Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases

Journal of Biological Chemistry

Volumn 285, Issue 5, 2010, Pages 3406-3416

  Humphrey, Rohan K ^a   Yu, Shu Mei ^a   Flores, Luis E ^a   Jhala, Ulupi S ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CELL; C TERMINUS; CELL LINES; DESTABILIZING EFFECT; GLUCOSE LEVEL; GLUCOSE-STIMULATED INSULIN SECRETIONS; METABOLIC LABELING; PANCREATIC BETA CELLS; PROTEIN LEVEL; STEADY-STATE LEVEL;

AMINO ACIDS; BIOCHEMISTRY; CELL CULTURE; GENE EXPRESSION; GROWTH KINETICS; INSULIN; PHOSPHORYLATION; PROTEINS;

GLUCOSE;

GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; PROTEIN KINASE B; SERINE; TRANSCRIPTION FACTOR PDX 1; CYCLOHEXIMIDE; HOMEODOMAIN PROTEIN; INSULIN; INSULIN PROMOTER FACTOR 1; PROTEIN SYNTHESIS INHIBITOR; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; GENE MAPPING; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RAT; STEADY STATE; ANIMAL; C57BL MOUSE; GENE EXPRESSION REGULATION; METABOLISM; PANCREAS ISLET; SPRAGUE DAWLEY RAT;

ANIMALS; CYCLOHEXIMIDE; GENE EXPRESSION REGULATION; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; PROTEIN SYNTHESIS INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; TRANS-ACTIVATORS;

EID: 77449116389     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.006734     Document Type: Article

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