F., Deak M., Morrice N.A., Kieloch A., Schutowski M., Prescott A.R., Clevers H.C., Alessi D.R. MO25 isoforms interact with STRADα/β enhancing their ability to bind, activate and localise LKB1. EMBO J 2003, 22:5102-5114.
-
(2003)
EMBO J
, vol.22
, pp. 5102-5114
-
-
Boudeau, J.1
Baas, A.F.2
Deak, M.3
Morrice, N.A.4
Kieloch, A.5
Schutowski, M.6
Prescott, A.R.7
Clevers, H.C.8
Alessi, D.R.9
-
27
-
-
72949115493
-
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
-
Zeqiraj E., Filippi B.M., Deak M., Alessi D.R., van Aalten D.M.F. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science 2009, 326(5960):1707-1711.
-
(2009)
Science
, vol.326
, Issue.5960
, pp. 1707-1711
-
-
Zeqiraj, E.1
Filippi, B.M.2
Deak, M.3
Alessi, D.R.4
van Aalten, D.M.F.5
-
28
-
-
67649950358
-
ATP and MO25α regulate the conformational state of the STRADα pseudokinase and activation of the LKB1 tumour suppressor
-
Zeqiraj E., Filippi B.M., Goldie S., Navratilova I., Boudeau J., Deak M., Alessi D.R., van Aalten D.M.F. ATP and MO25α regulate the conformational state of the STRADα pseudokinase and activation of the LKB1 tumour suppressor. PLoS Biol 2009, 7(6):e1000126.
-
(2009)
PLoS Biol
, vol.7
, Issue.6
-
-
Zeqiraj, E.1
Filippi, B.M.2
Goldie, S.3
Navratilova, I.4
Boudeau, J.5
Deak, M.6
Alessi, D.R.7
van Aalten, D.M.F.8
-
29
-
-
1542269006
-
PKA: a portrait of protein kinase dynamics
-
Taylor S.S., Yang J., Wu J., Haste N.M., Radzio-Andzelm E., Anand G. PKA: a portrait of protein kinase dynamics. Biochim Biophys Acta 2004, 1697(1-2):259-269.
-
(2004)
Biochim Biophys Acta
, vol.1697
, Issue.1-2
, pp. 259-269
-
-
Taylor, S.S.1
Yang, J.2
Wu, J.3
Haste, N.M.4
Radzio-Andzelm, E.5
Anand, G.6
-
30
-
-
0029029617
-
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
-
Jeffrey P.D., Russo A.A., Polyak K., Gibbs E., Hurwitz J., Massagué J., Pavletich N.P. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 1995, 376:313-320.
-
(1995)
Nature
, vol.376
, pp. 313-320
-
-
Jeffrey, P.D.1
Russo, A.A.2
Polyak, K.3
Gibbs, E.4
Hurwitz, J.5
Massagué, J.6
Pavletich, N.P.7
-
31
-
-
25144502820
-
Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR
-
Dar A.C., Dever T.E., Sicheri F. Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell 2005, 122(6):887-900.
-
(2005)
Cell
, vol.122
, Issue.6
, pp. 887-900
-
-
Dar, A.C.1
Dever, T.E.2
Sicheri, F.3
-
32
-
-
13244291292
-
Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA
-
Kim C., Xuong N.-H., Taylor S.S. Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science 2005, 307(5710):690-696.
-
(2005)
Science
, vol.307
, Issue.5710
, pp. 690-696
-
-
Kim, C.1
Xuong, N.-H.2
Taylor, S.S.3
-
33
-
-
57149120091
-
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure
-
Komander D., Garg R., Wan P.T.C., Ridley A.J., Barford D. Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure. EMBO J 2008, 27(23):3175-3185.
-
(2008)
EMBO J
, vol.27
, Issue.23
, pp. 3175-3185
-
-
Komander, D.1
Garg, R.2
Wan, P.T.C.3
Ridley, A.J.4
Barford, D.5
-
34
-
-
33644848599
-
ILK, PINCH and parvin: the tIPP of integrin signalling
-
Legate K.R., Montanez E., Kudlacek O., Fassler R. ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol 2006, 7(1):20-31.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, Issue.1
, pp. 20-31
-
-
Legate, K.R.1
Montanez, E.2
Kudlacek, O.3
Fassler, R.4
-
35
-
-
75049085759
-
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!
-
Wickstrom S.A., Lange A., Montanez E., Fassler R. The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!. EMBO J 2010, 29(2):281-291.
-
(2010)
EMBO J
, vol.29
, Issue.2
, pp. 281-291
-
-
Wickstrom, S.A.1
Lange, A.2
Montanez, E.3
Fassler, R.4
-
36
-
-
71149097258
-
The pseudoactive site of ilk is essential for its binding to α-parvin and localization to focal adhesions
-
Fukuda K., Gupta S., Chen K., Wu C., Qin J. The pseudoactive site of ilk is essential for its binding to α-parvin and localization to focal adhesions. Mol Cell 2009, 36(5):819-830.
-
(2009)
Mol Cell
, vol.36
, Issue.5
, pp. 819-830
-
-
Fukuda, K.1
Gupta, S.2
Chen, K.3
Wu, C.4
Qin, J.5
-
37
-
-
33745002702
-
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
-
Zhang X., Gureasko J., Shen K., Cole P.A., Kuriyan J. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 2006, 125:1137-1149.
-
(2006)
Cell
, vol.125
, pp. 1137-1149
-
-
Zhang, X.1
Gureasko, J.2
Shen, K.3
Cole, P.A.4
Kuriyan, J.5
-
38
-
-
67549145398
-
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment
-
Jura N., Endres N.F., Engel K., Deindl S., Das R., Lamers M.H., Wemmer D.E., Zhang X., Kuriyan J. Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell 2009, 137(7):1293-1307.
-
(2009)
Cell
, vol.137
, Issue.7
, pp. 1293-1307
-
-
Jura, N.1
Endres, N.F.2
Engel, K.3
Deindl, S.4
Das, R.5
Lamers, M.H.6
Wemmer, D.E.7
Zhang, X.8
Kuriyan, J.9
-
39
-
-
76049128717
-
Structural analysis of the catalytically inactive kinase domain of the human egf receptor 3
-
Jura N., Shan Y., Cao X., Shaw D.E., Kuriyan J. Structural analysis of the catalytically inactive kinase domain of the human egf receptor 3. Proc Natl Acad Sci 2009, 106(51):21608-21613.
-
(2009)
Proc Natl Acad Sci
, vol.106
, Issue.51
, pp. 21608-21613
-
-
Jura, N.1
Shan, Y.2
Cao, X.3
Shaw, D.E.4
Kuriyan, J.5
-
40
-
-
58149204174
-
Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site
-
Scheeff E.D., Eswaran J., Bunkoczi G., Knapp S., Manning G. Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. Structure 2009, 17(1):128-138.
-
(2009)
Structure
, vol.17
, Issue.1
, pp. 128-138
-
-
Scheeff, E.D.1
Eswaran, J.2
Bunkoczi, G.3
Knapp, S.4
Manning, G.5
-
41
-
-
33845197964
-
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism
-
Kornev A.P., Haste N.M., Taylor S.S., Eyck L.F.T. Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc Natl Acad Sci USA 2006, 103:17783-17788.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 17783-17788
-
-
Kornev, A.P.1
Haste, N.M.2
Taylor, S.S.3
Eyck, L.F.T.4
-
42
-
-
33746615234
-
Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase
-
Kang T.-H., Kim K.-T. Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase. Nat Cell Biol 2006, 8(8):863-869.
-
(2006)
Nat Cell Biol
, vol.8
, Issue.8
, pp. 863-869
-
-
Kang, T.-H.1
Kim, K.-T.2
-
43
-
-
38049016957
-
VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues
-
Kang T.-H., Kim K.-T. VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues. Biochim Biophys Acta 2008, 1783(1):49-58.
-
(2008)
Biochim Biophys Acta
, vol.1783
, Issue.1
, pp. 49-58
-
-
Kang, T.-H.1
Kim, K.-T.2
-
44
-
-
58149189627
-
ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity
-
Labesse G., Gelin M., Bessin Y., Lebrun M., Papoin J., Cerdan R., Arold S.T., Dubremetz J.-F. ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity. Structure 2009, 17(1):139-146.
-
(2009)
Structure
, vol.17
, Issue.1
, pp. 139-146
-
-
Labesse, G.1
Gelin, M.2
Bessin, Y.3
Lebrun, M.4
Papoin, J.5
Cerdan, R.6
Arold, S.T.7
Dubremetz, J.-F.8
-
45
-
-
65449134710
-
Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii
-
Qiu W., Wernimont A., Tang K., Taylor S., Lunin V., Schapira M., Fentress S., Hui R., Sibley L.D. Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii. EMBO J 2009, 28(7):969-979.
-
(2009)
EMBO J
, vol.28
, Issue.7
, pp. 969-979
-
-
Qiu, W.1
Wernimont, A.2
Tang, K.3
Taylor, S.4
Lunin, V.5
Schapira, M.6
Fentress, S.7
Hui, R.8
Sibley, L.D.9
-
46
-
-
37649004940
-
Structure of the dual enzyme ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing
-
Lee K.P.K., Dey M., Neculai D., Cao C., Dever T.E., Sicheri F. Structure of the dual enzyme ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell 2008, 132:89-100.
-
(2008)
Cell
, vol.132
, pp. 89-100
-
-
Lee, K.P.K.1
Dey, M.2
Neculai, D.3
Cao, C.4
Dever, T.E.5
Sicheri, F.6
-
47
-
-
0036198368
-
Evolution of the membrane guanylate cyclase transduction system
-
Sharma R.K. Evolution of the membrane guanylate cyclase transduction system. Mol Cell Biochem 2002, 230(1-2):3-30.
-
(2002)
Mol Cell Biochem
, vol.230
, Issue.1-2
, pp. 3-30
-
-
Sharma, R.K.1
-
48
-
-
27644591220
-
Atrial natriuretic peptide-dependent photolabeling of a regulatory ATP-binding site on the natriuretic peptide receptor-A
-
Joubert S., Jossart C., McNicoll N., Lean A.D. Atrial natriuretic peptide-dependent photolabeling of a regulatory ATP-binding site on the natriuretic peptide receptor-A. FEBS J 2005, 272(21):5572-5583.
-
(2005)
FEBS J
, vol.272
, Issue.21
, pp. 5572-5583
-
-
Joubert, S.1
Jossart, C.2
McNicoll, N.3
Lean, A.D.4
-
49
-
-
0035822658
-
Functional inactivation of the human guanylyl cyclase C receptor: modeling and mutation of the protein kinase-like domain
-
Bhandari R., Srinivasan N., Mahaboobi M., Ghanekar Y., Suguna K., Visweswariah S.S. Functional inactivation of the human guanylyl cyclase C receptor: modeling and mutation of the protein kinase-like domain. Biochemistry 2001, 40(31):9196-9206.
-
(2001)
Biochemistry
, vol.40
, Issue.31
, pp. 9196-9206
-
-
Bhandari, R.1
Srinivasan, N.2
Mahaboobi, M.3
Ghanekar, Y.4
Suguna, K.5
Visweswariah, S.S.6
-
50
-
-
32344440494
-
The kinase homology domain of receptor guanylyl cyclase C: ATP binding and identification of an adenine nucleotide sensitive site
-
Jaleel M., Saha S., Shenoy A.R., Visweswariah S.S. The kinase homology domain of receptor guanylyl cyclase C: ATP binding and identification of an adenine nucleotide sensitive site. Biochemistry 2006, 45(6):1888-1898.
-
(2006)
Biochemistry
, vol.45
, Issue.6
, pp. 1888-1898
-
-
Jaleel, M.1
Saha, S.2
Shenoy, A.R.3
Visweswariah, S.S.4
-
51
-
-
27644575157
-
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
-
Kolch W. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 2005, 6(11):827-837.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, Issue.11
, pp. 827-837
-
-
Kolch, W.1
-
52
-
-
67650488974
-
Signaling dynamics of the KSR1 scaffold complex
-
McKay M.M., Ritt D.A., Morrison D.K. Signaling dynamics of the KSR1 scaffold complex. Proc Natl Acad Sci USA 2009, 106(27):11022-11027.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.27
, pp. 11022-11027
-
-
McKay, M.M.1
Ritt, D.A.2
Morrison, D.K.3
-
53
-
-
67449164361
-
KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals
-
Dougherty M.K., Ritt D.A., Zhou M., Specht S.I., Monson D.M., Veenstra T.D., Morrison D.K. KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals. Mol Cell 2009, 34(6):652-662.
-
(2009)
Mol Cell
, vol.34
, Issue.6
, pp. 652-662
-
-
Dougherty, M.K.1
Ritt, D.A.2
Zhou, M.3
Specht, S.I.4
Monson, D.M.5
Veenstra, T.D.6
Morrison, D.K.7
-
54
-
-
0035195491
-
The Ste5p scaffold
-
Elion E.A. The Ste5p scaffold. J Cell Sci 2001, 114(Pt 22):3967-3978.
-
(2001)
J Cell Sci
, vol.114
, Issue.PT 22
, pp. 3967-3978
-
-
Elion, E.A.1
-
55
-
-
32444442870
-
The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway
-
Bhattacharyya R.P., Remenyi A., Good M.C., Bashor C.J., Falick A.M., Lim W.A. The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway. Science 2006, 311(5762):822-826.
-
(2006)
Science
, vol.311
, Issue.5762
, pp. 822-826
-
-
Bhattacharyya, R.P.1
Remenyi, A.2
Good, M.C.3
Bashor, C.J.4
Falick, A.M.5
Lim, W.A.6
-
56
-
-
62149128986
-
The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation
-
Good M., Tang G., Singleton J., Remenyi A., Lim W.A. The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell 2009, 136(6):1085-1097.
-
(2009)
Cell
, vol.136
, Issue.6
, pp. 1085-1097
-
-
Good, M.1
Tang, G.2
Singleton, J.3
Remenyi, A.4
Lim, W.A.5
-
57
-
-
0344393408
-
Regulation of MAP kinase signaling modules by scaffold proteins in mammals
-
Morrison D.K., Davis R.J. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol 2003, 19(NIL):91-118.
-
(2003)
Annu Rev Cell Dev Biol
, vol.19
, Issue.NIL
, pp. 91-118
-
-
Morrison, D.K.1
Davis, R.J.2
-
58
-
-
70349438995
-
A dimerization-dependent mechanism drives raf catalytic activation
-
Rajakulendran T., Sahmi M., Lefrançois M., Sicheri F., Therrien M. A dimerization-dependent mechanism drives raf catalytic activation. Nature 2009, 461(7263):542-545.
-
(2009)
Nature
, vol.461
, Issue.7263
, pp. 542-545
-
-
Rajakulendran, T.1
Sahmi, M.2
Lefrançois, M.3
Sicheri, F.4
Therrien, M.5
-
59
-
-
0037033012
-
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
-
Saharinen P., Silvennoinen O. The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem 2002, 277(49):47954-47963.
-
(2002)
J Biol Chem
, vol.277
, Issue.49
, pp. 47954-47963
-
-
Saharinen, P.1
Silvennoinen, O.2
-
60
-
-
0038371050
-
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
-
Saharinen P., Vihinen M., Silvennoinen O. Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain. Mol Biol Cell 2003, 14(4):1448-1459.
-
(2003)
Mol Biol Cell
, vol.14
, Issue.4
, pp. 1448-1459
-
-
Saharinen, P.1
Vihinen, M.2
Silvennoinen, O.3
-
61
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter E.J., Scott L.M., Campbell P.J., East C., Fourouclas N., Swanton S., Vassiliou G.S., Bench A.J., Boyd E.M., Curtin N., et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005, 365(9464):1054-1061.
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
East, C.4
Fourouclas, N.5
Swanton, S.6
Vassiliou, G.S.7
Bench, A.J.8
Boyd, E.M.9
Curtin, N.10
-
62
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C., Ugo V., Couedic J.-P.L., Staerk J., Delhommeau F., Lacout C., Garcon L., Raslova H., Berger R., Bennaceur-Griscelli A., et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005, 434(7037):1144-1148.
-
(2005)
Nature
, vol.434
, Issue.7037
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Couedic, J.-P.L.3
Staerk, J.4
Delhommeau, F.5
Lacout, C.6
Garcon, L.7
Raslova, H.8
Berger, R.9
Bennaceur-Griscelli, A.10
-
63
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
Levine R.L., Wadleigh M., Cools J., Ebert B.L., Wernig G., Huntly B.J.P., Boggon T.J., Wlodarska I., Clark J.J., Moore S., et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 2005, 7(4):387-397.
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
Ebert, B.L.4
Wernig, G.5
Huntly, B.J.P.6
Boggon, T.J.7
Wlodarska, I.8
Clark, J.J.9
Moore, S.10
-
64
-
-
33847393317
-
Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia
-
Malinge S., Ben-Abdelali R., Settegrana C., Radford-Weiss I., Debre M., Beldjord K., Macintyre E.A., Villeval J.-L., Vainchenker W., Berger R., et al. Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia. Blood 2007, 109(5):2202-2204.
-
(2007)
Blood
, vol.109
, Issue.5
, pp. 2202-2204
-
-
Malinge, S.1
Ben-Abdelali, R.2
Settegrana, C.3
Radford-Weiss, I.4
Debre, M.5
Beldjord, K.6
Macintyre, E.A.7
Villeval, J.-L.8
Vainchenker, W.9
Berger, R.10
-
65
-
-
54349086521
-
Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
-
Bercovich D., Ganmore I., Scott L.M., Wainreb G., Birger Y., Elimelech A., Shochat C., Cazzaniga G., Biondi A., Basso G., et al. Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. Lancet 2008, 372(9648):1484-1492.
-
(2008)
Lancet
, vol.372
, Issue.9648
, pp. 1484-1492
-
-
Bercovich, D.1
Ganmore, I.2
Scott, L.M.3
Wainreb, G.4
Birger, Y.5
Elimelech, A.6
Shochat, C.7
Cazzaniga, G.8
Biondi, A.9
Basso, G.10
-
66
-
-
60249086789
-
Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia
-
Kearney L., Castro D.G.D., Yeung J., Procter J., Horsley S.W., Eguchi-Ishimae M., Bateman C.M., Anderson K., Chaplin T., Young B.D., et al. Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia. Blood 2009, 113(3):646-648.
-
(2009)
Blood
, vol.113
, Issue.3
, pp. 646-648
-
-
Kearney, L.1
Castro, D.G.D.2
Yeung, J.3
Procter, J.4
Horsley, S.W.5
Eguchi-Ishimae, M.6
Bateman, C.M.7
Anderson, K.8
Chaplin, T.9
Young, B.D.10
-
67
-
-
58249089943
-
Evolution of protein phosphatases in plants and animals
-
Moorhead G.B.G., Wever V.D., Templeton G., Kerk D. Evolution of protein phosphatases in plants and animals. Biochem J 2009, 417(2):401-409.
-
(2009)
Biochem J
, vol.417
, Issue.2
, pp. 401-409
-
-
Moorhead, G.B.G.1
Wever, V.D.2
Templeton, G.3
Kerk, D.4
-
68
-
-
33750564444
-
TAK1-binding protein 1 is a pseudophosphatase
-
Conner S.H., Kular G., Peggie M., Shepherd S., Schuttelkopf A.W., Cohen P., Aalten D.M.F.V. TAK1-binding protein 1 is a pseudophosphatase. Biochem J 2006, 399(3):427-434.
-
(2006)
Biochem J
, vol.399
, Issue.3
, pp. 427-434
-
-
Conner, S.H.1
Kular, G.2
Peggie, M.3
Shepherd, S.4
Schuttelkopf, A.W.5
Cohen, P.6
Aalten, D.M.F.V.7
-
69
-
-
58249138122
-
Large-scale structural analysis of the classical human protein tyrosine phosphatome
-
Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Muller S., Knapp S. Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell 2009, 136(2):352-363.
-
(2009)
Cell
, vol.136
, Issue.2
, pp. 352-363
-
-
Barr, A.J.1
Ugochukwu, E.2
Lee, W.H.3
King, O.N.F.4
Filippakopoulos, P.5
Alfano, I.6
Savitsky, P.7
Burgess-Brown, N.A.8
Muller, S.9
Knapp, S.10
-
70
-
-
70350324906
-
Pseudophosphatases: grab and hold on
-
Tonks N.K. Pseudophosphatases: grab and hold on. Cell 2009, 139(3):464-465.
-
(2009)
Cell
, vol.139
, Issue.3
, pp. 464-465
-
-
Tonks, N.K.1
-
71
-
-
33750555919
-
Ubiquitin-binding domains
-
Hurley J.H., Lee S., Prag G. Ubiquitin-binding domains. Biochem J 2006, 399(3):361-372.
-
(2006)
Biochem J
, vol.399
, Issue.3
, pp. 361-372
-
-
Hurley, J.H.1
Lee, S.2
Prag, G.3
-
72
-
-
28344456279
-
A genomic and functional inventory of deubiquitinating enzymes
-
Nijman S.M.B., Luna-Vargas M.P.A., Velds A., Brummelkamp T.R., Dirac A.M.G., Sixma T.K., Bernards R. A genomic and functional inventory of deubiquitinating enzymes. Cell 2005, 123(5):773-786.
-
(2005)
Cell
, vol.123
, Issue.5
, pp. 773-786
-
-
Nijman, S.M.B.1
Luna-Vargas, M.P.A.2
Velds, A.3
Brummelkamp, T.R.4
Dirac, A.M.G.5
Sixma, T.K.6
Bernards, R.7
-
73
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan P.T.C., Garnett M.J., Roe S.M., Lee S., Niculescu-Duvaz D., Good V.M., Jones C.M., Marshall C.J., Springer C.J., Barford D., Marais R. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 2004, 116(6):855-867.
-
(2004)
Cell
, vol.116
, Issue.6
, pp. 855-867
-
-
Wan, P.T.C.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
Good, V.M.6
Jones, C.M.7
Marshall, C.J.8
Springer, C.J.9
Barford, D.10
Marais, R.11
|